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15 FDF Dossiers, 4 Europe, 2 Canada, 3 South Africa, 6 Listed Dossiers

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1 SPI Pharma
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8 Parenteral
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7 Solubilizers
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5 Taste Masking
4 Granulation
4 Surfactant & Foaming Agents
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Synopsis

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Chemistry

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Also known as: Orthoboric acid, 10043-35-3, Boracic acid, Borofax, Boron hydroxide, Boron trihydroxide

Molecular Formula

BH₃O₃

Molecular Weight

61.84 g/mol

InChI Key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

FDA UNII

R57ZHV85D4

Boric Acid is a weakly acidic hydrate of boric oxide with mild antiseptic, antifungal, and antiviral properties. The exact mechanism of action of boric acid is unknown; generally cytotoxic to all cells. It is used in the treatment of yeast infections and cold sores.

1 2D Structure

Boric Acid

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

boric acid

2.1.2 InChI

InChI=1S/BH3O3/c2-1(3)4/h2-4H

2.1.3 InChI Key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

2.1.4 Canonical SMILES

B(O)(O)O

2.2 Other Identifiers

2.2.1 UNII

R57ZHV85D4

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Boron Oxide Hydroxide

2. Orthoboric Acid

2.3.2 Depositor-Supplied Synonyms

1. Orthoboric Acid

2. 10043-35-3

3. Boracic Acid

4. Borofax

5. Boron Hydroxide

6. Boron Trihydroxide

7. Three Elephant

8. Boric Acid (bh3o3)

9. Basilit B

10. Trihydroxyborane

11. Trihydroxyborone

12. 11113-50-1

13. Boric Acid (h3bo3)

14. Flea Prufe

15. Super Flea Eliminator

16. Orthoboric Acid (b(oh)3)

17. Orthoborsaeure

18. Borsaeure

19. Borsaure

20. Acidum Boricum

21. Nci-c56417

22. Dr.'s 1 Flea Terminator Dt

23. Boric Acid (van)

24. Bluboro

25. Dr.'s 1 Flea Terminator Dfpbo

26. Dr.'s 1 Flea Terminator Df

27. Collyrium Eye Wash

28. Dr.'s 1 Flea Terminator Dtpbo

29. B(oh)3

30. Boricum Acidum

31. Trihydroxidoboron

32. Ant Flip

33. Homberg's Salt

34. Mfcd00011337

35. Nsc 81726

36. Boric Acid (tn)

37. (10b)orthoboric Acid

38. Nsc-81726

39. Ins No.284

40. R57zhv85d4

41. Chebi:33118

42. Ins-284

43. [b(oh)3]

44. Boric Acid (h(sub 3)bo(sub 3))

45. Ncgc00090745-02

46. Optibor

47. Dsstox_cid_194

48. Orthboric Acid

49. E-284

50. Kjel-sorb™ Solution

51. Dsstox_rid_75425

52. Dsstox_gsid_20194

53. Borsaure [german]

54. Caswell No. 109

55. Boron, Reference Standard Solution

56. Kjel-sorb

57. Kill-off

58. Ortho-boric Acid

59. Boric Acid [usan:jan]

60. Hydrogen Orthoborate

61. Bo3

62. Ccris 855

63. Niban Granular Bait

64. Cas-10043-35-3

65. Hsdb 1432

66. Boric Acid [jan:nf]

67. Boric Acid, Acs

68. Einecs 233-139-2

69. Epa Pesticide Chemical Code 011001

70. Orthoboric Acid (h3bo3)

71. Unii-r57zhv85d4

72. Orthoborc Acd

73. Ai3-02406

74. Boric Acid, Powder

75. Bluboro (salt/mix)

76. Boric Acid, Granular

77. Boric Acid Acs Grade

78. Boric Acid, Puratronic?

79. Wln: Qbqq

80. Boric Acid [ii]

81. Boric Acid [mi]

82. Boric Acid, Acs Reagent

83. Boric Acid [jan]

84. Heptaoxotetra-borate(2-)

85. Bmse000941

86. Boric Acid (jp15/nf)

87. Boric Acid (jp17/nf)

88. Boric Acid [inci]

89. Acidum Boricum (salt/mix)

90. Ec 233-139-2

91. Boric Acid [vandf]

92. Boric Acid, Nf/usp Grade

93. H3bo3

94. Boric Acid [mart.]

95. Boric Acid [usp-rs]

96. Boric Acid [who-dd]

97. Boric Acid, Biochemical Grade

98. Bidd:er0252

99. Boracic Acid, Orthoboric Acid

100. Boricum Acidum [hpus]

101. Chembl42403

102. Boric Acid Electrophoresis Grade

103. Collyrium Eye Wash (salt/mix)

104. Dtxsid1020194

105. Bdbm39817

106. Kgbxlfkzbhkpev-uhfffaoysa-

107. Boric Acid [ep Impurity]

108. Boric Acid [ep Monograph]

109. Boric Acid, 99.9% Metals Basis

110. Bcp21018

111. Boric Acid, 99.99% Metals Basis

112. Boric Acid, Bioxtra, >=99.5%

113. Nsc81726

114. Einecs 237-478-7

115. Tox21_111004

116. Tox21_202185

117. Tox21_301000

118. 1332-77-0 (di-potassium Salt)

119. Bc-140

120. Stl445672

121. Boric Acid, 99.998% Metals Basis

122. Akos015833571

123. Zinc245189278

124. Boric Acid, Acs Reagent, >=99.5%

125. Db11326

126. 11113-50-1;boric Acid;boracic Acid

127. Boric Acid, 99.97% Trace Metals Basis

128. Boric Acid, Usp, 99.5-100.5%

129. Ncgc00090745-01

130. Ncgc00090745-03

131. Ncgc00090745-04

132. Ncgc00090745-05

133. Ncgc00254902-01

134. Ncgc00259734-01

135. Boric Acid, Crude Natural, Containing Not More Than 85 Per Cent Ofh3bo3 Calculated On The Dry Weight

136. Boric Acid, Reagentplus(r), >=99.5%

137. Bp-13473

138. Boric Acid, 99.999% Trace Metals Basis

139. Boric Acid, Saj First Grade, >=99.5%

140. Boric Acid, For Electrophoresis, >=99.5%

141. Boric Acid, Jis Special Grade, >=99.5%

142. B7305

143. Boric Acid, Vetec(tm) Reagent Grade, 98%

144. Ft-0623166

145. Ft-0623167

146. Boric Acid, Tablet, 1 G Boric Acid Per Tablet

147. D01089

148. A800201

149. Q187045

150. J-000132

151. J-523836

152. Boric Acid, >=99.5%, Suitable For Amino Acid Analysis

153. Boric Acid, Nist(r) Srm(r) 951a, Isotopic Standard

154. Boric Acid, Nist(r) Srm(r) 973, Acidimetric Standard

155. Boric Acid, Bioultra, For Molecular Biology, >=99.5% (t)

156. Boric Acid, United States Pharmacopeia (usp) Reference Standard

157. Boric Acid, Cell Culture Tested, Plant Cell Culture Tested, >=99.5%

158. Boric Acid, Biotechnology Performance Certified, >=99.5% (titration), Cell Culture Tested

159. Boric Acid, P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., 99.5-100.5%

160. Boron Standard Solution, 1 Mg/ml B, Suitable For Atomic Absorption Spectrometry, 1000 Ppm B

161. Buffer Solution, Ph 11.00 (?0.01 At 25?c), No Color, Specpure?, Nist Traceable

162. Boric Acid, Bioreagent, For Molecular Biology, Suitable For Cell Culture, Suitable For Plant Cell Culture, >=99.5%

163. Boric Acid, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., Buffer Substance, >=99.8%

164. Boric Acid, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Nf, 99.5-100.5%, Powder

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	BH₃O₃
Molecular Weight	61.84 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Exact Mass	62.0175241 g/mol
Monoisotopic Mass	62.0175241 g/mol
Topological Polar Surface Area	60.7 Å²
Heavy Atom Count	4
Formal Charge	0
Complexity	8
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

/Former use:/ The substance is included in rectal suppositories for hemorrhoids ...

