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    Chemistry

    Click the arrow to open the dropdown
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    Also known as: 179324-69-7, Velcade, Ps-341, Ldp-341, Bortezomib (ps-341), Radiciol
    Molecular Formula
    C19H25BN4O4
    Molecular Weight
    384.2  g/mol
    InChI Key
    GXJABQQUPOEUTA-RDJZCZTQSA-N
    FDA UNII
    69G8BD63PP
    Bortezomib
    A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA.
    Bortezomib is a Proteasome Inhibitor. The mechanism of action of bortezomib is as a Proteasome Inhibitor.
    1 2D Structure

    Bortezomib

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
    2.1.2 InChI
    InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1
    2.1.3 InChI Key
    GXJABQQUPOEUTA-RDJZCZTQSA-N
    2.1.4 Canonical SMILES
    B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
    2.1.5 Isomeric SMILES
    B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O
    2.2 Other Identifiers
    2.2.1 UNII
    69G8BD63PP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 341, Ps

    2. Ldp 341

    3. Ldp-341

    4. Ldp341

    5. Ps 341

    6. Ps-341

    7. Ps341

    8. Velcade

    2.3.2 Depositor-Supplied Synonyms

    1. 179324-69-7

    2. Velcade

    3. Ps-341

    4. Ldp-341

    5. Bortezomib (ps-341)

    6. Radiciol

    7. Ps 341

    8. ((r)-3-methyl-1-((s)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic Acid

    9. Dpba

    10. Ldp 341

    11. Bortezomib Accord

    12. Nsc-681239

    13. [(1r)-3-methyl-1-[[(2s)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic Acid

    14. Bortezomib (velcade)

    15. N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide

    16. Mln-341

    17. [(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid

    18. Mg 341

    19. Mg-341

    20. Boronic Acid, B-[(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]-

    21. Nsc 681239

    22. 69g8bd63pp

    23. Chembl325041

    24. Peptide Boronate

    25. Chebi:52717

    26. Nsc681239

    27. Ncgc00242506-02

    28. S1013

    29. Dsstox_cid_20980

    30. Dsstox_rid_79609

    31. N-[(1r)-1-(dihydroxyboranyl)-3-methylbutyl]-nalpha-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide

    32. Dsstox_gsid_40980

    33. Pyz-phe-boroleu

    34. (r)-3-methyl-1-((s)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic Acid

    35. ((1r)-3-methyl-1-(((2s)-3-phenyl-2-((pyrazinylcarbonyl)amino)propanoyl)amino)butyl)boronic Acid

    36. [(1r)-3-methyl-1-({(2s)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic Acid

    37. Boronic Acid, ((1r)-3-methyl-1-(((2s)-1-oxo-3-phenyl-2-((pyrazinylcarbonyl)amino)propyl)amino)butyl)-

    38. N-((1s)-1-benzyl-2-(((1r)-1-(dihydroxyboranyl)-3-methylbutyl)amino)-2-oxoethyl)pyrazinecarboxamide

    39. Velcade (tn)

    40. Cas-179324-69-7

    41. Ps 341 (pharmaceutical)

    42. Unii-69g8bd63pp

    43. Brotezamide

    44. Proscript Boronic Acid

    45. Bortezomib [usan:inn:ban]

    46. Hsdb 7666

    47. Bortezomib Hydrate

    48. Bortezomib,velcade

    49. Lpd 341

    50. Lpd-341

    51. Ncgc00168751-01

    52. Ncgc00181022-01

    53. Bortezomib- Bio-x

    54. Bortezomib [usan]

    55. Mfcd09056737

    56. Velcade (millenium)

    57. 3mg0

    58. Bortezomib [mi]

    59. Bortezomib [inn]

    60. Bortezomib [jan]

    61. Bortezomib [hsdb]

    62. Bortezomib [vandf]

    63. Bortezomib [mart.]

    64. Bortezomib [who-dd]

    65. Mls004774142

    66. Bortezomib (jan/usan/inn)

    67. Bortezomib [ema Epar]

    68. Schembl192129

    69. Gtpl6391

    70. Bortezomib [orange Book]

    71. Bortezomib Hydrate [jan]

    72. Dtxsid3040980

    73. Tox21_112630

    74. Tox21_112672

    75. Bdbm50069989

    76. Nsc756655

    77. Akos015909706

    78. Tox21_112672_1

    79. Zinc169746649

    80. Am81235

    81. Ccg-268449

    82. Cs-1039

    83. Db00188

    84. Nsc-756655

    85. Bortezomib (velcade,mg-341,ps-341)

    86. Ncgc00242506-01

    87. Ncgc00242506-06

    88. Ncgc00242506-07

    89. As-15721

    90. Bb164258

    91. Hy-10227

    92. Nci60_029010

    93. Smr003500787

    94. B5741

    95. Sw208077-3

    96. A18332

    97. D03150

    98. Ab01273951-01

    99. Ab01273951-02

    100. Ab01273951_03

    101. 324b697

    102. Q419319

    103. Sr-01000939863

    104. Sr-01000939863-2

    105. Brd-k88510285-001-02-0

    106. ((r)-3-methyl-1-((s)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronicacid

    107. (r)-3-methyl-1-((s)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic Acid

    108. (1r)-3-methyl-1-({(2s)-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propanoyl}amino)butylboronic Acid, Aldrichcpr

    109. (r)-3-methyl-1-((s)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butan-2-ylboronic Acid

    110. [(1r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]-butyl]boronic Acid

