menu
    • menu

    Find Benzyl Alcohol API manufacturers, exporters & distributors on PharmaCompass

    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    7

    API Suppliers

    API Suppliers

    5

    USDMF

    US DMFs Filed

    1

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    2

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 0

    MARKET PLACE

    7

    API

    0

    FDF

    0INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    0

    FDF Dossiers

    FDF Dossiers

    0

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    0 DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    7

    USP

    0

    JP

    0

    Others

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    DIGITAL CONTENT

    2

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    3

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Finished Drug Prices

    NA

    115 RELATED EXCIPIENT COMPANIES

    210EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: Phenylmethanol, Benzenemethanol, 100-51-6, Phenylcarbinol, Benzylalcohol, Benzoyl alcohol
    Molecular Formula
    C7H8O
    Molecular Weight
    108.14  g/mol
    InChI Key
    WVDDGKGOMKODPV-UHFFFAOYSA-N
    FDA UNII
    LKG8494WBH
    Benzyl Alcohol API
    A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
    Benzyl alcohol is a Pediculicide.
    1 2D Structure

    Benzyl Alcohol API

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    phenylmethanol
    2.1.2 InChI
    InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2
    2.1.3 InChI Key
    WVDDGKGOMKODPV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)CO
    2.2 Other Identifiers
    2.2.1 UNII
    LKG8494WBH
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Alcohol, Benzyl

