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Chemistry

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Also known as: 117772-70-0, Vinzam, Toraseptol, Azithromycin (hydrate), Azitro, 5fd1131i7s
Molecular Formula
C38H76N2O14
Molecular Weight
785.0  g/mol
InChI Key
SRMPHJKQVUDLQE-KUJJYQHYSA-N
FDA UNII
5FD1131I7S

Azithromycin Dihydrate
A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
1 2D Structure

Azithromycin Dihydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;dihydrate
2.1.2 InChI
InChI=1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1../s1
2.1.3 InChI Key
SRMPHJKQVUDLQE-KUJJYQHYSA-N
2.1.4 Canonical SMILES
CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
2.1.5 Isomeric SMILES
CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
2.2 Other Identifiers
2.2.1 UNII
5FD1131I7S
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azadose

2. Azithromycin

3. Azithromycin Monohydrate

4. Azitrocin

5. Azythromycin

6. Cp 62993

7. Cp-62993

8. Cp62993

9. Dihydrate, Azithromycin

10. Goxal

11. Monohydrate, Azithromycin

12. Sumamed

13. Toraseptol

14. Ultreon

15. Vinzam

16. Zentavion

17. Zithromax

18. Zitromax

2.3.2 Depositor-Supplied Synonyms

1. 117772-70-0

2. Vinzam

3. Toraseptol

4. Azithromycin (hydrate)

5. Azitro

6. 5fd1131i7s

7. 117772-70-0 (dihydrate)

8. Azithromycin Hydrate

9. Azitromax

10. Misultina

11. Tromix

12. Azadose

13. Ribotrex

14. Ultreon

15. Zenstavion

16. Azatek

17. Goxal

18. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one Dihydrate

19. Azithromycin (as Dihydrate)

20. Odaz

21. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranoside Dihydrate

22. Aciphar

23. Acitrocin

24. Azidromic

25. Azitral

26. Azitrix

27. Azitrom

28. Azitrox

29. Azitroxil

30. Azimix

31. Unii-5fd1131i7s

32. Azitrona Klonal

33. 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A Dihydrate

34. Azithromycin [mart.]

35. Schembl134723

36. Chebi:34546

37. Dtxsid80922539

38. Azithromycin Dihydrate 100 Microg/ml In Acetonitrile

39. Azithromycin Hydrate [jan]

40. Azithromycin Dihydrate [mi]

41. Ac-093

42. Hy-17506a

43. Azithromycin Dihydrate [vandf]

44. Akos015896370

45. Azithromycin Dihydrate [who-dd]

46. Azithromycin Dihydrate, >=98% (hplc)

47. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-13-((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one Dihydrate

48. 1-oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-d-xylo-hexopyranosyl)oxy)-, Dihydrate, (2r-(2r*,3s*,4r*,5r*,8r*,10r*,11r*,12s*,13s*,14r*))-

49. Azithromycin Dihydrate [orange Book]

50. Azithromycin Dihydrate [ep Monograph]

51. Azithromycin Dihydrate [usp Monograph]

52. 772a700

53. N-methyl-11-aza-10-deoxo-10-dihydro Erythromycin A

54. Q27116139

55. Azithromycin, United States Pharmacopeia (usp) Reference Standard

56. N-methyl-11-aza-10-deoxo-10-dihydroerythromycin A Dihydrate

57. Azithromycin, Pharmaceutical Secondary Standard; Certified Reference Material

58. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-onedihydrate

59. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-o

60. (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;dihydrate

61. 1-oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-c-methyl-3-o-methyl-?-l-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-?-d-xylo-hexopyranosyl]oxy]-, Dihydrate, (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 785.0 g/mol
Molecular Formula C38H76N2O14
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count16
Rotatable Bond Count7
Exact Mass784.52965510 g/mol
Monoisotopic Mass784.52965510 g/mol
Topological Polar Surface Area182 Ų
Heavy Atom Count54
Formal Charge0
Complexity1150
Isotope Atom Count0
Defined Atom Stereocenter Count18
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


4.2 FDA Pharmacological Classification
4.2.1 Pharmacological Classes
Macrolides [CS]; Macrolide Antimicrobial [EPC]

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Certificate Number : R1-CEP 2008-315 - Rev 04

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Substance Number : 1649

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Certificate Number : R1-CEP 2007-206 - Rev 03

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Certificate Number : R1-CEP 2007-230 - Rev 04

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Certificate Number : R0-CEP 2021-114 - Rev 00

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Issue Date : 2023-07-31

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Certificate Number : R1-CEP 2007-119 - Rev 06

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Issue Date : 2022-09-29

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Certificate Number : R1-CEP 2012-212 - Rev 00

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06-Jan-2021
29-Oct-2024
KGS
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