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Symbiotec Betamethasone Sodium Phosphate

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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xyz-pharma-m-2024-10-07

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With Fermion, start the journey of your innovative API.

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

34 API Suppliers, 10 USDMF, 3 CEP/COS, 3 JDMF, 6 EU WC, 1 KDMF, 10 NDC API, 24 Listed Suppliers, $ API Reference Price

34 API Suppliers
10 USDMF
3 CEP/COS
3 JDMF
6 EU WC
1 KDMF
10 NDC API
24 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

27 FDF Dossiers, 5 FDA Orange Book, 8 Europe, 1 Canada, 9 South Africa, 4 Listed Dossiers

27 FDF Dossiers
5 FDA Orange Book
8 Europe
1 Canada
9 South Africa
4 Listed Dossiers

RELATED EXCIPIENT COMPANIES

2 Actylis, 1 Finar

relatedExcipients
2 Actylis
1 Finar

EXCIPIENTS BY APPLICATIONS

2 Solubilizers, 1 Parenteral

excipientsByApplications
2 Solubilizers
1 Parenteral

DIGITAL CONTENT

3 NEWS #PharmaBuzz

media
3 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

8 Finished Drug Prices, 3 Annual Reports

globalSalesInformation
8 Finished Drug Prices
3 Annual Reports

MARKET PLACE

13 APIs, 1 FDF Dossiers

marketPlace
13 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

3 EDQM , 1 USP , 2 JP , 1 Others

otherSolutions
3 EDQM
1 USP
2 JP
1 Others

Symbiotec Betamethasone Sodium Phosphate

Synopsis

ACTIVE PHARMA INGREDIENTS

34

API Suppliers

10

USDMF

3

CEP/COS

CEP/COS Certifications

3

JDMF

6

EU WC

1

KDMF

10

NDC API

0

VMF

24

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,441

MARKET PLACE

13

API

1

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

27

FDF Dossiers

5

FDA Orange Book

FDA (Orange Book)

8

Europe

1

Canada

0

Australia

9

South Africa

4

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

3

EDQM

1

USP

2

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

3

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

338

Finished Drug Prices

3 RELATED EXCIPIENT COMPANIES

3EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 151-73-5, Bentelan, Betamethasone 21-phosphate disodium salt, Betamethasone 21-phosphate disodium, Betamethasone disodium phosphate, Betamethazone disodium phosphate

Molecular Formula

C₂₂H₂₈FNa₂O₈P

Molecular Weight

516.4 g/mol

InChI Key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

FDA UNII

7BK02SCL3W

Betamethasone Sodium Phosphate

Betamethasone Sodium Phosphate is the disodium salt of the 21-phosphate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone sodium phosphate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.

1 2D Structure

Betamethasone Sodium Phosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate

2.1.2 InChI

InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1

2.1.3 InChI Key

PLCQGRYPOISRTQ-LWCNAHDDSA-L

2.1.4 Canonical SMILES

CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

2.1.5 Isomeric SMILES

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COP(=O)([O-])[O-])O)C)O)F)C.[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

7BK02SCL3W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Bentelan

2. Betamethason Sodium Phosphate

3. Betamethasone 21-phosphate

4. Betamethasone Disodium Phosphate

5. Betamethasone Disodium Phosphate, (11beta)-isomer

6. Betamethasone Phosphate

7. Betamethasone Sodium Phosphate, (11beta,16beta)-isomer

8. Betnesol

9. Celestone Phosphate

10. Rinderone

2.3.2 Depositor-Supplied Synonyms

1. 151-73-5

2. Bentelan

3. Betamethasone 21-phosphate Disodium Salt

4. Betamethasone 21-phosphate Disodium

5. Betamethasone Disodium Phosphate

6. Betamethazone Disodium Phosphate

7. Betamethasone 21-disodium Phosphate

8. Beta-methasone Sodium Phosphate

9. Betamethasone 21-phosphate Sodium Salt

10. 7bk02scl3w

11. Chebi:3078

12. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

13. Betamethasone Sodium Phosphate, Usp

14. Disodium Betamethasone 21-phosphate

15. Beta-methasone Phosphate

16. Celestone Phosphate Injection

17. Nsc 90616

18. Disodium;[2-[(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Phosphate

19. Sodium 2-((8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Phosphate

20. Nsc-90616

21. Beta-methasone, Disodium Phosphate

22. Einecs 205-797-0

23. Unii-7bk02scl3w

24. Beta-methasone Disodium Phosphate

25. Mfcd00200361

26. Betamethasone Sodium Phosphate [usp:jan]

27. Betamethasonesodiumphosphate

28. Schembl8418

29. Dsstox_cid_27137

30. Dsstox_rid_82144

31. Dsstox_gsid_47137

32. Chembl1200762

33. Dtxsid8047137

34. Tox21_302467

35. Akos015896371

36. Ac-2162

37. Ncgc00256717-01

38. As-62442

39. Cas-151-73-5

40. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11.beta.,16.beta.)-

41. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, Disodium Salt, (11beta,16beta)-

42. Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

43. Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-, 21-(dihydrogen Phosphate), Disodium Salt

44. Betamethasone Sodium Phosphate (jp17/usp)

45. Betamethasone Sodium Phosphate [jan]

46. B4110

47. Betamethasone 21-phosphate Disodium, >=97%

48. Betamethasone Sodium Phosphate [mart.]

49. Betamethasone Sodium Phosphate [vandf]

50. Betamethasone Sodium Phosphate [usp-rs]

51. Betamethasone Sodium Phosphate [who-dd]

52. D00972

53. Betamethasone Sodium Phosphate [green Book]

54. Betamethasone Sodium Phosphate [ep Impurity]

55. Betamethasone Sodium Phosphate [ep Monograph]

56. Betamethasone Sodium Phosphate [orange Book]

57. J-008838

58. Betamethasone Sodium Phosphate [usp Monograph]

59. Q27105936

60. Betamethasone Sodium Phosphate Component Of Celestone Soluspan

61. Celestone Soluspan Component Betamethasone Sodium Phosphate

62. Betamethasone Sodium Phosphate, European Pharmacopoeia (ep) Reference Standard

63. Betamethasone Sodium Phosphate, United States Pharmacopeia (usp) Reference Standard

64. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 21-(disodium Phosphate)

65. Disodium 9-fluoro-11beta,17-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-21-yl Phosphate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₂H₂₈FNa₂O₈P
Molecular Weight	516.4 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	516.13012157 g/mol
Monoisotopic Mass	516.13012157 g/mol
Topological Polar Surface Area	147 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	962
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

API SUPPLIERS

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USDMF

01

Symbiotec Pharmalab Private Ltd

India

Antibody Engineering

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

Contact Supplier

Contact Supplier

India

Digital Content

Betamethasone Sodium Phosphate Usp

GDUFA

DMF Review : Complete

Rev. Date : 2023-10-25

Pay. Date : 2023-10-03

DMF Number : 37466

Submission : 2022-09-09

Status : Active

Type : II

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

02

Antibioticos Spa

Italy

Antibody Engineering

Not Confirmed

03

Curia Spain Sau

U.S.A

Antibody Engineering

Not Confirmed

04

Diosynth Bv

United Kingdom

Antibody Engineering

Not Confirmed

05

Hovione Farmaciencia Sa

Portugal

Antibody Engineering

Not Confirmed

06

Mahima Life Sciences Private Ltd

India

Antibody Engineering

Not Confirmed

07

Compania Espanola De Sintesis Quimic...

Spain

Antibody Engineering

Not Confirmed

08

Societa Italiana Corticosteroidi Spa

Italy

Antibody Engineering

Not Confirmed

09

Hoechst Marion Roussel Sa

Country

Antibody Engineering

Not Confirmed

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CEP/COS

01

CURIA SPAIN S.A.U. Boecillo ES

U.S.A

Antibody Engineering

Not Confirmed

02

CURIA SPAIN S.A.U. Boecillo ES

U.S.A

Antibody Engineering

Not Confirmed

03

SYMBIOTICA SPECIALITY INGREDIENTS S...

Malaysia

Antibody Engineering

Not Confirmed

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JDMF

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EU WC

01

Symbiotec Pharmalab

India

Antibody Engineering

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

Contact Supplier

Contact Supplier

India

Digital Content

Betamethasone 21-disodium phosphateBP/EP/USP

Date of Issue : 2022-07-05

Valid Till : 2025-07-02

Written Confirmation Number : WC-0161A2

Address of the Firm : 385/2, Pigdamber, Rau, Indore-453 331, MP, India

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

02

Symbiotec Pharmalab

India

Antibody Engineering

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

Contact Supplier

Contact Supplier

India

Digital Content

Betamethasone Sodium Phosphate (BP/Ph.Eur/USP)

Date of Issue : 2022-08-31

Valid Till : 2025-07-02

Written Confirmation Number : WC-0162

Address of the Firm : Plot No. 5, 6, 7 & 8 Special Economic Zone, Phase II, Pithampur, Dist: Dhar, MP-...

