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Chemistry

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Also known as: Delta-gluconolactone, 90-80-2, D-glucono-1,5-lactone, Gluconic acid lactone, D-gluconolactone, 1,5-gluconolactone
Molecular Formula
C6H10O6
Molecular Weight
178.14  g/mol
InChI Key
PHOQVHQSTUBQQK-SQOUGZDYSA-N
FDA UNII
WQ29KQ9POT

Beta-Glucono-1,5-Lactone
Gluconolactone is a naturally occurring polyhydroxy acid (PHA) with metal chelating, moisturizing and antioxidant activity. Gluconolactone can be produced by enzymatic oxidation of D-glucose oxidation. Its ability in free radicals scavenging accounts for its antioxidant property. It is used in cosmetic product and as a coagulant in tofu processing. (NCI05)
Gluconolactone is a Calculi Dissolution Agent. The mechanism of action of gluconolactone is as an Irrigation.
1 2D Structure

Beta-Glucono-1,5-Lactone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one
2.1.2 InChI
InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1
2.1.3 InChI Key
PHOQVHQSTUBQQK-SQOUGZDYSA-N
2.1.4 Canonical SMILES
C(C1C(C(C(C(=O)O1)O)O)O)O
2.1.5 Isomeric SMILES
C([C@@H]1[C@H]([C@@H]([C@H](C(=O)O1)O)O)O)O
2.2 Other Identifiers
2.2.1 UNII
WQ29KQ9POT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Beta-glucono-1,5-lactone

