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Chemistry

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Also known as: Azd1152, 722543-31-9, Azd-1152, Barasertib [inn], Azd 1152, 957881-03-7
Molecular Formula
C26H31FN7O6P
Molecular Weight
587.5  g/mol
InChI Key
GBJVVSCPOBPEIT-UHFFFAOYSA-N
FDA UNII
16XC2U7W8N

Barasertib
Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types.
1 2D Structure

Barasertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1H-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl dihydrogen phosphate
2.1.2 InChI
InChI=1S/C26H31FN7O6P/c1-2-34(10-12-40-41(36,37)38)9-4-11-39-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(35)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17H,2,4,9-12,15H2,1H3,(H,30,35)(H2,36,37,38)(H2,28,29,31,32,33)
2.1.3 InChI Key
GBJVVSCPOBPEIT-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCOP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
16XC2U7W8N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1h-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)(ethyl)amino)ethyl Dihydrogen Phosphate

2. Azd 1152

3. Azd-1152

4. Azd1152

2.3.2 Depositor-Supplied Synonyms

1. Azd1152

2. 722543-31-9

3. Azd-1152

4. Barasertib [inn]

5. Azd 1152

6. 957881-03-7

7. Barasertib (who-dd)

8. 2-(ethyl(3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1h-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl Dihydrogen Phosphate

9. 16xc2u7w8n

10. Chembl415049

11. Barasertib [who-dd]

12. 2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoethyl)-1h-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)amino)ethyl Dihydrogen Phosphate

13. 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-n-(3-fluorophenyl)-1h-pyrazole-3-acetamide

14. 2-(ethyl(3-((4-((3-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1h-pyrazol-5-yl)amino)quinazolin-7-yl)oxy)propyl)amino)ethyl Dihydrogen Phosphate

15. 2-[ethyl-[3-[4-[[5-[2-(3-fluoroanilino)-2-oxoethyl]-1h-pyrazol-3-yl]amino]quinazolin-7-yl]oxypropyl]amino]ethyl Dihydrogen Phosphate

16. Azd1152 (barasertib)

17. Barasertibum

18. Unii-16xc2u7w8n

19. 2-{ethyl[3-({4-[(5-(2-[(3-fluorophenyl)amino]-2-oxoethyl}-1h-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl Dihydrogen Phosphate

20. Kinome_3324

21. 2-naphthylacrylate

22. Schembl613582

23. Gtpl7332

24. Schembl16671950

25. Dtxsid00222583

26. Chebi:167636

27. Bcpp000362

28. Hms3674c21

29. Hms3747e05

30. Bcp01734

31. Bcp13793

32. Cs-d0326

33. Ex-a3656

34. Azd1152-hqpa Dihydrogen Phosphate

35. Bdbm50241089

36. Nsc799355

37. Zinc43129461

38. Bcp9000360

39. Cs-0978

40. Cs-w000582

41. Db11747

42. Nsc-799355

43. Sb16659

44. Azd1152, 33

45. Ncgc00378734-03

46. Ac-35703

47. As-17018

48. Hy-10127

49. Db-074538

50. A9414

51. Ft-0662378

52. Ft-0736007

53. A15011

54. 543e319

55. 881a037

56. Q27074865

57. 1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2- (phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-

58. 1h-pyrazole-3-acetamide, 5-((7-(3-(ethyl(2-(phosphonooxy)ethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-

59. 1h-pyrazole-3-acetamide,5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-n-(3-fluorophenyl)-

60. 2-[ethyl(3-{[4-({5-[2-(3-fluoroanilino)-2-oxoethyl]-1h-pyrazol-3-yl}amino)quinazolin-7-yl]oxy}propyl)amino]ethyl Dihydrogen Phosphate

61. 2-ethyl3-4-5-2-3-fluorophenylamino)-2-oxoethyl)-1h-pyrazol-3-ylamino)quinazolin-7-yloxy)propyl)amino)ethyl Dihydrogen Phosphate

62. N-(3-fluorophenyl)-3-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propyloxy]quinazoline-4-yl]amino]-1h-pyrazole-5-acetamide

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 587.5 g/mol
Molecular Formula C26H31FN7O6P
XLogP3-0.4
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count15
Exact Mass587.20574689 g/mol
Monoisotopic Mass587.20574689 g/mol
Topological Polar Surface Area175 Ų
Heavy Atom Count41
Formal Charge0
Complexity859
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 722543-31-9 / Barasertib API manufacturers, exporters & distributors?

Barasertib manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Barasertib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Barasertib manufacturer or Barasertib supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Barasertib manufacturer or Barasertib supplier.

PharmaCompass also assists you with knowing the Barasertib API Price utilized in the formulation of products. Barasertib API Price is not always fixed or binding as the Barasertib Price is obtained through a variety of data sources. The Barasertib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Barasertib

Synonyms

Azd1152, 722543-31-9, Azd-1152, Barasertib [inn], Azd 1152, 957881-03-7

Cas Number

722543-31-9

Unique Ingredient Identifier (UNII)

16XC2U7W8N

About Barasertib

Barasertib is an orally bioavailable, small-molecule, dihydrogen phosphate prodrug of the pyrazoloquinazoline Aurora kinase inhibitor AZD1152-hydroxyquinazoline pyrazol anilide (AZD1152-HQPA) with potential antineoplastic activity. Upon administration and rapid conversion from the prodrug form in plasma, AZD1152-HQPA specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis. Consequently, cell division and cell proliferation are inhibited and apoptosis is induced in Aurora kinase B-overexpressing tumor cells. Aurora kinase B, a serine/threonine protein kinase that functions in the attachment of the mitotic spindle to the centromere, is overexpressed in a wide variety of cancer cell types.

Barasertib Manufacturers

A Barasertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Barasertib, including repackagers and relabelers. The FDA regulates Barasertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Barasertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Barasertib Suppliers

A Barasertib supplier is an individual or a company that provides Barasertib active pharmaceutical ingredient (API) or Barasertib finished formulations upon request. The Barasertib suppliers may include Barasertib API manufacturers, exporters, distributors and traders.

Barasertib GMP

Barasertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Barasertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Barasertib GMP manufacturer or Barasertib GMP API supplier for your needs.

Barasertib CoA

A Barasertib CoA (Certificate of Analysis) is a formal document that attests to Barasertib's compliance with Barasertib specifications and serves as a tool for batch-level quality control.

Barasertib CoA mostly includes findings from lab analyses of a specific batch. For each Barasertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Barasertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Barasertib EP), Barasertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Barasertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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