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ACTIVE PHARMA INGREDIENTS

7 API Suppliers, 1 USDMF, 2 EU WC, 1 NDC API, 4 Listed Suppliers, $ API Reference Price

7 API Suppliers
1 USDMF
2 EU WC
1 NDC API
4 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

5 Drugs in Development

5 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 FDA Orange Book

1 FDF Dossiers
1 FDA Orange Book

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 10 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
10 NEWS #PharmaBuzz

PATENTS & EXCLUSIVITIES

6 US Patents, 1 US Exclusivities

patents
6 US Patents
1 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

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EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

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0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

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Chemistry

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Also known as: 1118567-05-7, Egt1442, Egt-1442, Thr-1442, Bexagliflozin [usan], Egt0001442

Molecular Formula

C₂₄H₂₉ClO₇

Molecular Weight

464.9 g/mol

InChI Key

BTCRKOKVYTVOLU-SJSRKZJXSA-N

FDA UNII

EY00JF42FV

Bexagliflozin is under investigation for the treatment of Type 2 Diabetes Mellitus. Bexagliflozin has been investigated for the treatment of Diabetes Mellitus and Type2 Diabetes Mellitus.

1 2D Structure

Bexagliflozin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-(2-cyclopropyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

2.1.2 InChI

InChI=1S/C24H29ClO7/c25-19-8-3-15(24-23(29)22(28)21(27)20(13-26)32-24)12-16(19)11-14-1-4-17(5-2-14)30-9-10-31-18-6-7-18/h1-5,8,12,18,20-24,26-29H,6-7,9-11,13H2/t20-,21-,22+,23-,24+/m1/s1

2.1.3 InChI Key

BTCRKOKVYTVOLU-SJSRKZJXSA-N

2.1.4 Canonical SMILES

C1CC1OCCOC2=CC=C(C=C2)CC3=C(C=CC(=C3)C4C(C(C(C(O4)CO)O)O)O)Cl

2.1.5 Isomeric SMILES

C1CC1OCCOC2=CC=C(C=C2)CC3=C(C=CC(=C3)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)Cl

2.2 Other Identifiers

2.2.1 UNII

EY00JF42FV

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol

2.3.2 Depositor-Supplied Synonyms

1. 1118567-05-7

2. Egt1442

3. Egt-1442

4. Thr-1442

5. Bexagliflozin [usan]

6. Egt0001442

7. Ey00jf42fv

8. (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol

9. Chembl1808388

10. Thr1442

11. Bexagliflozin (usan)

12. Egt-0001442

13. (2s,3r,4r,5s,6r)-2-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol

14. (2s,3r,4r,5s,6r)-2-[4-chloro-3-[[4-(2-cyclopropyloxyethoxy)phenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

15. D-glucitol, 1,5-anhydro-1-c-(4-chloro-3-((4-(2-(cyclopropyloxy)ethoxy)phenyl)methyl)phenyl)-, (1s)-

16. Unii-ey00jf42fv

17. Egt1442; Bexagliflozin

18. Bexagliflozin [inn]

19. Schembl302200

20. Bexagliflozin [who-dd]

21. Ex-a2332

22. Bdbm50349249

23. Zinc59047505

24. Bexagliflozin(thr1442egt1442)

25. Cs-5702

26. Db12236

27. (1s)-1,5-anhydro-1-c-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-d-glucitol

28. Ac-33643

29. As-55919

30. Hy-17604

31. C71393

32. D10865

33. J-500393

34. Q27277423

2.4 Create Date

2009-03-30

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₂₉ClO₇
Molecular Weight	464.9 g/mol
XLogP3	2.4
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	9
Exact Mass	464.1601810 g/mol
Monoisotopic Mass	464.1601810 g/mol
Topological Polar Surface Area	109 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	569
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Treatment of type II diabetes mellitus

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Hypoglycemic Agents

Substances which lower blood glucose levels. (See all compounds classified as Hypoglycemic Agents.)

API SUPPLIERS

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USDMF

01

Piramal Pharma Ltd

India

ASC 2024

Not Confirmed

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EU WC

01

02

Piramal Pharma Solutions

U.S.A

ASC 2024

Not Confirmed

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NDC API

01

Piramal Pharma Limited

U.S.A

ASC 2024

Not Confirmed

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Listed Suppliers

01

Metrochem API Private Limited

India

CPhI Worldwide, Milan

Booth #3A33

Metrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Contact Supplier

India

Virtual Booth

Digital Content

Bexagliflozin

About the Company :

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product ...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer

02

Moehs Iberica

Spain

CPhI Worldwide, Milan

Booth #4A33

Moehs Group, a reference company in the production of pharmaceutical active ingredients.

Contact Supplier

Spain

Virtual Booth

Digital Content

Bexagliflozin

About the Company : Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 ...

Since its founding in 1962, MOEHS has produced Active Pharmaceutical Ingredients (APIs) for the international pharmaceutical industry. Thanks to a business history of more than 50 years, MOEHS has considerable technical experience in the production of these substances. At Moehs Group we have a large tradition and experience in the area of manufacturing of active pharmaceutical and veterinary ingredients, agrochemicals, nutraceutical, cosmetic, as well as fine chemistry in general, with high levels of quality and safety standards-GMP´s, ICH, approved by the FDA and TGA.

03

Jinan Tantu Chemicals

China

CPhI Worldwide, Milan

Attending

Jinan Tantu Chemicals offers customized R&D services & production of small molecule APIs & pharmaceutical intermediates.

Contact Supplier

China

Virtual Booth

Digital Content

Bexagliflozin

About the Company : Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include c...

Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our core services include customized R&D as well as the production of small molecule pharmaceutical intermediates and Active Pharmaceutical Ingredients (APIs) for both international and domestic pharmaceutical firms. Our capabilities span from laboratory-scale kilograms to commercial ton-scale production. Additionally, we are committed to independent research and development, as well as the production and sales of high-end pharmaceutical intermediates and API products.