    2. Benzenemethanol

    2.3.2 Depositor-Supplied Synonyms

    1. Phenylmethanol

    2. Benzenemethanol

    3. 100-51-6

    4. Phenylcarbinol

    5. Benzylalcohol

    6. Benzoyl Alcohol

    7. Benzenecarbinol

    8. Hydroxytoluene

    9. Phenylmethyl Alcohol

    10. Alpha-toluenol

    11. (hydroxymethyl)benzene

    12. Phenolcarbinol

    13. Benzal Alcohol

    14. Alpha-hydroxytoluene

    15. Benzylic Alcohol

    16. Alcool Benzylique

    17. Benzylicum

    18. Methanol, Phenyl-

    19. Phenylcarbinolum

    20. Hydroxymethylbenzene

    21. Phenyl-methanol

    22. Benzyl-alcohol

    23. Euxyl K 100

    24. 66072-40-0

    25. Bentalol

    26. Ulesfia

    27. .alpha.-hydroxytoluene

    28. Aromatic Alcohol

    29. Caswell No. 081f

    30. Fema No. 2137

    31. .alpha.-toluenol

    32. Benzyl Alcohol (natural)

    33. Alcool Benzilico [dcit]

    34. Itch-x

    35. Alcoholum Benzylicum

    36. Nci-c06111

    37. Benzenmethanol

    38. Benzylalkohol

    39. Aromatic Primary Alcohol

    40. Alcohol,benzyl

    41. Alcool Benzylique [inn-french]

    42. Benzyl Alkohol

    43. Alcohol Bencilico [inn-spanish]

    44. Methanol Benzene

    45. Alcoholum Benzylicum [inn-latin]

    46. Nsc 8044

    47. Hoch-ph-polymer

    48. Bnoh

    49. Benzyl Alcohol, Polymer-bound

    50. Nsc-8044

    51. Mfcd00004599

    52. Hydroxymethyl Resin (100-200 Mesh)

    53. Toluene,alpha-hydroxy

    54. Lkg8494wbh

    55. Chebi:17987

    56. Ins No.1519

    57. Ins-1519

    58. Hydroxymethyl Resin (200-400 Mesh)

    59. Ncgc00091865-01

    60. Phenyl Methanol

    61. Dsstox_cid_152

    62. E-1519

    63. Dsstox_rid_75404

    64. Dsstox_gsid_20152

    65. 185532-71-2

    66. Mbn

    67. Alcool Benzilico

    68. Alcohol, Benzyl

    69. Alcohol Bencilico

    70. Phenylmethan-1-ol

    71. Cas-100-51-6

    72. Hsdb 46

    73. Ulesfia (tn)

    74. Ccris 2081

    75. Benzyl Alcohol Natural

    76. Benzyl Alcohol [usan:inn:jan]

    77. Einecs 202-859-9

    78. Unii-lkg8494wbh

    79. Epa Pesticide Chemical Code 009502

    80. Brn 0878307

    81. Enzylalcohol

    82. Benzalalcohol

    83. Benzalcohol

    84. Bentanol

    85. Alcoolbenzylique

    86. Benzene-methanol

    87. Benzyl Alcohole

    88. A-hydroxytoluene

    89. A-toluenol

    90. Ai3-01680

    91. Benzyl Alcohol [inn:jan:nf]

    92. Alcohol Benzylicus

    93. Hoch2-ph-polymer

    94. Sunmorl Bk 20

    95. Nat. Benzyl Alcohol

    96. Phch2oh

    97. 201740-95-6

    98. Bn-oh

    99. Benzyl Alcohol-13c6

    100. Schembl147

    101. Benzyl Alcohol, Acs Grade

    102. Bmse000407

    103. C6h5ch2oh

    104. Chembl720

    105. Ec 202-859-9

    106. Wln: Q1r

    107. Benzyl Alcohol [ii]

    108. Benzyl Alcohol [mi]

    109. Pinapur™ 9 Ba-r

    110. Benzyl Alcohol (jp15/nf)

    111. Benzyl Alcohol [fcc]

    112. Benzyl Alcohol [inn]

    113. Benzyl Alcohol [jan]

    114. 4-06-00-02222 (beilstein Handbook Reference)

    115. Benzyl Alcohol [fhfi]

    116. Benzyl Alcohol [hsdb]

    117. Benzyl Alcohol [inci]

    118. Bidd:er0248

    119. Alcohol,benzyl [vandf]

    120. Benzyl Alcohol [vandf]

    121. Tb 13g

    122. Benzyl Alcohol [mart.]

    123. Benzyl Alcohol, Lr, >=99%

    124. Benzyl Alcohol (benzenemethanol)

    125. Benzyl Alcohol [usp-rs]

    126. Benzyl Alcohol [who-dd]

    127. Benzyl Alcohol [who-ip]

    128. Dtxsid5020152

    129. Bdbm16418

    130. Nsc8044

    131. Benzyl Alcohol (jp17/nf/inn)

    132. Benzyl Alcohol Reagent Acs Grade

    133. Hms3264b16

    134. Hms3885f10

    135. Pharmakon1600-01502555

    136. Zinc895302

    137. Benzyl Alcohol, Analytical Standard

    138. Benzyl Alcohol, Ar, >=99.5%

    139. Hy-b0892

    140. Benzyl Alcohol, Anhydrous, 99.8%

    141. Tox21_111172

    142. Tox21_202447

    143. Tox21_300044

    144. Bbl011938

    145. Benzyl Alcohol [orange Book]

    146. Mfcd03792087

    147. Nsc760098

    148. S4600

    149. Stl163453

    150. Benzyl Alcohol [ep Monograph]

    151. Benzyl Alcohol, >=99%, Fcc, Fg

    152. Akos000119907

    153. Benzyl Alcohol, Natural, >=98%, Fg

    154. Ccg-213843

    155. Db06770

    156. Nsc-760098

    157. Benzylalcohol 100 Microg/ml In Methanol

    158. Ncgc00091865-02

    159. Ncgc00091865-03

    160. Ncgc00091865-04

    161. Ncgc00254154-01

    162. Ncgc00259996-01

    163. Alcohol Benzylicus [who-ip Latin]

    164. Benzyl Alcohol, Acs Reagent, >=99.0%

    165. Benzyl Alcohol, Reagentplus(r), >=99%

    166. Benzyl Alcohol, Usp, 98.0-100.5%

    167. Benzylalcohol 1000 Microg/ml In Ethanol

    168. Benzyl Alcohol On Polystyrene, 3.5 Mmol/g

    169. B2378

    170. Benzyl Alcohol, Tested According To Ph.eur.

    171. Benzylalcohol 100 Microg/ml In Acetonitrile

    172. E1519

    173. Ft-0622812

    174. Benzyl Alcohol, P.a., Acs Reagent, 99.0%

    175. Benzyl Alcohol, Saj First Grade, >=98.5%

    176. A14564

    177. Benzyl Alcohol, Saj Special Grade, >=99.0%

    178. Benzyl Alcohol, Vetec(tm) Reagent Grade, 98%

    179. C00556

    180. C03485

    181. D00077

    182. D70182

    183. Q52353

    184. Ab01563201_01

    185. A800221

    186. Sr-01000872610

    187. J-000153

    188. Sr-01000872610-3

    189. Benzalkonium Chloride Impurity A [ep Impurity]

    190. F0001-0019

    191. Z955123784

    192. 3762963d-6c2a-4bff-ad94-3180e51bca68

    193. Benzyl Alcohol, Certified Reference Material, Tracecert(r)

    194. Benzyl Alcohol, European Pharmacopoeia (ep) Reference Standard

    195. Benzyl Alcohol, Puriss. P.a., Acs Reagent, >=99.0% (gc)

    196. Benzyl Alcohol, United States Pharmacopeia (usp) Reference Standard

    197. (hydroxymethyl)polystyrene, 200-400 Mesh, Extent Of Labeling: ~1.7 Mmol/g Loading