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 971

Aqueous solutions of boric acid are used topically for ophthalmic irrigation to cleanse, refresh, and soothe irritated eyes. Aqueous solutions of boric acid also are used for removal of loose foreign material, air pollutants (e.g., smog, pollen), or chlorinated water.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011

Boric acid, borates and perborates have been used as mild antiseptics or bacteriostats in eyewashes, mouthwashes, burn dressings, and diaper rash powders; however, the effectiveness of boric acid has largely been discredited.

Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 131

MEDICATION (VET): Antibacterial and antifungal. Used chiefly in aqueous solutions or powders for external use.

O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 218

A double-blind comparison was made of the use of 14 daily intravaginal gelatin capsules containing 600 mg of boric acid powder versus the use of identical capsules containing 100,000 U nystatin diluted to volume with cornstarch for the treatment of vulvovaginal candidiasis albicans. Cure rates for boric acid were 92% at 7 to 10 days after treatment and 72% at 30 days, whereas the nystatin cure rates were 64% at 7 to 10 days and 50% at 30 days. The speed of alleviation of signs and symptoms was similar for the two drugs. There were no untoward side effects, and cervical cytologic features were not affected.

PMID:7282789 Van Slyke KK et al; Am J Obstet Gynecol 141 (2): 145-8 (1981)

4.2 Drug Warning

... The chronic use of boric acid in rectal suppositories and in vaginal deodorants carries the risk of intoxication.

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 971

Borax and boric acid used in powders and ointments have resulted in serious poisonings and death.

Seiler, H.G., H. Sigel and A. Sigel (eds.). Handbook on the Toxicity of Inorganic Compounds. New York, NY: Marcel Dekker, Inc. 1988., p. 135

An outbreak of an illness in a newborn nursery consisting of vomiting, diarrhea, dehydration, and exfoliative dermatitis was mistakenly thought to be due to an infectious agent because Staphylococcus aureus was cultured from the nose, throat, and feces in two patients. The clinical picture was similar to Ritter's disease. However, because S. aureus was not found in other hospital cultures, boric acid toxicity was subsequently considered. It was discovered as a contaminant of the infant formula. Three infants died.

Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1323

Boric acid enhanced action of hypnotics, but devoid of activity itself.

PMID:4440819 Pham Huu Chanh et al; Agressologie 15 (1): 61-72 (1974)

Patients using boric acid ophthalmic solutions should be advised to consult a physician if ocular pain or visual changes occur, they experience continued ocular redness or irritation, or the condition worsens or persists. Patients with open wounds in or near the eyes should be advised to seek immediate medical treatment.

American Society of Health-System Pharmacists 2011; Drug Information 2011. Bethesda, MD. 2011

4.3 Minimum/Potential Fatal Human Dose

The fatal dose /in humans/ is thought to be 2000-3000 mg for infants, 5000-6000 mg for children, and 15,000-20,000 mg for adults.

Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1414

4.4 Drug Indication

No FDA- or EMA-approved therapeutic indications on its own.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Boric acid exhibits minimal bacteriostatic and antifungal activities. Boric acid is likely to mediate antifungal actions at high concentrations over prolonged exposures.

