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Chemistry

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Also known as: Bendrofluazide, 73-48-3, Naturetin, Aprinox, Benzhydroflumethiazide, Benzylrodiuran
Molecular Formula
C15H14F3N3O4S2
Molecular Weight
421.4  g/mol
InChI Key
HDWIHXWEUNVBIY-UHFFFAOYSA-N
FDA UNII
5Q52X6ICJI

Bendroflumethiazide
A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)
Bendroflumethiazide is a Thiazide Diuretic. The physiologic effect of bendroflumethiazide is by means of Increased Diuresis.
1 2D Structure

Bendroflumethiazide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-16,2,4-benzothiadiazine-7-sulfonamide
2.1.2 InChI
InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23)
2.1.3 InChI Key
HDWIHXWEUNVBIY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)CC2NC3=C(C=C(C(=C3)C(F)(F)F)S(=O)(=O)N)S(=O)(=O)N2
2.2 Other Identifiers
2.2.1 UNII
5Q52X6ICJI
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Aprinox

2. Bendrofluazide

3. Benzide

4. Benzide M

5. Benzide-m

6. Berkozide

7. Centyl

8. Esberizid

9. Naturetin

10. Naturine

11. Neo Naclex

12. Neo-naclex

13. Pluryl

14. Urizid

2.3.2 Depositor-Supplied Synonyms

1. Bendrofluazide

2. 73-48-3

3. Naturetin

4. Aprinox

5. Benzhydroflumethiazide

6. Benzylrodiuran

7. Berkozide

8. Centyl

9. Pluryl

10. Neo-naclex

11. Bentride

12. Bristuric

13. Bristuron

14. Flumesil

15. Niagaril

16. Plusuril

17. Poliuron

18. Sinesalin

19. Sodiuretic

20. Thiazidico

21. Benuron

22. Intolex

23. Livesan

24. Nikion

25. Orsile

26. Pluryle

27. Repicin

28. Salural

29. Salures

30. Urlea

31. Benzylhydroflumethiazide

32. Neo-rontyl

33. Relan Beta

34. Bhft

35. Rauzide

36. Benzydroflumethiazide

37. Bendrofumethiazide

38. Rautrax N

39. Bendroflumethiazidum

40. Bendroflumethazide

41. Bendroflumetiazida

42. Bendroflumethiazidum [inn-latin]

43. Bendroflumetiazida [inn-spanish]

44. Be 724-a

45. Bl H368

46. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide

47. Nsc-758229

48. 5q52x6icji

49. 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

50. 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

51. Mls000028558

52. Chebi:3013

53. Naturetin-2.5

54. Naturine

55. Flumersil

56. Naigaril

57. Nateretin

58. Smr000058802

59. Bendroflumethiazide-d5

60. Benzy-rodiuran

61. Dsstox_cid_2647

62. Bendroflumetiazide

63. Naturetin-5

64. Naturetin-10

65. 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

66. Dsstox_rid_76673

67. Dsstox_gsid_22647

68. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1lambda6,2,4-benzothiadiazine-7-sulfonamide

69. Bendroflumetiazide [dcit]

70. Ft 81

71. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4- Benzothiadiazine-7-sulfonamide

72. Naturetin (tn)

73. Hsdb 3293

74. Sr-01000000103

75. Einecs 200-800-1

76. Bendroflumethiazide [inn]

77. Unii-5q52x6icji

78. Brn 0373316

79. Neonaclex

80. Cas-73-48-3

81. Relan .beta.

82. Ncgc00016312-01

83. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1?^{6},2,4-benzothiadiazine-7-sulfonamide

84. Bendroflumethiazide (jan/usp/inn)

85. Prestwick_992

86. Behenic Fatty Acids

87. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide

88. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide

89. Bendroflumethiazide [usp:inn:ban:jan]

90. Spectrum_001386

91. Opera_id_1043

92. Prestwick0_000784

93. Prestwick1_000784

94. Prestwick2_000784

95. Prestwick3_000784

96. Spectrum2_001524

97. Spectrum3_001558

98. Spectrum4_000774

99. Spectrum5_001016

100. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

101. Chembl1684

102. Schembl26016

103. Bspbio_000888

104. Bspbio_003036

105. Kbiogr_001188

106. Kbioss_001866

107. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide

108. 4-27-00-08041 (beilstein Handbook Reference)

