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Symbiotec Betamethasone Acetate

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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xyz-pharma-m-2024-10-07

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With Fermion, start the journey of your innovative API.

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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xyz-pharma-m-2024-10-07

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

20 API Suppliers, 8 USDMF, 1 JDMF, 3 EU WC, 8 NDC API, 14 Listed Suppliers, $ API Reference Price

20 API Suppliers
8 USDMF
1 JDMF
3 EU WC
8 NDC API
14 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

11 FDF Dossiers, 3 FDA Orange Book, 2 Canada, 5 South Africa, 1 Listed Dossiers

11 FDF Dossiers
3 FDA Orange Book
2 Canada
5 South Africa
1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 1 ACG Worldwide, 2 Actylis, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 Corel Pharma Chem, 1 Finar, 3 Gangwal Chemicals, 4 Ideal Cures Pvt Ltd, 12 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 1 Microlex e.U, 1 Novo Excipients, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 6 Seppic, 1 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 2 The Dow Chemical Company

EXCIPIENTS BY APPLICATIONS

38 Coating Systems & Additives, 17 Controlled & Modified Release, 5 Film Formers & Plasticizers, 5 Empty Capsules, 4 Vegetarian Capsules, 4 Solubilizers, 3 Fillers, Diluents & Binders, 3 API Stability Enhancers, 2 Parenteral, 2 Taste Masking, 2 Granulation, 2 Coloring Agents, 2 Direct Compression, 2 Emulsifying Agents, 1 Co-Processed Excipients, 1 Disintegrants & Superdisintegrants, 1 Topical, 1 Rheology Modifiers, 1 Thickeners and Stabilizers, 1 Chewable & Orodispersible Aids

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

MARKET PLACE

6 APIs, 1 FDF Dossiers

marketPlace
6 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 USP , 3 Others

otherSolutions
3 USP
3 Others

Symbiotec Betamethasone Acetate

Synopsis

ACTIVE PHARMA INGREDIENTS

20

API Suppliers

8

USDMF

0

CEP/COS

CEP/COS Certifications

1

JDMF

3

EU WC

0

KDMF

8

NDC API

0

VMF

14

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 3,194

MARKET PLACE

6

API

1

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

11

FDF Dossiers

3

FDA Orange Book

FDA (Orange Book)

0

Europe

2

Canada

0

Australia

5

South Africa

1

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

3

USP

0

JP

3

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

1

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

NA

58 RELATED EXCIPIENT COMPANIES

97EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 987-24-6, Betamethasone 21-acetate, Beta-methasone acetate, Ti05ao53l7, Chebi:31275, 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate

Molecular Formula

C₂₄H₃₁FO₆

Molecular Weight

434.5 g/mol

InChI Key

AKUJBENLRBOFTD-QZIXMDIESA-N

FDA UNII

TI05AO53L7

Betamethasone Acetate

1 2D Structure

Betamethasone Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

2.1.2 InChI

InChI=1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17-,18-,19-,21-,22-,23-,24-/m0/s1

2.1.3 InChI Key

AKUJBENLRBOFTD-QZIXMDIESA-N

2.1.4 Canonical SMILES

CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C)O)C)O)F)C

2.1.5 Isomeric SMILES

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C)O)C)O)F)C

2.2 Other Identifiers

2.2.1 UNII

TI05AO53L7

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 987-24-6

2. Betamethasone 21-acetate

3. Beta-methasone Acetate

4. Ti05ao53l7

5. Chebi:31275

6. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate

7. Nsc-759196

8. (11b,16a)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate

9. (11beta,16beta)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl Acetate

10. 9-fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-21-yl Acetate

11. [2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

12. Betamethasone Acetate [jan]

13. Unii-ti05ao53l7

14. Betamethasone Acetate [usp:jan]

15. Betamethasone-acetate

16. Einecs 213-578-6

17. 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 21-acetate

18. Betamethason-21-acetat

19. Schembl7592

20. Betamethasone21-acetate

21. Chembl1200538

22. Dtxsid8022668

23. Betamethasone Acetate (jan/usp)

24. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 21-acetate

25. Amy39051

26. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(acetyloxy)-, (11.beta.,16.beta.)-