    198. (hydroxymethyl)polystyrene, 200-500 Mesh, Extent Of Labeling: ~1.1 Mmol/g Loading

    199. Benzyl Alcohol, Pharmaceutical Secondary Standard; Certified Reference Material

    200. Benzyl Alcohol, Pharmagrade, Usp/nf, Ph Eur, Manufactured Under Appropriate Gmp Controls For Pharma Or Biopharmaceutical Production.

    201. Benzyl Alcohol, Polymer-bound, 100-200 Mesh, Extent Of Labeling: 0.5-1.0 Mmol/g Loading, 1 % Cross-linked

    202. Benzyl Alcohol, Polymer-bound, 100-200 Mesh, Extent Of Labeling: 1.0-2.0 Mmol/g Loading, 1 % Cross-linked With Divinylbenzene

    203. Benzyl Alcohol, Polymer-bound, 70-90 Mesh, Extent Of Labeling: 0.5-1.0 Mmol/g Loading, 1 % Cross-linked With Divinylbenzene

    204. Benzyl Alcohol, Polymer-bound, 70-90 Mesh, Extent Of Labeling: 1.0-1.5 Mmol/g Loading, 1 % Cross-linked

    205. Benzyl Alcohol, Polymer-bound, 70-90 Mesh, Extent Of Labeling: 2.0-3.0 Mmol Loading, 1 % Cross-linked

    206. Benzyl Alcohol, Puriss., Meets Analytical Specification Of Ph.??eur., Bp, Nf, 99-100.5% (gc)

    207. Stratospheres(tm) Pl-hms (hydroxymethylstyrene) Resin, 50-100 Mesh, Extent Of Labeling: 2.0 Mmol Loading, 1 % Cross-linked

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 108.14 g/mol
    Molecular Formula C7H8O
    XLogP31.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count1
    Exact Mass108.057514874 g/mol
    Monoisotopic Mass108.057514874 g/mol
    Topological Polar Surface Area20.2 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity55.4
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameUlesfia
    Drug Label ULESFIA(benzyl alcohol) Lotion is supplied as a white topical lotion containing benzyl alcohol, 5%. Inactive ingredients in this formulation are water, mineral oil, sorbitan monooleate, polysorbate 80, carbomer 934P and trolamine....
    Active IngredientBenzyl alcohol
    Dosage FormLotion
    RouteTopical
    Strength5%
    Market StatusPrescription
    CompanyShionogi

    2 of 2  
    Drug NameUlesfia
    Drug Label ULESFIA(benzyl alcohol) Lotion is supplied as a white topical lotion containing benzyl alcohol, 5%. Inactive ingredients in this formulation are water, mineral oil, sorbitan monooleate, polysorbate 80, carbomer 934P and trolamine....
    Active IngredientBenzyl alcohol
    Dosage FormLotion
    RouteTopical
    Strength5%
    Market StatusPrescription
    CompanyShionogi

    4.2 Therapeutic Uses

    Anesthetics, Local; Pharmaceutic Aids

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    /On April 9, 2009, the U.S. Food and Drug Administration approved a new prescription medication for the treatment of head lice ( Pediculosis capitis ) infestation. Benzyl Alcohol Lotion, 5%, received full market approval as a prescription medication, for use in patients 6 months of age and older. Benzyl Alcohol Lotion, 5%, is the first head lice product approved by the FDA with benzyl alcohol as the active pharmaceutical ingredient.

    FDA; FDA Approves Benzyl Alcohol Lotion for the Treatment of Head Lice, FDA News (April 9, 2009) Available from, as of April 20, 2009: https://www.fda.gov/bbs/topics/NEWS/2009/NEW01993.html

    The safety and effectiveness of Benzyl Alcohol Lotion, 5%, was demonstrated in two studies of 628 people, 6 months of age and older, with active head lice infestation. The subjects received two, 10-minute treatments of either Benzyl Alcohol Lotion or a topical placebo, one week apart. Fourteen days after the final treatment, more than 75 percent of the subjects treated with Benzyl Alcohol Lotion, 5%, were lice free.

