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Chemistry

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Also known as: 104344-23-2, Zebeta, Bisoprolol hemifumarate, Bisoprolol monofumarate, Fondril, Maintate
Molecular Formula
C22H35NO8
Molecular Weight
441.5  g/mol
InChI Key
RZPZLFIUFMNCLY-WLHGVMLRSA-N
FDA UNII
U057CX04H0

Bisoprolol Fumarate
A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
1 2D Structure

Bisoprolol Fumarate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(E)-but-2-enedioic acid;1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
2.1.2 InChI
InChI=1S/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
2.1.3 InChI Key
RZPZLFIUFMNCLY-WLHGVMLRSA-N
2.1.4 Canonical SMILES
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
2.1.5 Isomeric SMILES
CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=C/C(=O)O)\C(=O)O
2.2 Other Identifiers
2.2.1 UNII
U057CX04H0
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Bisoprolol

2. Bisoprolol Fumarate (1:1) Salt, (+-)-isomer

3. Bisoprolol Fumarate (2:1) Salt, (+-)-isomer

4. Bisoprolol Hydrochloride

5. Bisoprolol Methanesulfonate Salt

6. Bisoprolol, (+-)-isomer

7. Bisoprolol, (-)-isomer

8. Bisoprolol, Fumarate (1:1) Salt

9. Bisoprolol, Fumarate (2:1) Salt

10. Cl 297939

11. Cl-297939

12. Cl297939

13. Concor

14. Emd 33512

15. Emd-33512

16. Emd33512

17. Fumarate, Bisoprolol

18. Hydrochloride, Bisoprolol

2.3.2 Depositor-Supplied Synonyms

1. 104344-23-2

2. Zebeta

3. Bisoprolol Hemifumarate

4. Bisoprolol Monofumarate

5. Fondril

6. Maintate

7. Concor

8. 105878-43-1

9. Bisoprolol (fumarate)

10. Bisoprolol Hemifumarate Salt

11. U057cx04h0

12. Emd33512

13. Ta-4708

14. Cl-297939

15. 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol,(2e)-2-monobutenedioate

16. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (2e)-2-butenedioate (1:1)

17. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (2e)-2-butenedioate (1:1) (salt)

18. 2-propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (e)-2-butenedioate (1:1) (salt)

19. Smr000471619

20. Emd-33512

21. Bisocard

22. Cardicor

23. Congescor

24. Sr-01000597980

25. Bisoprololfumarate

26. Concor Cor

27. 66722-45-0

28. Bisoprolol Fumarate (1:x)

29. Schembl41419

30. Mls001076669

31. Mls001401436

32. Unii-u057cx04h0

33. Chembl1200708

34. Bcpp000331

35. Hms1569a21

36. Hms2051i16

37. Hms2094o19

38. Hms2233f12

39. Hms3884o05

40. Pharmakon1600-01505704

41. Nsc759181

42. S1206

43. Akos005267174

44. Ac-5016

45. Bcp9000419

46. Ccg-100883

47. Ccg-213520

48. Nc00133

49. Nsc-759181

50. Hy-120829

51. B3994

52. Cs-0079270

53. Sw197151-3

54. 104b232

55. Q-200729

56. Sr-01000597980-4

57. Q27290514

58. 1-(4-((2-isopropoxyethoxy)methyl)phenoxy)-3-(isopropylamino)propan-2-ol Hemi-fumarate

59. 1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol Fumaric Acid Salt

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 441.5 g/mol
Molecular Formula C22H35NO8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count14
Exact Mass441.23626707 g/mol
Monoisotopic Mass441.23626707 g/mol
Topological Polar Surface Area135 Ų
Heavy Atom Count31
Formal Charge0
Complexity397
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameBisoprolol fumarate
Drug LabelBisoprolol fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate...
Active IngredientBisoprolol fumarate
Dosage FormTablet
RouteOral
Strength5mg; 10mg
Market StatusPrescription
CompanyTeva Pharms; Unichem Pharms (usa); Aurobindo Pharma; Sandoz; Mylan

2 of 4  
Drug NameZebeta
PubMed HealthBisoprolol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelZEBETA (bisoprolol fumarate) is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-but...
Active IngredientBisoprolol fumarate
Dosage FormTablet
RouteOral
Strength5mg; 10mg
Market StatusPrescription
CompanyTeva Womens

3 of 4  
Drug NameBisoprolol fumarate
Drug LabelBisoprolol fumarate is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-butenedioate...
Active IngredientBisoprolol fumarate
Dosage FormTablet
RouteOral
Strength5mg; 10mg
Market StatusPrescription
CompanyTeva Pharms; Unichem Pharms (usa); Aurobindo Pharma; Sandoz; Mylan

4 of 4  
Drug NameZebeta
PubMed HealthBisoprolol (By mouth)
Drug ClassesAntianginal, Antihypertensive, Cardiovascular Agent
Drug LabelZEBETA (bisoprolol fumarate) is a synthetic, beta1-selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is ()-1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(E)-2-but...
Active IngredientBisoprolol fumarate
Dosage FormTablet
RouteOral
Strength5mg; 10mg
Market StatusPrescription
CompanyTeva Womens

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS. (See all compounds classified as Adrenergic beta-1 Receptor Antagonists.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]

API Reference Price

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Cesar Martinell i Brunet, 12A 08191 RUBI BARCELONA SDNF Spain","customerAddress":"2ND FLOOR, CHINUBHAI CENTRE,"}]
12-Jan-2021
30-Nov-2024
KGS
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Average Price (USD/KGS)

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Quantity (KGS) & Unit rate (USD/KGS) over time

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DOSAGE - TABLET;ORAL - 10MG **Federal Registe...DOSAGE - TABLET;ORAL - 10MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19982

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DOSAGE - TABLET;ORAL - 5MG **Federal Register...DOSAGE - TABLET;ORAL - 5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 19982

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