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Chemistry

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Also known as: 59170-23-9, Bevantololum, Bevantololum [inn-latin], 1-(3,4-dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol, 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol, 1-((3,4-dimethoxyphenethyl)amino)-3-(m-tolyloxy)propan-2-ol
Molecular Formula
C20H27NO4
Molecular Weight
345.4  g/mol
InChI Key
HXLAFSUPPDYFEO-UHFFFAOYSA-N
FDA UNII
34ZXW6ZV21

Bevantolol
Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.
1 2D Structure

Bevantolol

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol
2.1.2 InChI
InChI=1S/C20H27NO4/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3
2.1.3 InChI Key
HXLAFSUPPDYFEO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=CC=C1)OCC(CNCCC2=CC(=C(C=C2)OC)OC)O
2.2 Other Identifiers
2.2.1 UNII
34ZXW6ZV21
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bevantolol Hydrochloride

2. Ci 775

3. Ci-775

2.3.2 Depositor-Supplied Synonyms

1. 59170-23-9

2. Bevantololum

3. Bevantololum [inn-latin]

4. 1-(3,4-dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol

5. 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol

6. 1-((3,4-dimethoxyphenethyl)amino)-3-(m-tolyloxy)propan-2-ol

7. Nsc-132348

8. 1-[2-(3,4-dimethoxyphenyl)ethylamino]-3-(3-methylphenoxy)propan-2-ol

9. 34zxw6zv21

10. Chebi:238698

11. 1-(3,4-dimethoxyphenethylamino)-3-m-tolyloxy-propan-2-ol

12. 1-[2-(3,4-dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-ol

13. Bevantolol [inn:ban]

14. (+/-)-bevantolol; Dl-bevantolol; Nsc 132348

15. 1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol

16. (+-)-bevantolol

17. Brn 2769444

18. Unii-34zxw6zv21

19. (+/-)-bevantolol

20. Bevantolol [mi]

21. Bevantolol [inn]

22. Bevantolol [who-dd]

23. Schembl49721

24. Mls003876814

25. Chembl314010

26. Dtxsid70860597

27. Hms3604b08

28. Hy-a0249

29. Nsc132348

30. 1-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-3-(3-methylphenoxy)propan-2-ol

31. 2-propanol, 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-

32. Akos016014301

33. Db01295

34. Nsc 132348

35. Smr002529477

36. A917858

37. L013370

38. Q1956953

39. 1-[[2-(3,4-dimethoxyphenyl) Ethyl]amino]-3-(3-methyl-phenoxy)-2-propanol

40. (+/-)-1-((3,4-dimethoxyphenethyl)amino)-3-(m-tolyloxy)-2-propanol

41. 2-propanol, 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-, (+/-)-

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 345.4 g/mol
Molecular Formula C20H27NO4
XLogP33
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass345.19400834 g/mol
Monoisotopic Mass345.19400834 g/mol
Topological Polar Surface Area60 Ų
Heavy Atom Count25
Formal Charge0
Complexity355
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the treatment of angina pectoris and hypertension.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.


5.2 MeSH Pharmacological Classification

Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)


5.3 ATC Code

C - Cardiovascular system

C07 - Beta blocking agents

C07A - Beta blocking agents

C07AB - Beta blocking agents, selective

C07AB06 - Bevantolol


5.4 Mechanism of Action

Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.


ABOUT THIS PAGE

Bevantolol Manufacturers

A Bevantolol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bevantolol, including repackagers and relabelers. The FDA regulates Bevantolol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bevantolol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Bevantolol Suppliers

A Bevantolol supplier is an individual or a company that provides Bevantolol active pharmaceutical ingredient (API) or Bevantolol finished formulations upon request. The Bevantolol suppliers may include Bevantolol API manufacturers, exporters, distributors and traders.

click here to find a list of Bevantolol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Bevantolol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Bevantolol Drug Master File in Japan (Bevantolol JDMF) empowers Bevantolol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Bevantolol JDMF during the approval evaluation for pharmaceutical products. At the time of Bevantolol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Bevantolol suppliers with JDMF on PharmaCompass.

Bevantolol GMP

Bevantolol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Bevantolol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bevantolol GMP manufacturer or Bevantolol GMP API supplier for your needs.

Bevantolol CoA

A Bevantolol CoA (Certificate of Analysis) is a formal document that attests to Bevantolol's compliance with Bevantolol specifications and serves as a tool for batch-level quality control.

Bevantolol CoA mostly includes findings from lab analyses of a specific batch. For each Bevantolol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Bevantolol may be tested according to a variety of international standards, such as European Pharmacopoeia (Bevantolol EP), Bevantolol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bevantolol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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