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ACTIVE PHARMA INGREDIENTS

20 API Suppliers, 9 USDMF, 4 CEP/COS, 2 JDMF, 3 EU WC, 3 KDMF, 3 NDC API, 8 Listed Suppliers, $ API Reference Price

20 API Suppliers
9 USDMF
4 CEP/COS
2 JDMF
3 EU WC
3 KDMF
3 NDC API
8 Listed Suppliers
$ API Reference Price

INTERMEDIATES

6 Intermediates Suppliers

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

40 FDF Dossiers, 15 FDA Orange Book, 11 Europe, 4 Australia, 4 South Africa, 6 Listed Dossiers

40 FDF Dossiers
15 FDA Orange Book
11 Europe
4 Australia
4 South Africa
6 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc, 16 SPI Pharma, 2 Seqens, 2 DKSH, 2 Faran Shimi Pharmaceutical, 10 Gangwal Healthcare, 2 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 1 ACG Worldwide, 10 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 12 BASF, 1 Clariant, 10 Corel Pharma Chem, 4 DFE Pharma, 2 Finar, 8 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 4 Ingredion Pharma Solutions, 23 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 1 Novo Excipients, 2 Pharmatrans-Sanaq, 2 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 21 Roquette, 13 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 2 The Dow Chemical Company, 2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders, 46 Coating Systems & Additives, 33 Direct Compression, 24 Controlled & Modified Release, 21 Thickeners and Stabilizers, 19 Disintegrants & Superdisintegrants, 17 Co-Processed Excipients, 17 Solubilizers, 16 Parenteral, 15 Chewable & Orodispersible Aids, 15 Granulation, 15 Taste Masking, 12 Film Formers & Plasticizers, 12 Topical, 6 Lubricants & Glidants, 5 Empty Capsules, 5 API Stability Enhancers, 4 Vegetarian Capsules, 4 Coloring Agents, 4 Emulsifying Agents, 4 Rheology Modifiers, 3 Surfactant & Foaming Agents

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 6 NEWS #PharmaBuzz

media
1 DATA COMPILATION #PharmaFlow
6 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 9 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
9 Finished Drug Prices

MARKET PLACE

4 APIs

marketPlace
4 APIs

REF. STANDARDS & IMPURITIES

5 EDQM , 1 USP , 9 Others

otherSolutions
5 EDQM
1 USP
9 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 924

MARKET PLACE

API

FDF

6INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

4,820,042

Annual Reports (USD Million)

Finished Drug Prices

201 RELATED EXCIPIENT COMPANIES

351EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 63659-19-8, Betaxolol hcl, Betoptic, Kerlone, Betoptima, Lokren

Molecular Formula

C₁₈H₃₀ClNO₃

Molecular Weight

343.9 g/mol

InChI Key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

FDA UNII

6X97D2XT0O

A cardioselective beta-1-adrenergic antagonist with no partial agonist activity.

1 2D Structure

Betaxolol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

2.1.2 InChI

InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H

2.1.3 InChI Key

CHDPSNLJFOQTRK-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)NCC(COC1=CC=C(C=C1)CCOCC2CC2)O.Cl

2.2 Other Identifiers

2.2.1 UNII

6X97D2XT0O

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Alcon, Betaxolol

2. Alo 1401 02

3. Alo-1401-02

4. Alo140102

5. Betaxolol

6. Betaxolol Alcon

7. Betoptic

8. Betoptima

9. Hydrochloride, Betaxolol

10. Kerlon

11. Kerlone

12. Oxodal

13. Sl 75212

14. Sl-75212

15. Sl75212

2.3.2 Depositor-Supplied Synonyms

1. 63659-19-8

2. Betaxolol Hcl

3. Betoptic

4. Kerlone

5. Betoptima

6. Lokren

7. Betaxolol (hydrochloride)

8. Alo 1401-02

9. Sl75212

10. Betaxolol Hydrochloride (betoptic)

11. Nsc-760048

12. Alo-1401-02

13. Betoptic S

14. Mls000863279

15. 6x97d2xt0o

16. Dextrobetaxolol (hydrochloride)

17. Kerlon

18. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

19. Alo-140102

20. Smr000058420

21. Sl-7521210

22. Sl 75.212-10

23. Sl-75.212-10

24. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hydrochloride

25. Betaxolo Hydrochloride

26. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

27. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+-)-

28. Chebi:643228

29. Chemical Name: 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanol Hydrochloride

30. Betaxolol Hydrochloride [usan]

31. Sr-01000000108

32. Einecs 264-384-3

33. Mfcd00242959

34. Sl-75212-10

35. Unii-6x97d2xt0o

36. Kerlong

37. Sl-75212

38. Levobetaxololhcl

39. Sl 75 212-10

40. Betoptic (tn)

41. Prestwick_779

42. Kerlone (tn)

43. Betaxolol Hydrochloride [usan:usp:jan]

44. Cpd000058420

45. Opera_id_878

46. (+-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

47. 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-isopropylaminopropan-2-ol Hydrochloride

