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1. 1-((4-biphenylyl)-phenylmethyl)-1h-imidazole
2. Amycor
3. Bay H 4502
4. Bay H-4502
5. Bifokey
6. Bifomyk
7. Bifon
8. Moldina
9. Mycospor
1. 60628-96-8
2. Mycospor
3. Trifonazole
4. Bifonazol
5. Bay H 4502
6. Amycor
7. Azolmen
8. Bifonazol [inn-spanish]
9. Bifonazolum [inn-latin]
10. 1-[phenyl-(4-phenylphenyl)methyl]imidazole
11. Bay H-4502
12. 1-((4-biphenylyl)phenylmethyl)-1h-imidazole
13. 1-(alpha-(4-biphenylyl)benzyl)imidazole
14. (+-)-1-(p,alpha-diphenylbenzyl)imidazole
15. Bay-h-4502
16. 1h-imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-
17. 1-(p,alpha-diphenylbenzyl)imidazole
18. D01ac10
19. 1-([1,1'-biphenyl]-4-yl(phenyl)methyl)-1h-imidazole
20. Nsc-758954
21. Mls000028576
22. Chembl277535
23. Qyj305z91o
24. Bifonazolum
25. Chebi:78692
26. 1-[biphenyl-4-yl(phenyl)methyl]-1h-imidazole
27. 1h-imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-
28. (+-)1-([1,1'-biphenyl]-4-ylphenylmethyl)-1h-imidazole
29. Ncgc00018254-03
30. Smr000058970
31. 1-[biphenyl-4-yl(phenyl)methyl]imidazole
32. Dsstox_cid_25631
33. Dsstox_rid_81013
34. Dsstox_gsid_45631
35. Mycospor (tn)
36. Cas-60628-96-8
37. (+/-)-bifonazole
38. Sr-01000003136
39. Einecs 262-336-6
40. 1-(biphenyl-4-yl(phenyl)methyl)-1h-imidazole
41. Brn 0618427
42. Unii-qyj305z91o
43. Mycosporan
44. Bedriol
45. Bifonazole,(s)
46. Bifonazole [usan:inn:ban:jan]
47. Mfcd00865567
48. Cpd000058970
49. Bifonazole [mi]
50. Bifonazole [inn]
51. Bifonazole [jan]
52. Opera_id_1656
53. Spectrum2_000035
54. Spectrum3_001970
55. (.+/-.)-bifonazole
56. Bifonazole [usan]
57. Imidazole, 1-(alpha-(4-biphenylyl)benzyl)-
58. 1-((4-biphenylyl)-phenylmethyl)-1h-imidazole
59. 1-(biphenyl-4-yl-phenyl-methyl)-1h-imidazole
60. Bifonazole [mart.]
61. Cid_2378
62. Bifonazole [who-dd]
63. Schembl36803
64. Bspbio_003570
65. 5-23-04-00292 (beilstein Handbook Reference)
66. Mls000759537
67. Mls001074074
68. Mls001424050
69. Spectrum1505309
70. Spbio_000129
71. Bifonazole (jp17/usan/inn)
72. Bifonazole [ep Impurity]
73. Bifonazole, >=98% (hplc)
74. Dtxsid9045631
75. Bifonazole For System Suitability
76. Kbio3_002922
77. Bifonazole [ep Monograph]
78. Hms1922b18
79. Hms2051f04
80. Hms2090k13
81. Hms2093b09
82. Hms2232j24
83. Hms3374h02
84. Hms3393f04
85. Hms3651g21
86. Hms3715l21
87. Pharmakon1600-01505309
88. 1h-imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+-)-
89. Amy32554
90. Bcp22297
91. Hy-b0301
92. Tox21_110850
93. Bdbm50128548
94. Ccg-39996
95. Dl-338
96. Nsc758954
97. S1854
98. Stk618771
99. Akos005553008
100. Tox21_110850_1
101. Ab07497
102. Bcp9000410
103. Ccg-100993
104. Db04794
105. Ks-5111
106. Nc00243
107. Nsc 758954
108. Mrf-0000274
109. Ncgc00018254-02
110. Ncgc00018254-04
111. Ncgc00018254-05
112. Ncgc00018254-08
113. Ncgc00018254-09
114. Ncgc00089815-02
115. Ncgc00089815-03
116. Ncgc00089815-04
117. Ac-15414
118. Bp164253
119. Sbi-0206755.p001
120. 1-(.alpha.-(4-biphenylyl)benzyl)imidazole
121. 1-(alpha,4-diphenylbenzyl)imidazole
122. 1-[alpha-(4-biphenylyl)-benzyl]-imidazole
123. (biphenyl-4-yl)-imidazol-1-yl-phenylmethane
124. B4173
125. Ft-0652733
126. Sw197623-3
127. Vu0239694-7
128. 1-[phenyl(4-phenylphenyl)methyl]-1h-imidazole
129. 28b968
130. D01775
131. Imidazole, 1-(.alpha.-(4-biphenylyl)benzyl)-
132. Ab00383029-16
133. Ab00383029_17
134. Ab00383029_18
135. (.+/-.)-1-(p,.alpha.-diphenylbenzyl)imidazole
136. A832816
137. Q421162
138. 1-(1-biphenyl-4-yl-2-phenyl-methyl)-1h-imidazole
139. Q-200717
140. Sr-01000003136-4
141. Sr-01000003136-6
142. (+/-)-1-(p,.alpha.-diphenylbenzyl)imidazole
143. 1-[phenyl-(4-phenylphenyl)methyl]imidazole;bifonazole
144. Brd-a94543220-001-02-3
145. Brd-a94543220-001-12-2
146. 1-(biphenyl-4-yl-phenyl-methyl)-1h-imidazole (bifonazole)
147. 1-(biphenyl-4-yl-phenyl-methyl)-1h-imidazole( Bifanozole)
148. 1-(biphenyl-4-yl-phenyl-methyl)-1h-imidazole(bifonazole)
149. 1-[[1,1'-biphenyl]-4-yl(phenyl)methyl]-1h-imidazole #
150. Bifonazole, European Pharmacopoeia (ep) Reference Standard
151. 1h-imidazole, 1-([1,1'-biphenyl]-4-ylphenylmethyl)-, (.+/-.)-
152. 1h-imidazole, 1-((1,1'-biphenyl)-4-ylphenylmethyl)-, (+/-)-
153. Bifonazole, Pharmaceutical Secondary Standard; Certified Reference Material
154. Bifonazole For System Suitability, European Pharmacopoeia (ep) Reference Standard
Molecular Weight | 310.4 g/mol |
---|---|
Molecular Formula | C22H18N2 |
XLogP3 | 4.8 |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 1 |
Rotatable Bond Count | 4 |
Exact Mass | 310.146998583 g/mol |
Monoisotopic Mass | 310.146998583 g/mol |
Topological Polar Surface Area | 17.8 Ų |
Heavy Atom Count | 24 |
Formal Charge | 0 |
Complexity | 362 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
Bifonazole is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.
Antifungal Agents
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)
D01AC10
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
D - Dermatologicals
D01 - Antifungals for dermatological use
D01A - Antifungals for topical use
D01AC - Imidazole and triazole derivatives
D01AC10 - Bifonazole
Absorption
Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).
Hepatic.
1-2 hours
Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.