109. Mls001076062

110. Mls002548857

111. Divk1c_000274

112. Spectrum1503104

113. Spbio_001308

114. Spbio_002827

115. (.+/-.)-bendroflumethiazide

116. Bpbio1_000978

117. Gtpl7122

118. Bendroflumethiazide [mi]

119. Dtxsid5022647

120. Bendroflumethiazide [jan]

121. Hms500n16

122. Kbio1_000274

123. Kbio2_001866

124. Kbio2_004434

125. Kbio2_007002

126. Kbio3_002536

127. Bendroflumethiazide [hsdb]

128. Ninds_000274

129. Bendroflumethiazide [vandf]

130. Hms1570m10

131. Hms1922e15

132. Hms2092j16

133. Hms2097m10

134. Hms2230g10

135. Hms3259d17

136. Hms3370i20

137. Hms3714m10

138. Pharmakon1600-01503104

139. Bendroflumethiazide [mart.]

140. Bcp24525

141. Hy-b1363

142. Bendroflumethiazide [usp-rs]

143. Bendroflumethiazide [who-dd]

144. Tox21_110365

145. Ccg-39302

146. Mfcd00078963

147. Nsc758229

148. Akos024255718

149. Tox21_110365_1

150. Bendroflumethiazide, Analytical Standard

151. Db00436

152. Hs-0095

153. Nc00664

154. Nsc 758229

155. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide

156. Idi1_000274

157. Bendroflumethiazide [ep Impurity]

158. Bendroflumethiazide [orange Book]

159. Ncgc00018194-02

160. Ncgc00018194-03

161. Ncgc00018194-04

162. Ncgc00018194-08

163. Ncgc00089729-02

164. Ncgc00089729-03

165. (+-)-3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

166. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide, (+-)-

167. 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

168. 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

169. 3-benzyl-1,1-dioxo-6-(trifluoromethyl)-3,4-dihydro-2h-1$l^{6},2,4-benzothiadiazine-7-sulfonamide

170. Bendroflumethiazide [ep Monograph]

171. Bendroflumethiazide [usp Monograph]

172. Sbi-0051772.p002

173. Corzide Component Bendroflumethiazide

174. Ab00052315

175. Cs-0013104

176. Eu-0009291

177. Ft-0662518

178. Ft-0662519

179. Ft-0662520

180. Sw028069-4

181. Unm000000601501

182. Bendroflumethiazide Component Of Corzide

183. C07758

184. D00650

185. Ab00052315_15

186. Ab00052315_16

187. 073b483

188. A851258

189. Q1169164

190. Sr-01000000103-2

191. Sr-01000000103-4

192. Brd-a80017228-001-05-9

193. Brd-a80017228-001-15-8

194. Z2786051551

195. Bendroflumethiazide, British Pharmacopoeia (bp) Reference Standard

196. Bendroflumethiazide, European Pharmacopoeia (ep) Reference Standard

197. Bendroflumethiazide, United States Pharmacopeia (usp) Reference Standard

198. 3-benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

199. (+/-)-3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

200. 2h-1,2,4-benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide, (+/-)-

201. 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide

202. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide #

203. 3-benzyl-6-(trifluoromethyl)-3,4-dihydro-2h-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 421.4 g/mol
Molecular Formula C15H14F3N3O4S2
XLogP31.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count3
Exact Mass421.03778277 g/mol
Monoisotopic Mass421.03778277 g/mol
Topological Polar Surface Area135 Ų
Heavy Atom Count27
Formal Charge0
Complexity740
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameCorzide
PubMed HealthNadolol/Bendroflumethiazide (By mouth)
Drug ClassesBeta-Adrenergic Blocker, Nonselective/Thiazide Combination
Active Ingredientnadolol; Bendroflumethiazide
Dosage FormTablet
RouteOral
Strength5mg; 80mg; 40mg
Market StatusPrescription
CompanyKing Pharms

2 of 2  
Drug NameCorzide
PubMed HealthNadolol/Bendroflumethiazide (By mouth)
Drug ClassesBeta-Adrenergic Blocker, Nonselective/Thiazide Combination
Active Ingredientnadolol; Bendroflumethiazide
Dosage FormTablet
RouteOral
Strength5mg; 80mg; 40mg
Market StatusPrescription
CompanyKing Pharms