2. Delta-gluconolactone

3. Gdl (gluconate)

4. Gluconic Lactone

5. Glucono-delta-lactone

6. Gulonic Acid Gamma-lactone

2.3.2 Depositor-Supplied Synonyms

1. Delta-gluconolactone

2. 90-80-2

3. D-glucono-1,5-lactone

4. Gluconic Acid Lactone

5. D-gluconolactone

6. 1,5-gluconolactone

7. Glucono Delta-lactone

8. D-(+)-glucono-1,5-lactone

9. D-gluconic Acid Lactone

10. D-gluconic Acid Delta-lactone

11. 1,5-d-gluconolactone

12. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one

13. Gluconic Lactone

14. Glucono Delta Lactone

15. Gluconic Delta-lactone

16. Fujiglucon

17. D-delta-gluconolactone

18. Delta-d-gluconolactone

19. Deltagluconolactone

20. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-one

21. D-gluconic Delta-lactone

22. D-(+)-gluconic Acid Delta-lactone

23. Glucarolactone

24. Glucono-delta-lactone

25. D-aldonolactone

26. Beta-glucono-1,5-lactone

27. D-gluconic Acid-delta-lactone

28. Gluconolactone [usp]

29. Lysactone

30. Riken Lactone

31. D-threo-aldono-1,5-lactone

32. 1335-57-5

33. Ai3-19578

34. Gluconic Acid Anhydride

35. Gluconic Acid, Delta-lactone, D-

36. Glucono .delta. Lactone

37. Glucono .delta.-lactone

38. .delta.-d-gluconolactone

39. Wq29kq9pot

40. 4253-68-3

41. Gluconic Acid Delta-lactone

42. Ins No.575

43. Chebi:16217

44. D-gluconic Acid .delta.-lactone

45. Ins-575

46. Nsc-34393

47. Nsc-758238

48. Gluconolactone (usp)

49. E-575

50. Nsc 34393

51. Dsstox_cid_6549

52. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one

53. Dsstox_rid_78147

54. Dsstox_gsid_26549

55. 135820-79-0

56. D-gluconic Acid, .delta.-lactone

57. Glucolactone

58. D-gluconic Acid D-lactone

59. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2h-pyran-2-one

60. Cas-90-80-2

61. .delta.-gluconolactone

62. D-glucono-delta-lactone

63. Lgc

64. Hsdb 488

65. D-gluconic Acid-1,5-lactone

66. Einecs 202-016-5

67. Unii-wq29kq9pot

68. Gluconic Acid Lactone (6ci)

69. Nsc34393

70. Delta-gluconic Acid Delta-lactone

71. Glucono--lactone

72. Gluconodeltalactone

73. Delta-aldonolactone

74. Gluconate, Lactone

75. Ncgc00095002-01

76. Delta Gluconolactone

77. Gamma-gluconolactone

78. Gdl

79. D-glucono-d-lactone

80. Mfcd00006647

81. Glucono Gamma-lactone

82. Glucono-1,5-lactone

83. Glucono 1,5-lactone

84. D-glucono1,5-lactone

85. Gluconic Acid D-lactone

86. Delta-delta-gluconolactone

87. 1,5-delta-gluconolactone

88. Bmse000230

89. Delta-gluconic Acid Lactone

90. Delta-glucono-delta-lactone

91. Ec 202-016-5

92. Gluconolactone [ii]

93. Gluconolactone [mi]

94. Delta-glucono-1,5-lactone

95. Delta-gluconic Delta-lactone

96. Glucono-delta-lactone(gdl)

97. Schembl15320

98. Gluconolactone [hsdb]

99. Gluconolactone [inci]

100. Delta-gluconic Acid D-lactone

101. Mls002207105

102. D-gluconic Acid 1,5-lactone

103. Gluconolactone [mart.]

104. Gluconolactone [usp-rs]

105. Gluconolactone [who-dd]

106. Chembl1200829

107. D-(+)-gluconic Acid D-lactone

108. Dtxsid0026549

109. Delta-gluconic Acid 1,5-lactone

110. Delta-gluconic Acid-1,5-lactone

111. Delta-gluconic Acid-delta-lactone

112. D(+)-gluconic Acid Gamma-lactone

113. Glucono-

114. A-lactone Usp26 Fcciv

115. Cs-m3768

116. D-(+)-gluconic Acid-delta Lactone

117. Delta-(+)-gluconic Acid D-lactone

118. Glucono Delta-lactone [fcc]

119. Hy-i0301

120. Zinc2539702

121. Gluconolactone [orange Book]

122. Tox21_111383

123. Tox21_200429

124. Bdbm50366565

125. Glucono-delta-lactone [vandf]

126. Gluconolactone [usp Monograph]

127. Akos016843888

128. Tox21_111383_1

129. Db04564

130. Delta-(+)-gluconic Acid-delta Lactone

131. Ds-4779

132. Ncgc00257983-01

133. Ncgc00344522-01

134. Renacidin Component Gluconolactone

135. Ac-13150

136. E575

137. Smr001306715

138. Gluconolactone Component Of Renacidin

139. G0039

140. C00198

141. D04332

142. P19765

143. D-(+)-gluconic Acid Delta-lactone, >=99.0%

144. Gluconolactone, Meets Usp Testing Specifications

145. Q114174

146. W-100325

147. 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-one

148. 3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-one

149. D-(+)-gluconic Acid Delta-lactone, Analytical Standard

150. Wurcs=2.0/1,1,0/[a2122h_1-5]/1/

151. A88519cb-a562-4c9c-b925-0a6b1701f841

152. Gluconolactone, United States Pharmacopeia (usp) Reference Standard

153. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydropyran-2-one

154. (3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one (non-preferred Name)

155. (3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-one; Gluconolactone

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 178.14 g/mol
Molecular Formula C6H10O6
XLogP3-2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass178.04773803 g/mol
Monoisotopic Mass178.04773803 g/mol
Topological Polar Surface Area107 Ų
Heavy Atom Count12
Formal Charge0
Complexity181
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

MEDICATION (VET): ...Mixture in urine helps dissolve urinary tract stones containing calcium carbonate, tricalcium phosphate, calcium oxalates, & magnesium ammonium phosphates but usually none containing uric acid, urates, cystineine, or some oxalates.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 240


MEDICATION (VET): 0.5% Solution can be used for irrigating the urethra & bladder when indicated. Similar strength as a rinse can help maintain in dwelling urethral catheters free of calcification.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 240


5 Pharmacology and Biochemistry
5.1 FDA Pharmacological Classification
5.1.1 Active Moiety
GLUCONOLACTONE
5.1.2 FDA UNII
WQ29KQ9POT
5.1.3 Pharmacological Classes
Mechanisms of Action [MoA] - Irrigation

FDF Dossiers

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Estilad

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Sodium DNA; Sodium Hyaluronate; Sodium Chloride; GLYCERIN; GLUCONOLACTONE; Sodium Benzoate; Calcium Gluconate

Brand Name :

Dosage Form : Solution

Dosage Strength :

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Canada

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02

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CITRIC ACID; GLUCONOLACTONE; MAGNESIUM CARBONATE

Brand Name : RENACIDIN

Dosage Form : SOLUTION;IRRIGATION

Dosage Strength : 6.602GM/100ML;198MG/100ML;3.177GM/100ML

Packaging :

Approval Date : 1990-10-02

Application Number : 19481

Regulatory Info : RX

Registration Country : USA

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ABOUT THIS PAGE

Beta-Glucono-1,5-Lactone Manufacturers

A Beta-Glucono-1,5-Lactone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Beta-Glucono-1,5-Lactone, including repackagers and relabelers. The FDA regulates Beta-Glucono-1,5-Lactone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Beta-Glucono-1,5-Lactone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Beta-Glucono-1,5-Lactone Suppliers

A Beta-Glucono-1,5-Lactone supplier is an individual or a company that provides Beta-Glucono-1,5-Lactone active pharmaceutical ingredient (API) or Beta-Glucono-1,5-Lactone finished formulations upon request. The Beta-Glucono-1,5-Lactone suppliers may include Beta-Glucono-1,5-Lactone API manufacturers, exporters, distributors and traders.

Beta-Glucono-1,5-Lactone GMP

Beta-Glucono-1,5-Lactone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Beta-Glucono-1,5-Lactone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Beta-Glucono-1,5-Lactone GMP manufacturer or Beta-Glucono-1,5-Lactone GMP API supplier for your needs.

Beta-Glucono-1,5-Lactone CoA

A Beta-Glucono-1,5-Lactone CoA (Certificate of Analysis) is a formal document that attests to Beta-Glucono-1,5-Lactone's compliance with Beta-Glucono-1,5-Lactone specifications and serves as a tool for batch-level quality control.

Beta-Glucono-1,5-Lactone CoA mostly includes findings from lab analyses of a specific batch. For each Beta-Glucono-1,5-Lactone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Beta-Glucono-1,5-Lactone may be tested according to a variety of international standards, such as European Pharmacopoeia (Beta-Glucono-1,5-Lactone EP), Beta-Glucono-1,5-Lactone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Beta-Glucono-1,5-Lactone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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