48. Chembl1691

49. Schembl42794

50. Mls000028464

51. Mls000758269

52. Mls001148209

53. Mls001424199

54. Mls002222261

55. Betaxolol Hydrochloride- Bio-x

56. Sl 75212 Hcl

57. Betaxolol For Peak Identification

58. Hy-b0381a

59. Dtxsid30979876

60. Mci-144

61. Hms1569m05

62. Pharmakon1600-01505512

63. (2s)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride

64. Bcp02967

65. Betaxolol Hydrochloride [mi]

66. Tox21_500193

67. Betaxolol Hydrochloride (jp17/usp)

68. Betaxolol Hydrochloride [jan]

69. Nsc760048

70. Akos015843993

71. Ac-1412

72. Bcp9000394

73. Betaxolol Hydrochloride [mart.]

74. Betaxolol Hydrochloride [vandf]

75. Ccg-101057

76. Ccg-213473

77. Lp00193

78. Nc00307

79. Nsc 760048

80. Betaxolol Hydrochloride [usp-rs]

81. Betaxolol Hydrochloride [who-dd]

82. Betaxolol Hydrochloride, >98% (hplc)

83. Ncgc00093669-01

84. Ncgc00093669-02

85. Ncgc00260878-01

86. As-18082

87. Bb164245

88. Bcp0726000249

89. B4474

90. Betaxolol Hydrochloride [orange Book]

91. Eu-0100193

92. Ft-0645228

93. S1827

94. Sw196917-4

95. Betaxolol Hydrochloride [ep Monograph]

96. B 5683

97. Betaxolol Hydrochloride [usp Monograph]

98. D00598

99. T71164

100. Kerledex Component Betaxolol Hydrochloride

101. 659x198

102. A803574

103. Betaxolol Hydrochloride Component Of Kerledex

104. Q-200714

105. Sr-01000000108-2

106. Sr-01000000108-4

107. Sr-01000000108-9

108. Betoptic Pilo Component Betaxolol Hydrochloride

109. Q27105180

110. Betaxolol Hydrochloride Component Of Betoptic Pilo

111. Betaxolol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

112. Betaxolol Hydrochloride, United States Pharmacopeia (usp) Reference Standard

113. 1-(isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hcl

114. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydron;chloride

115. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-isopropylamino-2-propanolhydrochloride

116. Betaxolol For Peak Identification, European Pharmacopoeia (ep) Reference Standard

117. (+/-)-1-(p-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)-2-propanol Hydrochloride

118. 1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)propan-2-ol Hydrochloride;levobetaxolol Hydrochloride

119. 2-propanol, 1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-, Hydrochloride, (+/-)-

120. 72424-72-7

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₃₀ClNO₃
Molecular Weight	343.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	11
Exact Mass	343.1914215 g/mol
Monoisotopic Mass	343.1914215 g/mol
Topological Polar Surface Area	50.7 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	286
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Betaxolol hydrochloride
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	Betaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	10mg; eq 0.5% base; 20mg
Market Status	Prescription
Company	Wockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

2 of 6
Drug Name	Betoptic
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	BETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base
Market Status	Prescription
Company	Alcon

3 of 6
Drug Name	Betoptic s
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Suspension/drops
Route	Ophthalmic
Strength	eq 0.25% base
Market Status	Prescription
Company	Alcon

4 of 6
Drug Name	Betaxolol hydrochloride
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	Betaxolol Ophthalmic Solution USP, contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molecular...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops; Tablet
Route	Ophthalmic; Oral
Strength	10mg; eq 0.5% base; 20mg
Market Status	Prescription
Company	Wockhardt; Epic Pharma; Kvk Tech; Bausch And Lomb; Akorn

5 of 6
Drug Name	Betoptic
PubMed Health	Betaxolol (Into the eye)
Drug Classes	Antiglaucoma
Drug Label	BETOPTIC Sterile Ophthalmic Solution contains betaxolol hydrochloride, a cardioselective beta-adrenergic receptor blocking agent, in a sterile isotonic solution. Betaxolol hydrochloride is a white, crystalline powder, soluble in water, with a molec...
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Solution/drops
Route	Ophthalmic
Strength	eq 0.5% base
Market Status	Prescription
Company	Alcon

6 of 6
Drug Name	Betoptic s
Active Ingredient	Betaxolol hydrochloride
Dosage Form	Suspension/drops
Route	Ophthalmic
Strength	eq 0.25% base
Market Status	Prescription
Company	Alcon

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)

Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

API SUPPLIERS

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USDMF

01

Abbott Laboratories Chemical And Agr...