    FDA; FDA Approves Benzyl Alcohol Lotion for the Treatment of Head Lice, FDA News (April 9, 2009) Available from, as of April 20, 2009: https://www.fda.gov/bbs/topics/NEWS/2009/NEW01993.html

    In each of two double-blind studies, 25 patients suffering from early progressive idiopathic cataracts, subcapsular or cortical in site, received one drop of saline containing 0.07% benzyl alcohol every 8 hours. The eyelid was held open for at least 2 minutes. Treatment continued for 22 months. In one study, a control group received placebo, whereas in the other study, the control group received an anticataract medication. Clinical findings were recorded every 30 days for the first 14 months, then patients were followed for up to 18 and 22 months. A significant (p < .01) increase in visual acuity (VA) was observed in patients treated with benzyl alcohol after 30 and 60 days as compared to those receiving either placebo or the medication. Compared to those placebo or medication treated, a significant (p < .01) decrease in lens opacity was noted in 19 and 17 patients treated with benzyl alcohol, respectively. In the course of the studies, a significant increase in the number of surgeries for cataracts was noted in patients not receiving benzyl alcohol. One patient treated with benzyl alcohol required surgery after 22 months compared to 38 total who had received either placebo or medication. benzyl alcohol was well tolerated except in two patients (4%) where tolerance was fair in one and poor in the other.

    PMID:11766131 Nair B; Int J Toxicol 20 Suppl 3: 23-50 (2001)

    For more Therapeutic Uses (Complete) data for BENZYL ALCOHOL (12 total), please visit the HSDB record page.

    4.3 Drug Warning

    Common side effects of /Benzyl Alcohol Lotion, 5%/ include irritations of the skin, scalp, and eyes, and numbness at the site of application. As with all medications, it is important to use benzyl alcohol, 5%, as labeled to maximize benefits and minimize risks. The product should be applied only to the scalp or the hair attached to the scalp. It is not approved for use in children younger than six months. Use in premature infants could lead to serious respiratory, heart- or brain-related adverse events such as seizure, coma, or death.

    FDA; FDA Approves Benzyl Alcohol Lotion for the Treatment of Head Lice, FDA News (April 9, 2009) Available from, as of April 20, 2009: https://www.fda.gov/bbs/topics/NEWS/2009/NEW01993.html

    It also seems prudent to avoid the use of products containing benzyl alcohol to pregnant patients within whom the benzyl alcohol molecule, given its small size, presumably crosses the placental barrier into immature fetal tissues as readily as it crosses the blood-brain barrier.

    Organization for Economic Cooperation and Development; Screening Information Data Set for Benzoates, CAS #s 65-85-0, 532-32-1, 582-25-2, 100-51-6 p.294 (2001). Available from, as of July 9 2008: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html

    Premature neonates may receive multiple drugs in the neonatal intensive care unit, some of which may contain benzyl alcohol. As there may be no safe lower dose of benzyl alcohol in these patients, it would seem prudent to avoid the use of multiple dose vials containing benzyl alcohol whenever alternatives exist.

    Organization for Economic Cooperation and Development; Screening Information Data Set for Benzoates, CAS #s 65-85-0, 532-32-1, 582-25-2, 100-51-6 p.294 (2001). Available from, as of July 9, 2008: https://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html

    Benzyl alcohol is believe to have a role in the increased frequency of cerebral intraventricular hemorrhages and mortality reported in very-low-birth-weight (VLBW) infants (weight < 1000 g) who received flush solutions preserved with benzyl alcohol. An increased incidence of developmental delay and cerebral palsy is also noted in the same VLBW patient population, suggesting a secondary damaging effect of benzyl alcohol.

    Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 8th Ed. 2006., McGraw-Hill, New York, N.Y., p. 831

    For more Drug Warnings (Complete) data for BENZYL ALCOHOL (6 total), please visit the HSDB record page.

