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Chemistry

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Also known as: Nazasetron, 123040-69-7, Azasetron [inn], 123039-99-6, 77hc7urr9z, N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide
Molecular Formula
C17H20ClN3O3
Molecular Weight
349.8  g/mol
InChI Key
WUKZPHOXUVCQOR-UHFFFAOYSA-N
FDA UNII
77HC7URR9Z

Azasetron
1 2D Structure

Azasetron

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide
2.1.2 InChI
InChI=1S/C17H20ClN3O3/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23)
2.1.3 InChI Key
WUKZPHOXUVCQOR-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4
2.2 Other Identifiers
2.2.1 UNII
77HC7URR9Z
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azasetron, (+-)-isomer

2. N-(1-azabicyclo(2.2.2)oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4 -dihydro-2h-1,4-benzoxazine-8-carboxamide Hydrochloride

3. Y 25130

4. Y-25130

2.3.2 Depositor-Supplied Synonyms

1. Nazasetron

2. 123040-69-7

3. Azasetron [inn]

4. 123039-99-6

5. 77hc7urr9z

6. N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide

7. Azasetron (inn)

8. Ncgc00024563-02

9. Y-25130

10. Dsstox_cid_25651

11. Dsstox_rid_81029

12. Dsstox_gsid_45651

13. 2h-1,4-benzoxazine-8-carboxamide, N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-3,4-dihydro-4-methyl-3-oxo-

14. Cas-123040-69-7

15. Seroton

16. (r)-azasetron

17. 6-chloro-4-methyl-3-oxo-n-(quinuclidin-3-yl)-3,4-dihydro-2h-benzo[b][1,4]oxazine-8-carboxamide

18. Azasetron [mi]

19. Biomol-nt_000105

20. Unii-77hc7urr9z

21. Azasetron [who-dd]

22. Schembl17190

23. Bpbio1_001397

24. Gtpl2285

25. Chembl1598608

26. Dtxsid7045651

27. Schembl13186328

28. Arazasetron, (+/-)-

29. Chebi:91712

30. Tox21 110906

31. Tox21_110906

32. Akos015964402

33. Tox21_110906_1

34. Sb18701

35. (+-)-6-chloro-3,4-dihydro-4-methyl-3-oxo-n-3-quinuclidinyl-2h-1,4-benzoxazine-8-carboxamide

36. (- )-6-chloro-3,4-dihydro-4-methyl-3-oxo-n-3-quinuclidinyl-2h-1,4-benzoxazine-8-carboxamide

37. Ncgc00024563-03

38. Ncgc00024563-04

39. Ncgc00024563-05

40. D07481

41. Ab00640014_08

42. 040a697

43. Q4832285

44. Brd-a44133049-001-01-5

45. Brd-a68360487-003-01-0

46. 6-chloro-3,4-dihydro-4-methyl-3-oxo-n-(3-quinuclidinyl)-2h-1,4-benzoxazine-8-carboxamide

47. 6-chloro-3,4-dihyro-4-methyl-3-oxo-n-(3-quinuclidinyl)-2h-1,4-benzoxazine-8-carboxamide

48. N-(1-azabicyclo[2.2.2]octan-8-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide

49. (+/-)-6-chloro-3,4-dihydro-4-methyl-3-oxo-n-3-quinuclidinyl-2h-1,4-benzoxazine-8-carboxamide

50. N-1-azabicyclo[2.2.2]oct-3-yl-6-chloro-4-methyl-3-oxo-3,4-dihydro-2h-1,4-benzoxazine-8-carboxamide

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 349.8 g/mol
Molecular Formula C17H20ClN3O3
XLogP31.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass349.1193192 g/mol
Monoisotopic Mass349.1193192 g/mol
Topological Polar Surface Area61.9 Ų
Heavy Atom Count24
Formal Charge0
Complexity523
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


Serotonin Antagonists

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS. (See all compounds classified as Serotonin Antagonists.)


ABOUT THIS PAGE

Azasetron Manufacturers

A Azasetron manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Azasetron, including repackagers and relabelers. The FDA regulates Azasetron manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Azasetron API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Azasetron manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Azasetron Suppliers

A Azasetron supplier is an individual or a company that provides Azasetron active pharmaceutical ingredient (API) or Azasetron finished formulations upon request. The Azasetron suppliers may include Azasetron API manufacturers, exporters, distributors and traders.

click here to find a list of Azasetron suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Azasetron GMP

Azasetron Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Azasetron GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Azasetron GMP manufacturer or Azasetron GMP API supplier for your needs.

Azasetron CoA

A Azasetron CoA (Certificate of Analysis) is a formal document that attests to Azasetron's compliance with Azasetron specifications and serves as a tool for batch-level quality control.

Azasetron CoA mostly includes findings from lab analyses of a specific batch. For each Azasetron CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Azasetron may be tested according to a variety of international standards, such as European Pharmacopoeia (Azasetron EP), Azasetron JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Azasetron USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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