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1. 1-(tert-butylamino)-3-((2-methylindo)-4-yl)-2-propanol Benzoate
2. Bopindolol, (+-)-isomer
3. Lt 31-200
1. 62658-63-3
2. Rac Bopindolol
3. Bopindolol [inn]
4. Sandonorm
5. 1-(tert-butylamino)-3-((2-methyl-1h-indol-4-yl)oxy)propan-2-yl Benzoate
6. (+/-)-bopindolol
7. [1-(tert-butylamino)-3-[(2-methyl-1h-indol-4-yl)oxy]propan-2-yl] Benzoate
8. Kt304vzo57
9. Bopindolol (inn)
10. 2-propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1h-indol-4-yl)oxy]-, Benzoate (ester)
11. Ncgc00163155-01
12. Sandonorm (tn)
13. Dsstox_cid_2684
14. 1-(tert-butylamino)-3-[(2-methyl-1h-indol-4-yl)oxy]propan-2-yl Benzoate
15. Dsstox_rid_76690
16. Dsstox_gsid_22684
17. (+-)-bopindolol
18. Bopindololum
19. Bopindololum [inn-latin]
20. Cas-62658-63-3
21. Unii-kt304vzo57
22. Rac Bopindolol-[d9]
23. Bopindolol [mi]
24. (+-)-4-(2-benzoyloxy-3-tert-butylaminopropoxy)-2-methylindole
25. (+-)-1-(tert-butylamino)-3-((2-methylindol-4-yl)oxy)-2-propanol Benzoate (ester)
26. Bopindolol [who-dd]
27. Schembl49500
28. (+-)-1-((1,1-dimethylethyl)amino)-3-((2-methyl-1h-indol-4-yl)oxy)-2-propanol Benzoate (ester)
29. 2-propanol, 1-((1,1-dimethylethyl)amino)-3-((2-methyl-1h-indol-4-yl)oxy)-, Benzoate (ester), (+-)-
30. 69010-88-4
31. Mls003882860
32. Bopindolol, Bopindolol Maleate
33. Chembl357995
34. Dtxsid6022684
35. Chebi:143782
36. Hms2089o20
37. Hy-b1562
38. Tox21 112017
39. Tox21_112017
40. Akos016014321
41. Tox21_112017_1
42. Db08807
43. Ncgc00163155-02
44. Ncgc00263654-01
45. Lt-31200
46. Smr001550598
47. Cs-0013446
48. Ft-0663594
49. D07537
50. Ab01275452-01
51. A922919
52. L013383
53. Q834660
54. Sr-05000001453
55. Sr-05000001453-1
56. 4-(2-benzoyloxy-3-t-butylamino-propoxy) -2-methyl Indole
57. 4-(2-benzoyloxy-3-tert.butylaminopropoxy)-2-methyl-indole
58. 1-(tert-butylamino)-3-(2-methyl-1h-indol-4-yloxy)propan-2-yl Benzoate
59. 2-(tert-butylamino)-1-{[(2-methyl-1h-indol-4-yl)oxy]methyl}ethyl Benzoate
60. (+/-)-1-(tert-butylamino)-3-((2-methylindol-4-yl)oxy)-2-propanol Benzoate (ester)
61. 2-[(1,1-dimethylethyl)amino]-1-{[(2-methyl-1h-indol-4-yl)oxy]methyl}ethyl Benzoate
62. 1-((1,1-dimethylethyl)amino)-3-((2-methyl-1h-indol-4-yl)oxy)-2-propanol Benzoate Ester
| Molecular Weight | 380.5 g/mol |
|---|---|
| Molecular Formula | C23H28N2O3 |
| XLogP3 | 4.7 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 9 |
| Exact Mass | 380.20999276 g/mol |
| Monoisotopic Mass | 380.20999276 g/mol |
| Topological Polar Surface Area | 63.4 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 499 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
Bopindolol is a prodrug of pindolol. Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
Adrenergic beta-Antagonists
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)
C - Cardiovascular system
C07 - Beta blocking agents
C07A - Beta blocking agents
C07AA - Beta blocking agents, non-selective
C07AA17 - Bopindolol
Bopindolol (as pindolol) non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
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A Bopindolol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bopindolol, including repackagers and relabelers. The FDA regulates Bopindolol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bopindolol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Bopindolol supplier is an individual or a company that provides Bopindolol active pharmaceutical ingredient (API) or Bopindolol finished formulations upon request. The Bopindolol suppliers may include Bopindolol API manufacturers, exporters, distributors and traders.
click here to find a list of Bopindolol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A Bopindolol DMF (Drug Master File) is a document detailing the whole manufacturing process of Bopindolol active pharmaceutical ingredient (API) in detail. Different forms of Bopindolol DMFs exist exist since differing nations have different regulations, such as Bopindolol USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A Bopindolol DMF submitted to regulatory agencies in the US is known as a USDMF. Bopindolol USDMF includes data on Bopindolol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Bopindolol USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of Bopindolol suppliers with USDMF on PharmaCompass.
Bopindolol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Bopindolol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bopindolol GMP manufacturer or Bopindolol GMP API supplier for your needs.
A Bopindolol CoA (Certificate of Analysis) is a formal document that attests to Bopindolol's compliance with Bopindolol specifications and serves as a tool for batch-level quality control.
Bopindolol CoA mostly includes findings from lab analyses of a specific batch. For each Bopindolol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Bopindolol may be tested according to a variety of international standards, such as European Pharmacopoeia (Bopindolol EP), Bopindolol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bopindolol USP).
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