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LGM Nicotinamide Adenine Dinucleotide

Synopsis

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Also known as: Nicotinamide adenine dinucleotide, Nad+, Enzopride, Diphosphopyridine nucleotide, 53-84-9, Adenine-nicotinamide dinucleotide

Molecular Formula

C₂₁H₂₈N₇O₁₄P₂+

Molecular Weight

664.4 g/mol

InChI Key

BAWFJGJZGIEFAR-NNYOXOHSSA-O

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

1 2D Structure

Beta Nicotinamide Adenine Dinucleotide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

2.1.2 InChI

InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p+1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

2.1.3 InChI Key

BAWFJGJZGIEFAR-NNYOXOHSSA-O

2.1.4 Canonical SMILES

C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

2.1.5 Isomeric SMILES

C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Adenine Dinucleotide, Dihydronicotinamide

2. Coenzyme I

3. Dihydronicotinamide Adenine Dinucleotide

4. Dinucleotide, Dihydronicotinamide Adenine

5. Dinucleotide, Nicotinamide-adenine

6. Diphosphopyridine Nucleotide

7. Dpn

8. Nad

9. Nadh

10. Nadide

11. Nicotinamide Adenine Dinucleotide

12. Nicotinamide-adenine Dinucleotide

13. Nucleotide, Diphosphopyridine

2.2.2 Depositor-Supplied Synonyms

1. Nicotinamide Adenine Dinucleotide

2. Nad+

3. Enzopride

4. Diphosphopyridine Nucleotide

5. 53-84-9

6. Adenine-nicotinamide Dinucleotide

7. Nad

8. Nadidum [inn-latin]

9. Nadida [inn-spanish]

10. Nad(+)

11. Chebi:15846

12. [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3s,4r,5r)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl Hydrogen Phosphate

13. 151411-04-0

14. Nicotinamide-adenine Dinucleotide

15. Brn 3584133

16. Sr-05000001677

17. Nadide [usan:ban:inn:jan]

18. Nad Cation

19. [[(2r,3s,4r,5r)-5-[(3r)-3-aminocarbonyl-3,4-dihydro-2h-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl Phosphate

20. 121053-11-0

21. Naj

22. Txe

23. Spectrum_000973

24. Nicotinamide Adenine Dinucleotide (nad+)

25. [[(2~{r},3~{s},4~{r},5~{r})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-4-[[5-[4-cyano-2-[(~{e})-hydroxyiminomethyl]phenoxy]-1-oxidanyl-3~{h}-2,1$l^{4}-benzoxaborol-1-yl]oxy]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl Hydrogen Phosphate

26. 9jm

27. Adenosine 5'-(trihydrogen Diphosphate), P'-5'-ester With 3-(aminocarbonyl)-1-beta-d-ribofuranosylpyridinium, Inner Salt

28. Prestwick3_000741

29. Pyridinium, 3-carbamoyl-1-beta-d-ribofuranosyl-, Hydroxide, 5'-ester With Adenosine 5'-5'-(trihydrogen Pyrophosphate), Inner Salt

30. Spectrum2_001056

31. Spectrum3_000511

32. Spectrum4_000065

33. Spectrum5_001291

34. Bmse000053

35. Nadide (jan/usan/inn)

36. Bspbio_000722

37. Bspbio_002061

38. Kbiogr_000589

39. Kbioss_001453

40. Divk1c_000189

41. Spbio_001012

42. Bpbio1_000796

43. Chembl3039307

44. Schembl14478781

45. Kbio1_000189

46. Kbio2_001453

47. Kbio2_004021

48. Kbio2_006589

49. Kbio3_001561

50. Ninds_000189

51. Zinc8214766

52. Idi1_000189

53. 65085-09-8

54. C00003

55. D00002

56. 036d253

57. Sr-05000001677-1

58. Sr-05000001677-3

59. Brd-a11132253-001-01-7

60. Q26987253

61. 1-[5-o-[(5'-adenylyloxy)phosphonyl]-beta-d-ribofuranosyl]-3-(aminocarbonyl)pyridinium

62. Coconut Oil, Polymer With Benzoic Acid, Glycerol, Pentaerythritol And Phthalic Anhydride

63. 865-05-4

64. Adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-d-ribitol-5-yl] Dihydrogen Diphosphate}

2.3 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₈N₇O₁₄P₂+
Molecular Weight	664.4 g/mol
XLogP3	-5.9
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	11
Exact Mass	664.11694759 g/mol
Monoisotopic Mass	664.11694759 g/mol
Topological Polar Surface Area	318 Å²
Heavy Atom Count	44
Formal Charge	1
Complexity	1130
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

API SUPPLIERS

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USDMF

01

Ss Pharma Llc

India

Antibody Engineering

Not Confirmed

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ß-nicotinamide Adenine Dinucleotide

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 39720

Submission : 2024-04-09

Status : Active

Type : II

02

Bontac Bio-engineering Shenzhen Co L...

