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    Also known as: 151-73-5, Bentelan, Betamethasone 21-phosphate disodium salt, Betamethasone 21-phosphate disodium, Betamethasone disodium phosphate, Betamethazone disodium phosphate
    Molecular Formula
    C22H28FNa2O8P
    Molecular Weight
    516.4  g/mol
    InChI Key
    PLCQGRYPOISRTQ-LWCNAHDDSA-L
    FDA UNII
    7BK02SCL3W
    Betamethasone Sodium Phosphate
    Betamethasone Sodium Phosphate is the disodium salt of the 21-phosphate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone sodium phosphate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
    1 2D Structure

    Betamethasone Sodium Phosphate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate
    2.1.2 InChI
    InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1
    2.1.3 InChI Key
    PLCQGRYPOISRTQ-LWCNAHDDSA-L
    2.1.4 Canonical SMILES
    CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.1.5 Isomeric SMILES
    C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    7BK02SCL3W
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Bentelan

    2. Betamethason Sodium Phosphate

    3. Betamethasone 21-phosphate

    4. Betamethasone Disodium Phosphate

    5. Betamethasone Disodium Phosphate, (11beta)-isomer

    6. Betamethasone Phosphate

    7. Betamethasone Sodium Phosphate, (11beta,16beta)-isomer

    8. Betnesol

    9. Celestone Phosphate

    10. Rinderone

    2.3.2 Depositor-Supplied Synonyms

    1. 151-73-5

    2. Bentelan

    3. Betamethasone 21-phosphate Disodium Salt

    4. Betamethasone 21-phosphate Disodium

    5. Betamethasone Disodium Phosphate

    6. Betamethazone Disodium Phosphate

    7. Betamethasone 21-disodium Phosphate

    8. Beta-methasone Sodium Phosphate

    9. Betamethasone 21-phosphate Sodium Salt

    10. 7bk02scl3w

    11. Chebi:3078

    12. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

    13. Betamethasone Sodium Phosphate, Usp

    14. Disodium Betamethasone 21-phosphate

    15. Beta-methasone Phosphate

    16. Celestone Phosphate Injection

    17. Nsc 90616

    18. Disodium;[2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Phosphate

    19. Sodium 2-((8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Phosphate

    20. Nsc-90616

    21. Beta-methasone, Disodium Phosphate

    22. Einecs 205-797-0

    23. Unii-7bk02scl3w

    24. Beta-methasone Disodium Phosphate

    25. Mfcd00200361

    26. Betamethasone Sodium Phosphate [usp:jan]

    27. Betamethasonesodiumphosphate

    28. Schembl8418

    29. Dsstox_cid_27137

    30. Dsstox_rid_82144

    31. Dsstox_gsid_47137

    32. Chembl1200762

    33. Dtxsid8047137

    34. Tox21_302467

    35. Akos015896371

    36. Ac-2162

    37. Ncgc00256717-01

    38. As-62442

    39. Cas-151-73-5

    40. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11.beta.,16.beta.)-

    41. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11beta,16beta)-

    42. Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

    43. Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

    44. Betamethasone Sodium Phosphate (jp17/usp)

    45. Betamethasone Sodium Phosphate [jan]

    46. B4110

    47. Betamethasone 21-phosphate Disodium, >=97%

    48. Betamethasone Sodium Phosphate [mart.]

    49. Betamethasone Sodium Phosphate [vandf]

    50. Betamethasone Sodium Phosphate [usp-rs]

    51. Betamethasone Sodium Phosphate [who-dd]

    52. D00972

    53. Betamethasone Sodium Phosphate [green Book]

    54. Betamethasone Sodium Phosphate [ep Impurity]

    55. Betamethasone Sodium Phosphate [ep Monograph]

    56. Betamethasone Sodium Phosphate [orange Book]

    57. J-008838

    58. Betamethasone Sodium Phosphate [usp Monograph]

    59. Q27105936

    60. Betamethasone Sodium Phosphate Component Of Celestone Soluspan

    61. Celestone Soluspan Component Betamethasone Sodium Phosphate

    62. Betamethasone Sodium Phosphate, European Pharmacopoeia (ep) Reference Standard

    63. Betamethasone Sodium Phosphate, United States Pharmacopeia (usp) Reference Standard

    64. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

    65. Disodium 9-fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-21-yl Phosphate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 516.4 g/mol
    Molecular Formula C22H28FNa2O8P
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count3
    Exact Mass516.13012157 g/mol
    Monoisotopic Mass516.13012157 g/mol
    Topological Polar Surface Area147 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity962
    Isotope Atom Count0
    Defined Atom Stereocenter Count8
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

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    08-Jan-2021
    22-Oct-2024
    KGS
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