    111. 1610526-91-4

    112. Boronic Acid, (3-methyl-1-((1-oxo-3-phenyl-2-((pyrazinylcarbonyl)amino)propyl)amino)butyl)-, (s-(r*,s*))-

    113. Boronic Acid, [(1(r)-3-methyl-1-[[(2s)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]-

    114. N-((1s)-1-benzyl-2-(((1r)-1-(dihydroxyboranyl)-3-methylbutyl)amino)2-oxoethylpyrazinecarboxamide

    115. N-[(1r)-1-(dihydroxyboranyl)-3-methylbutyl]-n(alpha)-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 384.2 g/mol
    Molecular Formula C19H25BN4O4
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count9
    Exact Mass384.1968855 g/mol
    Monoisotopic Mass384.1968855 g/mol
    Topological Polar Surface Area124 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity500
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameVelcade
    PubMed HealthBortezomib (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelVELCADE (bortezomib) for Injection is an antineoplastic agent available for intravenous injection or subcutaneous use. Each single use vial contains 3.5 mg of bortezomib as a sterile lyophilized powder. Inactive ingredient: 35 mg mannitol, USP.Bort...
    Active IngredientBortezomib
    Dosage FormInjectable
    RouteIntravenous, subcutaneous
    Strength3.5mg/vial
    Market StatusPrescription
    CompanyMillennium Pharms

    2 of 2  
    Drug NameVelcade
    PubMed HealthBortezomib (Injection)
    Drug ClassesAntineoplastic Agent
    Drug LabelVELCADE (bortezomib) for Injection is an antineoplastic agent available for intravenous injection or subcutaneous use. Each single use vial contains 3.5 mg of bortezomib as a sterile lyophilized powder. Inactive ingredient: 35 mg mannitol, USP.Bort...
    Active IngredientBortezomib
    Dosage FormInjectable
    RouteIntravenous, subcutaneous
    Strength3.5mg/vial
    Market StatusPrescription
    CompanyMillennium Pharms

    4.2 Therapeutic Uses

    Antineoplastic Agents; Protease Inhibitors

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Bortezomib injection is indicated for the treatment of patients with multiple myeloma who have received at least 1 prior therapy. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    Bortezomib injection is indicated for the treatment of patients with mantle cell lymphoma who have received at least 1 prior therapy. /Included in US product label/

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    4.3 Drug Warning

    Known hypersensitivity to bortezomib, boron, or mannitol.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 929

    Bortezomib mainly causes sensory peripheral neuropathy, but severe motor peripheral neuropathy also has been reported. In the phase III trial, peripheral neuropathy occurred in 36% of patients receiving bortezomib and 9% of patients receiving dexamethasone. Grade 3 or 4 peripheral neuropathy occurred in 7 or less than 1%, respectively, of patients receiving bortezomib. Following dosage adjustments, amelioration or resolution of peripheral neuropathy was reported in 51% of patients with grade 2 or higher peripheral neuropathy within a median of 3.5 months from onset. About 8% of patients discontinued bortezomib therapy because of peripheral neuropathy.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 929

    Patients receiving bortezomib should be monitored for manifestations of neuropathy (eg, burning sensation, hyperesthesia, hypoesthesia, paresthesia, discomfort, neuropathic pain). Dose and/or frequency of administration of bortezomib should be adjusted in patients who experience new-onset or exacerbation of peripheral neuropathy.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 929

    In the phase III trial, asthenia (ie, fatigue, malaise, weakness) was reported in 61% of patients receiving bortezomib and 45% of patients receiving dexamethasone. Grade 3 asthenia occurred in 12 versus 6%, respectively, of patients receiving bortezomib or dexamethasone. About 3% of patients receiving bortezomib and 2% of patients receiving dexamethasone discontinued therapy because of asthenia.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 929

    For more Drug Warnings (Complete) data for BORTEZOMIB (26 total), please visit the HSDB record page.

    4.4 Drug Indication

    Bortezomib is indicated for the treatment of adult patients with multiple myeloma or mantle cell lymphoma.

    FDA Label

    Velcade as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone is indicated for the treatment of adult patients with progressive multiple myeloma who have received at least 1 prior therapy and who have already undergone or are unsuitable for haematopoietic stem cell transplantation.

    Velcade in combination with melphalan and prednisone is indicated for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for high dose chemotherapy with haematopoietic stem cell transplantation.

    Velcade in combination with dexamethasone, or with dexamethasone and thalidomide, is indicated for the induction treatment of adult patients with previously untreated multiple myeloma who are eligible for high dose chemotherapy with haematopoietic stem cell transplantation.

    Velcade in combination with rituximab, cyclophosphamide, doxorubicin and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma who are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib Hospira as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone is indicated for the treatment of adult patients with progressive multiple myeloma who have received at least 1 prior therapy and who have already undergone or are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib Hospira in combination with melphalan and prednisone is indicated for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib Hospira in combination with dexamethasone, or with dexamethasone and thalidomide, is indicated for the induction treatment of adult patients with previously untreated multiple myeloma who are eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib Hospira in combination with rituximab, cyclophosphamide, doxorubicin and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma who are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone is indicated for the treatment of adult patients with progressive multiple myeloma who have received at least 1 prior therapy and who have already undergone or are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib in combination with melphalan and prednisone is indicated for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib in combination with dexamethasone, or with dexamethasone and thalidomide, is indicated for the induction treatment of adult patients with previously untreated multiple myeloma who are eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib in combination with rituximab, cyclophosphamide, doxorubicin and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma who are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib SUN as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone is indicated for the treatment of adult patients with progressive multiple myeloma who have received at least 1 prior therapy and who have already undergone or are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib SUN in combination with melphalan and prednisone is indicated for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib SUN in combination with dexamethasone, or with dexamethasone and thalidomide, is indicated for the induction treatment of adult patients with previously untreated multiple myeloma who are eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib SUN in combination with rituximab, cyclophosphamide, doxorubicin and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma who are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib Accord as monotherapy or in combination with pegylated liposomal doxorubicin or dexamethasone is indicated for the treatment of adult patients with progressive multiple myeloma who have received at least 1 prior therapy and who have already undergone or are unsuitable for haematopoietic stem cell transplantation.

    Bortezomib Accord in combination with melphalan and prednisone is indicated for the treatment of adult patients with previously untreated multiple myeloma who are not eligible for highdose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib Accord in combination with dexamethasone, or with dexamethasone and thalidomide, is indicated for the induction treatment of adult patients with previously untreated multiple myeloma who are eligible for highdose chemotherapy with haematopoietic stem cell transplantation.

    Bortezomib Accord in combination with rituximab, cyclophosphamide, doxorubicin and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma who are unsuitable for haematopoietic stem cell transplantation.

