Find Boldine manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

FDF Dossiers

FDF Dossiers

0

FDA Orange Book

FDA (Orange Book)

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 476-70-0, Uniboldina, Boldin, (s)-boldine, Boldine chloroform, 1,10-dimethoxy-2,9-dihydroxyaporphine
Molecular Formula
C19H21NO4
Molecular Weight
327.4  g/mol
InChI Key
LZJRNLRASBVRRX-ZDUSSCGKSA-N
FDA UNII
8I91GE2769

Boldine
(9S)-4,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0,.0,]heptadeca-1(16),2(7),3,5,13(17),14-hexaene-5,15-diol is a natural product found in Lindera umbellata, Damburneya salicifolia, and other organisms with data available.
1 2D Structure

Boldine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
2.1.2 InChI
InChI=1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1
2.1.3 InChI Key
LZJRNLRASBVRRX-ZDUSSCGKSA-N
2.1.4 Canonical SMILES
CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O
2.1.5 Isomeric SMILES
CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)O)OC)O
2.2 Other Identifiers
2.2.1 UNII
8I91GE2769
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 476-70-0

2. Uniboldina

3. Boldin

4. (s)-boldine

5. Boldine Chloroform

6. 1,10-dimethoxy-2,9-dihydroxyaporphine

7. (+)-boldine

8. Nsc 65689

9. 2,9-dihydroxy-1,10-dimethoxyaporphine

10. (s)-(+)-boldine

11. 1,10-dimethoxy-6a-alpha-aporphine-2,9-diol

12. (6as)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-2,9-diol

13. Chebi:3148

14. Chembl388342

15. 4h-dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6as)-

16. 8i91ge2769

17. (s)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-2,9-diol

18. 4h-dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6as)-

19. 4h-dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (s)-

20. (+)-(s)-boldine

21. Einecs 207-509-9

22. Brn 0094036

23. Nsc-65689

24. Ex Peumus Boldus

25. Unii-8i91ge2769

26. Aprophine Alkaloid

27. 4h-dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (s)-

28. Prestwick_46

29. Boldine [mi]

30. Prestwick3_000600

31. Boldine [who-dd]

32. 6aalpha-aporphine-2,9-diol, 1,10-dimethoxy-

33. Boldine, Analytical Standard

34. Bspbio_000480

35. 5-21-06-00118 (beilstein Handbook Reference)

36. Cid_10154

37. Mls002153899

38. Schembl177550

39. Boldine [ep Monograph]

40. 6a-alpha-aporphine-2,9-diol, 1,10-dimethoxy-

41. Bpbio1_000528

42. Cid_248507

43. Dtxsid40883394

44. 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-4h-dibenzo[de,g]quinoline-2,9-diol

45. Hms2096h22

46. Hms2235b04

47. Zinc135449

48. Hy-n6973

49. Tnp00245

50. Bdbm50202318

51. Mfcd00135040

52. S9050

53. Zb1855

54. Boldine, Analytical Reference Material

55. 2,6-dihydroxy-3,5-dimethoxyaporphine

56. Akos015912953

57. Ccg-208461

58. Ncgc00016454-01

59. Ncgc00016454-02

60. Ncgc00017314-01

61. Ncgc00179547-01

62. Ac-34043

63. As-17759

64. Cas-476-70-0

65. Smr001233248

66. Cs-0013445

67. C09365

68. 1,10-dimethoxy-6a-.alpha.-aporphine-2,9-diol

69. 476b700

70. 6a.alpha.-aporphine-2,9-diol, 1,10-dimethoxy-

71. A872092

72. Q2070105

73. 1,10-dimethoxy-6a.alpha.-aporphine-2,9-diol

74. Brd-k03440695-001-02-6

75. Boldine, European Pharmacopoeia (ep) Reference Standard

76. 1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-2,9-diol, (s)-

77. (6as)-5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-4h-dibenzo(de,g)quinoline-2,9-diol

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 327.4 g/mol
Molecular Formula C19H21NO4
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass327.14705815 g/mol
Monoisotopic Mass327.14705815 g/mol
Topological Polar Surface Area62.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity461
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)


Neuromuscular Depolarizing Agents

Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation. (See all compounds classified as Neuromuscular Depolarizing Agents.)


ABOUT THIS PAGE

Looking for 476-70-0 / Boldine API manufacturers, exporters & distributors?

Boldine manufacturers, exporters & distributors 1

41

PharmaCompass offers a list of Boldine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Boldine manufacturer or Boldine supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Boldine manufacturer or Boldine supplier.

PharmaCompass also assists you with knowing the Boldine API Price utilized in the formulation of products. Boldine API Price is not always fixed or binding as the Boldine Price is obtained through a variety of data sources. The Boldine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Boldine

Synonyms

476-70-0, Uniboldina, Boldin, (s)-boldine, Boldine chloroform, 1,10-dimethoxy-2,9-dihydroxyaporphine

Cas Number

476-70-0

Unique Ingredient Identifier (UNII)

8I91GE2769

About Boldine

(9S)-4,16-dimethoxy-10-methyl-10-azatetracyclo[7.7.1.0,.0,]heptadeca-1(16),2(7),3,5,13(17),14-hexaene-5,15-diol is a natural product found in Lindera umbellata, Damburneya salicifolia, and other organisms with data available.

Boldine Manufacturers

A Boldine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Boldine, including repackagers and relabelers. The FDA regulates Boldine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Boldine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Boldine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Boldine Suppliers

A Boldine supplier is an individual or a company that provides Boldine active pharmaceutical ingredient (API) or Boldine finished formulations upon request. The Boldine suppliers may include Boldine API manufacturers, exporters, distributors and traders.

click here to find a list of Boldine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Boldine GMP

Boldine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Boldine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Boldine GMP manufacturer or Boldine GMP API supplier for your needs.

Boldine CoA

A Boldine CoA (Certificate of Analysis) is a formal document that attests to Boldine's compliance with Boldine specifications and serves as a tool for batch-level quality control.

Boldine CoA mostly includes findings from lab analyses of a specific batch. For each Boldine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Boldine may be tested according to a variety of international standards, such as European Pharmacopoeia (Boldine EP), Boldine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Boldine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty