Find Berzosertib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

API Suppliers

API Suppliers

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

0

Listed Suppliers

Other Suppliers

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: Ve-822, 1232416-25-9, Vx-970, Ve822, Vx970, Ve 822
Molecular Formula
C24H25N5O3S
Molecular Weight
463.6  g/mol
InChI Key
JZCWLJDSIRUGIN-UHFFFAOYSA-N
FDA UNII
L423PRV3V3

Berzosertib
Berzosertib is an inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. Upon administration, berzosertib selectively binds to and inhibits ATR kinase activity and prevents ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress.
1 2D Structure

Berzosertib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine
2.1.2 InChI
InChI=1S/C24H25N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-12,14-15,26H,13H2,1-3H3,(H2,25,27)
2.1.3 InChI Key
JZCWLJDSIRUGIN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)S(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C3=CC(=NO3)C4=CC=C(C=C4)CNC)N
2.2 Other Identifiers
2.2.1 UNII
L423PRV3V3
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-pyrazinamine, 3-(3-(4-((methylamino)methyl)phenyl)-5-isoxazolyl)-5-(4-((1-methylethyl)sulfonyl)phenyl)-

2. 3-(3-(4-((methylamino)methyl)phenyl)-1,2-oxazol-5-yl)-5-(4-(propane-2-sulfonyl)phenyl)pyrazin-2-amine

3. Ve-822

4. Vx-970

2.3.2 Depositor-Supplied Synonyms

1. Ve-822

2. 1232416-25-9

3. Vx-970

4. Ve822

5. Vx970

6. Ve 822

7. Berzosertib [usan]

8. Ve-822 (vx-970)

9. L423prv3v3

10. M6620

11. 2-pyrazinamine, 3-(3-(4-((methylamino)methyl)phenyl)-5-isoxazolyl)-5-(4-((1-methylethyl)sulfonyl)phenyl)-

12. 3-(3-{4-[(methylamino)methyl]phenyl}-1,2-oxazol-5-yl)-5-[4-(propane-2-sulfonyl)phenyl]pyrazin-2-amine

13. 3-[3-[4-(methylaminomethyl)phenyl]-1,2-oxazol-5-yl]-5-(4-propan-2-ylsulfonylphenyl)pyrazin-2-amine

14. 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine

15. M-6620

16. 3-(3-(4-((methylamino)methyl)phenyl)-1,2-oxazol-5-yl)-5-(4-(propane-2-sulfonyl)phenyl)pyrazin-2-amine

17. Bdbm50226746

18. 2-pyrazinamine, 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-

19. 3-[3-[4-[(methylamino)methyl]phenyl]-5-isoxazolyl]-5-[4-[(1-methylethyl)sulfonyl]phenyl]-2-pyrazinamine

20. 5-(4-(isopropylsulfonyl)phenyl)-3-(3-(4-((methylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-amine.

21. Unii-l423prv3v3

22. 3-(3-(4-((methylamino)methyl)phenyl)-5-isoxazolyl)-5-(4-((1-methylethyl)sulfonyl)phenyl)-2-pyrazinamine

23. Vx-970;berzosertib

24. Berzosertib [inn]

25. Berzosertib (usan/inn)

26. Berzosertib (ve-822)

27. Agn-pc-0cxkb3

28. Berzosertib [who-dd]

29. Gtpl8003

30. Schembl3061890

31. Chembl3989870

32. Ex-a529

33. Chebi:131166

34. Bdbm350085

35. Dtxsid601025940

36. Hms3653c05

37. Hms3747i11

38. Bcp07948

39. Mfcd27976794

40. Nsc777718

41. S7102

42. Us10208027, Compound Ii-1

43. Us10208027, Compound Ii-2

44. Us10208027, Compound Ii-3

45. Us10208027, Compound Ii-4

46. Vx 970

47. Zinc96170459

48. Akos025404905

49. Ccg-264673

50. Cs-1861

51. Db11794

52. Nsc-777718

53. Sb17265

54. Ncgc00386313-07

55. Ac-32951

56. As-17041

57. Da-46989

58. Hy-13902

59. Ft-0700136

60. Sw220202-1

61. A13289

62. D11148

63. A857986

64. Q27089129

65. 5-(4-isopropylsulfonylphenyl)-3-[3-[4-(methylaminomethyl)phenyl]isoxazol-5-yl]pyrazin-2-amine

66. Synthesis Of 3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isoxazol-5-yl]-5-(4-isopropylsulfonylphenyl)pyrazin-2-amine

2.4 Create Date
2012-08-20
3 Chemical and Physical Properties
Molecular Weight 463.6 g/mol
Molecular Formula C24H25N5O3S
XLogP32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass463.16781085 g/mol
Monoisotopic Mass463.16781085 g/mol
Topological Polar Surface Area132 Ų
Heavy Atom Count33
Formal Charge0
Complexity714
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

ABOUT THIS PAGE

Berzosertib Manufacturers

A Berzosertib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Berzosertib, including repackagers and relabelers. The FDA regulates Berzosertib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Berzosertib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Berzosertib Suppliers

A Berzosertib supplier is an individual or a company that provides Berzosertib active pharmaceutical ingredient (API) or Berzosertib finished formulations upon request. The Berzosertib suppliers may include Berzosertib API manufacturers, exporters, distributors and traders.

Berzosertib GMP

Berzosertib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Berzosertib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Berzosertib GMP manufacturer or Berzosertib GMP API supplier for your needs.

Berzosertib CoA

A Berzosertib CoA (Certificate of Analysis) is a formal document that attests to Berzosertib's compliance with Berzosertib specifications and serves as a tool for batch-level quality control.

Berzosertib CoA mostly includes findings from lab analyses of a specific batch. For each Berzosertib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Berzosertib may be tested according to a variety of international standards, such as European Pharmacopoeia (Berzosertib EP), Berzosertib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Berzosertib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty