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Besifloxacin Hydrochloride

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ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 6 USDMF, 1 EU WC, 4 NDC API, 4 Listed Suppliers, $ API Reference Price

7 API Suppliers
6 USDMF
1 EU WC
4 NDC API
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 1 FDA Orange Book, 1 Canada, 1 South Africa, 1 Listed Dossiers

4 FDF Dossiers
1 FDA Orange Book
1 Canada
1 South Africa
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 12 SPI Pharma, 1 Faran Shimi Pharmaceutical, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 Actylis, 3 BASF, 1 Finar, 3 Gangwal Chemicals, 1 Ingredion Pharma Solutions, 2 Kerry, 1 Lubrizol Life Science Health, 2 Microlex e.U, 1 Nanjing Bold Chemical, 1 Pluviaendo, 3 Roquette, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders, 11 Chewable & Orodispersible Aids, 10 Direct Compression, 9 Taste Masking, 8 Parenteral, 5 Solubilizers, 4 Co-Processed Excipients, 4 Granulation, 3 Disintegrants & Superdisintegrants, 3 Thickeners and Stabilizers, 2 Topical, 1 API Stability Enhancers, 1 Controlled & Modified Release, 1 Lubricants & Glidants

excipientsByApplications
17 Fillers, Diluents & Binders
11 Chewable & Orodispersible Aids
10 Direct Compression
9 Taste Masking
8 Parenteral
5 Solubilizers
4 Co-Processed Excipients
4 Granulation
3 Disintegrants & Superdisintegrants
3 Thickeners and Stabilizers
2 Topical
1 API Stability Enhancers
1 Controlled & Modified Release
1 Lubricants & Glidants

DIGITAL CONTENT

2 NEWS #PharmaBuzz

media
2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

globalSalesInformation
1 US Medicaid Prescriptions

MARKET PLACE

3 APIs, 1 FDF Dossiers

marketPlace
3 APIs
1 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents, 1 Health Canada Patents

patents
4 US Patents
1 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 16,006

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

14,250,102

Annual Reports (USD Million)

Finished Drug Prices

41 RELATED EXCIPIENT COMPANIES

79EXCIPIENTS BY APPLICATIONS

Chemistry

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Click the button for full data set

Also known as: Besifloxacin hcl, 405165-61-9, Besivance, Besifloxacin (hydrochloride), Bol-303224-a, Besifloxacin hydrochloride [usan]

Molecular Formula

C₁₉H₂₂Cl₂FN₃O₃

Molecular Weight

430.3 g/mol

InChI Key

PMQBICKXAAKXAY-HNCPQSOCSA-N

FDA UNII

7506A6J57T

1 2D Structure

Besifloxacin Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid;hydrochloride

2.1.2 InChI

InChI=1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H/t10-;/m1./s1

2.1.3 InChI Key

PMQBICKXAAKXAY-HNCPQSOCSA-N

2.1.4 Canonical SMILES

C1CCN(CC(C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F.Cl

2.1.5 Isomeric SMILES

C1CCN(C[C@@H](C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F.Cl

2.2 Other Identifiers

2.2.1 UNII

7506A6J57T

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 7-((3r)-aminohexahydro-1h-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

2. 7-(3-aminohexahydro-1h-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid

3. Besifloxacin

4. Besivance

5. Bol-303224-a

2.3.2 Depositor-Supplied Synonyms

1. Besifloxacin Hcl

2. 405165-61-9

3. Besivance

4. Besifloxacin (hydrochloride)

5. Bol-303224-a

6. Besifloxacin Hydrochloride [usan]

7. Ss734

8. Besifloxacin Hcl (besivance)

9. Besifloxacin (as Hydrochloride)

10. Ss-734

11. 7506a6j57t

12. 405165-61-9 (hcl)

13. Unii-7506a6j57t

14. Besifloxacin Hydrochloride (usan)

15. (+)-7-((3r)-3-aminohexahydro-1h-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

16. (+)-7-[(3r)-3-aminohexahydro-1h-azepin-1-yl]-8-chloro-1- Cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride.

17. (r)-7-(3-aminoazepan-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Hydrochloride

18. 3-quinolinecarboxylic Acid, 7-((3r)-3-aminohexahydro-1h-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, Monohydrochloride

19. 7-[(3r)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic Acid;hydrochloride

20. Bol 303224a

21. Besivance (tn)

22. Besivance Hydrochloride

23. 7-[(3r)-3-aminohexahydro-1h-azepin-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride

24. Schembl291598

25. Chembl1201761

26. Dtxsid20193529

27. Besifloxacin Hydrochloride- Bio-x

28. Amy18155

29. Ex-a1339

30. Mfcd14636632

31. S3055

32. Akos025401618

33. Besifloxacin Hydrochloride [mi]

34. Ccg-221259

35. Cs-0713

36. Ac-23367

37. Bb164241

38. Besifloxacin Hydrochloride [mart.]

39. Besifloxacin Hydrochloride [vandf]

40. Hy-17028

41. Besifloxacin Hydrochloride [who-dd]

42. Besifloxacin Hydrochloride [orange Book]

43. C75052

44. D08872

45. 165b619

46. A848253

47. J-519840

48. Q27266315

49. Besifloxacin Hydrochloride 100 Microg/ml In Acetonitrile:water

50. (r)-7-(3-aminohexahydro-1h-azepin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrochloride

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₂Cl₂FN₃O₃
Molecular Weight	430.3 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	429.1022251 g/mol
Monoisotopic Mass	429.1022251 g/mol
Topological Polar Surface Area	86.9 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	656
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Topoisomerase II Inhibitors

Compounds that inhibit the activity of DNA TOPOISOMERASE II. Included in this category are a variety of ANTINEOPLASTIC AGENTS which target the eukaryotic form of topoisomerase II and ANTIBACTERIAL AGENTS which target the prokaryotic form of topoisomerase II. (See all compounds classified as Topoisomerase II Inhibitors.)

API SUPPLIERS

01

Micro Labs Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

02

ALP Pharm

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

03

Indoco Remedies Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

04

Maithri Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

05

HEC Pharm

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

06

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

07

Globofarm International

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

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USDMF

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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SERVICES","customerCountry":"LEBANON","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"10400","totalValueFC":"20509.9","currency":"USD","unitRateINR":856363.875,"date":"30-Apr-2024","totalValueINR":"1712727.75","totalValueInUsd":"20509.9","indian_port":"Bangalore Air","hs_no":"29334900","bill_no":"9505496","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"NO 31, RACE COURSE ROAD,BANGALORE, BENGALURU,KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724956200,"product":"BESIFLOXACIN HYDROCHLORIDE","address":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,","city":"MUMBAI.MAHARASHTRA","supplier":"INDOCO REMEDIES LIMITED","supplierCountry":"INDIA","foreign_port":"JEDDAH","customer":"TO ORDER","customerCountry":"SAUDI ARABIA","quantity":"2.50","actualQuantity":"2.5","unit":"KGS","unitRateFc":"17000","totalValueFC":"41996.5","currency":"USD","unitRateINR":1409043.6000000001,"date":"30-Aug-2024","totalValueINR":"3522609","totalValueInUsd":"41996.5","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"3610144","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,, MUMBAI.MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727029800,"product":"BESIFLOXACIN HYDROCHLORIDE IH (MICRONIZED & STERILE) BATCH NO. - BES\/B\/MS\/24\/001 MFG. DATE - DEC, 2023 RETEST","address":"PLOT NO.B-29\/1 MIDC","city":"MAHAD","supplier":"FLAX LABORATORIES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BEIRUT","customer":"AFRIKA TRADE & ","customerCountry":"LEBANON","quantity":"0.35","actualQuantity":"350","unit":"GMS","unitRateFc":"10.3","totalValueFC":"3542","currency":"USD","unitRateINR":848.06700000000001,"date":"23-Sep-2024","totalValueINR":"296823.45","totalValueInUsd":"3542","indian_port":"Bombay Air","hs_no":"29242990","bill_no":"4261423","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"LEBANON","selfForZScoreResived":"Micronized","supplierPort":"Bombay Air","supplierAddress":"PLOT NO.B-29\/1 MIDC, MAHAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"BESIFLOXACIN HYDROCHLORIDE","address":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,","city":"MUMBAI.MAHARASHTRA","supplier":"INDOCO REMEDIES LIMITED","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"TO ORDER","customerCountry":"BRAZIL","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"21000","totalValueFC":"1940.7","currency":"USD","unitRateINR":1630720,"date":"30-Oct-2024","totalValueINR":"163072","totalValueInUsd":"1940.7","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5297286","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,, MUMBAI.MAHARASHTRA","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

7 API Suppliers

6 USDMF

1 EU WC

4 NDC API

4 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers

1 FDA Orange Book

1 Canada

1 South Africa

1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

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12 SPI Pharma

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1 Nanjing Well Pharmaceutical

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4 Actylis

3 BASF

1 Finar

3 Gangwal Chemicals

1 Ingredion Pharma Solutions

2 Kerry

1 Lubrizol Life Science Health

2 Microlex e.U

1 Nanjing Bold Chemical

1 Pluviaendo

3 Roquette

1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

1 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

17 Fillers, Diluents & Binders

11 Chewable & Orodispersible Aids

10 Direct Compression

9 Taste Masking

8 Parenteral

5 Solubilizers

4 Co-Processed Excipients

4 Granulation

3 Disintegrants & Superdisintegrants

3 Thickeners and Stabilizers

2 Topical

1 API Stability Enhancers

1 Controlled & Modified Release

1 Lubricants & Glidants

DIGITAL CONTENT

2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

MARKET PLACE

3 APIs

1 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents

1 Health Canada Patents

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 16,006

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

GLOBAL SALES INFORMATION

79EXCIPIENTS BY APPLICATIONS

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02

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