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    Chemistry

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    Also known as: 1330-43-4, Borax anhydrous, Borax glass, Borax, fused, Boric acid (h2b4o7), sodium salt, Boron sodium oxide (b4na2o7)
    Molecular Formula
    B4Na2O7
    Molecular Weight
    201.2  g/mol
    InChI Key
    UQGFMSUEHSUPRD-UHFFFAOYSA-N
    FDA UNII
    8191EN8ZMD
    Borax Solution
    1 2D Structure

    Borax Solution

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane
    2.1.2 InChI
    InChI=1S/B4O7.2Na/c5-1-7-3-9-2(6)10-4(8-1)11-3;;/q-2;2*+1
    2.1.3 InChI Key
    UQGFMSUEHSUPRD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    B1(OB2OB(OB(O1)O2)[O-])[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    8191EN8ZMD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Disodium Borate, Heptahydrate

    2. Disodium Borate, Monohydrate

    3. Komex

    4. Monosodium Metaborate

    5. Sodium Borate

    6. Sodium Borate (nabo2)

    7. Sodium Diborate

    8. Sodium Meta Borate

    9. Sodium Metaborate

    2.3.2 Depositor-Supplied Synonyms

    1. 1330-43-4

    2. Borax Anhydrous

    3. Borax Glass

    4. Borax, Fused

    5. Boric Acid (h2b4o7), Sodium Salt

    6. Boron Sodium Oxide (b4na2o7)

    7. Na2b4o7

    8. Sodium Tetraborate, Anhydrous

    9. Sodiumtetraborate

    10. Sodium Borate Anhydrous

    11. Anhydrous Borax

    12. Sodium Biborate

    13. Fused Borax

    14. Sodium Pyroborate

    15. Sodium Borate, Anhydrous

    16. 8191en8zmd

    17. Sodium Tetraborate (na2b4o7)

    18. Mfcd00081185

    19. Boric Acid (h2b4o7), Disodium Salt

    20. Disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane

    21. 12267-73-1

    22. Disodium;[oxido(oxoboranyloxy)boranyl]oxy-oxoboranyloxyborinate

    23. Mfcd00163147

    24. Komex

    25. Borax, Anhydrous

    26. Borax, Dehydrated

    27. Sodium Boron Oxide

    28. Rasorite 65

    29. Fused Sodium Borate

    30. Boric Acid, Disodium Salt

    31. Sodium Borate [mi]

    32. Unii-8191en8zmd

    33. Borate-buffered Saline (5x)

    34. Sodium Borate [who-dd]

    35. Hsdb 5025

    36. Sodium Tetraborate [hsdb]

    37. Dtxsid101014358

    38. Fr 28

    39. Sodium Tetraborate [vandf]

    40. Einecs 215-540-4

    41. Mfcd07784974

    42. Borates, Tetrasodium Salts, Anhydrous

    43. Akos015903865

    44. Akos030228253

    45. Db14505

    46. Borates, Tetra, Sodium Salts, Anhydrous

    47. Borate, 0.5m Buffer Solution, Ph 8.0

    48. Borate, 0.5m Buffer Solution, Ph 8.5

    49. Borate, 0.5m Buffer Solution, Ph 9.0

    50. Borate, 0.5m Buffer Solution, Ph 9.5

    51. Sodium Tetraborate, Anhydrous, Puratronic

    52. Ft-0696539

    53. Sodium Borate, 0.5m Buffer Solution, Ph 8.0

    54. Sodium Borate, 0.5m Buffer Solution, Ph 8.5

    55. Sodium Borate, 0.5m Buffer Solution, Ph 9.0

    56. Sodium Tetraborate,trace Metals Grade 99.95%

    57. J-006292

    58. Disodium Bicyclo[3.3.1]tetraboroxane-3,7-bis(olate)

    59. 1310383-93-7

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 201.2 g/mol
    Molecular Formula B4Na2O7
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count0
    Exact Mass201.9811616 g/mol
    Monoisotopic Mass201.9811616 g/mol
    Topological Polar Surface Area92.3 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity121
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MEDICATION (VET): Has been used as antiseptic, detergent, astringent for mucous membrane

