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    Also known as: 151-73-5, Bentelan, Betamethasone 21-phosphate disodium salt, Betamethasone 21-phosphate disodium, Betamethasone disodium phosphate, Betamethazone disodium phosphate
    Molecular Formula
    C22H28FNa2O8P
    Molecular Weight
    516.4  g/mol
    InChI Key
    PLCQGRYPOISRTQ-LWCNAHDDSA-L
    FDA UNII
    7BK02SCL3W
    Betamethasone Sodium Phosphate
    Betamethasone Sodium Phosphate is the disodium salt of the 21-phosphate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone sodium phosphate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
    1 2D Structure

    Betamethasone Sodium Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
    2.1.2 InChI
    InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1
    2.1.3 InChI Key
    PLCQGRYPOISRTQ-LWCNAHDDSA-L
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.1.5 Isomeric SMILES
    C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    7BK02SCL3W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bentelan

    2. Betamethason Sodium Phosphate

    3. Betamethasone 21-phosphate

    4. Betamethasone Disodium Phosphate

    5. Betamethasone Disodium Phosphate, (11beta)-isomer

    6. Betamethasone Phosphate

    7. Betamethasone Sodium Phosphate, (11beta,16beta)-isomer

    8. Betnesol

    9. Celestone Phosphate

    10. Rinderone

    2.3.2 Depositor-Supplied Synonyms

    1. 151-73-5

    2. Bentelan

    3. Betamethasone 21-phosphate Disodium Salt

    4. Betamethasone 21-phosphate Disodium

    5. Betamethasone Disodium Phosphate

    6. Betamethazone Disodium Phosphate

    7. Betamethasone 21-disodium Phosphate

    8. Beta-methasone Sodium Phosphate

    9. Betamethasone 21-phosphate Sodium Salt

    10. 7bk02scl3w

    11. Chebi:3078

    12. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

    13. Betamethasone Sodium Phosphate, Usp

    14. Disodium Betamethasone 21-phosphate

    15. Beta-methasone Phosphate

    16. Celestone Phosphate Injection

    17. Nsc 90616

    18. Disodium;[2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Phosphate

    19. Sodium 2-((8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Phosphate

    20. Nsc-90616

    21. Beta-methasone, Disodium Phosphate

    22. Einecs 205-797-0

    23. Unii-7bk02scl3w

    24. Beta-methasone Disodium Phosphate

    25. Mfcd00200361

    26. Betamethasone Sodium Phosphate [usp:jan]

    27. Betamethasonesodiumphosphate

    28. Schembl8418

    29. Dsstox_cid_27137

    30. Dsstox_rid_82144

    31. Dsstox_gsid_47137

    32. Chembl1200762

    33. Dtxsid8047137

    34. Tox21_302467

    35. Akos015896371

    36. Ac-2162

    37. Ncgc00256717-01

    38. As-62442

    39. Cas-151-73-5

    40. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11.beta.,16.beta.)-

    41. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11beta,16beta)-

    42. Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

    43. Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

    44. Betamethasone Sodium Phosphate (jp17/usp)

    45. Betamethasone Sodium Phosphate [jan]

    46. B4110

    47. Betamethasone 21-phosphate Disodium, >=97%

    48. Betamethasone Sodium Phosphate [mart.]

    49. Betamethasone Sodium Phosphate [vandf]

    50. Betamethasone Sodium Phosphate [usp-rs]

    51. Betamethasone Sodium Phosphate [who-dd]

    52. D00972

    53. Betamethasone Sodium Phosphate [green Book]

    54. Betamethasone Sodium Phosphate [ep Impurity]

    55. Betamethasone Sodium Phosphate [ep Monograph]

    56. Betamethasone Sodium Phosphate [orange Book]

    57. J-008838

    58. Betamethasone Sodium Phosphate [usp Monograph]

    59. Q27105936

    60. Betamethasone Sodium Phosphate Component Of Celestone Soluspan

    61. Celestone Soluspan Component Betamethasone Sodium Phosphate

    62. Betamethasone Sodium Phosphate, European Pharmacopoeia (ep) Reference Standard

    63. Betamethasone Sodium Phosphate, United States Pharmacopeia (usp) Reference Standard

    64. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

    65. Disodium 9-fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-21-yl Phosphate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 516.4 g/mol
    Molecular Formula C22H28FNa2O8P
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count3
    Exact Mass516.13012157 g/mol
    Monoisotopic Mass516.13012157 g/mol
    Topological Polar Surface Area147 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity962
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

