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Chemistry

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Also known as: Brilaroxazine, 1239729-06-6, X8l60ba01i, 6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2h-benzo[b][1,4]oxazin-3(4h)-one, 2h-1,4-benzoxazin-3(4h)-one, 6-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-, 2h-1,4-benzoxazin-3(4h)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-
Molecular Formula
C22H25Cl2N3O3
Molecular Weight
450.4  g/mol
InChI Key
PMKMNTBZJOXTJW-UHFFFAOYSA-N
FDA UNII
X8L60BA01I

Brilaroxazine
Brilaroxazine (RP5063) is an investigational atypical antipsychotic which is under development by Reviva Pharmaceuticals for the treatment of schizophrenia and schizoaffective disorder. Reviva Pharmaceuticals also intends to investigate RP5063 for the treatment of bipolar disorder, major depressive disorder, psychosis/agitation associated with Alzheimer's disease, Parkinson's disease psychosis, attention deficit hyperactivity disorder (ADD/ADHD), and autism. As of May 2015, it is in phase III clinical trials for schizophrenia.
1 2D Structure

Brilaroxazine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-4H-1,4-benzoxazin-3-one
2.1.2 InChI
InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)
2.1.3 InChI Key
PMKMNTBZJOXTJW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1CCCCOC2=CC3=C(C=C2)OCC(=O)N3)C4=C(C(=CC=C4)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
X8L60BA01I
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Brilaroxazine

2. 1239729-06-6

3. X8l60ba01i

4. 6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2h-benzo[b][1,4]oxazin-3(4h)-one

5. 2h-1,4-benzoxazin-3(4h)-one, 6-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-

6. 2h-1,4-benzoxazin-3(4h)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-

7. 6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2h-benzo(b)(1,4)oxazin-3(4h)-one

8. Brilaroxazin

9. Brilaroxazine [inn]

10. Unii-x8l60ba01i

11. Brilaroxazine [who-dd]

12. Schembl3404085

13. Bdbm312188

14. Dtxsid001136921

15. Db09226

16. Rp-5063

17. Us9604944, 15b (example 14)

18. Hy-109112

19. Cs-0077721

20. 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-2h-1,4-benzoxazin-3(4h)-one

21. 6-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-4h-1,4-benzoxazin-3-one

22. 2036070-48-9

2.4 Create Date
2010-09-07
3 Chemical and Physical Properties
Molecular Weight 450.4 g/mol
Molecular Formula C22H25Cl2N3O3
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass449.1272971 g/mol
Monoisotopic Mass449.1272971 g/mol
Topological Polar Surface Area54 Ų
Heavy Atom Count30
Formal Charge0
Complexity562
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for the treatment of schizophrenia and schizoaffective disorder.


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ABOUT THIS PAGE

Brilaroxazine Manufacturers

A Brilaroxazine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Brilaroxazine, including repackagers and relabelers. The FDA regulates Brilaroxazine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Brilaroxazine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Brilaroxazine Suppliers

A Brilaroxazine supplier is an individual or a company that provides Brilaroxazine active pharmaceutical ingredient (API) or Brilaroxazine finished formulations upon request. The Brilaroxazine suppliers may include Brilaroxazine API manufacturers, exporters, distributors and traders.

Brilaroxazine GMP

Brilaroxazine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Brilaroxazine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Brilaroxazine GMP manufacturer or Brilaroxazine GMP API supplier for your needs.

Brilaroxazine CoA

A Brilaroxazine CoA (Certificate of Analysis) is a formal document that attests to Brilaroxazine's compliance with Brilaroxazine specifications and serves as a tool for batch-level quality control.

Brilaroxazine CoA mostly includes findings from lab analyses of a specific batch. For each Brilaroxazine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Brilaroxazine may be tested according to a variety of international standards, such as European Pharmacopoeia (Brilaroxazine EP), Brilaroxazine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Brilaroxazine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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