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. 13th Edition, Whitehouse Station, NJ: Merck and Co., Inc., 2001., p. 1537

    MEDICATION (VET): Has been used as an exptl growth promoter in poultry feeds.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 50

    /Exptl Ther:/ The in vivo spermicidal action of a pharmacological association consisting of 0.080 g of sodium tetraborate decahydrate, 0.075 g lactic acid, 0.020 g 8-hydroxyquinoline sulphate, 0.005 g sodiopropionate, and hydrosoluble excipient 1820 g polyethylene glycol in the form of vaginal containers, has been investigated. The study is part of a more general investigation of alternative systems to the use of estro-progestins. The experimental scheme applied in the present study provided for the use of this association in 28 volunteer couples who were definitely fertile and during the pre- and postovulatory periods. A normal postcoital test was carried out on each, with samples taken from the posterior fornix and cervical canal using a speculum. The results showed that the preparation possesses profound spermicidal activity and is therefore considered a useful alternative to oral contraceptives. /Sodium tetraborate decahydrate/

    PMID:6787483 Oriz C et al; Minerva Ginecol 33 (1): 113-6 (1981)

    4.2 Drug Indication

    No FDA- or EMA-approved therapeutic indications on its own.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Boric acid exhibits minimal bacteriostatic and antifungal activities. Boric acid is likely to mediate antifungal actions at high concentrations over prolonged exposures.

    5.2 Absorption, Distribution and Excretion

    Absorption

    Boric acid is well absorbed from the gastrointestinal tract, open wounds, and serous cavities but displays limited absorption in intact skin. Following intraperitoneal injection in mice, the peak concentration was reached in about 1.0-1.5 hr in the brain whereas the value was 0.5 hr in other tissues.

    Route of Elimination

    Regardless the route of administration, boric acid predominantly undergoes rapid renal excretion of >90% of total administered dose as unchanged form. Small amounts are also excreted into sweat, saliva, and feces. Following administration as ointment, urinary excretion of boric acid accounted for only 1% of the administered dose.

    Volume of Distribution

    Volume of distribution ranges from 0.17 to 0.5 L/kg in humans, where large amounts of boric acid are localized in brain, liver, and kidney.

    Clearance

    A case report of acute boric acid poisoning following oral ingestion of 21 g of boric acid presents the total body clearance of 0.99 L/h before hemodialysis.

    The pharmacokinetics of boron was studied in rats by administering a 1 mL oral dose of sodium tetraborate solution to several groups of rats (n=20) at eleven different dose levels ranging from 0-0.4 mg/100 g bw as boron. Twenty-four-hour urine samples were collected after boron administration. After 24 hr the average urinary recovery rate for this element was 99.6-7.9. The relationship between boron dose and excretion was linear (r=0.999) with a regression coefficient of 0.954. This result suggests that the oral bioavailability (F) of boron was complete. Another group of rats (n=10) was given a single oral /intubation/ of 2 mL of sodium tetraborate solution containing 0.4 mg of boron/100 g bw. The serum decay of boron was followed and found to be monophasic. The data were interpreted according to a one-compartment open model. The appropriate pharmacokinetic parameters were estimated as follows: absorption half-life, t1/2a=0.608-0.432 hr; elimination half-life, t1/2=4.64-1.19 hr; volume of distribution, Vd=142.0-30.2 mL/100 g bw.; total clearance, Ctot=0.359 - 0.0285 mL/min/100 g bw. The maximum boron concentration in serum after administration (Cmax) was 2.13-0.270 mg/L, and the time needed to reach this maximum concentration (Tmax) was 1.76-0.887 hr. ...Results suggest that orally administered boric acid is rapidly and completely absorbed from the gastrointestinal tract into the blood stream. Boric acid in the intravascular space does not have a strong affinity to serum proteins, and rapidly diffuses to the extravascular space in proportion to blood flow without massive accumulation or binding in tissues. The main route of boron excretion from the body is via glomerular filtration. It may be inferred that there is partial tubular resorption at low plasma levels.

