Find Belotecan manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

NDC API

NDC API

0

VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Camtobell, 256411-32-2, Belotecan [inn], Belotecan free base, Ckd 602, 27z82m2g1n
Molecular Formula
C25H27N3O4
Molecular Weight
433.5  g/mol
InChI Key
LNHWXBUNXOXMRL-VWLOTQADSA-N
FDA UNII
27Z82M2G1N

Belotecan
Belotecan has been investigated for the treatment of Epithelial Ovarian Cancer.
1 2D Structure

Belotecan

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(19S)-19-ethyl-19-hydroxy-10-[2-(propan-2-ylamino)ethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
2.1.2 InChI
InChI=1S/C25H27N3O4/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3/t25-/m0/s1
2.1.3 InChI Key
LNHWXBUNXOXMRL-VWLOTQADSA-N
2.1.4 Canonical SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O
2.1.5 Isomeric SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O
2.2 Other Identifiers
2.2.1 UNII
27Z82M2G1N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 7-(2-(n-isopropylamino)ethyl)camptothecin

2. Belotecan Hydrochloride

3. Ckd 602

4. Ckd-602

5. Ckd602

2.3.2 Depositor-Supplied Synonyms

1. Camtobell

2. 256411-32-2

3. Belotecan [inn]

4. Belotecan Free Base

5. Ckd 602

6. 27z82m2g1n

7. 256411-32-2 (free Base)

8. (4s)-4-ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1,12-dihydro-14h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h)-dione

9. Ckd602

10. (s)-4-ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-3,4,12,14-tetrahydro-1h-pyrano[3',4'

11. (s)-4-ethyl-4-hydroxy-11-(2-(isopropylamino)ethyl)-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

12. Unii-27z82m2g1n

13. Belotecan [mi]

14. Belotecan [mart.]

15. Belotecan [who-dd]

16. Schembl18983

17. Chembl2111084

18. Dtxsid60180332

19. Chebi:135702

20. Bcp08118

21. Ex-a5717

22. Zinc3826691

23. Db12459

24. Hy-13566

25. Cs-0007189

26. 411c322

27. Q4884574

28. (19s)-19-ethyl-19-hydroxy-10-[2-(propan-2-ylamino)ethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

29. (4s)-11-[2-(isopropylamino)ethyl]-4-hydroxy-4-ethyl-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

30. (4s)-4-ethyl-4-hydroxy-11-(2-((1-methylethyl)amino)ethyl)-1,12-dihydro-14h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h)-dione

31. 1h-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4h,12h)-dione, 4-ethyl-4-hydroxy-11-(2-((1-methylethyl)amino)ethyl)-, (4s)-

2.4 Create Date
2006-04-29
3 Chemical and Physical Properties
Molecular Weight 433.5 g/mol
Molecular Formula C25H27N3O4
XLogP31.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass433.20015635 g/mol
Monoisotopic Mass433.20015635 g/mol
Topological Polar Surface Area91.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity865
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Topoisomerase I Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE I. (See all compounds classified as Topoisomerase I Inhibitors.)


4.2 ATC Code

L - Antineoplastic and immunomodulating agents

L01 - Antineoplastic agents

L01C - Plant alkaloids and other natural products

L01CE - Topoisomerase 1 (top1) inhibitors

L01CE04 - Belotecan


ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty