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Chemistry

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Also known as: Brifentanil [inn], 101345-71-5, 6gdt77pqbw, N-[(3r,4s)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-n-(2-fluorophenyl)-2-methoxyacetamide, Brifentanilum, Brifentanyl
Molecular Formula
C20H29FN6O3
Molecular Weight
420.5  g/mol
InChI Key
KKMGCTVJCQYQPV-WBVHZDCISA-N
FDA UNII
6GDT77PQBW

Brifentanil
Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable itching and respiratory depression.
1 2D Structure

Brifentanil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[(3R,4S)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-N-(2-fluorophenyl)-2-methoxyacetamide
2.1.2 InChI
InChI=1S/C20H29FN6O3/c1-4-25-20(29)26(23-22-25)12-11-24-10-9-17(15(2)13-24)27(19(28)14-30-3)18-8-6-5-7-16(18)21/h5-8,15,17H,4,9-14H2,1-3H3/t15-,17+/m1/s1
2.1.3 InChI Key
KKMGCTVJCQYQPV-WBVHZDCISA-N
2.1.4 Canonical SMILES
CCN1C(=O)N(N=N1)CCN2CCC(C(C2)C)N(C3=CC=CC=C3F)C(=O)COC
2.1.5 Isomeric SMILES
CCN1C(=O)N(N=N1)CCN2CC[C@@H]([C@@H](C2)C)N(C3=CC=CC=C3F)C(=O)COC
2.2 Other Identifiers
2.2.1 UNII
6GDT77PQBW
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(2-(4-ethyl-4,5-dihydro-5-oxo1h-tetrazolyl)ethyl)-3-methyl-4-(n-(2-fluorophenyl)methoxyacetamido)piperidine

2. A 3331

3. A-3331

4. A-3331.hcl

5. Brifentanil Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. Brifentanil [inn]

2. 101345-71-5

3. 6gdt77pqbw

4. N-[(3r,4s)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-n-(2-fluorophenyl)-2-methoxyacetamide

5. Brifentanilum

6. Brifentanyl

7. N-[(3s,4r)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-n-(2-fluorophenyl)-2-methoxyacetamide

8. Brifentanilo

9. Unii-6gdt77pqbw

10. Brifentanilum [inn-latin]

11. Brifentanilo [inn-spanish]

12. A-3331-

13. Brifentanil [who-dd]

14. Schembl488879

15. Dtxsid20143867

16. Db09172

17. Q4967117

18. (+/-)-cis-n-(1-(2-(4-ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-3-methyl-4-piperidyl)-2'-fluoro-2-methoxyacetanilide

19. Acetamide, N-((3r,4s)-1-(2-(4-ethyl-4,5-dihydro-5-oxo-1h-tetrazol-1-yl)ethyl)-3-methyl-4-piperidinyl)-n-(2-fluorophenyl)-2-methoxy-, Rel-

20. Acetamide, N-(1-(2-(4-ethyl-4,5-dihydro-5-oxo-1h-tetrazol-1-yl)ethyl)-3-methyl-4-piperidinyl)-n-(2-fluorophenyl)-2-methoxy-, Cis-

21. Acetamide, N-(1-(2-(4-ethyl-4,5-dihydro-5-oxo-1h-tetrazol-1-yl)ethyl)-3-methyl-4-piperidinyl)-n-(2-fluorophenyl)-2-methoxy-, Cis-(+/-)-

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 420.5 g/mol
Molecular Formula C20H29FN6O3
XLogP32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass420.22851697 g/mol
Monoisotopic Mass420.22851697 g/mol
Topological Polar Surface Area81 Ų
Heavy Atom Count30
Formal Charge0
Complexity636
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 101345-71-5 / Brifentanil API manufacturers, exporters & distributors?

Brifentanil manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Brifentanil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Brifentanil manufacturer or Brifentanil supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Brifentanil manufacturer or Brifentanil supplier.

PharmaCompass also assists you with knowing the Brifentanil API Price utilized in the formulation of products. Brifentanil API Price is not always fixed or binding as the Brifentanil Price is obtained through a variety of data sources. The Brifentanil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Brifentanil

Synonyms

Brifentanil [inn], 101345-71-5, 6gdt77pqbw, N-[(3r,4s)-1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-3-methylpiperidin-4-yl]-n-(2-fluorophenyl)-2-methoxyacetamide, Brifentanilum, Brifentanyl

Cas Number

101345-71-5

Unique Ingredient Identifier (UNII)

6GDT77PQBW

About Brifentanil

Brifentanil (also known as A-3331) is an analog of fentanyl, a potent opioid. This drug is classified as an opioid analgesic and was developed in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable itching and respiratory depression.

Brifentanil Manufacturers

A Brifentanil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Brifentanil, including repackagers and relabelers. The FDA regulates Brifentanil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Brifentanil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Brifentanil Suppliers

A Brifentanil supplier is an individual or a company that provides Brifentanil active pharmaceutical ingredient (API) or Brifentanil finished formulations upon request. The Brifentanil suppliers may include Brifentanil API manufacturers, exporters, distributors and traders.

Brifentanil GMP

Brifentanil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Brifentanil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Brifentanil GMP manufacturer or Brifentanil GMP API supplier for your needs.

Brifentanil CoA

A Brifentanil CoA (Certificate of Analysis) is a formal document that attests to Brifentanil's compliance with Brifentanil specifications and serves as a tool for batch-level quality control.

Brifentanil CoA mostly includes findings from lab analyses of a specific batch. For each Brifentanil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Brifentanil may be tested according to a variety of international standards, such as European Pharmacopoeia (Brifentanil EP), Brifentanil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Brifentanil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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