    4.4 Drug Indication

    Ulesfia (benzyl alcohol) lotion is indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Ulesfia Lotion does not have ovicidal activity.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anesthetics, Local

    Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

    5.2 FDA Pharmacological Classification
    5.2.1 Active Moiety
    BENZYL ALCOHOL
    5.2.2 FDA UNII
    LKG8494WBH
    5.2.3 Pharmacological Classes
    Pediculicide [EPC]
    5.3 ATC Code

    P - Antiparasitic products, insecticides and repellents

    P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents

    P03A - Ectoparasiticides, incl. scabicides

    P03AX - Other ectoparasiticides, incl. scabicides

    P03AX06 - Benzyl alcohol

    5.4 Absorption, Distribution and Excretion

    The percutaneous absorption was determined in vivo in rhesus monkeys. Absorption through occluded skin was high (56-80 %) in 24 hr. No correlation was seen between skin penetration and the octanol-water partition coefficient. Under unoccluded conditions skin penetration was reduced (32 %), because of evaporation of the compound.

    OECD; SIDS Initial Assessment Report for SIAM 13. Report on Benzoates: Benzoic acid, Sodium benzoate, Potassium benzoate, Benzyl alcohol (CAS No: 65-85-0, 532-32-1, 582-25-2, 100-51-6) p.298 UNEP Publications (November 2001). Available from, as of November 18, 2014: https://www.inchem.org/pages/sids.html

    High levels of benzyl alcohol (5-500 ug/10 mL plasma) were found in uremic patients on hemodialysis; benzyl alcohol was not detected in normal controls.

    OECD; SIDS Initial Assessment Report for SIAM 13. Report on Benzoates: Benzoic acid, Sodium benzoate, Potassium benzoate, Benzyl alcohol (CAS No: 65-85-0, 532-32-1, 582-25-2, 100-51-6) p.294 UNEP Publications (November 2001). Available from, as of November 18, 2014: https://www.inchem.org/pages/sids.html

    Rabbits given 1 g of benzyl alcohol sc eliminated 300-400 mg of hippuric acid within the following 24 hr. Within 6 hr after oral administration of 0.40 g benzyl alcohol/kg bw, rabbits eliminated 65.7% of dose as hippuric acid in the urine.

    Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2704

    In humans and animals, benzyl alcohol was readily absorbed from the gastrointestinal tract. Percutaneous absorption was high following topical use. Rhesus monkeys absorbed 56-80% of a topical dose administered under occlusive conditions in 24 hours; absorption was less under unoccluded conditions due to evaporation. Benzyl alcohol rapidly disappeared from the injection site following intramuscular administration in rats; the disappearance half-life was estimated to be less than 10 minutes. ...

    European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Benzyl Alcohol, Summary Report (1997). Available from, as of July 8, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/Benzylalcohol.pdf

    For more Absorption, Distribution and Excretion (Complete) data for BENZYL ALCOHOL (6 total), please visit the HSDB record page.

    5.5 Metabolism/Metabolites

    Benzyl alcohol is normally oxidized rapidly to benzoic acid, conjugated with glycine in the liver, and excreted as hippuric acid. However, this metabolic pathway may not be well developed in premature infants. The benzyl alcohol may therefore have been metabolized to benzoic acid, which could not be conjugated by the immature liver but accumulated, causing metabolic acidosis ... .

    CDC/MMWR; Neonatal Deaths Associated With Use Of Benzyl Alcohol -- United States. Morbidity and Mortality Weekly Repost 31(22);290-1 (June 11, 1982). Available from, as of July 23, 2008: https://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm

    When metabolized, benzyl alcohol is converted to benzoic acid by simple oxidation. The relevant data, therefore, relate to benzoic acid and sodium benzoate.

    PMID:11766131 Nair B; Int J Toxicol 20 Suppl 3: 23-50 (2001)

    Benzyl alcohol was an intermediate product in the metabolic pathway of benzyl acetate; the subsequent metabolism was identical to that of benzyl alcohol.

    European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Benzyl Alcohol, Summary Report (1997). Available from, as of July 8, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/Benzylalcohol.pdf

    In adults, benzyl alcohol is oxidized to benzoic acid, conjugated in the liver with glycine, and excreted in the urine as hippuric acid. The immature metabolic capacities of infants diminish their ability to metabolize and excrete benzyl alcohol. Preterm babies have a greater ability to metabolize benzyl alcohol to benzoic acid than do term babies, but are unable to convert benzoic acid to hippuric acid, possibly because of glycine deficiency. This results in the accumulation of benzoic acid.

    Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 8th Ed. 2006., McGraw-Hill, New York, N.Y., p. 831

    For more Metabolism/Metabolites (Complete) data for BENZYL ALCOHOL (8 total), please visit the HSDB record page.

