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Symbiotec Betamethasone Valerate

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

45 API Suppliers, 18 USDMF, 11 CEP/COS, 4 JDMF, 7 EU WC, 1 KDMF, 9 NDC API, 27 Listed Suppliers, $ API Reference Price

45 API Suppliers
18 USDMF
11 CEP/COS
4 JDMF
7 EU WC
1 KDMF
9 NDC API
27 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

99 FDF Dossiers, 34 FDA Orange Book, 18 Europe, 14 Canada, 18 Australia, 3 South Africa, 12 Listed Dossiers

99 FDF Dossiers
34 FDA Orange Book
18 Europe
14 Canada
18 Australia
3 South Africa
12 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CREAM;TOPICAL - EQ 0.1% BASE, OINTMENT;TOPICAL - EQ 0.1% BASE, LOTION;TOPICAL - EQ 0.1% BASE, AEROSOL, FOAM;TOPICAL - 0.12%

drugProductComposition
CREAM;TOPICAL - EQ 0.1% BASE
OINTMENT;TOPICAL - EQ 0.1% BASE
LOTION;TOPICAL - EQ 0.1% BASE
AEROSOL, FOAM;TOPICAL - 0.12%

RELATED EXCIPIENT COMPANIES

2 Seqens, 1 DKSH, 4 Nanjing Well Pharmaceutical, 3 Actylis, 16 BASF, 1 Clariant, 1 Corel Pharma Chem, 2 Finar, 2 Gangwal Chemicals, 2 Lubrizol Life Science Health, 2 Nomisma Healthcare, 2 Seppic, 1 Valens Pharmachem

relatedExcipients
2 Seqens
1 DKSH
4 Nanjing Well Pharmaceutical
3 Actylis
16 BASF
1 Clariant
1 Corel Pharma Chem
2 Finar
2 Gangwal Chemicals
2 Lubrizol Life Science Health
2 Nomisma Healthcare
2 Seppic
1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

25 Topical, 10 Solubilizers, 9 Thickeners and Stabilizers, 5 Controlled & Modified Release, 5 Emulsifying Agents, 4 Film Formers & Plasticizers, 3 Parenteral, 3 Surfactant & Foaming Agents, 2 Granulation, 2 Lubricants & Glidants, 1 Coating Systems & Additives, 1 Direct Compression, 1 Rheology Modifiers

excipientsByApplications
25 Topical
10 Solubilizers
9 Thickeners and Stabilizers
5 Controlled & Modified Release
5 Emulsifying Agents
4 Film Formers & Plasticizers
3 Parenteral
3 Surfactant & Foaming Agents
2 Granulation
2 Lubricants & Glidants
1 Coating Systems & Additives
1 Direct Compression
1 Rheology Modifiers

DIGITAL CONTENT

5 NEWS #PharmaBuzz

media
5 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 11 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
11 Finished Drug Prices

MARKET PLACE

9 APIs

marketPlace
9 APIs

PATENTS & EXCLUSIVITIES

2 Health Canada Patents

patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

5 EDQM , 2 USP , 5 JP , 2 Others

otherSolutions
5 EDQM
2 USP
5 JP
2 Others

Symbiotec Betamethasone Valerate

Synopsis

ACTIVE PHARMA INGREDIENTS

45

API Suppliers

18

USDMF

11

CEP/COS

CEP/COS Certifications

4

JDMF

7

EU WC

1

KDMF

9

NDC API

0

VMF

27

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 1,254

MARKET PLACE

9

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

99

FDF Dossiers

34

FDA Orange Book

FDA (Orange Book)

18

Europe

14

Canada

18

Australia

3

South Africa

12

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

5

EDQM

2

USP

5

JP

2

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

2

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

5

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

10,800,800

Annual Reports (USD Million)

NA

Finished Drug Prices

39 RELATED EXCIPIENT COMPANIES

71EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Betamethasone 17-valerate, 2152-44-5, Betnovate, Betaderm, Luxiq, Beta-val

Molecular Formula

C₂₇H₃₇FO₆

Molecular Weight

476.6 g/mol

InChI Key

SNHRLVCMMWUAJD-SUYDQAKGSA-N

FDA UNII

9IFA5XM7R2

Betamethasone Valerate

The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.