    Treatment of mantle cell lymphoma

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Bortezomib works to target the ubiquitin-proteasome pathway, an essential molecular pathway that regulates intracellular concentrations of proteins and promotes protein degradation. The ubiquitin-proteasome pathway is often dysregulated in pathological conditions, leading to aberrant pathway signalling and the formation of malignant cells. In one study, patient-derived chronic lymphocytic leukemia (CLL) cells contained 3-fold higher levels of chymotrypsin-like proteasome activity than normal lymphocytes. By reversibly inhibiting proteasome, bortezomib prevents proteasome-mediated proteolysis. Bortezomib exerts a cytotoxic effect on various cancer cell types _in vitro_ and delays tumour growth _in vivo_ in nonclinical tumour models. Bortezomib inhibits the proteasome activity in a dose-dependent manner. In one pharmacodynamic study, more than 75% of proteasome inhibition was observed in whole blood samples within one hour after dosing of bortezomib.

    5.2 MeSH Pharmacological Classification

    Antineoplastic Agents

    Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    BORTEZOMIB
    5.3.2 FDA UNII
    69G8BD63PP
    5.3.3 Pharmacological Classes
    Proteasome Inhibitors [MoA]; Proteasome Inhibitor [EPC]
    5.4 ATC Code

    L01XG01

    L01XG01

    L01XG01

    L01XG01

    L01XX32

    L01XX32

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    L - Antineoplastic and immunomodulating agents

    L01 - Antineoplastic agents

    L01X - Other antineoplastic agents

    L01XG - Proteasome inhibitors

    L01XG01 - Bortezomib

    5.5 Absorption, Distribution and Excretion

    Absorption

    Following intravenous administration of 1 mg/m2 and 1.3 mg/m2 doses, the mean Cmax of bortezomib were 57 and 112 ng/mL, respectively. In a twice-weekly dosing regimen, the Cmax ranged from 67 to 106 ng/mL at the dose of 1 mg/m2 and 89 to 120 ng/mL for the 1.3 mg/m2 dose. In patients with multiple myeloma, the Cmax of bortezomib followig subcutaneous administration was lower than that of intravenously-administered dose; however, the total systemic exposure of the drug was equivalent for both routes of administration. There is a wide interpatient variability in drug plasma concentrations.

    Route of Elimination

    Bortezomib is eliminated by both renal and hepatic routes.

    Volume of Distribution

    The mean distribution volume of bortezomib ranged from approximately 498 to 1884 L/m2 in patients with multiple myeloma receiving a single- or repeat-dose of 1 mg/m2 or 1.3 mg/m2. Bortezomib distributes into nearly all tissues, except for the adipose and brain tissue.

    Clearance

    Following the administration of a first dose of 1 mg/m2 and 1.3 mg/m2, the mean mean total body clearances were 102 and 112 L/h, respectively. The clearances were 15 and 32 L/h after the subsequent dose of 1 and 1.3 mg/m2, respectively.

    Following intravenous administration of 1 mg/sq m and 1.3 mg/sq m doses to 24 patients with multiple myeloma (n=12, per each dose level), the mean maximum plasma concentrations of bortezomib (Cmax) after the first dose (Day 1) were 57 and 112 ng/mL, respectively.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    In subsequent doses, when administered twice weekly, the mean maximum observed plasma concentrations ranged from 67 to 106 ng/mL for the 1 mg/sq m dose and 89 to 120 ng/mL for the 1.3 mg/sq m dose. The mean elimination half-life of bortezomib upon multiple dosing ranged from 40 to 193 hours after the 1 mg/sq m dose and 76 to 108 hours after the 1.3 mg/sq m dose. The mean total body clearances was 102 and 112 L/hr following the first dose for doses of 1 mg/sq m and 1.3 mg/sq m, respectively, and ranged from 15 to 32 L/hr following subsequent doses for doses of 1 and 1.3 mg/sq m, respectively.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    The mean distribution volume of bortezomib ranged from approximately 498 to 1884 L/sq m following single- or repeat-dose administration of 1 mg/sq m or 1.3mg/sq m to patients with multiple myeloma. This suggests bortezomib distributes widely to peripheral tissues. The binding of bortezomib to human plasma proteins averaged 83% over the concentration range of 100 to 1000 ng/mL.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    It is not known whether bortezomib is excreted in human milk.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    For more Absorption, Distribution and Excretion (Complete) data for BORTEZOMIB (6 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    Bortezomib is primarily metabolized by CYP3A4, CYP2C19, and CYP1A2. CYP2D6 and CYP2C9 are also involved in drug metabolism, but to a smaller extent. Oxidative deboronation, which involves the removal of boronic acid from the parent compound, is the main metabolic pathway. Metabolites of bortezomib are pharmacologically inactive and more than 30 metabolites have been identified in human and animal studies.

    In vitro studies with human liver microsomes and human cDNA-expressed cytochrome P450 isozymes indicate that bortezomib is primarily oxidatively metabolized via cytochrome P450 enzymes 3A4, 2C19, and 1A2. Bortezomib metabolism by CYP 2D6 and 2C9 enzymes is minor. The major metabolic pathway is deboronation to form 2 deboronated metabolites that subsequently undergo hydroxylation to several metabolites. Deboronated bortezomib metabolites are inactive as 26S proteasome inhibitors. Pooled plasma data from 8 patients at 10 min and 30 min after dosing indicate that the plasma levels of metabolites are low compared to the parent drug.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    ... The P450 inhibition potential of bortezomib and its major deboronated metabolites M1 and M2 and their dealkylated metabolites M3 and M4 was evaluated in human liver microsomes for the major P450 isoforms 1A2, 2C9, 2C19, 2D6, and 3A4/5. Bortezomib, M1, and M2 were found to be mild inhibitors of CYP2C19 (IC(50) approximately 18.0, 10.0, and 13.2 microM, respectively), and M1 was also a mild inhibitor of CYP2C9 (IC(50) approximately 11.5 microM). However, bortezomib, M1, M2, M3, and M4 did not inhibit other P450s (IC(50) values > 30 microM). There also was no time-dependent inhibition of CYP3A4/5 by bortezomib or its major metabolites. ...