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EUR. 11.1 (FOC)","address":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H","city":"AHMEDABAD,GUJARAT","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"ZYDUS LIFESCIENCES LIMITED","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"1","totalValueFC":"10.1","currency":"USD","unitRateINR":"84.1","date":"07-Dec-2023","totalValueINR":"841","totalValueInUsd":"10.1","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"9109963","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PARQUE TECNOLOGICO DE BOECILLO, PARCELA 105, 47151 BOECILLO, VALLADOLID, Valladolid, , Spain Spain","customerAddress":"ZYDUS TOWER, SARKHEJ-GANDHINAGAR,H"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719167400,"product":"BETAMETHASONE SODIUM PHOSPHATE USP 2023, PH.EUR. 11.1 (VALUEFOR CUSTOMS PURPOSE ONLY) (FOC)","address":"PLOT 121 GIDC MAKARPURA INDL.ESTATE","city":"VADODARA","supplier":"CURIA","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"VIATRIS","customerCountry":"INDIA","quantity":"0.01","actualQuantity":"10","unit":"GMS","unitRateFc":"1","totalValueFC":"10.2","currency":"USD","unitRateINR":"85.2","date":"24-Jun-2024","totalValueINR":"852.48","totalValueInUsd":"10.2","indian_port":"Bombay Air","hs_no":"29372200","bill_no":"4155845","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"PARQUE TECHNOLOGICO DE BOECILLOPARCELA 105 47151 BOECILLOVALLADOID, SPAIN","customerAddress":"PLOT 121 GIDC MAKARPURA INDL.ESTATE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720981800,"product":"BETAMETHASONE SODIUM PHOSPHATE USP","address":"HETERO CORPORATE, NO. 7-2-A2,","city":"HYDERABAD","supplier":"HOVIONE","supplierCountry":"PORTUGAL","foreign_port":"LISBON","customer":"HETERO DRUGS","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"60000","totalValueFC":"6061.7","currency":"USD","unitRateINR":"5067000","date":"15-Jul-2024","totalValueINR":"506700","totalValueInUsd":"6061.7","indian_port":"Hyderabad Air","hs_no":"29372200","bill_no":"4510610","productDescription":"API","marketType":"REGULATED MARKET","country":"PORTUGAL","selfForZScoreResived":"Pharma Grade","supplierPort":"LISBON","supplierAddress":"Sete Casas 2674-506 Loures Loures,, PortugalSDNF Portugal","customerAddress":"HETERO CORPORATE, NO. 7-2-A2,"}]
    08-Jan-2021
    31-Dec-2024
    KGS
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    ABOUT THIS PAGE

    Betamethasone Sodium Phosphate Manufacturers

    A Betamethasone Sodium Phosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Betamethasone Sodium Phosphate, including repackagers and relabelers. The FDA regulates Betamethasone Sodium Phosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Betamethasone Sodium Phosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Betamethasone Sodium Phosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Betamethasone Sodium Phosphate Suppliers

    A Betamethasone Sodium Phosphate supplier is an individual or a company that provides Betamethasone Sodium Phosphate active pharmaceutical ingredient (API) or Betamethasone Sodium Phosphate finished formulations upon request. The Betamethasone Sodium Phosphate suppliers may include Betamethasone Sodium Phosphate API manufacturers, exporters, distributors and traders.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Betamethasone Sodium Phosphate USDMF

    A Betamethasone Sodium Phosphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Betamethasone Sodium Phosphate active pharmaceutical ingredient (API) in detail. Different forms of Betamethasone Sodium Phosphate DMFs exist exist since differing nations have different regulations, such as Betamethasone Sodium Phosphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Betamethasone Sodium Phosphate DMF submitted to regulatory agencies in the US is known as a USDMF. Betamethasone Sodium Phosphate USDMF includes data on Betamethasone Sodium Phosphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Betamethasone Sodium Phosphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with USDMF on PharmaCompass.