U.S.A

Cosmoprof India

Not Confirmed

02

Indoco Remedies Ltd

India

Cosmoprof India

Not Confirmed

03

Lusochimica Spa

Italy

Cosmoprof India

Not Confirmed

04

Olon Spa

Italy

Cosmoprof India

Not Confirmed

05

Sifavitor Srl

Italy

Cosmoprof India

Not Confirmed

06

Smith And Nephew Res Ltd

Canada

Cosmoprof India

Not Confirmed

07

Laboratoires Detudes Et De Recherche...

Country

Cosmoprof India

Not Confirmed

08

Laboratoires Detudes Et De Recherche...

Country

Cosmoprof India

Not Confirmed

09

Laboratoires Detudes Et De Recherche...

Country

Cosmoprof India

Not Confirmed

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CEP/COS

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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PHARMA","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1000","unit":"GMS","unitRateFc":"2.7","totalValueFC":"2912.4","currency":"EUR","unitRateINR":"225.1","date":"14-May-2022","totalValueINR":"225088.5","totalValueInUsd":"2912.4","indian_port":"DELHI AIR","hs_no":"29221190","bill_no":"8687881","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"212 ASHIRWAD COMMERCIAL COMPLEX,D- 1 GREEN PARK,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1702319400,"product":"BETAXOLOL HYDROCHLORIDE:-FOR EXAMINATION,TEST OR ANALYSIS PURPOSE ONLY","address":"COMMERCE HOUSE V,BESIDES VODAFONE","city":"AHMEDABAD, GUJARAT. INDIA.","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"ACULIFE HEALTHCARE","customerCountry":"INDIA","quantity":"1.80","actualQuantity":"1.8","unit":"KGS","unitRateFc":"3050","totalValueFC":"5559.7","currency":"USD","unitRateINR":"257115","date":"12-Dec-2023","totalValueINR":"462807","totalValueInUsd":"5559.7","indian_port":"Ahmedabad Air","hs_no":"29221990","bill_no":"9183586","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"STRADA RIVOLTANA KM.6\/7-20053RODANO (MI), ITALY","customerAddress":"COMMERCE HOUSE V,BESIDES VODAFONE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714156200,"product":"RE-IMPORT- BETAXOLOL HYDROCHLORIDE EP (FOC\/NCV) BATCH NO.BX\/012\/09\/23","address":"206, ERIC HOUSE, 16TH ROAD,","city":"MUMBAI, MAHARASHTRA.","supplier":"SUDAIWA PTE LTD","supplierCountry":"INDIA","foreign_port":"PRAGUE - RUZYNE","customer":"PIONEER AGRO INDUSTRIES SANVIN LABORATORIES PRIVAT","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"905","totalValueFC":"18702.7","currency":"USD","unitRateINR":"78090.4","date":"27-Apr-2024","totalValueINR":"1561808.49","totalValueInUsd":"18702.7","indian_port":"Bombay Air","hs_no":"29420090","bill_no":"3237888","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"85 GENTING LANE #08-03 SINGAPORE 349569 SHIPPED BY:PHARMAGEN GMBH, FRIEDRICHEBERT-ANLAGE 36,60325 FRANKFU Singapore","customerAddress":"206, ERIC HOUSE, 16TH ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Direct Compression

Controlled & Modified Release

Thickeners and Stabilizers

Disintegrants & Superdisintegrants

Co-Processed Excipients

Solubilizers

Parenteral

Chewable & Orodispersible Aids

Granulation

Taste Masking

Film Formers & Plasticizers

Topical

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

20 API Suppliers

9 USDMF

4 CEP/COS

2 JDMF

3 EU WC

3 KDMF

3 NDC API

8 Listed Suppliers

$ API Reference Price

INTERMEDIATES

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

40 FDF Dossiers

15 FDA Orange Book

11 Europe

4 Australia

4 South Africa

6 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

16 SPI Pharma

2 Seqens

2 DKSH

2 Faran Shimi Pharmaceutical

10 Gangwal Healthcare

2 Nanjing Well Pharmaceutical

1 Pfanstiehl

1 ACG Worldwide

10 Actylis

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

12 BASF

1 Clariant

10 Corel Pharma Chem

4 DFE Pharma

2 Finar

8 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

4 Ingredion Pharma Solutions

23 Kerry

3 Kima Chemical

6 Lonza Capsugel

8 Microlex e.U

1 Nanjing Bold Chemical

2 Nomisma Healthcare

1 Novo Excipients

2 Pharmatrans-Sanaq

2 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

21 Roquette

13 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

9 Sigachi Industries

2 The Dow Chemical Company

2 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders

46 Coating Systems & Additives

33 Direct Compression

24 Controlled & Modified Release

21 Thickeners and Stabilizers

19 Disintegrants & Superdisintegrants

17 Co-Processed Excipients

17 Solubilizers

16 Parenteral

15 Chewable & Orodispersible Aids

15 Granulation

15 Taste Masking

12 Film Formers & Plasticizers

12 Topical

6 Lubricants & Glidants

5 Empty Capsules