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

03

Symbiotec Pharmalab

India

Antibody Engineering

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

Contact Supplier

Contact Supplier

India

Digital Content

Betamethasone Sodium Phosphate (BP/EP/USP)

Date of Issue : 2022-09-30

Valid Till : 2025-07-02

Written Confirmation Number : WC-0161

Address of the Firm : 385/2, Pigdamber, Rau, Indore-453 331, MP, India

Symbiotec Pharmalab

Product Web Link

Digital Content

Corporate PDF

04

Avik Pharmaceutical Limited

India

Antibody Engineering

Not Confirmed

05

Great Pacific Exports

India

Antibody Engineering

Not Confirmed

06

Halcyon Labs Private Limited

India

Antibody Engineering

Not Confirmed

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KDMF

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API Reference Price

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ANNIE BESANT ROAD, WORLI,","city":"BOMBAY ,MAHARASHTRA","supplier":"SKANT HEALTHCARE LTD.","supplierCountry":"INDIA","foreign_port":"BASLE","customer":"TO THE ORDER","customerCountry":"SWITZERLAND","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1130.3","totalValueFC":"2237.2","currency":"USD","unitRateINR":81440.300000000003,"date":"01-Feb-2021","totalValueINR":"162880.6","totalValueInUsd":"2237.2","indian_port":"BOMBAY AIR","hs_no":"29372200","bill_no":"8323143","productDescription":"API","marketType":"REGULATED MARKET","country":"SWITZERLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"3-A, SHIV SAGAR ESTATE, NORTH WING,DR. 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ANNIE BESANT ROAD, WORLI,","city":"BOMBAY ,MAHARASHTRA","supplier":"SKANT HEALTHCARE LTD.","supplierCountry":"INDIA","foreign_port":"BOGOTA","customer":"TO THE ORDER","customerCountry":"COLOMBIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"1043.1","totalValueFC":"5161.2","currency":"USD","unitRateINR":75154.100000000006,"date":"03-Feb-2021","totalValueINR":"375770.5","totalValueInUsd":"5161.2","indian_port":"BOMBAY AIR","hs_no":"29372200","bill_no":"8365907","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"COLOMBIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"3-A, SHIV SAGAR ESTATE, NORTH WING,DR. ANNIE BESANT ROAD, WORLI,, BOMBAY ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"BETAMETHASONE SODIUM PHOSPHATE","year":"2021","qtr":"Q1","strtotime":1613413800,"product":"BETAMETHASONE SODIUM PHOSPHATE USP ( HAL OGENATED DERIVATIVES OF CORTICOSTEROIDAL HARMONES )","address":"7\/A, BADRINATH APARTMENT, SHIMPOLIROAD, NEAR SONI WADI, BORIVALI (W)","city":"MUMBAI, MAHARASHTRA","supplier":"AADIVIGHNESH CHEM","supplierCountry":"INDIA","foreign_port":"SANTIAGO DE CHILE -","customer":"M C S ","customerCountry":"CHILE","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"1186.1","totalValueFC":"2347.5","currency":"USD","unitRateINR":85455.375,"date":"16-Feb-2021","totalValueINR":"170910.75","totalValueInUsd":"2347.5","indian_port":"BOMBAY AIR","hs_no":"29372200","bill_no":"8689025","productDescription":"API","marketType":"REGULATED MARKET","country":"CHILE","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"7\/A, BADRINATH APARTMENT, SHIMPOLIROAD, NEAR SONI WADI, BORIVALI (W), MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"BETAMETHASONE SODIUM PHOSPHATE","year":"2021","qtr":"Q1","strtotime":1613673000,"product":"BETAMETHASONE SODIUM PHOSPHATE USP 43 -","address":"3-A, SHIV SAGAR ESTATE, NORTH WING,DR. 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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ORGANON CANADA INC.

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Brand Name : Betnovate

United Kingdom

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Brand Name : Diprosone

U.S.A

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Brand Name : Betnovate Scalp Appl

United Kingdom

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Brand Name : Betnovate Scalp Appl

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Brand Name : Betnovate

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Brand Name : Betnovate

United Kingdom

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Brand Name : Betnesol

Italy

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Brand Name : Betafloroto

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