    Betamethasone Sodium Phosphate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Betamethasone Sodium Phosphate Drug Master File in Japan (Betamethasone Sodium Phosphate JDMF) empowers Betamethasone Sodium Phosphate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Betamethasone Sodium Phosphate JDMF during the approval evaluation for pharmaceutical products. At the time of Betamethasone Sodium Phosphate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with JDMF on PharmaCompass.

    Betamethasone Sodium Phosphate KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Betamethasone Sodium Phosphate Drug Master File in Korea (Betamethasone Sodium Phosphate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Betamethasone Sodium Phosphate. The MFDS reviews the Betamethasone Sodium Phosphate KDMF as part of the drug registration process and uses the information provided in the Betamethasone Sodium Phosphate KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Betamethasone Sodium Phosphate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Betamethasone Sodium Phosphate API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Betamethasone Sodium Phosphate suppliers with KDMF on PharmaCompass.

    Betamethasone Sodium Phosphate CEP

    A Betamethasone Sodium Phosphate CEP of the European Pharmacopoeia monograph is often referred to as a Betamethasone Sodium Phosphate Certificate of Suitability (COS). The purpose of a Betamethasone Sodium Phosphate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Betamethasone Sodium Phosphate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Betamethasone Sodium Phosphate to their clients by showing that a Betamethasone Sodium Phosphate CEP has been issued for it. The manufacturer submits a Betamethasone Sodium Phosphate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Betamethasone Sodium Phosphate CEP holder for the record. Additionally, the data presented in the Betamethasone Sodium Phosphate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Betamethasone Sodium Phosphate DMF.

    A Betamethasone Sodium Phosphate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Betamethasone Sodium Phosphate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with CEP (COS) on PharmaCompass.

    Betamethasone Sodium Phosphate WC

    A Betamethasone Sodium Phosphate written confirmation (Betamethasone Sodium Phosphate WC) is an official document issued by a regulatory agency to a Betamethasone Sodium Phosphate manufacturer, verifying that the manufacturing facility of a Betamethasone Sodium Phosphate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Betamethasone Sodium Phosphate APIs or Betamethasone Sodium Phosphate finished pharmaceutical products to another nation, regulatory agencies frequently require a Betamethasone Sodium Phosphate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with Written Confirmation (WC) on PharmaCompass.

    Betamethasone Sodium Phosphate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Betamethasone Sodium Phosphate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Betamethasone Sodium Phosphate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Betamethasone Sodium Phosphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Betamethasone Sodium Phosphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Betamethasone Sodium Phosphate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Betamethasone Sodium Phosphate suppliers with NDC on PharmaCompass.

    Betamethasone Sodium Phosphate GMP

    Betamethasone Sodium Phosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Betamethasone Sodium Phosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Betamethasone Sodium Phosphate GMP manufacturer or Betamethasone Sodium Phosphate GMP API supplier for your needs.

    Betamethasone Sodium Phosphate CoA

    A Betamethasone Sodium Phosphate CoA (Certificate of Analysis) is a formal document that attests to Betamethasone Sodium Phosphate's compliance with Betamethasone Sodium Phosphate specifications and serves as a tool for batch-level quality control.

    Betamethasone Sodium Phosphate CoA mostly includes findings from lab analyses of a specific batch. For each Betamethasone Sodium Phosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Betamethasone Sodium Phosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Betamethasone Sodium Phosphate EP), Betamethasone Sodium Phosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Betamethasone Sodium Phosphate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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