5.2 MeSH Pharmacological Classification

Insecticides

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

5.3 ATC Code

S - Sensory organs

S02 - Otologicals

S02A - Antiinfectives

S02AA - Antiinfectives

S02AA03 - Boric acid

5.4 Absorption, Distribution and Excretion

Absorption

Boric acid is well absorbed from the gastrointestinal tract, open wounds, and serous cavities but displays limited absorption in intact skin. Following intraperitoneal injection in mice, the peak concentration was reached in about 1.0-1.5 hr in the brain whereas the value was 0.5 hr in other tissues.

Route of Elimination

Regardless the route of administration, boric acid predominantly undergoes rapid renal excretion of >90% of total administered dose as unchanged form. Small amounts are also excreted into sweat, saliva, and feces. Following administration as ointment, urinary excretion of boric acid accounted for only 1% of the administered dose.

Volume of Distribution

Volume of distribution ranges from 0.17 to 0.5 L/kg in humans, where large amounts of boric acid are localized in brain, liver, and kidney.

Clearance

A case report of acute boric acid poisoning following oral ingestion of 21 g of boric acid presents the total body clearance of 0.99 L/h before hemodialysis.

Boric acid is readily absorbed from GI tract, serous cavities, and abraded or inflamed skin. It does not penetrate intact skin. Approximately 50% of given dose is excreted within 24 hr. During chronic administration, plateau in urinary excretion is reached only after 2 wk. ... Large amounts of boric acid are localized in brain, liver, and kidney. ... Intracytoplasmic inclusions in pancreas /have been noted/ in fatal cases. /Boric acid/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 995

In animals, boric acid has been shown to be readily absorbed from the GI tract. Among the species studied were rats, rabbits, sheep, and cattle.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V3 p.535

... Boric acid (5%) was applied topically to 10-15% of the body surface of rabbits with an occlusive dressing for 1.5 hr per day for 4 consecutive days. Minimal amounts of boric acid were absorbed across intact skin and slightly abraded skin of rabbits as measured by excretion of B in urine. Absorption was greater in rabbits with more seriously damaged skin.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V3 p.535

In rats given boric acid in an ointment, urinary excretion accounted for only 1% of the administered dose. However, boric acid applied to the skin of rats in an aqueous jelly was absorbed, with 23% of the administered dose appearing in the urine.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V3 p.535

For more Absorption, Distribution and Excretion (Complete) data for BORIC ACID (24 total), please visit the HSDB record page.

5.5 Metabolism/Metabolites

No metabolic pathways reported.

Metabolism of inorganic borates by biological systems is not feasible owing to the excessive energy (523 kJ/mol) required to break the boron-oxygen bond. Inorganic borates, in low concentrations, convert to boric acid at physiological pH in the aqueous layer overlying mucosal surfaces prior to absorption. This is supported by the evidence in both human and animal studies, where more than 90% of the administered dose of borate is excreted as boric acid. There is evidence in both in vitro and in vivo systems that boric acid has an affinity for cis-hydroxyl groups, and this may be the mechanism that explains the biological effects of boric acid. However, this attachment is known to be reversible and concentration dependent, responding to clearance mechanisms.

WHO; Environmental Health Criteria 204: Boron p.62 (1998). Available from, as of May 12, 2005: https://www.inchem.org/pages/ehc.html

5.6 Biological Half-Life

According to human cases of poisoning, the elimination half-life of boric acid ranges from 13 to 24 hours.

The kinetics of elimination of boron have been evaluated in human volunteers given boric acid via the intravenous and oral routes. The half-life for elimination was the same by either route in these studies and was approximately 21 hr.

WHO; Environmental Health Criteria 204: Boron p.66 (1998). Available from, as of May 12, 2005: https://www.inchem.org/pages/ehc.html

A mean half-life of 13.4 hours (range, 4 to 28 hours) was reported in nine human cases of poisoning /with boric acid/.

Dart, R.C. (ed). Medical Toxicology. Third Edition, Lippincott Williams & Wilkins. Philadelphia, PA. 2004., p. 1322

In humans, the reported excretion half-life is between 13 and 21 hr.

Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1435

The elimination half-life reported for rats is 4.6 hr.

Krieger, R. (ed.). Handbook of Pesticide Toxicology. Volume 2, 2nd ed. 2001. Academic Press, San Diego, California., p. 1435

... Excretion is relatively rapid, occurring over a period of a few to several days, with a half-life of elimination of 24 hr or less.

WHO; Environmental Health Criteria 204: Boron p.66 (1998). Available from, as of May 12, 2005: https://www.inchem.org/pages/ehc.html

5.7 Mechanism of Action

Information regarding the mechanism of action of boric acid in mediating its antibacterial or antifungal actions is limited. Boric acid inhibits biofilm formation and hyphal transformation of _Candida albicans_, which are critical virulence factors. In addition, arrest of fungal growth was observed with the treatment of boric acid.

Boric acid and its derivatives have been shown to promote riboflavinuria in both animals and man. Boric acid complexes with the polyhydroxyl ribitol side chain of riboflavin and greatly increases its water solubility.

PMID:3319474 Pinto JT, Rivlin S; Drug Nutr Interact 5 (3): 143-51 (1987)

API SUPPLIERS

01

Merck Group

Germany

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Medlab Asia & Asia Health

Not Confirmed

02

S D Fine Chem Limited

India

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Medlab Asia & Asia Health

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Germany

Medlab Asia & Asia Health

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Sd Fine Chem Ltd

India

Medlab Asia & Asia Health

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U.S.A

Antibody Engineering

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02

Merck KGaA Darmstadt DE

Germany

Antibody Engineering

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JDMF

01

Toyama Pharmaceutical Co., Ltd.

Japan

Antibody Engineering

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02

Toyama Pharmaceutical Co., Ltd.

