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Chemistry

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Also known as: 5633-14-7, Benzetimide hcl, Dioxatrine, Benzetimide hydrochloride [usan], Benzetimide (hydrochloride), 2-[1-benzyl-4-piperidyl]-2-phenylglutarimide
Molecular Formula
C23H27ClN2O2
Molecular Weight
398.9  g/mol
InChI Key
XSOOSXRNMDUWEM-UHFFFAOYSA-N
FDA UNII
V6ERX20PHB

Benzetimide hydrochloride
A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.
1 2D Structure

Benzetimide hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride
2.1.2 InChI
InChI=1S/C23H26N2O2.ClH/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18;/h1-10,20H,11-17H2,(H,24,26,27);1H
2.1.3 InChI Key
XSOOSXRNMDUWEM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC1C2(CCC(=O)NC2=O)C3=CC=CC=C3)CC4=CC=CC=C4.Cl
2.2 Other Identifiers
2.2.1 UNII
V6ERX20PHB
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Benzetimide

2. Dexbenzetimid

3. Dexbenzetimide

4. Dexetimide

5. Dextro Benzetimide

6. Dextro-benzetimide

7. R 16470

8. R-16470

9. R16470

10. Spasmentral

11. Tremblex

2.3.2 Depositor-Supplied Synonyms

1. 5633-14-7

2. Benzetimide Hcl

3. Dioxatrine

4. Benzetimide Hydrochloride [usan]

5. Benzetimide (hydrochloride)

6. 2-[1-benzyl-4-piperidyl]-2-phenylglutarimide

7. Mcn-jr-4929-11

8. V6erx20phb

9. Janssen R 492

10. Janssen-r-492

11. Janssen R 4929

12. 2-(1-benzyl-4-piperidyl)-2-phenylglutarimide Monohydrochloride

13. Spasmentral

14. 5633-14-7 (hcl)

15. 3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione,hydrochloride

16. (3,4'-bipiperidine)-2,6-dione, 3-phenyl-1'-(phenylmethyl)-, Monohydrochloride

17. Benzetimide Hydrochloride (usan)

18. Mcn-jr4929

19. Mcn-jr 4929

20. Einecs 227-072-8

21. Unii-v6erx20phb

22. Dioxatrine (tn)

23. R 4929

24. Dl-2-(1-benzyl-4-piperidyl)-2-phenylglutarimide Hydrochloride

25. Dl-1-benzyl-4-(2,6-dioxo-3-phenyl-3-piperidyl)piperidine Hydrochloride

26. Mls001201802

27. Schembl635393

28. Chembl545131

29. Hy-b1547a

30. Dtxsid101036320

31. Bcp11991

32. Bcp28424

33. Glutarimide, 2-(1-benzyl-4-piperidyl)-2-phenyl-, Hydrochloride

34. Benzetimide Hydrochloride [mi]

35. 3-phenyl-1'-(phenylmethyl)(3,4'-bipiperidine)-2,6-dione Monohydrochloride

36. Akos025402010

37. Cs-5308

38. Ac-28141

39. Smr000718634

40. Ft-0696859

41. R4929

42. D03087

43. Q27291593

44. 1'-benzyl-3-phenyl-3,4'-bipiperidine-2,6-dione Hydrochloride

45. Benzetimide Hcl; R4929 Hcl; R 4929 Hcl; R-4929 Hcl

46. 3-(1-benzylpiperidin-4-yl)-3-phenylpiperidine-2,6-dione;hydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 398.9 g/mol
Molecular Formula C23H27ClN2O2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass398.1761058 g/mol
Monoisotopic Mass398.1761058 g/mol
Topological Polar Surface Area49.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity529
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)


Parasympatholytics

Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)


ABOUT THIS PAGE

Looking for 5633-14-7 / Benzetimide hydrochloride API manufacturers, exporters & distributors?

Benzetimide hydrochloride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Benzetimide hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Benzetimide hydrochloride manufacturer or Benzetimide hydrochloride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Benzetimide hydrochloride manufacturer or Benzetimide hydrochloride supplier.

PharmaCompass also assists you with knowing the Benzetimide hydrochloride API Price utilized in the formulation of products. Benzetimide hydrochloride API Price is not always fixed or binding as the Benzetimide hydrochloride Price is obtained through a variety of data sources. The Benzetimide hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Benzetimide hydrochloride

Synonyms

5633-14-7, Benzetimide hcl, Dioxatrine, Benzetimide hydrochloride [usan], Benzetimide (hydrochloride), 2-[1-benzyl-4-piperidyl]-2-phenylglutarimide

Cas Number

5633-14-7

Unique Ingredient Identifier (UNII)

V6ERX20PHB

About Benzetimide hydrochloride

A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide.

Benzetimide hydrochloride Manufacturers

A Benzetimide hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Benzetimide hydrochloride, including repackagers and relabelers. The FDA regulates Benzetimide hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Benzetimide hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Benzetimide hydrochloride Suppliers

A Benzetimide hydrochloride supplier is an individual or a company that provides Benzetimide hydrochloride active pharmaceutical ingredient (API) or Benzetimide hydrochloride finished formulations upon request. The Benzetimide hydrochloride suppliers may include Benzetimide hydrochloride API manufacturers, exporters, distributors and traders.

Benzetimide hydrochloride GMP

Benzetimide hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Benzetimide hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Benzetimide hydrochloride GMP manufacturer or Benzetimide hydrochloride GMP API supplier for your needs.

Benzetimide hydrochloride CoA

A Benzetimide hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Benzetimide hydrochloride's compliance with Benzetimide hydrochloride specifications and serves as a tool for batch-level quality control.

Benzetimide hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Benzetimide hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Benzetimide hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Benzetimide hydrochloride EP), Benzetimide hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Benzetimide hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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