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    Chemistry

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    Also known as: 63659-19-8, Betaxolol hcl, Betoptic, Kerlone, Betoptima, Lokren
    Molecular Formula
    C18H30ClNO3
    Molecular Weight
    343.9  g/mol
    InChI Key
    CHDPSNLJFOQTRK-UHFFFAOYSA-N
    FDA UNII
    6X97D2XT0O
    Betaxolol
    A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.
    1 2D Structure

    Betaxolol

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H
    2.1.3 InChI Key
    CHDPSNLJFOQTRK-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    6X97D2XT0O
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Alcon, Betaxolol

    2. Alo 1401 02

    3. Alo-1401-02

    4. Alo140102

    5. Betaxolol

    6. Betaxolol Alcon

    7. Betoptic

    8. Betoptima

    9. Hydrochloride, Betaxolol

    10. Kerlon

    11. Kerlone

    12. Oxodal

    13. Sl 75212

    14. Sl-75212

    15. Sl75212

    2.3.2 Depositor-Supplied Synonyms

    1. 63659-19-8

    2. Betaxolol Hcl

    3. Betoptic

    4. Kerlone

    5. Betoptima

    6. Lokren

    7. Betaxolol (hydrochloride)

    8. Alo 1401-02

    9. Sl75212

    10. Betaxolol Hydrochloride (betoptic)

    11. Nsc-760048

    12. Alo-1401-02

    13. Betoptic S

    14. Mls000863279

    15. 6x97d2xt0o

    16. Dextrobetaxolol (hydrochloride)

    17. Kerlon

    18. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

    19. Alo-140102

    20. Smr000058420

    21. Sl-7521210

    22. Sl 75.212-10

    23. Sl-75.212-10

    24. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hydrochloride

    25. Betaxolo Hydrochloride

    26. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

    27. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+-)-

    28. Chebi:643228

    29. Chemical Name: 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

    30. Betaxolol Hydrochloride [usan]

    31. Sr-01000000108

    32. Einecs 264-384-3

    33. Mfcd00242959

    34. Sl-75212-10

    35. Unii-6x97d2xt0o

    36. Kerlong

    37. Sl-75212

    38. Levobetaxololhcl

    39. Sl 75 212-10

    40. Betoptic (tn)

    41. Prestwick_779

    42. Kerlone (tn)

    43. Betaxolol Hydrochloride [usan:usp:jan]

    44. Cpd000058420

    45. Opera_id_878

    46. (+-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

    47. 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-ol Hydrochloride

    48. Chembl1691

    49. Schembl42794

    50. Mls000028464

    51. Mls000758269

    52. Mls001148209

    53. Mls001424199

    54. Mls002222261

    55. Betaxolol Hydrochloride- Bio-x

    56. Sl 75212 Hcl

    57. Betaxolol For Peak Identification

    58. Hy-b0381a

    59. Dtxsid30979876

    60. Mci-144

    61. Hms1569m05

    62. Pharmakon1600-01505512

    63. (2s)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

    64. Bcp02967

    65. Betaxolol Hydrochloride [mi]

    66. Tox21_500193

    67. Betaxolol Hydrochloride (jp17/usp)

    68. Betaxolol Hydrochloride [jan]

    69. Nsc760048

    70. Akos015843993

    71. Ac-1412

    72. Bcp9000394

    73. Betaxolol Hydrochloride [mart.]

    74. Betaxolol Hydrochloride [vandf]

    75. Ccg-101057

    76. Ccg-213473

    77. Lp00193

    78. Nc00307

    79. Nsc 760048

    80. Betaxolol Hydrochloride [usp-rs]

    81. Betaxolol Hydrochloride [who-dd]

    82. Betaxolol Hydrochloride, >98% (hplc)

    83. Ncgc00093669-01

    84. Ncgc00093669-02

    85. Ncgc00260878-01

    86. As-18082

    87. Bb164245

    88. Bcp0726000249

    89. B4474

    90. Betaxolol Hydrochloride [orange Book]

    91. Eu-0100193

    92. Ft-0645228

    93. S1827

    94. Sw196917-4

    95. Betaxolol Hydrochloride [ep Monograph]

    96. B 5683

    97. Betaxolol Hydrochloride [usp Monograph]

    98. D00598

    99. T71164

    100. Kerledex Component Betaxolol Hydrochloride

    101. 659x198

    102. A803574

    103. Betaxolol Hydrochloride Component Of Kerledex

    104. Q-200714

    105. Sr-01000000108-2

    106. Sr-01000000108-4

    107. Sr-01000000108-9

    108. Betoptic Pilo Component Betaxolol Hydrochloride

    109. Q27105180

    110. Betaxolol Hydrochloride Component Of Betoptic Pilo

    111. Betaxolol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    112. Betaxolol Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    113. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hcl