4.2 Therapeutic Uses

Antihypertensive Agents; Diuretics, Thiazide

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


IT IS INDICATED IN CONTROL OF EDEMA, CONGESTIVE HEART FAILURE, NEPHROSIS & NEPHRITIS, CIRRHOSIS & ASCITES, & OTHER EDEMATOUS STATES. ... IT IS ALSO OF VALUE IN HYPERTENSION ALONE OR WHEN COMBINED WITH OTHER ANTIHYPERTENSIVES.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868


THIAZIDE DRUGS...USUALLY FIRST DRUG TO BE EMPLOYED IN TREATMENT OF HYPERTENSION. SINCE THIAZIDES INDUCE ONLY LIMITED (10%) REDN IN BLOOD PRESSURE THEY ARE USEFUL EITHER IN MILD CASES OF HYPERTENSION OR AS ADJUNCTIVE THERAPY TO OTHER DRUGS. /THIAZIDE DIURETICS/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868


THIAZIDE DIURETICS ARE EFFECTIVE AS ADJUNCTIVE THERAPY IN EDEMA ASSOC WITH CONGESTIVE HEART FAILURE, HEPATIC CIRRHOSIS, & CORTICOSTEROID & ESTROGEN THERAPY, AS WELL AS EDEMA DUE TO VARIOUS FORMS OF RENAL DYSFUNCTION...& SEVERE EDEMA DUE TO PREGNANCY. /THIAZIDE DIURETICS/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868


For more Therapeutic Uses (Complete) data for BENDROFLUMETHIAZIDE (10 total), please visit the HSDB record page.


4.3 Drug Warning

PERIODIC SERUM ELECTROLYTE DETERMINATION SHOULD BE DONE ON ALL PT IN ORDER TO DETECT ELECTROLYTE IMBALANCE SUCH AS HYPONATREMIA, HYPOCHLOREMIC ALKALOSIS, & HYPOKALEMIA. /THIAZIDE DIURETICS/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868


THIAZIDE DIURETICS ARE CONTRAINDICATED IN ANURIA, PATIENTS HYPERSENSITIVE TO THESE & OTHER SULFONAMIDE DRUGS, & IN OTHERWISE HEALTHY PREGNANT WOMEN WITH OR WITHOUT MILD EDEMA. ...SHOULD BE USED WITH CAUTION IN PATIENTS WITH RENAL DISEASE, SINCE THEY MAY PPT AZOTEMIA. /THIAZIDE DIURETICS/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 868


PLASMA POTASSIUM CONCN SHOULD BE DETERMINED PERIODICALLY IN PT WHO RECEIVE THIAZIDE DIURETICS FOR EXTENDED PERIODS. /THIAZIDE DIURETICS/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 832


Maternal Medication usually Compatible with Breast-Feeding: Bendroflumethiazide: Reported Sign or Symptom in Infant or Effect on Lactation: Suppresses lactation. /From Table 6/

Report of the American Academy of Pediatrics Committee on Drugs in Pediatrics 93 (1): 140 (1994)


For more Drug Warnings (Complete) data for BENDROFLUMETHIAZIDE (20 total), please visit the HSDB record page.


4.4 Minimum/Potential Fatal Human Dose

3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT FOR 70 KG PERSON (150 LB). /BENZOTHIADIAZIDE DIURETICS/

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-239


4.5 Drug Indication

For the treatment of high blood pressure and management of edema related to heart failure.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Bendroflumethiazide, a thiazide diuretic, removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.


5.2 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Diuretics

Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)


Sodium Chloride Symporter Inhibitors

Agents that inhibit SODIUM CHLORIDE SYMPORTERS. They act as DIURETICS. Excess use is associated with HYPOKALEMIA. (See all compounds classified as Sodium Chloride Symporter Inhibitors.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
BENDROFLUMETHIAZIDE
5.3.2 FDA UNII
5Q52X6ICJI
5.3.3 Pharmacological Classes
Chemical Structure [CS] - Thiazides
5.4 ATC Code

C - Cardiovascular system

C03 - Diuretics

C03A - Low-ceiling diuretics, thiazides

C03AA - Thiazides, plain

C03AA01 - Bendroflumethiazide


5.5 Absorption, Distribution and Excretion

Absorption

Absorbed relatively rapidly after oral administration


MOST CMPD ARE RAPIDLY EXCRETED WITHIN 3-6 HR. BENDROFLUMETHIAZIDE...LONGER DURATION OF ACTION THAT IS CORRELATED WITH...SLOWER EXCRETION.