China

Antibody Engineering

Not Confirmed

03

Sigma F And D Div Ltd

U.S.A

Antibody Engineering

Not Confirmed

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INDUSTRIA AUTOMOTRIZ NO 301 50071 TOLUCA, EDO. DE MEXICO CP 50071 MX","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728412200,"product":"NADOLOL NADOLOL","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"APOTEX INC","supplierCountry":"MEXICO","foreign_port":"MEXICO CITY","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"346.36","actualQuantity":"346.36","unit":"KGS","unitRateFc":"625","totalValueFC":"218596.4","currency":"USD","unitRateINR":"53031.3","date":"09-Oct-2024","totalValueINR":"18367903.75","totalValueInUsd":"218596.4","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29221990","bill_no":"6027620","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"MEXICO CITY","supplierAddress":"AV. INDUSTRIA AUTOMOTRIZ NO 301 50071 TOLUCA, EDO. DE MEXICO CP 50071 MX","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728498600,"product":"B-NADH (BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE, REDUCED FORM, DISODIUM SALT) (ABBREVIATION) (CAT-44320900) (LOT.010410)(","address":"SHOP NO.37,GR,FLR,THE GREAT EASTERN","city":"PLOT NO.20,SEC-4,NERUL, NAVI MUMBAI","supplier":"NISSHIN SEIFUN GROUP","supplierCountry":"JAPAN","foreign_port":"TOKYO - NARITA","customer":"NISSHIN SEIFUN GROUP","customerCountry":"INDIA","quantity":"2.50","actualQuantity":"2500","unit":"GMS","unitRateFc":"201.2","totalValueFC":"6108.4","currency":"INR","unitRateINR":"205.3","date":"10-Oct-2024","totalValueINR":"513263.89","totalValueInUsd":"6108.4","indian_port":"Bombay Air","hs_no":"29349990","bill_no":"6058057","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"6-10, 3-CHROME, AZUSAWA, ITABASHI-K U, TOKYO 174-8505 SDNF Japan","customerAddress":"SHOP NO.37,GR,FLR,THE GREAT EASTERN"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729276200,"product":"10004669103 B-NADP, DISODIUM SALT","address":"PLOT NO. 114 ROADX NO.15, MIDC","city":"MUMBAI","supplier":"F. HOFFMANN-LA ROCHE","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"F. HOFFMANN-LA ROCHE","customerCountry":"INDIA","quantity":"1.50","actualQuantity":"1.5","unit":"KGS","unitRateFc":"286615","totalValueFC":"5116.5","currency":"INR","unitRateINR":"286615","date":"19-Oct-2024","totalValueINR":"429922.5","totalValueInUsd":"5116.5","indian_port":"Madras Air","hs_no":"29349990","bill_no":"6213926","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"DIAGNOSTICS FINANCE & IC SUPPLY (60 09), FORRENSTRASSE 2, CH-6343 ROTKR EUZ, Switzerland Switzerland","customerAddress":"PLOT NO. 114 ROADX NO.15, MIDC"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729449000,"product":"6A-METHYL-11B, 17A-DIHYDROXY-1, 4-PREGNADIENE-3, 20-DIONE (P1)","address":"15\/10 GORANI COMPOUND","city":"INDORE","supplier":"HANGZHOU DAWN RAY ","supplierCountry":"CHINA","foreign_port":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","customer":"BALAJI STEROIDS AND HORMONES PRIVATE LIMITED","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"440","totalValueFC":"22241.8","currency":"USD","unitRateINR":"37378","date":"21-Oct-2024","totalValueINR":"1868900","totalValueInUsd":"22241.8","indian_port":"Indore-EPZ\/SEZ","hs_no":"29379090","bill_no":"1007471","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HANGZHOU XIAOSHAN INTERNATIONAL APT, 33","supplierAddress":"N\/A","customerAddress":"15\/10 GORANI COMPOUND"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729881000,"product":"NONADYL","address":"PLOT NO.26,2ND CROSS,JIGANI","city":"BANGALORE","supplier":"GIVAUDAN INTERNATIONAL SA","supplierCountry":"SWITZERLAND","foreign_port":"GENEVA","customer":"GIVAUDAN INDIA PRIVATE ","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"90.7","totalValueFC":"91.6","currency":"USD","unitRateINR":"7700.7","date":"26-Oct-2024","totalValueINR":"7700.72","totalValueInUsd":"91.6","indian_port":"Bangalore Air","hs_no":"29051990","bill_no":"6350732","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"GENEVA","supplierAddress":"CHEMIN DE LA PARFUMERIE 5 CH-1214 VERNIER , SWITZERLAND","customerAddress":"PLOT NO.26,2ND CROSS,JIGANI"}]

Number of Transactions

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Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ACTIVE PHARMA INGREDIENTS

5 API Suppliers

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9 Empty Capsules

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6 Chewable & Orodispersible Aids

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