Find AZD4635 manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Azd4635, 1321514-06-0, Imaradenant, Azd-4635, Htl-1071, Htl1071
Molecular Formula
C15H11ClFN5
Molecular Weight
315.73  g/mol
InChI Key
NCWQLHHDGDXIJN-UHFFFAOYSA-N
FDA UNII
770140J08A

AZD4635
Imaradenant is an orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, imaradenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.
1 2D Structure

AZD4635

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine
2.1.2 InChI
InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22)
2.1.3 InChI Key
NCWQLHHDGDXIJN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=CC(=N1)Cl)C2=C(N=C(N=N2)N)C3=CC=C(C=C3)F
2.2 Other Identifiers
2.2.1 UNII
770140J08A
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Azd4635

2. 1321514-06-0

3. Imaradenant

4. Azd-4635

5. Htl-1071

6. Htl1071

7. Imaradenant [inn]

8. Azd 4635

9. 770140j08a

10. 1,2,4-triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-

11. 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

12. Imaradenant [who-dd]

13. Schembl2320714

14. Chembl4594442

15. Gtpl11153

16. Azd 4635 [who-dd]

17. Bdbm493757

18. Unii-770140j08a

19. Amy16806

20. Bcp25990

21. Ex-a1681

22. Nsc802101

23. Us10988455, Example 1(xcv)

24. Akos037515559

25. Azd4635 (htl1071)

26. Nsc-802101

27. Ac-30333

28. Bs-15183

29. Hy-101980

30. Cs-0022379

31. S8720

32. A16820

33. C72299

34. A902721

35. 5-(4-fluorophenyl)-6-(2-chloro-6-methyl-pyridin-4-yl)-1,2,4-triazin-3-amine

36. F9q

2.4 Create Date
2015-02-02
3 Chemical and Physical Properties
Molecular Weight 315.73 g/mol
Molecular Formula C15H11ClFN5
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass315.0687012 g/mol
Monoisotopic Mass315.0687012 g/mol
Topological Polar Surface Area77.6 Ų
Heavy Atom Count22
Formal Charge0
Complexity366
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1321514-06-0 / AZD4635 API manufacturers, exporters & distributors?

AZD4635 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of AZD4635 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right AZD4635 manufacturer or AZD4635 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred AZD4635 manufacturer or AZD4635 supplier.

PharmaCompass also assists you with knowing the AZD4635 API Price utilized in the formulation of products. AZD4635 API Price is not always fixed or binding as the AZD4635 Price is obtained through a variety of data sources. The AZD4635 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

AZD4635

Synonyms

1321514-06-0, Imaradenant, Azd-4635, Htl-1071, Htl1071, Imaradenant [inn]

Cas Number

1321514-06-0

Unique Ingredient Identifier (UNII)

770140J08A

About AZD4635

Imaradenant is an orally bioavailable antagonist of the adenosine A2A receptor (A2AR; ADORA2A), with potential immunomodulating and antineoplastic activities. Upon administration, imaradenant selectively binds to and inhibits A2AR expressed on T-lymphocytes. This blocks tumor-released adenosine from interacting with A2AR and prevents the adenosine/A2AR-mediated inhibition of T-lymphocytes. This results in the proliferation and activation of T-lymphocytes, and stimulates a T-cell-mediated immune response against tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits T-cell proliferation and activation. Adenosine is often overproduced by cancer cells and plays a key role in immunosuppression.

AZD4635 Manufacturers

A AZD4635 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of AZD4635, including repackagers and relabelers. The FDA regulates AZD4635 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. AZD4635 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

AZD4635 Suppliers

A AZD4635 supplier is an individual or a company that provides AZD4635 active pharmaceutical ingredient (API) or AZD4635 finished formulations upon request. The AZD4635 suppliers may include AZD4635 API manufacturers, exporters, distributors and traders.

AZD4635 GMP

AZD4635 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of AZD4635 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right AZD4635 GMP manufacturer or AZD4635 GMP API supplier for your needs.

AZD4635 CoA

A AZD4635 CoA (Certificate of Analysis) is a formal document that attests to AZD4635's compliance with AZD4635 specifications and serves as a tool for batch-level quality control.

AZD4635 CoA mostly includes findings from lab analyses of a specific batch. For each AZD4635 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

AZD4635 may be tested according to a variety of international standards, such as European Pharmacopoeia (AZD4635 EP), AZD4635 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (AZD4635 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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