27. Zinc4212130

28. Betamethasone Acetate [vandf]

29. Betamethasone Acetate [mart.]

30. Akos015896575

31. Betamethasone Acetate [usp-rs]

32. Betamethasone Acetate [who-dd]

33. Nsc 759196

34. Betamethasone Acetate [green Book]

35. Betamethasone Acetate [ep Impurity]

36. Betamethasone Acetate [orange Book]

37. Betamethasone Acetate [ep Monograph]

38. B3165

39. Betamethasone Acetate [usp Monograph]

40. Osurnia Component Betamethasone Acetate

41. D01402

42. T71509

43. Betamethasone Acetate 100 Microg/ml In Methanol

44. Betamethasone Acetate Component Of Osurnia

45. 987m246

46. Betamethasone Valerate Impurity A [ep Impurity]

47. Dexamethasone Acetate Impurity D [ep Impurity]

48. Q27114254

49. Celestone Soluspan Component Betamethasone Acetate

50. Betamethasone Acetate Component Of Celestone Soluspan

51. Betamethasone Acetate, European Pharmacopoeia (ep) Reference Standard

52. Betamethasone Acetate, United States Pharmacopeia (usp) Reference Standard

53. Betamethasone Acetate, Pharmaceutical Secondary Standard; Certified Reference Material

54. 9alpha-fluoro-16beta-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate

55. Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16beta)-

56. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(acetyloxy)-, (11beta,16beta)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₁FO₆
Molecular Weight	434.5 g/mol
XLogP3	2.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	4
Exact Mass	434.21046687 g/mol
Monoisotopic Mass	434.21046687 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	910
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

API SUPPLIERS

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USDMF

01

Roussell Uclaf

France

AES 2024

Not Confirmed

Sanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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France

Digital Content

Betamethasone Acetate

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 7716

Submission : 1988-10-18

Status : Inactive

Type : II

Sanofi Company Banner

Portfolio PDF

Product Web Link

Digital Content

02

Teva Pharmaceutical Industries Ltd

Israel

CPhI WW Frankfurt

TAPI offers customized CDMO Solutions for API development and manufacturing services.

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Israel

Digital Content

Betamethasone Acetate

GDUFA

DMF Review : Complete

Rev. Date : 2016-04-01

Pay. Date : 2016-03-04

DMF Number : 15327

Submission : 2001-03-01

Status : Active

Type : II

TAPI Company Banner

Product Web Link

Digital Content

Corporate PDF

03

Diosynth Bv

United Kingdom

AES 2024

Not Confirmed

04

Gland Pharma Ltd

India

AES 2024

Not Confirmed

05

Hikma Pharmaceuticals Llc

United Kingdom

AES 2024

Not Confirmed

06

Hovione Farmaciencia Sa

Portugal

AES 2024

Not Confirmed

07

Compania Espanola De Sintesis Quimic...

Spain

AES 2024

Not Confirmed

08

Societa Italiana Corticosteroidi Spa

Italy

AES 2024

Not Confirmed

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JDMF

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EU WC

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NDC API

01

Symbiotec Pharmalab Private Limited

India

AES 2024

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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India

Digital Content

BETAMETHASONE ACETATE

NDC Package Code : 22552-0041

Start Marketing Date : 2014-12-10

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1g/g)

Marketing Category : BULK INGREDIENT

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

02

Curia Spain SAU

U.S.A

AES 2024

Not Confirmed

03

Hovione FarmaCiencia SA

Portugal

AES 2024

Not Confirmed

04

NEWCHEM SPA

Italy

AES 2024

Not Confirmed

05

Professional Compounding Centers of...

United Kingdom

AES 2024

Not Confirmed

06

Sicor S.r.l.

