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Chemistry

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Also known as: 946128-88-7, Ro5126766, Ro-5126766, Ch5126766, Ro-5126766 free base, Avutometinib
Molecular Formula
C21H18FN5O5S
Molecular Weight
471.5  g/mol
InChI Key
LMMJFBMMJUMSJS-UHFFFAOYSA-N
FDA UNII
D0D4252V97

Avutometinib
Avutometinib is an orally bioavailable inhibitor of the serine/threonine protein kinases Raf and mitogen-activated protein kinase kinase (MAP2K, MAPK/ERK kinase, or MEK), with potential antineoplastic activity. Upon oral administration, avutometinib specifically targets, binds to and inhibits the kinase activities of Raf and MEK, resulting in the inhibition of Raf/MEK-mediated signal transduction pathways. This results in the inhibition of Raf/MEK-dependent tumor cell proliferation and survival. The RAS/RAF/MEK/extracellular signal-regulated kinase (ERK) signaling pathway is often dysregulated in human cancers and plays a key role in tumor cell proliferation, differentiation and survival.
1 2D Structure

Avutometinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one
2.1.2 InChI
InChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27)
2.1.3 InChI Key
LMMJFBMMJUMSJS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F
2.2 Other Identifiers
2.2.1 UNII
D0D4252V97
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ch5126766

2. Ro5126766

2.3.2 Depositor-Supplied Synonyms

1. 946128-88-7

2. Ro5126766

3. Ro-5126766

4. Ch5126766

5. Ro-5126766 Free Base

6. Avutometinib

7. Ro 5126766

8. Ch-5126766

9. Rg-7304

10. Cki-27

11. Ro5126766(ch5126766)

12. Chebi:78825

13. Ro 5126766 - Bio-x

14. Vs-6766

15. Chembl3264002

16. Ro5126766 (ch5126766)

17. D0d4252v97

18. R-7304

19. N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2h-chromen-3-yl]methyl}pyridin-2-yl)-n'-methylsulfuric Diamide

20. Sulfamide, N-(3-fluoro-4-((4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2h-1-benzopyran-3-yl)methyl)-2-pyridinyl)-n'-methyl-

21. 3wig

22. Chu

23. Avutometinib [inn]

24. Schembl960093

25. Unii-d0d4252v97

26. Gtpl11867

27. Bcp21067

28. Ex-a2151

29. Bdbm50010462

30. Nsc758248

31. Nsc800871

32. S7170

33. Zinc68247388

34. Akos030527032

35. Ccg-269457

36. Compound 1 [pmid: 24900832]

37. Cs-5254

38. Db15254

39. Nsc-758248

40. Nsc-800871

41. Sb16628

42. Ro 5126766 [who-dd]

43. Ac-35949

44. Da-40233

45. Hy-18652

46. Ch 5126766

47. Ft-0737411

48. A916428

49. Ro5126766; Ch5126766

50. Q27147976

51. Ro 5126766; Ro5126766; Ch5126766; Ch5126766; Ch 5126766

52. 3-[(2-((n-methylsulfamoyl)amino)-3-fluoropyridin-4-yl)methyl]-4-methyl-7-(pyrimidin-2-yloxy)-chromen-2-one

53. 3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one

54. N-(3-fluoro-4-((4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2h-chromen-3-yl)methyl)pyridin-2-yl)-n'-methylsulfamide

2.4 Create Date
2007-08-27
3 Chemical and Physical Properties
Molecular Weight 471.5 g/mol
Molecular Formula C21H18FN5O5S
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count11
Rotatable Bond Count7
Exact Mass471.10126803 g/mol
Monoisotopic Mass471.10126803 g/mol
Topological Polar Surface Area141 Ų
Heavy Atom Count33
Formal Charge0
Complexity845
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Avutometinib Manufacturers

A Avutometinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Avutometinib, including repackagers and relabelers. The FDA regulates Avutometinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Avutometinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Avutometinib Suppliers

A Avutometinib supplier is an individual or a company that provides Avutometinib active pharmaceutical ingredient (API) or Avutometinib finished formulations upon request. The Avutometinib suppliers may include Avutometinib API manufacturers, exporters, distributors and traders.

Avutometinib GMP

Avutometinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Avutometinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Avutometinib GMP manufacturer or Avutometinib GMP API supplier for your needs.

Avutometinib CoA

A Avutometinib CoA (Certificate of Analysis) is a formal document that attests to Avutometinib's compliance with Avutometinib specifications and serves as a tool for batch-level quality control.

Avutometinib CoA mostly includes findings from lab analyses of a specific batch. For each Avutometinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Avutometinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Avutometinib EP), Avutometinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Avutometinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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