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Chemistry

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Also known as: Azd4547, 1035270-39-3, Azd 4547, N-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3s,5r)-3,5-dimethylpiperazin-1-yl)benzamide, 2167og1ekj, Chebi:63453
Molecular Formula
C26H33N5O3
Molecular Weight
463.6  g/mol
InChI Key
VRQMAABPASPXMW-HDICACEKSA-N
FDA UNII
2167OG1EKJ

AZD4547
FGFR Inhibitor AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.
1 2D Structure

AZD4547

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3S,5R)-3,5-dimethylpiperazin-1-yl]benzamide
2.1.2 InChI
InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
2.1.3 InChI Key
VRQMAABPASPXMW-HDICACEKSA-N
2.1.4 Canonical SMILES
CC1CN(CC(N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@@H](N1)C)C2=CC=C(C=C2)C(=O)NC3=NNC(=C3)CCC4=CC(=CC(=C4)OC)OC
2.2 Other Identifiers
2.2.1 UNII
2167OG1EKJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azd4547

2. N-(5-(2-(3,5-dimethoxyphenyl)ethyl)-2h-pyrazol-3-yl)-4-(3,5-diemthylpiperazin-1-yl)benzamide

2.3.2 Depositor-Supplied Synonyms

1. Azd4547

2. 1035270-39-3

3. Azd 4547

4. N-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3s,5r)-3,5-dimethylpiperazin-1-yl)benzamide

5. 2167og1ekj

6. Chebi:63453

7. Rel-n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethyl-1-piperazinyl]benzamide

8. Kb-74810

9. N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide

10. N-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide

11. N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-4-(cis-3,5-dimethylpiperazin-1-yl)benzamide

12. N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide

13. Unii-2167og1ekj

14. 66t

15. Schembl63884

16. Absk091

17. N-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3r,5s)-rel-3,5-dimethylpiperazin-1-yl)benzamide

18. Absk-091

19. Gtpl7707

20. Schembl15250892

21. Dtxsid80145887

22. Azd 4547 [who-dd]

23. Amy16612

24. Ex-a1578

25. Mfcd22580423

26. Nsc764239

27. Nsc765338

28. Nsc799346

29. S2801

30. Zinc95616598

31. Akos024464898

32. Bcp9000364

33. Ccg-269382

34. Cs-0971

35. Db12247

36. Nsc-764239

37. Nsc-765338

38. Nsc-799346

39. Ncgc00346713-01

40. Ncgc00346713-05

41. Ac-28442

42. As-17054

43. Hy-13330

44. Rel-n-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3r,5s)-3,5-dimethylpiperazin-1-yl)benzamide

45. Sw219341-1

46. J-000994

47. J-524217

48. Q27074746

49. Benzamide, N-(5-(2-(3,5-dimethoxyphenyl)ethyl)-1h-pyrazol-3-yl)-4-((3r,5s)-3,5-dimethyl-1-piperazinyl)-, Rel-

50. N-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3r,5s)-3,5-dimethylpiperazin-1-yl)benzamide, Rel-

51. N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-[(3s,5r)-3,5-dimethylpiperazin-1-yl]benzamide

52. N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin -1-yl]benzamide

53. N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide

2.4 Create Date
2011-04-25
3 Chemical and Physical Properties
Molecular Weight 463.6 g/mol
Molecular Formula C26H33N5O3
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass463.25833993 g/mol
Monoisotopic Mass463.25833993 g/mol
Topological Polar Surface Area91.5 Ų
Heavy Atom Count34
Formal Charge0
Complexity622
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1035270-39-3 / AZD4547 API manufacturers, exporters & distributors?

AZD4547 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of AZD4547 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right AZD4547 manufacturer or AZD4547 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred AZD4547 manufacturer or AZD4547 supplier.

PharmaCompass also assists you with knowing the AZD4547 API Price utilized in the formulation of products. AZD4547 API Price is not always fixed or binding as the AZD4547 Price is obtained through a variety of data sources. The AZD4547 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

AZD4547

Synonyms

1035270-39-3, Azd 4547, N-(5-(3,5-dimethoxyphenethyl)-1h-pyrazol-3-yl)-4-((3s,5r)-3,5-dimethylpiperazin-1-yl)benzamide, 2167og1ekj, Chebi:63453, Rel-n-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl]-4-[(3r,5s)-3,5-dimethyl-1-piperazinyl]benzamide

Cas Number

1035270-39-3

Unique Ingredient Identifier (UNII)

2167OG1EKJ

About AZD4547

FGFR Inhibitor AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation, differentiation and survival.

AZD4547 Manufacturers

A AZD4547 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AZD4547, including repackagers and relabelers. The FDA regulates AZD4547 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AZD4547 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

AZD4547 Suppliers

A AZD4547 supplier is an individual or a company that provides AZD4547 active pharmaceutical ingredient (API) or AZD4547 finished formulations upon request. The AZD4547 suppliers may include AZD4547 API manufacturers, exporters, distributors and traders.

AZD4547 GMP

AZD4547 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AZD4547 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AZD4547 GMP manufacturer or AZD4547 GMP API supplier for your needs.

AZD4547 CoA

A AZD4547 CoA (Certificate of Analysis) is a formal document that attests to AZD4547's compliance with AZD4547 specifications and serves as a tool for batch-level quality control.

AZD4547 CoA mostly includes findings from lab analyses of a specific batch. For each AZD4547 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AZD4547 may be tested according to a variety of international standards, such as European Pharmacopoeia (AZD4547 EP), AZD4547 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AZD4547 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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