    PMID:16443666 LU C et al; Drug Metab Dispos 34 (4): 702-8 (2006)

    ... Bortezomib binds the proteasome via the boronic acid moiety, and therefore, the presence of this moiety is necessary to achieve proteasome inhibition. Metabolites in plasma obtained from patients receiving a single intravenous dose of bortezomib were identified and characterized by liquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS). Metabolite standards that were synthesized and characterized by LC/MS/MS and high field nuclear magnetic resonance spectroscopy (NMR) were used to confirm metabolite structures. The principal biotransformation pathway observed was oxidative deboronation, most notably to a pair of diastereomeric carbinolamide metabolites. Further metabolism of the leucine and phenylalanine moieties produced tertiary hydroxylated metabolites and a metabolite hydroxylated at the benzylic position, respectively. Conversion of the carbinolamides to the corresponding amide and carboxylic acid was also observed. Human liver microsomes adequately modeled the in vivo metabolism of bortezomib, as the principal circulating metabolites were observed in vitro. Using cDNA-expressed cytochrome P450 isoenzymes, it was determined that several isoforms contributed to the metabolism of bortezomib, including CYP3A4, CYP2C19, CYP1A2, CYP2D6, and CYP2C9. ...

    PMID:15764713 Pekol T et al; Drug Metab Dispos 33 (6): 771-7 (2005)

    5.7 Biological Half-Life

    The mean elimination half-life of bortezomib ranged from 40 to 193 hours following a multiple dosing regimen at a 1 mg/m2 dose. The half-life ranged from 76 to 108 hours after multiple dosing of 1.3 mg/m2 bortezomib.

    The mean elimination half-life of bortezomib upon multiple dosing ranged from 40 to 193 hours after the 1 mg/sq m dose and 76 to 108 hours after the 1.3 mg/sq m dose.

    US Natl Inst Health; DailyMed. Current Medication Information for Velcade (Bortezomib) (January 2008). Available from, as of November 25, 2008: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6358

    5.8 Mechanism of Action

    The ubiquitin-proteasome pathway is a homeostatic proteolytic pathway for intracellular protein degradation: proteins marked with a poly-ubiquitin chain are degraded to small peptides and free ubiquitin by the proteasome, which is a large multimeric protease. Aberrant proteasome-dependent proteolysis, as seen in some malignancies, can lead to uncontrolled cell division, leading to tumorigenesis, cancer growth, and spread. Bortezomib is a reversible inhibitor of the 26S proteasome, which is made up of a 20S core complexed with a 19S regulatory complex. Individual -subunits allow specific catalytic action of the 20S core. In mammalian cells, bortezomib is a potent inhibitor of the proteasomes chymotryptic-like activity, which is attributed to the 5-subunit of the 20S core particle. Bortezomib binds to the active site of the threonine hydroxyl group in the 5-subunit. A probing study showed bortezomib also binding to and inhibiting the 1-subunit, which mediates the caspase-like activity of the proteasome, and 1i-subunit, which is an altered subunit that is expressed to form immunoproteasomes in response to cell stress or inflammation. By inhibiting the proteasome-mediated degradation of key proteins that promote cell apoptosis, bortezomib induces a cell cycle arrest during the G2-M phase. It is believed that multiple mechanisms, other than proteasome inhibition, may be involved in the anticancer activity of bortezomib. The anticancer activity of bortezomib was largely associated with suppression of the NF-B signalling pathway, resulting in the downregulation of anti-apoptotic target genes and expression of anti-apoptic proteins. This may be explained by bortezomib preventing uncontrolled degradation of IB, which is an inhibitory protein of NF-B. NOXA, which is a pro-apoptotic factor, induced by bortezomib selectively in cancer cells; thus, it is suggested to be another key mechanism of bortezomib.

    Bortezomib, a modified dipeptidyl boronic acid, is an antineoplastic agent. The drug reversibly inhibits the 26S proteasome, a large protein complex that degrades ubiquitinated proteins. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Inhibition of the 26S proteasome by bortezomib prevents targeted proteolysis and causes disruption of normal homeostatic mechanisms, which can lead to cell death. In vitro studies indicate that bortezomib is cytotoxic to a variety of cancer cell types. Bortezomib has been shown to cause a delay in tumor growth in vivo in tumor models, including multiple myeloma.

    American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 931

    ... The mechanisms underlying /bortezomib/ cancer cell toxicity are complex. A growing body of evidence suggests proteasome inhibition-dependent regulation of the BCL-2 family is a critical requirement. In particular, the stabilization of BH3-only proteins BIK, NOXA and BIM, appear to be essential for effecting BAX- and BAK-dependent cell death. ...

    PMID:17828309 Fennell DA et al; Oncogene 27 (9): 1189-97 (2008)

    Proteasome inhibition is a novel, targeted approach in cancer therapy. Both natural and synthetic proteasome inhibitors selectively penetrate cancer cells, disrupting the orderly destruction of key regulatory proteins involved in tumorigenesis and metastasis. Disrupting the orderly destruction of regulatory proteins causes an imbalance of these proteins within the cell, which interferes with the systematic activation of signaling pathways required to maintain tumor cell growth and survival; therefore, cellular replication is inhibited and apoptosis ensues. ...

    PMID:15688597 Jung L et al; Oncology (Williston Park) 18 (14 Suppl 11): 4-13 (2004)

    Bortezomib (PS-341, Velcade) is a potent and selective inhibitor of the proteasome that is currently under investigation for the treatment of solid malignancies. /Investigators/ have shown previously that bortezomib has activity in pancreatic cancer models and that the drug induces endoplasmic reticulum (ER) stress but also suppresses the unfolded protein response (UPR). Because the UPR is an important cytoprotective mechanism, /investigators/ hypothesized that bortezomib would sensitize pancreatic cancer cells to ER stress-mediated apoptosis. Here, /the authors/ show that bortezomib promotes apoptosis triggered by classic ER stress inducers (tunicamycin and thapsigargin) via a c-Jun NH(2)-terminal kinase (JNK)-dependent mechanism. /They/ also show that cisplatin stimulates ER stress and interacts with bortezomib to increase ER dilation, intracellular Ca(2+) levels, and cell death. Importantly, combined therapy with bortezomib plus cisplatin induced JNK activation and apoptosis in orthotopic pancreatic tumors resulting in a reduction in tumor burden. Taken together, the data establish that bortezomib sensitizes pancreatic cancer cells to ER stress-induced apoptosis and show that bortezomib strongly enhances the anticancer activity of cisplatin.