Italy

AES 2024

Not Confirmed

07

Sicor S.r.l.

Italy

AES 2024

Not Confirmed

08

SYMBIOTICA SPECIALITY INGREDIENTS S...

Malaysia

AES 2024

Not Confirmed

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"BETAMETHASONE ACETATE","year":"2021","qtr":"Q1","strtotime":1612809000,"product":"BETAMETHASONE ACETATE USP","address":"385\/2, GRAM PIGDEMBER,NEAR HOTEL MASHAL, RAU","city":"INDORE, M.P.","supplier":"SYMBIOTEC PHARMALAB","supplierCountry":"INDIA","foreign_port":"LOS ANGELES","customer":"CUSTOPHARM","customerCountry":"UNITED STATES","quantity":"4.95","actualQuantity":"4.95","unit":"KGS","unitRateFc":"55000","totalValueFC":"269096.1","currency":"USD","unitRateINR":3957979.7979797977,"date":"09-Feb-2021","totalValueINR":"19592000","totalValueInUsd":"269096.1","indian_port":"BOMBAY AIR","hs_no":"29372900","bill_no":"8527422","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"385\/2, GRAM PIGDEMBER,NEAR HOTEL MASHAL, RAU, INDORE, M.P.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1635877800,"product":"BETAMETHASONE ACETATE USP (STERILE MICRO","address":"H N.8-2-269\/W\/4,1ST FLOOR,PLOT NO. 4,WOMENS,S CO-OP. SOCIETY,ROAD NO.2","city":"BANJARA HILLS HYDERABAD,TELANGANA","supplier":"HRV GLOBAL LIFE SCIENCES","supplierCountry":"INDIA","foreign_port":"IMAM KHOMEINI ARPT","customer":"EXIR PH.CO","customerCountry":"IRAN","quantity":"19.00","actualQuantity":"19","unit":"KGS","unitRateFc":"2532","totalValueFC":"47562","currency":"USD","unitRateINR":186421.05263157896,"date":"03-Nov-2021","totalValueINR":"3542000","totalValueInUsd":"47562","indian_port":"HYDERABAD AIR","hs_no":"29372900","bill_no":"5808685","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"IRAN","selfForZScoreResived":"Sterile","supplierPort":"HYDERABAD AIR","supplierAddress":"H N.8-2-269\/W\/4,1ST FLOOR,PLOT NO. 4,WOMENS,S CO-OP. SOCIETY,ROAD NO.2, BANJARA HILLS HYDERABAD,TELANGANA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1696012200,"product":"PHARMACEUTICAL RAW MATERIAL (ACTIVE PHARMACEUTICAL INGREDIENTS) BETAMETHASONE ACETATE USP43 \/ EP10 MICRONISED STERILE","address":"3-A, SHIV SAGAR ESTATE, NORTH WING,","city":"BOMBAY ,MAHARASHTRA","supplier":"SKANT HEALTHCARE LTD.","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"TO THE ORDER","customerCountry":"SWITZERLAND","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"2970","totalValueFC":"5878.9","currency":"USD","unitRateINR":244000,"date":"30-Sep-2023","totalValueINR":"488000","totalValueInUsd":"5878.9","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"4326298","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Micronized","supplierPort":"Bombay Air","supplierAddress":"3-A, SHIV SAGAR ESTATE, NORTH WING,, BOMBAY ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"BETAMETHASONE ACETATE","year":"2021","qtr":"Q2","strtotime":1621017000,"product":"BETAMETHASONE ACETATE RELATED COMPOUND D (QTY: 1 X 20 MG, PRICE: USD 2230)(FOC)","address":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,","city":"HYDERABAD-A.P.","supplier":"USP","supplierCountry":"INDIA","foreign_port":"WASHINGTON DULLES I","customer":"UNITED STATES PHARMACOPEIA - INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.00002","unit":"KGS","unitRateFc":"111500000","totalValueFC":"2317.7","currency":"USD","unitRateINR":"8488423000","date":"15-May-2021","totalValueINR":"169768.46","totalValueInUsd":"2317.7","indian_port":"HYDERABAD AIR","hs_no":"29372900","bill_no":"3956901","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WASHINGTON DULLES I","supplierAddress":"","customerAddress":"106, FIRST FLOOR , ASHOKA BHOOPALCHAMBERS BEGUMPET, S.P. ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1642703400,"product":"BETAMETHASONE ACETATE MICRONIZED","address":"P. NO 53, ALEAP INDUSTRIAL ESTATE, ,GAJULARAMARAM BEHIND PRAGATHINAGAR","city":"KUKATPALLY HYDERABAD,TELANGANA","supplier":"SICOR SOCIETA ITALIANA CORTICOSTEROIDI SRL","supplierCountry":"ITALY","foreign_port":"#N\/A","customer":"ORBICULAR PHARMACEUTICAL TECHNOLOGIES ","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.045","unit":"KGS","unitRateFc":"24170","totalValueFC":"1257.1","currency":"EUR","unitRateINR":"2081037.1","date":"21-Jan-2022","totalValueINR":"93646.67","totalValueInUsd":"1257.1","indian_port":"HYDERABAD AIR","hs_no":"29372200","bill_no":"7181073","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"#N\/A","supplierAddress":"","customerAddress":"P. NO 53, ALEAP INDUSTRIAL ESTATE, ,GAJULARAMARAM BEHIND PRAGATHINAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1689273000,"product":"BETAMETHASONE ACETATE MICRONIZED (API) (FREE OF COST)","address":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam","city":"Kelambakkam","supplier":"SICOR - SOCIETAITALIANA CORTICOSTEROIDI","supplierCountry":"ITALY","foreign_port":"NA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"0.01","unit":"KGS","unitRateFc":"27118","totalValueFC":"274.7","currency":"USD","unitRateINR":"2257574.1","date":"14-Jul-2023","totalValueINR":"22575.966","totalValueInUsd":"274.7","indian_port":"BOMBAY AIR","hs_no":"29372200","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Micronized","supplierPort":"NA","supplierAddress":"","customerAddress":"No. 9\/215, Pudupakkam - Vandalur Main Road Pudupakkam"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713378600,"product":"BETAMETHASONE ACETATE STERILE","address":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,","city":"MUMBAI.MAHARASHTRA","supplier":"HIKMA PHARMACEUTICALS","supplierCountry":"JORDAN","foreign_port":"AMMAN","customer":"INDOCO REMEDIES LIMITED","customerCountry":"INDIA","quantity":"0.45","actualQuantity":"0.452","unit":"KGS","unitRateFc":"145000","totalValueFC":"66201.4","currency":"USD","unitRateINR":"12230750","date":"18-Apr-2024","totalValueINR":"5528299","totalValueInUsd":"66201.4","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"3083694","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"JORDAN","selfForZScoreResived":"Sterile","supplierPort":"AMMAN","supplierAddress":"CHEMICAL PLANT 21 SALEEM BIN HARETHSTREET INDUSTRIAL AREA BAYADER WADI EL-SEER P.O.BOX 182400, AMMAN (JO JORDAN","customerAddress":"INDOCO HOUSE,166 CST RD.VIDYANAGRI,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728930600,"product":"BETAMETHASONE ACETATE API (FREE OF COST)","address":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM","city":"","supplier":"TEVA API","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"PAR PHARMACEUTICAL","customerCountry":"INDIA","quantity":"0.05","actualQuantity":"0.05","unit":"KGS","unitRateFc":"34764","totalValueFC":"1755.2","currency":"USD","unitRateINR":"2949725.4","date":"15-Oct-2024","totalValueINR":"147486.27","totalValueInUsd":"1755.2","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"6136156","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"PIET HEINKADE 107 GM AMSTERDAM 01019 HOLLAND NL","customerAddress":"OLD NO.1\/63, NEW NO.1\/58 PUDUPAKKAM"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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