1 2D Structure

Betamethasone Valerate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] pentanoate

2.1.2 InChI

InChI=1S/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,21-,24-,25-,26-,27-/m0/s1

2.1.3 InChI Key

SNHRLVCMMWUAJD-SUYDQAKGSA-N

2.1.4 Canonical SMILES

CCCCC(=O)OC1(C(CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)C)C(=O)CO

2.1.5 Isomeric SMILES

CCCCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CO

2.2 Other Identifiers

2.2.1 UNII

9IFA5XM7R2

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 17-valerate, Betamethasone

2. Betamethasone 17 Valerate

3. Betamethasone 17-valerate

4. Betnovate

5. Flubenisolonvalerate

6. Valerate, Betamethasone

2.3.2 Depositor-Supplied Synonyms

1. Betamethasone 17-valerate

2. 2152-44-5

3. Betnovate

4. Betaderm

5. Luxiq

6. Beta-val

7. Betatrex

8. Tokuderm

9. Valnac

10. Betamethasone-17-valerate

11. Celestoderm

12. Bedermin

13. Bextasol

14. Stanoval

15. Rinderon V

16. Dermovaleas

17. Betneval

18. Dermosol

19. Beta-methasone 17-valerate

20. Ecoval 70

21. Betamethasone 17a-valerate

22. Betamethasone (as Valerate)

23. 9ifa5xm7r2

24. Chebi:31277

25. Betamethasone Valerate (betnovate)

26. Nsc-755912

27. [(8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] Pentanoate

28. Betnovateat

29. Celeston Valerate

30. 9-fluoro-11.beta.,17,21-trihydroxy-16.beta.-methylpregna-1,4-diene-3,20-dione 17-valerate

31. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-17-valerate

32. 9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate

33. 9-fluoro-11beta,21-dihydroxy-16beta-methyl-3,20-dioxopregna-1,4-dien-17-yl Valerate

34. Topagen (veterinary)

35. Gentocin (veterinary)

36. Betamethasone Valerate (betamethasone 17-valerate)

37. Bettamousse

38. Betaval

39. Fuciderm

40. Betoid

41. Celestoderm V

42. Celestoderm-v

43. Betnesol V

44. Betnesol-v

45. Celestan V

46. Celestan-v

47. Celestane V

48. Ncgc00274064-01

49. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopentyl)oxy)-, (11.beta.,16.beta.)-

50. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (11.beta.,16.beta.)-

51. Einecs 218-439-3

52. Betamethasoni Valeras

53. Rinderon-v (tn)

54. Betamethasone-valerate

55. Luxiq (tn)

56. Topagen (salt/mix)

57. Beta-val (tn)

58. Betatrex (salt/mix)

59. Gentocin (salt/mix)

60. Chlorophytum Borivilanum

61. Betamethason-17-valerate

62. Dsstox_cid_2673

63. Unii-9ifa5xm7r2

64. Schembl7270

65. Chembl1497

66. Dsstox_rid_76684

67. Dsstox_gsid_22673

68. Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopentyl)oxy)-, (11beta,16beta)-

69. Betamethasone 17alpha-valerate

70. Dtxsid7022673

71. Hy-b0727

72. Zinc3882052

73. Betamethasone Valerate (jp17/usp)

74. Betamethasone Valerate [jan]

75. Tox21_302288

76. Betamethasone Valerate [usan]

77. S1690

78. Betamethasone Valerate [vandf]

79. Akos015994704

80. Betamethasone Valerate [mart.]

81. Betamethasone Valerate [usp-rs]

82. Betamethasone Valerate [who-dd]

83. Betamethasone Valerate [who-ip]

84. Ccg-269509

85. Ks-1198

86. Nsc 755912

87. 9-fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione-17-valerate

88. 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate

89. Betamethasone 17-valerate [mi]

90. Betamethasone Valerate [usan:usp:jan]

91. Ncgc00255185-01

92. (11beta,16beta)-9-fluoro-11,21-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate

93. (2s,10s,11s,13s,15s,17s,1r,14r)-1-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13, 15-trimethyl-5-oxotetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-3,6-dien-14-yl Pe Ntanoate