    PMID:16357177 Nawrocki ST et al; Cancer Res 65 (24): 11658-66 (2005)

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    About the Company : Located in beautiful Spring City-Jinan,Jiwan is a high-tech pharmaceutical company,specializing in R&D, technology transfer and technical consulting of biotechnology and pharmaceut...

    Located in beautiful Spring City-Jinan,Jiwan is a high-tech pharmaceutical company,specializing in R&D, technology transfer and technical consulting of biotechnology and pharmaceutical technology. Moreover, Jiwan has the right of dealing import and export business of APIs,intermediates and fine chemical goods. Jiwan has a group of high-level specialists from various fields of pharmaceutics and its related sciences who have rich experence and professional research talents and have been working together for more than 10 years.
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    29-Mar-2021
    26-Oct-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    Drugs in Development

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    • Development Update
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Sarclisa Recommended for EU Approval for Newly Diagnosed Multiple Myeloma

    Details:

    Sarclisa (isatuximab) approved as a first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.


    Lead Product(s): Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area: Oncology Brand Name: Sarclisa

    Study Phase: ApprovedProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable November 14, 2024

    Sanofi Company Banner

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    Sanofi

    France
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    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Lead Product(s) : Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sarclisa Recommended for EU Approval for Newly Diagnosed Multiple Myeloma

    Details : Sarclisa (isatuximab) approved as a first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.

    Brand Name : Sarclisa

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    November 14, 2024

    Sanofi Company Banner

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    Virtual Booth

    • Development Update
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Sanofi Wins US Approval for Multiple Myeloma Drug in Newly Diagnosed Patients

    Details:

    Sarclisa (isatuximab) approved as a first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.


    Lead Product(s): Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area: Oncology Brand Name: Sarclisa

    Study Phase: ApprovedProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable September 21, 2024

    Sanofi Company Banner

    02

    Sanofi

    France
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Lead Product(s) : Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sanofi Wins US Approval for Multiple Myeloma Drug in Newly Diagnosed Patients

    Details : Sarclisa (isatuximab) approved as a first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.

    Brand Name : Sarclisa

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    September 21, 2024

    Sanofi Company Banner

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    Virtual Booth

    • Development Update
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Sarclisa Treatment Significantly Improves Survival in Multiple Myeloma Patients

    Details:

    Sarclisa (isatuximab) will be the first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.


    Lead Product(s): Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area: Oncology Brand Name: Sarclisa

    Study Phase: Phase IIIProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable August 08, 2024

    Sanofi Company Banner

    03

    Sanofi

    France
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Lead Product(s) : Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sarclisa Treatment Significantly Improves Survival in Multiple Myeloma Patients

    Details : Sarclisa (isatuximab) will be the first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.

    Brand Name : Sarclisa

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    August 08, 2024

    Sanofi Company Banner

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    Virtual Booth

    • Development Update
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Sarclisa Accepted for FDA Priority Review in Newly Diagnosed Multiple Myeloma

    Details:

    Sarclisa (isatuximab) will be the first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.


    Lead Product(s): Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area: Oncology Brand Name: Sarclisa

    Study Phase: Phase IIIProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable May 27, 2024

    Sanofi Company Banner

    04

    Sanofi

    France
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Lead Product(s) : Isatuximab,Bortezomib,Lenalidomide

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sarclisa Accepted for FDA Priority Review in Newly Diagnosed Multiple Myeloma

    Details : Sarclisa (isatuximab) will be the first anti-CD38 therapy in combination with Bortezomib and Dexamethasone soc treatment for patients with newly diagnosed transplant-ineligible multiple myeloma.

    Brand Name : Sarclisa

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    May 27, 2024

    Sanofi Company Banner

    Stock Recap
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    Virtual Booth

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    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Sarclisa® (isatuximab) Phase 3 Trial Met Primary Endpoint of Progression Free Survival in Patients with Newly Diagnosed Multiple Myeloma Not Eligible f...

    Details:

    Sarclisa (isatuximab) is a CD38 monoclonal antibody in combination with standard-of-care bortezomib, lenalidomide and dexamethasone is being evaluated in newly diagnosed multiple myeloma not eligible for transplant.


    Lead Product(s): Isatuximab,Lenalidomide,Bortezomib

    Therapeutic Area: Oncology Brand Name: Sarclisa

    Study Phase: Phase IIIProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable December 08, 2023

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    Sanofi

    France
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    Antibody Engineering
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    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Lead Product(s) : Isatuximab,Lenalidomide,Bortezomib

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Sarclisa® (isatuximab) Phase 3 Trial Met Primary Endpoint of Progression Free Survival in Patient...

    Details : Sarclisa (isatuximab) is a CD38 monoclonal antibody in combination with standard-of-care bortezomib, lenalidomide and dexamethasone is being evaluated in newly diagnosed multiple myeloma not eligible for transplant.

    Brand Name : Sarclisa

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    December 08, 2023

    Sanofi Company Banner

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    Virtual Booth

    • Development Update
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Dr. Reddy's Laboratories Announces the Launch of Bortezomib for Injection, 3.5 mg Single-Dose Vial in the U.S. Market

    Details:

    Launch of Bortezomib for Injection 3.5 mg, the generic equivalent of Velcade® (bortezomib) Injection, in the U.S. market approved by the U.S. Food and Drug Administration, used to treat multiple myeloma and mantle cell lymphoma.


    Lead Product(s): Bortezomib

    Therapeutic Area: Oncology Brand Name: Bortezomib-Generic

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable July 27, 2022

    Dr Reddy Company Banner

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    Dr. Reddy's Laboratories

    India
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Lead Product(s) : Bortezomib

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Dr. Reddy's Laboratories Announces the Launch of Bortezomib for Injection, 3.5 mg Single-Dose Vial...