    Benzyl alcohol is a known human metabolite of toluene.

    S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

    5.6 Biological Half-Life

    The plasma half-life of benzyl alcohol administered as 2.5% solution in saline was found to be approximately 1.5 hr in dogs injected iv at doses of 52 and 105 mg/kg.

    Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4640

    Benzyl alcohol rapidly disappeared from the injection site following intramuscular administration in rats; the disappearance half-life was estimated to be less than 10 minutes. ...

    European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Benzyl Alcohol, Summary Report (1997). Available from, as of July 8, 2008: https://www.emea.europa.eu/pdfs/vet/mrls/Benzylalcohol.pdf

    5.7 Mechanism of Action

    Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.

    USDMF

    read-more
    read-more

    01

    Antibody Engineering
    Not Confirmed

    01

    Emerald Kalama Chemical Llc

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 20098

    Submission : 2006-12-28

    Status : Inactive

    Type : II

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    Antibody Engineering
    Not Confirmed

    02

    Hubei Greenhome Materials Technology...

    China
    arrow
    Antibody Engineering
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 26780

    Submission : 2013-01-02

    Status : Active

    Type : IV

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    03

    Antibody Engineering
    Not Confirmed

    03

    Malhotra Organic Chemicals

    India
    arrow
    Antibody Engineering
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 36230

    Submission : 2021-09-13

    Status : Active

    Type : IV

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    04

    Sd Fine Chem Ltd

    India

    USDMF

    arrow
    Antibody Engineering
    Not Confirmed

    04

    Sd Fine Chem Ltd

    India
    arrow
    Antibody Engineering
    Not Confirmed

    GDUFA

    DMF Review : N/A

    Rev. Date :

    Pay. Date :

    DMF Number : 28706

    Submission : 2014-10-03

    Status : Active

    Type : IV

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    05

    Antibody Engineering
    Not Confirmed

    05

    Sigma Aldrich Ireland Ltd

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed

    GDUFA

    DMF Review : Complete

    Rev. Date : 2013-09-24

    Pay. Date : 2013-04-09

    DMF Number : 27017

    Submission : 2013-03-26

    Status : Active

    Type : II

    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    Listed Suppliers

    read-more
    read-more

    01

    Prakash Chemicals International

    India
    Antibody Engineering
    Not Confirmed
    arrow

    Prakash Chemicals International

    India
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    Post an Enquiry Post an Enquiry
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Benzyl Alcohole

    About the Company : Prakash Chemicals International, a global chemical distribution and manufacturing company caters to a wide range of industry verticals with a customer base spread across 118 countr...

    Prakash Chemicals International, a global chemical distribution and manufacturing company caters to a wide range of industry verticals with a customer base spread across 118 countries all over the world. The company partners with the chemical industry and offers an array of value-added products and bespoke solutions that accelerate growth for all its stakeholders.With more than 70 years of experience, we have evolved to be India’s leading player in bulk, specialty and performance chemicals.
    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    02

    Wuhan Biet

    China
    Antibody Engineering
    Not Confirmed
    arrow

    Wuhan Biet

    China
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
    Post an Enquiry Post an Enquiry
    Flag China
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Benzyl Alcohol API

    About the Company : Wuhan Biet Co., Ltd. was set up in July 2010. It specializes in the research and development, production, sales, and service of toluene oxidation. It is a sales company that produc...

    Wuhan Biet Co., Ltd. was set up in July 2010. It specializes in the research and development, production, sales, and service of toluene oxidation. It is a sales company that produces benzoic acid, sodium benzoate, benzyl benzoate, polyol benzoate, benzyl alcohol, and benzaldehyde by oxidation of toluene. We annually produce 50,000 tons of benzoic acid, 4,000 tons of benzyl benzoate, 10,000 tons of benzoic acid polyol esters, and 20,000 tons of sodium benzoate (including sodium benzoate powder 10,000 tons/year, sodium benzoate ball 5,000 tons/year, sodium benzoate column 5000 tons/year), 5000 tons of benzyl alcohol.
    blank

    Portfolio PDF

    Product Web Link

    Virtual Booth

    Digital Content

    Website

    Corporate PDF

    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Topical

    read-more
    read-more

    Solubilizers

    read-more
    read-more

    Coating Systems & Additives

    read-more
    read-more

    Parenteral

    read-more
    read-more

    01

    Nanjing Well Pharmaceutical

    China
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

    Brand Name : Polysorbate 20

    Application : Emulsifying Agents, Parenteral, Solubilizers, Surfactant & Foaming Agents, Thickeners and Stabilizers, Topical

    Excipient Details : Polysorbate 20 is used in parenteral products such as biologics. It is used as a solubilizer, surfactant, emulsifier & suspension stabilizer.