    114. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydron;chloride

    115. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanolhydrochloride

    116. Betaxolol For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    117. (+/-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

    118. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol Hydrochloride;levobetaxolol Hydrochloride

    119. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+/-)-

    120. 72424-72-7

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 343.9 g/mol
    Molecular Formula C18H30ClNO3
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count11
    Exact Mass343.1914215 g/mol
    Monoisotopic Mass343.1914215 g/mol
    Topological Polar Surface Area50.7 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity286
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameBetaxolol hydrochloride
    PubMed HealthBetaxolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelBetaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
    Active IngredientBetaxolol hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strength10mg; eq 0.5% base; 20mg
    Market StatusPrescription
    CompanyWockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

    2 of 6  
    Drug NameBetoptic
    PubMed HealthBetaxolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelBETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
    Active IngredientBetaxolol hydrochloride
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.5% base
    Market StatusPrescription
    CompanyAlcon

    3 of 6  
    Drug NameBetoptic s
    Active IngredientBetaxolol hydrochloride
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strengtheq 0.25% base
    Market StatusPrescription
    CompanyAlcon

    4 of 6  
    Drug NameBetaxolol hydrochloride
    PubMed HealthBetaxolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelBetaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
    Active IngredientBetaxolol hydrochloride
    Dosage FormSolution/drops; Tablet
    RouteOphthalmic; Oral
    Strength10mg; eq 0.5% base; 20mg
    Market StatusPrescription
    CompanyWockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

    5 of 6  
    Drug NameBetoptic
    PubMed HealthBetaxolol (Into the eye)
    Drug ClassesAntiglaucoma
    Drug LabelBETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
    Active IngredientBetaxolol hydrochloride
    Dosage FormSolution/drops
    RouteOphthalmic
    Strengtheq 0.5% base
    Market StatusPrescription
    CompanyAlcon

    6 of 6  
    Drug NameBetoptic s
    Active IngredientBetaxolol hydrochloride
    Dosage FormSuspension/drops
    RouteOphthalmic
    Strengtheq 0.25% base
    Market StatusPrescription
    CompanyAlcon

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Adrenergic beta-1 Receptor Antagonists

    Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

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INDIA.","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"1.80","actualQuantity":"1.8","unit":"KGS","unitRateFc":"3050","totalValueFC":"5573.1","currency":"USD","unitRateINR":"257115","date":"12-Dec-2023","totalValueINR":"462807","totalValueInUsd":"5573.1","indian_port":"Ahmedabad Air","hs_no":"29221990","bill_no":"9183586","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"STRADA RIVOLTANA KM.6\/7-20053RODANO (MI), ITALY","customerAddress":"COMMERCE HOUSE V,BESIDES VODAFONE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714156200,"product":"RE-IMPORT- BETAXOLOL HYDROCHLORIDE EP (FOC\/NCV) BATCH NO.BX\/012\/09\/23","address":"206, ERIC HOUSE, 16TH ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"SUDAIWA PTE LTD","supplierCountry":"INDIA","foreign_port":"PRAGUE - RUZYNE","customer":"PIONEER AGRO INDUSTRIES SANVIN LABORATORIES PRIVAT","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"905","totalValueFC":"18807.3","currency":"USD","unitRateINR":"78090.4","date":"27-Apr-2024","totalValueINR":"1561808.49","totalValueInUsd":"18807.3","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3237888","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"85 GENTING LANE #08-03 SINGAPORE 349569 SHIPPED BY:PHARMAGEN GMBH, FRIEDRICHEBERT-ANLAGE 36,60325 FRANKFU Singapore","customerAddress":"206, ERIC HOUSE, 16TH ROAD,"}]
    06-Feb-2021
    21-Aug-2024
    KGS
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    (USD/KGS)    		 Number of Transactions

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