Japan

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API Reference Price

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OF BORIC ACID 1PCS X 250GMS (PHARMA GARDE)","address":"GODREJ ONE, 8TH FLR, PIROJSHANAGAR, EASTERN EXPRESS HIGHWAY VIKHROLI-E","city":"MUMBAI","supplier":"MERCK GROUP","supplierCountry":"GERMANY","foreign_port":"NA","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"0.25","actualQuantity":"0.25","unit":"KGS","unitRateFc":"8134.2","totalValueFC":"26.1","currency":"INR","unitRateINR":"8146.4","date":"11-Jun-2022","totalValueINR":"2036.61","totalValueInUsd":"26.1","indian_port":"BOMBAY AIR","hs_no":"29054300","bill_no":"9076262","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"GODREJ ONE, 8TH FLR, PIROJSHANAGAR, EASTERN EXPRESS HIGHWAY VIKHROLI-E"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676917800,"product":"400068-CONF TETRAFLUOROBORIC ACID-DIETHYL ETHER COMP [2550ML \/ 1000]","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2.55","actualQuantity":"2.55","unit":"LTR","unitRateFc":"13084.8","totalValueFC":"474.2","currency":"INR","unitRateINR":"15359","date":"21-Feb-2023","totalValueINR":"39165.48","totalValueInUsd":"474.2","indian_port":"BANGALORE AIR","hs_no":"29091990","bill_no":"4742406","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1678386600,"product":"400068-CONF TETRAFLUOROBORIC ACID-DIETHYL ETHER COMP [2550ML]","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"2.55","actualQuantity":"2.55","unit":"LTR","unitRateFc":"13084.8","totalValueFC":"549.2","currency":"INR","unitRateINR":"17713","date":"10-Mar-2023","totalValueINR":"45168.11","totalValueInUsd":"549.2","indian_port":"BANGALORE AIR","hs_no":"29091990","bill_no":"4990827","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1683570600,"product":"TETRAFLUOROBORIC ACID DIETHYL ETHER COM 400068 CONF MKCR7713 ORGANIC CHEMICALS 12700 ML","address":"12BOMMASANDRA JIGANI LINK ROADINDL AREAANEKAL TQ BANGALORE","city":"BENGALURU","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"12.70","actualQuantity":"12.7","unit":"LTR","unitRateFc":"11078.5","totalValueFC":"2785.4","currency":"INR","unitRateINR":"18046.8","date":"09-May-2023","totalValueINR":"229194.74","totalValueInUsd":"2785.4","indian_port":"BANGALORE ICD","hs_no":"29091990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"United States","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"","customerAddress":"12BOMMASANDRA JIGANI LINK ROADINDL AREAANEKAL TQ BANGALORE"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708021800,"product":"D(-)-MANNITOL FOR THE DETERMINATION OF BORIC ACID 1PCS X 1KG(PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"7937.1","totalValueFC":"95.9","currency":"INR","unitRateINR":"7957","date":"16-Feb-2024","totalValueINR":"7956.97","totalValueInUsd":"95.9","indian_port":"Bombay Air","hs_no":"29054300","bill_no":"2165326","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1710181800,"product":"BORIC ACID COMPOUND (FOR LABORATORY USE ONLY)","address":"FLAT NO 710,7TH FLOOR,,ADITYA TRAD","city":"HYDERABAD,TELANGANA","supplier":"AIKON SCIENTIFIC LTD","supplierCountry":"CHINA","foreign_port":"HONG KONG","customer":"ANGENE INTERNATIONAL","customerCountry":"INDIA","quantity":"1.20","actualQuantity":"1200","unit":"GMS","unitRateFc":"0.3","totalValueFC":"413.9","currency":"USD","unitRateINR":"28.6","date":"12-Mar-2024","totalValueINR":"34365.97","totalValueInUsd":"413.9","indian_port":"Hyderabad Air","hs_no":"29420090","bill_no":"2535612","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"HONG KONG","supplierAddress":"ADD: 6TH,FLOOR,BLOCK G,PHASE 322TH, TIANSHENG ROAD,JIANGBEI NEW AREA,NANJING 210044 CN","customerAddress":"FLAT NO 710,7TH FLOOR,,ADITYA TRAD"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723141800,"product":"D(-)-MANNITOL FOR THE DETERMINATION OF BORIC ACID 8PCS X 1KG(PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"7937.1","totalValueFC":"758.9","currency":"INR","unitRateINR":"7957","date":"09-Aug-2024","totalValueINR":"63655.78","totalValueInUsd":"758.9","indian_port":"Bombay Air","hs_no":"29054300","bill_no":"4965430","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

10 API Suppliers

2 USDMF

2 CEP/COS

2 JDMF

1 EU WC

4 NDC API

4 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

15 FDF Dossiers

4 Europe

2 Canada

3 South Africa

6 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

1 SPI Pharma

2 DKSH

1 Faran Shimi Pharmaceutical

4 Nanjing Well Pharmaceutical

1 Pfanstiehl

6 Actylis

4 BASF

1 Beijing Mesochem Technology

1 Finar

3 Gangwal Chemicals

1 Hayashibara

4 Kerry

2 Pluviaendo

8 Roquette

3 Seppic

1 Valens Pharmachem

EXCIPIENTS BY APPLICATIONS

9 Coating Systems & Additives

9 Topical

8 Parenteral

7 Thickeners and Stabilizers

7 Solubilizers

7 Film Formers & Plasticizers

6 Fillers, Diluents & Binders

5 Taste Masking

4 Granulation

4 Surfactant & Foaming Agents

3 Co-Processed Excipients

3 Direct Compression

3 Emulsifying Agents

2 Controlled & Modified Release

2 Coloring Agents

1 Chewable & Orodispersible Aids

DIGITAL CONTENT

2 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 Finished Drug Prices

MARKET PLACE

10 APIs

4 EXCIPIENTS

1 Intermediates

REF. STANDARDS & IMPURITIES

1 USP

1 Others

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 191

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

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80EXCIPIENTS BY APPLICATIONS

01