Find Beta-D-N4-hydroxycytidine manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: N4-hydroxycytidine, Eidd-1931, Beta-d-n4-hydroxycytidine, N-hydroxycytidine, 3258-02-4, 4-n-hydroxycytidine
Molecular Formula
C9H13N3O6
Molecular Weight
259.22  g/mol
InChI Key
XCUAIINAJCDIPM-XVFCMESISA-N
FDA UNII
C3D11PV2O4

Beta-D-N4-hydroxycytidine
N4-Hydroxyctidine, or EIDD-1931, is a ribonucleoside analog which induces mutations in RNA virions. N4-hydroxycytidine was first described in the literature in 1980 as a potent mutagen of bacteria and phage. It has shown antiviral activity against Venezuelan equine encephalitis virus, and the human coronavirus HCoV-NL63 in vitro. N4-hydroxycytodine has been shown to inhibit SARS-CoV-2 as well as other human and bat coronaviruses in mice and human airway epithelial cells. It is orally bioavailable in mice and distributes into tissue before becoming the active 5-triphosphate form, which is incorporated into the genome of new virions, resulting in the accumulation of inactivating mutations. In non-human primates, N4-hydroxycytidine was poorly orally bioavailable. A [remdesivir] resistant mutant mouse hepatitis virus has also been shown to have increased sensitivity to N4-hydroxycytidine. The prodrug of N4-hydroxycytidine, [EIDD-2801], is also being investigated for its broad spectrum activity against the coronavirus family of viruses.
1 2D Structure

Beta-D-N4-hydroxycytidine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one
2.1.2 InChI
InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1
2.1.3 InChI Key
XCUAIINAJCDIPM-XVFCMESISA-N
2.1.4 Canonical SMILES
C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
2.1.5 Isomeric SMILES
C1=CN(C(=O)N=C1NO)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
2.2 Other Identifiers
2.2.1 UNII
C3D11PV2O4
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-oxime Uridine

2. Beta-d-n4-hydroxycytidine

3. Eidd-1931

4. N4-hydroxycytidine

2.3.2 Depositor-Supplied Synonyms

1. N4-hydroxycytidine

2. Eidd-1931

3. Beta-d-n4-hydroxycytidine

4. N-hydroxycytidine

5. 3258-02-4

6. 4-n-hydroxycytidine

7. C3d11pv2o4

8. 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)pyrimidin-2-one

9. 1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1h)-one

10. 4-oxime Uridine

11. N-4-hydroxycytidine

12. Cytidine, N-hydroxy-

13. Ccris 1074

14. 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyimino)-3,4-dihydropyrimidin-2(1h)-one

15. Unii-c3d11pv2o4

16. Eidd1931

17. Beta-d-n(4)-hydroxycytidine

18. N-hydroxy-3,4-dihydrocytidine

19. Schembl5190819

20. Chembl2178720

21. Eidd 1931

22. Gtpl10735

23. Dtxsid20186274

24. Chebi:180654

25. Ex-a3655

26. Mfcd01675695

27. At13085

28. Bs-47105

29. Hy-125033

30. Cs-0088698

31. 1-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxyamino)pyrimidin-2(1h)-one

32. 1-((2r,3r,4s,5r)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-hydroxyamino-1h-pyrimidin-2-one

33. 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hydroxyamino)-1,2-dihydropyrimidin-2-one

34. 1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4-(hydroxyamino)pyrimidin-2-one

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 259.22 g/mol
Molecular Formula C9H13N3O6
XLogP3-2.2
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass259.08043514 g/mol
Monoisotopic Mass259.08043514 g/mol
Topological Polar Surface Area135 Ų
Heavy Atom Count18
Formal Charge0
Complexity398
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

N4-hydroxycytidine and its prodrug [EIDD-2801] is being studied for its activity against a number of viral infections including influenza, MERS-CoV, and SARS-CoV-2.


5 Pharmacology and Biochemistry
5.1 Absorption, Distribution and Excretion

Absorption

N4-hydroxycytidine is orally bioavailable in mice but poorly bioavailable in non-human primates.


5.2 Metabolism/Metabolites

N4-hydroxycytidine distributes into tissues where it is is phosphorylated to the 5'-triphosphate form.


