Find Bisoctrizole manufacturers, exporters & distributors on PharmaCompass

Bisoctrizole

Interquim comes from an international group of 50 companies active in the pharma, hospital, diagnostics, fine chemicals & feed sectors.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

FINISHED DOSAGE FORMULATIONS

9 FDF Dossiers, 9 Canada

9 FDF Dossiers
9 Canada

RELATED EXCIPIENT COMPANIES

7 SPI Pharma, 1 DKSH, 1 Gangwal Healthcare, 3 Nanjing Well Pharmaceutical, 1 Aeon Procare, 1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 3 BASF, 5 Gangwal Chemicals, 3 Microlex e.U, 4 Roquette, 2 Seppic, 2 Sigachi Industries

relatedExcipients
7 SPI Pharma
1 DKSH
1 Gangwal Healthcare
3 Nanjing Well Pharmaceutical
1 Aeon Procare
1 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
3 BASF
5 Gangwal Chemicals
3 Microlex e.U
4 Roquette
2 Seppic
2 Sigachi Industries

EXCIPIENTS BY APPLICATIONS

8 Film Formers & Plasticizers, 7 Lubricants & Glidants, 7 Emulsifying Agents, 6 Coating Systems & Additives, 5 Topical, 5 Direct Compression, 5 Thickeners and Stabilizers, 5 Solubilizers, 4 Surfactant & Foaming Agents, 3 Co-Processed Excipients, 3 Fillers, Diluents & Binders, 2 Granulation, 2 Controlled & Modified Release, 1 Chewable & Orodispersible Aids, 1 API Stability Enhancers

excipientsByApplications
8 Film Formers & Plasticizers
7 Lubricants & Glidants
7 Emulsifying Agents
6 Coating Systems & Additives
5 Topical
5 Direct Compression
5 Thickeners and Stabilizers
5 Solubilizers
4 Surfactant & Foaming Agents
3 Co-Processed Excipients
3 Fillers, Diluents & Binders
2 Granulation
2 Controlled & Modified Release
1 Chewable & Orodispersible Aids
1 API Stability Enhancers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

media
1 NEWS #PharmaBuzz

REF. STANDARDS & IMPURITIES

3 USP , 3 Others

otherSolutions
3 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

33 RELATED EXCIPIENT COMPANIES

64EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 103597-45-1, Tinosorb m, Ultraviolet absorbent uv-360, Mbbt, Uv-360, Fat 75'634

Molecular Formula

C₄₁H₅₀N₆O₂

Molecular Weight

658.9 g/mol

InChI Key

FQUNFJULCYSSOP-UHFFFAOYSA-N

FDA UNII

8NT850T0YS

Bisoctrizole, or methylene bis-benzotriazolyl tetramethylbutylphenol, is a broad-spectrum organic UV filter that is marketed as Tinosorb M. It is a benzotriazole-based organic compound that absorbs, reflects, and scatters both UV-A and UV-B rays. Bisoctrizole is not approved by the FDA, but is approved in the EU and other parts of the world as a UV-filter in sunscreens, day care products and skin lightening products at a maximum concentration of 10%.

1 2D Structure

Bisoctrizole

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol

2.1.2 InChI

InChI=1S/C41H50N6O2/c1-38(2,3)24-40(7,8)28-20-26(36(48)34(22-28)46-42-30-15-11-12-16-31(30)43-46)19-27-21-29(41(9,10)25-39(4,5)6)23-35(37(27)49)47-44-32-17-13-14-18-33(32)45-47/h11-18,20-23,48-49H,19,24-25H2,1-10H3

2.1.3 InChI Key

FQUNFJULCYSSOP-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C)CC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC4=C(C(=CC(=C4)C(C)(C)CC(C)(C)C)N5N=C6C=CC=CC6=N5)O

2.2 Other Identifiers

2.2.1 UNII

8NT850T0YS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Methylene Bis-benzotriazolyl Tetramethylphenol

2. Tinosorb M

2.3.2 Depositor-Supplied Synonyms

1. 103597-45-1

2. Tinosorb M

3. Ultraviolet Absorbent Uv-360

4. Mbbt

5. Uv-360

6. Fat 75'634

7. Milestab-360

8. Tinuvin-360

9. Nsc-759873

10. 8nt850t0ys

11. 2-(benzotriazol-2-yl)-6-[[3-(benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol

12. 2,2'-methylenebis[6-(benzotriazol-2-yl)-4-tert-octylphenol]

13. Fat-75634

14. Ncgc00167544-01

15. 6,6'-methylenebis(2-(2h-benzo[d][1,2,3]triazol-2-yl)-4-(2-methylheptan-2-yl)phenol)