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 902


THIAZIDES ARE ABSORBED FROM GI TRACT & OWE THEIR USEFULNESS LARGELY TO THEIR EFFECTIVENESS BY ORAL ROUTE. ABSORPTION IS RELATIVELY RAPID. MOST AGENTS SHOW DEMONSTRABLE DIURETIC EFFECT WITHIN HR AFTER ORAL ADMIN. /BENZOTHIADIAZIDES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 831


IN GENERAL, THIAZIDES WITH RELATIVELY LONG DURATIONS OF ACTION SHOW PROPORTIONATELY HIGH DEGREE OF BINDING TO PLASMA PROTEINS & ARE REABSORBED... BY RENAL TUBULES. ... DRUG PASSES READILY THROUGH PLACENTAL BARRIER TO FETUS. ALL THIAZIDES PROBABLY UNDERGO ACTIVE SECRETION IN PROXIMAL TUBULE. /THIAZIDE DIURETICS/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 902


BENDROFLUMETHIAZIDE WAS ADMIN ORALLY TO 9 HEALTHY VOLUNTEERS. PEAK PLASMA LEVELS REACHED @ 1 + OR - 0.4 HR. CONCN DECLINED WITH MEAN T/2 OF 3 HR. APPARENT VOL OF DISTRIBUTION AVG 1.48 L/KG. MAJOR PART ELIMINATED VIA NONRENAL MECHANISMS. URINARY RECOVERY AVG 30%.

BEERMANN B ET AL; CLIN PHARMACOL THER 22(OCT) 385 (1977)


Bendroflumethiazide appears to be well absorbed from the GI tract. The drug is excreted unchanged in urine, and excretion is essentially complete within 24 hours.

McEvoy, G.K. (ed.). American Hospital Formulary Service-Drug Information 19 98. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 1998 (Plus Supplements)., p. 2166


5.6 Biological Half-Life

8.5 hours


Halflife is 3-3.9 hrs. /From table/

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 703


5.7 Mechanism of Action

As a diuretic, bendroflumethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like bendroflumethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of bendroflumethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.


...BENZOTHIADIAZIDES HAVE DIRECT EFFECT ON RENAL TUBULAR TRANSPORT OF SODIUM & CHLORIDE...INDEPENDENT OF ANY EFFECT ON CARBONIC ANHYDRASE. /THIAZIDE DIURETICS/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 899


NATURE OF CHEM INTERACTION BETWEEN THIAZIDES & SPECIFIC RENAL RECEPTORS RESPONSIBLE FOR CHLORURETIC EFFECT IS NOT KNOWN; NO CRITICAL ENZYMATIC REACTIONS HAVE BEEN IDENTIFIED. /THIAZIDE DIURETICS/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901


...MAY DECR EXCRETION OF URIC ACID IN MAN, THUS INCR ITS CONCN IN PLASMA. HYPERURICEMIC EFFECT RESULTS PRIMARILY FROM INHIBITION OF TUBULAR SECRETION OF URATE. ... UNLIKE MOST OTHER NATRIURETIC AGENTS...DECR RENAL EXCRETION OF CALCIUM RELATIVE TO THAT OF SODIUM... /ENHANCE/ EXCRETION OF MAGNESIUM... /THIAZIDE DIURETICS/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901


THIAZIDES INHIBIT REABSORPTION OF SODIUM &...CHLORIDE IN DISTAL SEGMENT. ... AS CLASS...HAVE IMPORTANT ACTION ON EXCRETION OF POTASSIUM THAT RESULTS FROM INCR SECRETION OF CATION BY DISTAL TUBULE. ... GLOMERULAR FILTRATION RATE MAY BE REDUCED BY THIAZIDES, PARTICULARLY WITH IV ADMIN FOR EXPTL PURPOSES. /THIAZIDE DIURETICS/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 901


For more Mechanism of Action (Complete) data for BENDROFLUMETHIAZIDE (11 total), please visit the HSDB record page.


API Reference Price

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27-Feb-2021
30-Sep-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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DOSAGE - TABLET;ORAL - 5MG;40MG **Federal Reg...DOSAGE - TABLET;ORAL - 5MG;40MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 18647

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DOSAGE - TABLET;ORAL - 5MG;80MG **Federal Reg...DOSAGE - TABLET;ORAL - 5MG;80MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 18647

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