    Pharmacopoeia Ref : ChP/USP/EP

    Technical Specs : NA

    Ingredient(s) : Polysorbate 20

    arrow
    Nanjing Well Polysorbate 20

    Excipients Web Link

    Market Place

    Digital Content

    Virtual Booth

    02

    Pluviaendo

    Turkey
    Antibody Engineering
    Not Confirmed
    arrow

    03

    Nanjing Well Pharmaceutical

    China
    arrow
    ASK
    US
    PHARMACOMPASS
    Upload
    your Marketing & Sales content

    ASK US

    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

    Brand Name : Polysorbate 80

    Application : Emulsifying Agents, Film Formers & Plasticizers, Parenteral, Solubilizers, Surfactant & Foaming Agents, Thickeners and Stabilizers, Topical

    Excipient Details : Polysorbate 80 is used as a plasticizer, solubilizer, emulsifier, surfactant, and suspension stabilizer. It is also used in parenteral products.

    Pharmacopoeia Ref : ChP/USP/EP/JP

    Technical Specs : NA

    Ingredient(s) : Polysorbate 80

    arrow
    Polysorbate 80

    Excipients Web Link

    Market Place

    Digital Content

    Virtual Booth

    04

    Nanjing Well Pharmaceutical

    China
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

    Brand Name : Propylene Glycol

    Application : Film Formers & Plasticizers, Parenteral, Thickeners and Stabilizers, Topical

    Excipient Details : Propylene glycol is used as a solvent & stabilizer in injections. It is also used in topical semi-solids & as a plasticizer in soft capsules.

    Pharmacopoeia Ref : ChP/USP/EP/JP

    Technical Specs : NA

    Ingredient(s) : Propylene Glycol

    arrow
    Nanjing Well Propylene Glycol

    Excipients Web Link

    Market Place

    Digital Content

    Virtual Booth

    05

    Nanjing Well Pharmaceutical

    China
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothNanjing Well is focused on R&D, production & sales of Pharmaceutical Excipients & Synthetic Lubricating base oils.

    Dosage Form : Injectable / Parenteral

    Grade : Parenteral

    Category : Parenteral

    Brand Name : Castor Oil

    Application : Parenteral

    Excipient Details : Castor oil is used as an oily solvent in parenteral dosage forms.

    Pharmacopoeia Ref : USP/EP/JP

    Technical Specs : NA

    Ingredient(s) : Castor Oil Excipient

    arrow
    Nanjing Well Castor Oil

    Excipients Web Link

    Market Place

    Digital Content

    Virtual Booth

    06

    Finar

    India
    Antibody Engineering
    Not Confirmed
    arrow

    07

    Nanjing Bold Chemical

    China
    Antibody Engineering
    Not Confirmed
    arrow

    08

    Actylis

    U.S.A
    Antibody Engineering
    Not Confirmed
    arrow

    09

    Actylis

    U.S.A
    Antibody Engineering
    Not Confirmed
    arrow

    10

    Seppic

    France
    Antibody Engineering
    Not Confirmed
    arrow
    Only 10 entries up to this point, click to access all click full view read-more
    click full view

    Emulsifying Agents

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Surfactant & Foaming Agents

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Fillers, Diluents & Binders

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Taste Masking

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    Rheology Modifiers

    read-more
    read-more

    Lubricants & Glidants

    read-more
    read-more

    API Stability Enhancers

    read-more
    read-more

    Chewable & Orodispersible Aids

    read-more
    read-more

    Granulation

    read-more
    read-more

    Soft Gelatin

    read-more
    read-more

    Disintegrants & Superdisintegrants

    read-more
    read-more

    Digital Content read-more

    Create Content with PharmaCompass, ask us

    DATA COMPILATION #PharmaFlow

    read-more
    read-more

    NEWS #PharmaBuzz

    read-more
    read-more

    Market Place

    Do you need sourcing support? Ask us

    REF. STANDARDS & IMPURITIES

    Upload your portfolio for free, ask us

    USP

    read-more
    read-more

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search