    Details : Launch of Bortezomib for Injection 3.5 mg, the generic equivalent of Velcade® (bortezomib) Injection, in the U.S. market approved by the U.S. Food and Drug Administration, used to treat multiple myeloma and mantle cell lymphoma.

    Brand Name : Bortezomib-Generic

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    July 27, 2022

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    Virtual Booth

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    Virtual BoothEver Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances & suspensions.

    EVER Pharma receives EU approval for a liquid ready to use Bortezomib formulation

    Details:

    Bortezomib EVER Pharma is a proteasome inhibitor small molecule drug candidate, which is indicated for the treatment of patients with multiple myeloma and mantle cell lymphoma.


    Lead Product(s): Bortezomib

    Therapeutic Area: Oncology Brand Name: Bortezomib EVER Pharma

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable February 09, 2022

    Ever Pharma CB

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    Ever Pharma

    Austria
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    Virtual BoothEver Pharma, highly specialized CDMO in producing complex injectables including high potency & controlled substances & suspensions.

    Lead Product(s) : Bortezomib

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    EVER Pharma receives EU approval for a liquid ready to use Bortezomib formulation

    Details : Bortezomib EVER Pharma is a proteasome inhibitor small molecule drug candidate, which is indicated for the treatment of patients with multiple myeloma and mantle cell lymphoma.

    Brand Name : Bortezomib EVER Pharma

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    February 09, 2022

    Ever Pharma CB

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    GSK's ADC Blenrep Delivers Survival Win Against J&J's Darzalex

    Details:

    Blenrep (belantamab mafodotin-blmf) is an anti-BCMA ADC. It is being evaluated in combination with pomalidomide, bortezomib and dexamethasone for the treatment of relapsed/refractory multiple myeloma.


    Lead Product(s): Belantamab Mafodotin,Bortezomib,Dexamethasone

    Therapeutic Area: Oncology Brand Name: Blenrep

    Study Phase: Phase IIIProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable November 14, 2024

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    08

    GSK

    United Kingdom
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    Antibody Engineering
    Not Confirmed

    GSK

    United Kingdom
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    Antibody Engineering
    Not Confirmed
    • fda
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Belantamab Mafodotin,Bortezomib,Dexamethasone

    Therapeutic Area : Oncology

    Highest Development Status : Phase III

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    GSK's ADC Blenrep Delivers Survival Win Against J&J's Darzalex

    Details : Blenrep (belantamab mafodotin-blmf) is an anti-BCMA ADC. It is being evaluated in combination with pomalidomide, bortezomib and dexamethasone for the treatment of relapsed/refractory multiple myeloma.

    Brand Name : Blenrep

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    November 14, 2024

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    DARZALEX Quadruplet Approved in EU for Newly Diagnosed Myeloma Patients

    Details:

    Darzalex (daratumumab) a CD38 inhibitor, being evaluated in combination with bortezomib, lenalidomide, dexamethasone for the treatment of newly diagnosed multiple myeloma.


    Lead Product(s): Daratumumab,Lenalidomide,Bortezomib

    Therapeutic Area: Oncology Brand Name: Darzalex

    Study Phase: ApprovedProduct Type: Large molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable October 23, 2024

    blank

    09

    Johnson & Johnson

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed

    Johnson & Johnson

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Daratumumab,Lenalidomide,Bortezomib

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    DARZALEX Quadruplet Approved in EU for Newly Diagnosed Myeloma Patients

    Details : Darzalex (daratumumab) a CD38 inhibitor, being evaluated in combination with bortezomib, lenalidomide, dexamethasone for the treatment of newly diagnosed multiple myeloma.

    Brand Name : Darzalex

    Molecule Type : Large molecule

    Upfront Cash : Not Applicable

    October 23, 2024

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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Antengene Announces XPOVIO® Approved in South Korea For Multiple Myeloma

    Details:

    XPOVIO (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.


    Lead Product(s): Selinexor,Bortezomib,Dexamethasone

    Therapeutic Area: Oncology Brand Name: Xpovio

    Study Phase: ApprovedProduct Type: Small molecule

    Sponsor: Not Applicable

    Deal Size: Not Applicable Upfront Cash: Not Applicable

    Deal Type: Not Applicable October 17, 2024

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    10

    Antengene

    China
    arrow
    Antibody Engineering
    Not Confirmed

    Antengene

    China
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    Lead Product(s) : Selinexor,Bortezomib,Dexamethasone

    Therapeutic Area : Oncology

    Highest Development Status : Approved

    Partner/Sponsor/Collaborator : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Antengene Announces XPOVIO® Approved in South Korea For Multiple Myeloma

    Details : XPOVIO (selinexor) approved for adult patients with multiple myeloma who have received at least one prior therapy, in combination with bortezomib and dexamethasone.

    Brand Name : Xpovio

    Molecule Type : Small molecule

    Upfront Cash : Not Applicable

    October 17, 2024

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    01

    Sanofi

    France
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    Not Confirmed
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    • WHO-GMP

    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Contact Supplier Contact Supplier
    Flag France
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Zentiva

    Dosage Form : Dry Sub

    Dosage Strength : 1mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    Sanofi Company Banner

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    Digital Content

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    Corporate PDF

    02

    Sanofi

    France
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    AES 2024
    Not Confirmed
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    • EDQM
    • WHO-GMP

    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

    Contact Supplier Contact Supplier
    Flag France
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Zentiva

    Dosage Form : Dry Sub

    Dosage Strength : 3.5mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    Sanofi Company Banner

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    Digital Content

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    03

    Dr. Reddy's Laboratories

    India
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    AES 2024
    Not Confirmed
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : RX

    Registration Country : USA

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date : 2022-07-26

    Application Number : 202963

    Regulatory Info : RX

    Registration Country : USA

    Dr Reddy Company Banner

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    Digital Content

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    04

    Dr. Reddy's Laboratories

    India
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    AES 2024
    Not Confirmed
    • fda
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    • WHO-GMP