16. Phenol, 2,2'-methylenebis(6-(2h-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-

17. Phenol, 2,2'-methylenebis[6-(2h-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-

18. Bisoctrizole [usan]

19. 2,2'-methylenebis

20. Bisoctrizole (usp/inn)

21. Bisoctrizole [mi]

22. Bisoctrizole [inn]

23. Dsstox_cid_26703

24. Dsstox_rid_81837

25. Unii-8nt850t0ys

26. Dsstox_gsid_46703

27. Schembl39191

28. Bisoctrizole [mart.]

29. Ultraviolet Absorber Uv-360

30. Bisoctrizole [usp-rs]

31. Bisoctrizole [who-dd]

32. Bisoctrizole [usan:usp:inn]

33. Chembl2104957

34. Dtxsid2046703

35. Bisoctrizole, Analytical Standard

36. Chebi:135865

37. Hms3264f09

38. Pharmakon1600-01503866

39. Bcp29317

40. Hy-b0897

41. Bisoctrizole [usp Monograph]

42. Tox21_112541

43. Mfcd00192289

44. Nsc759873

45. S4551

46. Uv 360

47. Zinc11677911

48. Akos015895745

49. Db11262

50. Nsc 759873

51. Ncgc00167544-02

52. Cas-103597-45-1

53. Ft-0642535

54. M1259

55. A14939

56. D03249

57. Ec 403-800-1

58. Ab01563348_01

59. A800767

60. Sr-01000883719

61. Tinosorb M Pound>>ultraviolet Absorbent Uv-360

62. J-525148

63. Q4918369

64. Sr-01000883719-1

65. Bis-[2-hydroxy-5-t-octyl-3-(benzotriazol-2-yl)-phe

66. Bis-[2-hydroxy-5-t-octyl-3-(benzotriazol-2-yl)-phenyl) Methane

67. Bis[3-(benzotriazol-2-yl)-2-hydroxy-5-tert-octylphenyl]methane

68. Bisoctrizole, United States Pharmacopeia (usp) Reference Standard

69. Methylene Bis-benzotriazolyl Tetramethylbutylphenol [inci]

70. 2,2'-methylene-bis[4-(1,1,3,3-tetramethylbutyl)-6-benzotriazol-2-yl-phenol]

71. 2,2'-methylenebis(6-(2-benzotriazolyl)-4-(1,1,3,3-tetramethylbutyl)phenol

72. 2,2'-methylenebis(6-(2-benzotriazolyl)-4-(1,1,3,3-tetramethylbutyl)phenol)

73. 2,2'-methylenebis(6-(2hbenzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]

74. 2,2'-methylenebis[6-(2h-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol], 99%

75. Bisoctrizole, Pharmaceutical Secondary Standard; Certified Reference Material

76. 2-(2h-1,2,3-benzotriazol-2-yl)-6-{[3-(2h-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenol

77. 3-(benzotriazol-2-yl)-2-[[2-(benzotriazol-2-yl)-6-hydroxy-4-(1,1,3,3-tetramethylbutyl)phenyl]methyl]-5-(1,1,3,3-tetramethylbutyl)phenol;2,2'-methylenebis[6-(2h-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol]

78. 6,6'-bis(2h-1,2,3-benzotriazol-2-yl)-4,4'-bis(2,4,4-trimethylpentan-2-yl)- 2,2'-methylenebiphenol

79. Phenol, 2,2'-methylenebis(6-(2h-benzotrialzol-2-yl)-4-(1,1,3,3-tetramethylbutyl)-

2.4 Create Date

2005-09-09

3 Chemical and Physical Properties

Molecular Formula	C₄₁H₅₀N₆O₂
Molecular Weight	658.9 g/mol
XLogP3	12.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	10
Exact Mass	658.39952486 g/mol
Monoisotopic Mass	658.39952486 g/mol
Topological Polar Surface Area	102 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	989
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Indication

Indicated for use as a sunscreen agent in cosmetic products.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Under the conditions of _in vitro_ androgen competitive binding assay, bisoctrizole displayed no intrinsic androgenic, estrogenic, nor uterotrophic activity.

5.2 Absorption, Distribution and Excretion

Absorption

A rat and human dermal penetration study _in vitro_ indicates that bisoctrizole displays minimal absorption through the skin, with only about 0.01% and 0.06 % of the applied dose penetration through the human and rat skin membrane, respectively. Despite low dermal uptake, potential bioaccumulation after repeated skin applications cannot be excluded.

Route of Elimination