5.3 Mechanism of Action

N4-hydroxycytidine is phosphorylated in tissue to the active 5-triphosphate form, which is incorporated into the genome of new virions, resulting in the accumulation of inactivating mutations, known as viral error catastrophe. A [remdesivir] resistant mutant mouse hepatitis virus has also been shown to have increased sensitivity to N4-hydroxycytidine.


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Looking for 3258-02-4 / Beta-D-N4-hydroxycytidine API manufacturers, exporters & distributors?

Beta-D-N4-hydroxycytidine manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Beta-D-N4-hydroxycytidine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Beta-D-N4-hydroxycytidine manufacturer or Beta-D-N4-hydroxycytidine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Beta-D-N4-hydroxycytidine manufacturer or Beta-D-N4-hydroxycytidine supplier.

PharmaCompass also assists you with knowing the Beta-D-N4-hydroxycytidine API Price utilized in the formulation of products. Beta-D-N4-hydroxycytidine API Price is not always fixed or binding as the Beta-D-N4-hydroxycytidine Price is obtained through a variety of data sources. The Beta-D-N4-hydroxycytidine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Beta-D-N4-hydroxycytidine

Synonyms

N4-hydroxycytidine, Eidd-1931, N-hydroxycytidine, 3258-02-4, 4-n-hydroxycytidine, C3d11pv2o4

Cas Number

3258-02-4

Unique Ingredient Identifier (UNII)

C3D11PV2O4

About Beta-D-N4-hydroxycytidine

N4-Hydroxyctidine, or EIDD-1931, is a ribonucleoside analog which induces mutations in RNA virions. N4-hydroxycytidine was first described in the literature in 1980 as a potent mutagen of bacteria and phage. It has shown antiviral activity against Venezuelan equine encephalitis virus, and the human coronavirus HCoV-NL63 in vitro. N4-hydroxycytodine has been shown to inhibit SARS-CoV-2 as well as other human and bat coronaviruses in mice and human airway epithelial cells. It is orally bioavailable in mice and distributes into tissue before becoming the active 5-triphosphate form, which is incorporated into the genome of new virions, resulting in the accumulation of inactivating mutations. In non-human primates, N4-hydroxycytidine was poorly orally bioavailable. A [remdesivir] resistant mutant mouse hepatitis virus has also been shown to have increased sensitivity to N4-hydroxycytidine. The prodrug of N4-hydroxycytidine, [EIDD-2801], is also being investigated for its broad spectrum activity against the coronavirus family of viruses.

Beta-D-N4-hydroxycytidine Manufacturers

A Beta-D-N4-hydroxycytidine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Beta-D-N4-hydroxycytidine, including repackagers and relabelers. The FDA regulates Beta-D-N4-hydroxycytidine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Beta-D-N4-hydroxycytidine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Beta-D-N4-hydroxycytidine Suppliers

A Beta-D-N4-hydroxycytidine supplier is an individual or a company that provides Beta-D-N4-hydroxycytidine active pharmaceutical ingredient (API) or Beta-D-N4-hydroxycytidine finished formulations upon request. The Beta-D-N4-hydroxycytidine suppliers may include Beta-D-N4-hydroxycytidine API manufacturers, exporters, distributors and traders.

Beta-D-N4-hydroxycytidine GMP

Beta-D-N4-hydroxycytidine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Beta-D-N4-hydroxycytidine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Beta-D-N4-hydroxycytidine GMP manufacturer or Beta-D-N4-hydroxycytidine GMP API supplier for your needs.

Beta-D-N4-hydroxycytidine CoA

A Beta-D-N4-hydroxycytidine CoA (Certificate of Analysis) is a formal document that attests to Beta-D-N4-hydroxycytidine's compliance with Beta-D-N4-hydroxycytidine specifications and serves as a tool for batch-level quality control.

Beta-D-N4-hydroxycytidine CoA mostly includes findings from lab analyses of a specific batch. For each Beta-D-N4-hydroxycytidine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Beta-D-N4-hydroxycytidine may be tested according to a variety of international standards, such as European Pharmacopoeia (Beta-D-N4-hydroxycytidine EP), Beta-D-N4-hydroxycytidine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Beta-D-N4-hydroxycytidine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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