    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : DISCN

    Registration Country : USA

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : POWDER;INTRAVENOUS

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date : 2019-10-04

    Application Number : 206927

    Regulatory Info : DISCN

    Registration Country : USA

    Dr Reddy Company Banner

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    05

    Dr. Reddy's Laboratories

    India
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    Not Confirmed
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

    Bortezomib

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Lead Market Dossiers- Filed

    Registration Country : India

    Dr Reddy Company Banner

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    Digital Content

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    06

    Dr. Reddy's Laboratories

    India
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    AES 2024
    Not Confirmed
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Contact Supplier Contact Supplier
    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Lead Market Dossiers- Approved in both US & EU

    Registration Country : India

    Bortezomib

    Brand Name :

    Dosage Form : Injection

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Lead Market Dossiers- Approved in both US & EU

    Registration Country : India

    Dr Reddy Company Banner

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    07

    Polfa Tarchomin

    Poland
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    AES 2024
    Not Confirmed
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    Virtual BoothPolfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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    Regulatory Info : Dossier Available

    Registration Country : Poland

    Bortezomib

    Brand Name :

    Dosage Form : Powder for Solution for Injection

    Dosage Strength : 3.5MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info : Dossier Available

    Registration Country : Poland

    Polfa Tarchomin

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    08

    NanoAlvand

    Iran
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    AES 2024
    Not Confirmed
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    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Flag Iran
    Virtual Booth Virtual Booth
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    Regulatory Info :

    Registration Country : Iran

    Bortezomib

    Brand Name : Alvocade

    Dosage Form : Vial

    Dosage Strength : 1MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    09

    NanoAlvand

    Iran
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    AES 2024
    Not Confirmed
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    Virtual BoothNanoAlvand is the entrance to Global Markets as a trusted Highly Potent Products manufacturer.

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    Flag Iran
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    Regulatory Info :

    Registration Country : Iran

    Bortezomib

    Brand Name : Alvocade

    Dosage Form : Vial

    Dosage Strength : 3.5MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Iran

    NanoAlvand

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    10

    Supriya Lifescience

    India
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    AES 2024
    Not Confirmed
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    Virtual BoothSupriya Lifesciences is a cGMP-compliant API manufacturing organization with a leadership position across key & niche products.

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    Flag India
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    Regulatory Info :

    Registration Country : India

    Bortezomib

    Brand Name :

    Dosage Form : Lyophilized Powder for Injection

    Dosage Strength : 1MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : India

    Supriya

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    01

    DR REDDYS

    India
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    AES 2024
    Not Confirmed
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Flag India
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-07-26

    Application Number : 202963

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    02

    DR REDDYS

    India
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    AES 2024
    Not Confirmed
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Flag India
    Virtual Booth Virtual Booth
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    RLD : No

    TE Code :

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : POWDER;INTRAVENOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2019-10-04

    Application Number : 206927

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

    Dr Reddy Company Banner

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    03

    APOTEX

    Canada
    AES 2024
    Not Confirmed
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    APOTEX

    Canada
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    AES 2024
    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-05-02

    Application Number : 205533

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    04

    BAXTER HLTHCARE CORP

    U.S.A
    AES 2024
    Not Confirmed
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    BAXTER HLTHCARE CORP

    U.S.A
    arrow
    AES 2024
    Not Confirmed
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    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-05-02

    Application Number : 213823

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    05

    FRESENIUS KABI USA

    U.S.A
    AES 2024
    Not Confirmed
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    FRESENIUS KABI USA

    U.S.A
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    AES 2024
    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-05-02

    Application Number : 209659

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    06

    JIANGSU HANSOH PHARM

    China
    AES 2024
    Not Confirmed
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    JIANGSU HANSOH PHARM

    China
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    AES 2024
    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
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    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-07-26

    Application Number : 215011

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    07

    HOSPIRA

    U.S.A
    AES 2024
    Not Confirmed
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    HOSPIRA

    U.S.A
    arrow
    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    RLD : Yes

    TE Code :

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : POWDER;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 2.5MG/VIAL

    Approval Date : 2022-05-02

    Application Number : 209191

    RX/OTC/DISCN : RX

    RLD : Yes

    TE Code :

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    08

    MEITHEAL

    U.S.A
    AES 2024
    Not Confirmed
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    MEITHEAL

    U.S.A
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    AES 2024
    Not Confirmed
    • fda
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    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-07-26

    Application Number : 212958

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    09

    MSN

    India
    AES 2024
    Not Confirmed
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    MSN

    India
    arrow
    AES 2024
    Not Confirmed
    • fda
    • EDQM
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    RLD : No

    TE Code : AP

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-07-26

    Application Number : 209622

    RX/OTC/DISCN : RX

    RLD : No

    TE Code : AP

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    10

    TEVA PHARMS USA

    Israel
    AES 2024
    Not Confirmed
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    TEVA PHARMS USA

    Israel
    arrow
    AES 2024
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Digital Content Digital Content

    RLD : No

    TE Code :

    BORTEZOMIB

    Brand Name : BORTEZOMIB

    Dosage Form : INJECTABLE;INTRAVENOUS, SUBCUTANEOUS

    Dosage Strength : 3.5MG/VIAL

    Approval Date : 2022-05-02

    Application Number : 205857

    RX/OTC/DISCN : DISCN

    RLD : No

    TE Code :

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    Europe

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    01

    Helvepharm AG

    France
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Zentiva

    Dosage Form : Dry Sub

    Dosage Strength : 1mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    Sanofi Company Banner

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    02

    Helvepharm AG

    France
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Zentiva

    Dosage Form : Dry Sub

    Dosage Strength : 3.5mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    Sanofi Company Banner

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    03

    Accord Healthcare Ltd.

    United Kingdom
    Antibody Engineering
    Not Confirmed
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    Accord Healthcare Ltd.