    PMID:9765061 Usuda K et al; Arch Toxicol 72 (8): 468-74 (1998)

    /Ten/ rats (n=10) were given a single oral injection of 2 mL of sodium tetraborate solution containing 0.4 mg of boron/100 g bw. The serum decay of boron was followed and found to be monophasic. The data were interpreted according to a one-compartment open model. The appropriate pharmacokinetic parameters were estimated as follows: absorption half-life, t1/2a=0.608-0.432 hr; elimination half-life, t1/2=4.64-1.19 hr; volume of distribution, Vd=142.0-30.2 mL/100 g bw.; total clearance, Ctot=0.359 - 0.0285 mL/min/100 g bw. The maximum boron concentration in serum after administration (Cmax) was 2.13-0.270 mg/L, and the time needed to reach this maximum concentration (Tmax) was 1.76-0.887 hr. ...Results suggest that orally administered boric acid is rapidly and completely absorbed from the gastrointestinal tract into the blood stream. Boric acid in the intravascular space does not have a strong affinity to serum proteins, and rapidly diffuses to the extravascular space in proportion to blood flow without massive accumulation or binding in tissues. The main route of boron excretion from the body is via glomerular filtration. It may be inferred that there is partial tubular resorption at low plasma levels.

    PMID:9765061 Usuda K et al; Arch Toxicol 72 (8): 468-74 (1998)

    Excretion occurs primarily in the urine.

    Sheftel, V.O.; Indirect Food Additives and Polymers. Migration and Toxicology. Lewis Publishers, Boca Raton, FL. 2000., p. 852

    5.3 Metabolism/Metabolites

    No metabolic pathways reported.

    5.4 Biological Half-Life

    According to human cases of poisoning, the elimination half-life of boric acid ranges from 13 to 24 hours.

    5.5 Mechanism of Action

    Information regarding the mechanism of action of boric acid in mediating its antibacterial or antifungal actions is limited. Boric acid inhibits biofilm formation and hyphal transformation of _Candida albicans_, which are critical virulence factors. In addition, arrest of fungal growth was observed with the treatment of boric acid.

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    ABOUT THIS PAGE

    Borax Solution Manufacturers

    A Borax Solution manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Borax Solution, including repackagers and relabelers. The FDA regulates Borax Solution manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Borax Solution API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Borax Solution Suppliers

    A Borax Solution supplier is an individual or a company that provides Borax Solution active pharmaceutical ingredient (API) or Borax Solution finished formulations upon request. The Borax Solution suppliers may include Borax Solution API manufacturers, exporters, distributors and traders.

    click here to find a list of Borax Solution suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Borax Solution JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Borax Solution Drug Master File in Japan (Borax Solution JDMF) empowers Borax Solution API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Borax Solution JDMF during the approval evaluation for pharmaceutical products. At the time of Borax Solution JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

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    Borax Solution CEP

    A Borax Solution CEP of the European Pharmacopoeia monograph is often referred to as a Borax Solution Certificate of Suitability (COS). The purpose of a Borax Solution CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Borax Solution EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Borax Solution to their clients by showing that a Borax Solution CEP has been issued for it. The manufacturer submits a Borax Solution CEP (COS) as part of the market authorization procedure, and it takes on the role of a Borax Solution CEP holder for the record. Additionally, the data presented in the Borax Solution CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Borax Solution DMF.

    A Borax Solution CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Borax Solution CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

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    Borax Solution GMP

    Borax Solution Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Borax Solution GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Borax Solution GMP manufacturer or Borax Solution GMP API supplier for your needs.

    Borax Solution CoA

    A Borax Solution CoA (Certificate of Analysis) is a formal document that attests to Borax Solution's compliance with Borax Solution specifications and serves as a tool for batch-level quality control.

    Borax Solution CoA mostly includes findings from lab analyses of a specific batch. For each Borax Solution CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Borax Solution may be tested according to a variety of international standards, such as European Pharmacopoeia (Borax Solution EP), Borax Solution JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Borax Solution USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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