Find Benfluorexum manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 23602-78-0, Benfluramate, Mediator, Minolip, N-(2-benzoyloxyethyl)norfenfluramine, Mediaxal
Molecular Formula
C19H20F3NO2
Molecular Weight
351.4  g/mol
InChI Key
CJAVTWRYCDNHSM-UHFFFAOYSA-N
FDA UNII
403FO0NQG3

Benfluorexum
Benfluorex is an antilipidemic agent that decreases the relative rate of hepatic triacylglycerol synthesis. Benfluorex was never approved for use in the United States and was withdrawn in the European Union because of an increased risk of pulmonary hypertension and valvular disease.
1 2D Structure

Benfluorexum

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl benzoate
2.1.2 InChI
InChI=1S/C19H20F3NO2/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16/h2-9,13-14,23H,10-12H2,1H3
2.1.3 InChI Key
CJAVTWRYCDNHSM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CC1=CC(=CC=C1)C(F)(F)F)NCCOC(=O)C2=CC=CC=C2
2.2 Other Identifiers
2.2.1 UNII
403FO0NQG3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(2-trifluoromethylphenyl)-2-(benzoyloxyethyl)aminopropane Hcl

2. 780 Se

3. Benfluorex Hydrochloride

4. Benfluorex Hydrochloride, (+-)-isomer

5. Benfluorex Maleate

6. Benfluorex, Methanesulfonate Salt

7. Benfluramate

8. Jp 992

9. S 780

10. Se 780

2.3.2 Depositor-Supplied Synonyms

1. 23602-78-0

2. Benfluramate

3. Mediator

4. Minolip

5. N-(2-benzoyloxyethyl)norfenfluramine

6. Mediaxal

7. Jp 992

8. 403fo0nqg3

9. Nsc-757396

10. Benfluorexum

11. 2-((1-(3-(trifluoromethyl)phenyl)propan-2-yl)amino)ethyl Benzoate

12. Benfluorexum [inn-latin]

13. Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, Benzoate

14. Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, Benzoate(ester)

15. Se 780

16. Smr000857234

17. 2-((alpha-methyl-m-(trifluoromethyl)phenethyl)amino)ethanol Benzoate (ester)

18. Einecs 245-777-9

19. Brn 4152887

20. Unii-403fo0nqg3

21. Benflurorex

22. Benfluorex [inn:ban:dcf]

23. Mediaxal (tn)

24. Spectrum_000272

25. Benfluorex [mi]

26. 2-(alpha-methyl-m-trifluoromethylphenethylamino)ethanol Benzoate

27. Benfluorex (inn/ban)

28. Benfluorex [inn]

29. Prestwick0_000367

30. Prestwick1_000367

31. Prestwick2_000367

32. Prestwick3_000367

33. Spectrum2_001217

34. Spectrum3_001383

35. Spectrum4_000806

36. Spectrum5_001421

37. N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylamine Benzoate

38. Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-, Benzoate

39. Benfluorex [who-dd]

40. Benfluorexhydrochloride

41. Bspbio_000493

42. Bspbio_002966

43. Kbiogr_001291

44. Kbioss_000752

45. Mls001333109

46. Mls001333110

47. Divk1c_000033

48. Schembl163648

49. Spbio_001034

50. Spbio_002414

51. Bpbio1_000543

52. Chembl400599

53. Dtxsid5048471

54. Chebi:93826

55. Hy-b1058a

56. Kbio1_000033

57. Kbio2_000752

58. Kbio2_003320

59. Kbio2_005888

60. Kbio3_002186

61. Ninds_000033

62. Hms2230n21

63. Hms3373e17

64. Hms3713i15

65. 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl Benzoate

66. 2-({1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl}amino)ethyl Benzoate

67. Jp-992

68. Se-780

69. Akos024319409

70. Ethanol, 2-(alpha-methyl-m-trifluoromethylphenethylamino)-, Benzoate

71. Ccg-220367

72. Db09022

73. Nsc 757396

74. Idi1_000033

75. Ncgc00178369-01

76. Ncgc00178369-02

77. Sbi-0051587.p002

78. Ab00053576

79. Cs-0013373

80. S-780

81. D07192

82. Ab00053576_13

83. Q421695

84. Brd-a22305049-003-05-2

85. Brd-a22305049-003-08-6

86. 2-(.alpha.-methyl-m-trifluoromethylphenethylamino)ethanol Benzoate

87. 2-((1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl)amino)ethyl Benzoate #

88. Benzoic Acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl Ester

89. Ethanol, 2-(.alpha.-methyl-m-trifluoromethylphenethylamino)-, Benzoate

90. N-(2-hydroxyethyl)-.alpha.-methyl-m-trifluoromethylphenethylamine Benzoate

91. 2-[[.alpha.-methyl-m-(trifluoromethyl)phenethyl]amino]ethanol Benzoate (ester)

92. Phenethylamine, N-(2-hydroxyethyl)-.alpha.-methyl-m-trifluoromethyl-, Benzoate

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 351.4 g/mol
Molecular Formula C19H20F3NO2
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass351.14461337 g/mol
Monoisotopic Mass351.14461337 g/mol
Topological Polar Surface Area38.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Appetite Depressants

Agents that are used to suppress appetite. (See all compounds classified as Appetite Depressants.)


Hypolipidemic Agents

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)


4.2 ATC Code

A - Alimentary tract and metabolism

A10 - Drugs used in diabetes

A10B - Blood glucose lowering drugs, excl. insulins

A10BX - Other blood glucose lowering drugs, excl. insulins

A10BX06 - Benfluorex


ABOUT THIS PAGE

Benfluorexum Manufacturers

A Benfluorexum manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Benfluorexum, including repackagers and relabelers. The FDA regulates Benfluorexum manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Benfluorexum API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Benfluorexum Suppliers

A Benfluorexum supplier is an individual or a company that provides Benfluorexum active pharmaceutical ingredient (API) or Benfluorexum finished formulations upon request. The Benfluorexum suppliers may include Benfluorexum API manufacturers, exporters, distributors and traders.

click here to find a list of Benfluorexum suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Benfluorexum USDMF

A Benfluorexum DMF (Drug Master File) is a document detailing the whole manufacturing process of Benfluorexum active pharmaceutical ingredient (API) in detail. Different forms of Benfluorexum DMFs exist exist since differing nations have different regulations, such as Benfluorexum USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Benfluorexum DMF submitted to regulatory agencies in the US is known as a USDMF. Benfluorexum USDMF includes data on Benfluorexum's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Benfluorexum USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Benfluorexum suppliers with USDMF on PharmaCompass.

Benfluorexum GMP

Benfluorexum Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Benfluorexum GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Benfluorexum GMP manufacturer or Benfluorexum GMP API supplier for your needs.

Benfluorexum CoA

A Benfluorexum CoA (Certificate of Analysis) is a formal document that attests to Benfluorexum's compliance with Benfluorexum specifications and serves as a tool for batch-level quality control.

Benfluorexum CoA mostly includes findings from lab analyses of a specific batch. For each Benfluorexum CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Benfluorexum may be tested according to a variety of international standards, such as European Pharmacopoeia (Benfluorexum EP), Benfluorexum JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Benfluorexum USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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