    United Kingdom
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Regulatory Info :

    Registration Country : Sweden

    bortezomib

    Brand Name : bortezomib Accord

    Dosage Form : POWDER FOR SOLUTION FOR INJECTION

    Dosage Strength : 3.5 MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Sweden

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    04

    Accord Healthcare AG

    United Kingdom
    Antibody Engineering
    Not Confirmed
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    Accord Healthcare AG

    United Kingdom
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Accord

    Dosage Form : Dry Sub

    Dosage Strength : 1mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    05

    Accord Healthcare AG

    United Kingdom
    Antibody Engineering
    Not Confirmed
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    Accord Healthcare AG

    United Kingdom
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Accord

    Dosage Form : Dry Sub

    Dosage Strength : 3.5mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    06

    Janssen-Cilag International NV

    Italy
    Antibody Engineering
    Not Confirmed
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    Janssen-Cilag International NV

    Italy
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Flag Italy
    Virtual Booth Virtual Booth
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    Regulatory Info :

    Registration Country : Sweden

    bortezomib

    Brand Name : VELCADE

    Dosage Form : PULVER TILL INJEKTIONSVÄTSKA, LÖSNING

    Dosage Strength : 1 MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Sweden

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    07

    Janssen-Cilag International

    Italy
    Antibody Engineering
    Not Confirmed
    arrow

    Janssen-Cilag International

    Italy
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Regulatory Info :

    Registration Country : Norway

    Bortezomib

    Brand Name : Velcade

    Dosage Form : Powder for injection fluid, resolution

    Dosage Strength : 3.5 mg

    Packaging : Hood glass

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Norway

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    08

    Janssen-Cilag AG

    Italy
    Antibody Engineering
    Not Confirmed
    arrow

    Janssen-Cilag AG

    Italy
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Virtual Booth Virtual Booth
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    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Velcade

    Dosage Form : Dry Sub

    Dosage Strength : 1mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    09

    Sandoz A / S,

    Switzerland
    Antibody Engineering
    Not Confirmed
    arrow

    Sandoz A / S,

    Switzerland
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Sweden

    bortezomib

    Brand Name : bortezomib Sandoz

    Dosage Form : POWDER FOR SOLUTION FOR INJECTION

    Dosage Strength : 3.5 MG

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Sweden

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    10

    Sandoz Pharmaceuticals AG

    Switzerland
    Antibody Engineering
    Not Confirmed
    arrow

    Sandoz Pharmaceuticals AG

    Switzerland
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info :

    Registration Country : Switzerland

    Bortezomibum

    Brand Name : Bortezomib Sandoz

    Dosage Form : Dry Sub

    Dosage Strength : 1mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    Canada

    read-more
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    01

    APOTEX INC

    Canada
    Antibody Engineering
    Not Confirmed
    arrow

    APOTEX INC

    Canada
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Flag Canada
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging : 10ML

    Approval Date :

    Application Number : 2456176

    Regulatory Info : Prescription

    Registration Country : Canada

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    02

    JANSSEN INC

    U.S.A
    Antibody Engineering
    Not Confirmed
    arrow

    JANSSEN INC

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Virtual Booth Virtual Booth
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : VELCADE

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging : 10 ML

    Approval Date :

    Application Number : 2262452

    Regulatory Info : Prescription

    Registration Country : Canada

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    03

    MARCAN PHARMACEUTICALS INC

    Canada
    Antibody Engineering
    Not Confirmed
    arrow

    MARCAN PHARMACEUTICALS INC

    Canada
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Virtual Booth Virtual Booth
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB FOR INJECTION

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number : 2493306

    Regulatory Info : Prescription

    Registration Country : Canada

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    04

    PFIZER CANADA ULC

    U.S.A
    Antibody Engineering
    Not Confirmed
    arrow

    PFIZER CANADA ULC

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    • WHO-GMP
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    Virtual Booth Virtual Booth
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB FOR INJECTION

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 2.5MG/VIAL

    Packaging : 10ML VIAL

    Approval Date :

    Application Number : 2467003

    Regulatory Info : Prescription

    Registration Country : Canada

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    05

    PHARMASCIENCE INC

    Canada
    Antibody Engineering
    Not Confirmed
    arrow

    PHARMASCIENCE INC

    Canada
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
    • WHO-GMP
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    Virtual Booth Virtual Booth
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : PMS-BORTEZOMIB

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number : 2466708

    Regulatory Info : Prescription

    Registration Country : Canada

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    06

    SANDOZ CANADA INCORPORATED

    Switzerland
    Antibody Engineering
    Not Confirmed
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    SANDOZ CANADA INCORPORATED

    Switzerland
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB FOR INJECTION SDZ

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number : 2503352

    Regulatory Info : Prescription

    Registration Country : Canada

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    07

    TARO PHARMACEUTICALS INC

    U.S.A
    Antibody Engineering
    Not Confirmed
    arrow

    TARO PHARMACEUTICALS INC

    U.S.A
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    • WHO-GMP
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : TARO-BORTEZOMIB

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 2.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number : 2511932

    Regulatory Info : Prescription

    Registration Country : Canada

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    08

    TEVA CANADA LIMITED

    Israel
    Antibody Engineering
    Not Confirmed
    arrow

    TEVA CANADA LIMITED

    Israel
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    • WHO-GMP
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB FOR INJECTION

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging : I.V.:3.5ML/S.C:1.4ML

    Approval Date :

    Application Number : 2423405

    Regulatory Info : Prescription

    Registration Country : Canada

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    09

    TEVA CANADA LIMITED

    Israel
    Antibody Engineering
    Not Confirmed
    arrow

    TEVA CANADA LIMITED

    Israel
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : ACT BORTEZOMIB

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging :

    Approval Date :

    Application Number : 2438399

    Regulatory Info : Prescription

    Registration Country : Canada

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    10

    DR REDDY'S LABORATORIES LTD

    Country
    Antibody Engineering
    Not Confirmed
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    DR REDDY'S LABORATORIES LTD

    Country
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
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    Regulatory Info : Prescription

    Registration Country : Canada

    BORTEZOMIB (BORTEZOMIB MANNITOL BORONIC ESTER)

    Brand Name : BORTEZOMIB FOR INJECTION

    Dosage Form : POWDER FOR SOLUTION

    Dosage Strength : 3.5MG/VIAL

    Packaging : SC: 1.4ML (2.5MG/ML) / IV: 3.5ML (1MG/ML)

    Approval Date :

    Application Number : 2452456

    Regulatory Info : Prescription

    Registration Country : Canada

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