94. Betamethasone Valerate [green Book]

95. Cas-2152-44-5

96. Betamethasone Valerate [orange Book]

97. Betamethasone Valerate [ep Monograph]

98. Betamethasone Valerate For System Suitability

99. Betamethasoni Valeras [who-ip Latin]

100. Cs-0009628

101. Betamethasone Valerate [usp Monograph]

102. D01357

103. Ab01274710-01

104. Ab01274710_02

105. 152m445

106. A815447

107. Q6445931

108. Betamethasone 17a-valerate 100 Microg/ml In Methanol

109. Brd-k34032314-001-04-1

110. (11.beta.,16.beta.)-9.alpha.-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 17.alpha.-valerate

111. (8s,9r,10s,11s,13s,14s,16s,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl Pentanoate

112. 9-fluoro-11.beta.,21-dihydroxy-16.beta.-methyl-3,20-dioxopregna-1,4-dien-17-yl Pentanoate #

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₃₇FO₆
Molecular Weight	476.6 g/mol
XLogP3	3.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	7
Exact Mass	476.25741706 g/mol
Monoisotopic Mass	476.25741706 g/mol
Topological Polar Surface Area	101 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	957
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Betamethasone valerate
PubMed Health	Betamethasone Valerate (On the skin)
Drug Classes	Corticosteroid, Intermediate
Drug Label	Luxq Foam contains betamethasone valerate, USP, a synthetic corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory agents.Betamethasone valerate is 9-...
Active Ingredient	Betamethasone valerate
Dosage Form	Lotion; Ointment; Cream; Aerosol, foam
Route	Topical
Strength	0.12%; eq 0.1% base
Market Status	Prescription
Company	Sti Pharma; Actavis Mid Atlantic; Perrigo; Fougera

2 of 2
Drug Name	Betamethasone valerate
PubMed Health	Betamethasone Valerate (On the skin)
Drug Classes	Corticosteroid, Intermediate
Drug Label	Luxq Foam contains betamethasone valerate, USP, a synthetic corticosteroid, for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory agents.Betamethasone valerate is 9-...
Active Ingredient	Betamethasone valerate
Dosage Form	Lotion; Ointment; Cream; Aerosol, foam
Route	Topical
Strength	0.12%; eq 0.1% base
Market Status	Prescription
Company	Sti Pharma; Actavis Mid Atlantic; Perrigo; Fougera

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)

Glucocorticoids

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Corticosteroid [EPC]; Corticosteroid Hormone Receptor Agonists [MoA]

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CEP/COS

01

SYMBIOTEC PHARMALAB PRIVATE LIMITED...

India

Antibody Engineering

Not Confirmed

Symbiotec: Global API manufacturer, specializing in Cortico-Steroids & Steroid-Hormone APIs.

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India

Digital Content

Betamethasone valerate, Micronised

Certificate Number : R1-CEP 2008-307 - Rev 00

Status : Valid

Issue Date : 2016-04-08

Type : Chemical

Substance Number : 811

Symbiotec Pharmalab

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02

Farmabios SpA Gropello Cairoli IT

Germany

Antibody Engineering

Not Confirmed

Axplora- The partner of choice for complex APIs.

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Germany

Digital Content

Betamethasone valerate, Micronised

Certificate Number : R1-CEP 2002-078 - Rev 03

Status : Valid

Issue Date : 2021-03-22

Type : Chemical

Substance Number : 811

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03

TEVA PHARMACEUTICAL INDUSTRIES LTD ...

Israel

CPhI WW Frankfurt

TAPI offers customized CDMO Solutions for API development and manufacturing services.

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Israel

Digital Content

Betamethasone valerate

Certificate Number : R1-CEP 2003-095 - Rev 04

Status : Valid

Issue Date : 2021-11-25

Type : Chemical

Substance Number : 811

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AURISCO PHARMACEUTICAL CO., LTD. Ti...

China

Antibody Engineering

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05

CURIA SPAIN S.A.U. Boecillo ES

U.S.A

Antibody Engineering

Not Confirmed

06

GlaxoSmithKline Research & Developm...

United Kingdom

Antibody Engineering

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GlaxoSmithKline Research & Developm...

United Kingdom

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08

HENAN LIHUA PHARMACEUTICAL CO., LTD...

China

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09

Pharmacia & Upjohn Company Kalamazo...

U.S.A

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10

SM BIOMED SDN BHD Sungai Petani MY

Malaysia

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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