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1. Anxyrex
2. Apo Bromazepam
3. Apo-bromazepam
4. Beta, Bromazepam
5. Bromalich
6. Bromaz 1a Pharma
7. Bromazanil
8. Bromazep Von Ct
9. Bromazepam Al
10. Bromazepam Beta
11. Bromazepam Heumann
12. Bromazepam Neuraxpharm
13. Bromazepam Ratiopharm
14. Bromazepam-neuraxpharm
15. Bromazepam-ratiopharm
16. Durazanil
17. Gen Bromazepam
18. Gen-bromazepam
19. Lexatin
20. Lexomil
21. Lexotan
22. Lexotanil
23. Ro 5-3350
24. Ro 53350
25. Von Ct, Bromazep
1. Lexotanil
2. Compedium
3. Durazanil
4. Lectopam
5. Lexotan
6. Creosedin
7. Lexaurin
8. Lexilium
9. Lekotam
10. Lexomil
11. 1812-30-2
12. Calmepam
13. Compendium
14. Normoc
15. La Xvii
16. Ro 5-3350
17. Bromazepamum [inn-latin]
18. Lexatin
19. 7-bromo-5-(2-pyridyl)-3h-1,4-benzodiazepin-2(1h)-one
20. 7-bromo-1,3-dihydro-5-(2-pyridyl)-2h-1,4-benzodiazepin-2-one
21. Bromazepam Civ
22. 2h-1,4-benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
23. Nsc 140669
24. 7-bromo-5-pyridin-2-yl-1,3-dihydro-1,4-benzodiazepin-2-one
25. Ultramidol
26. 7-bromo-1,3-dihydro-5-(2-pyridyl)-2h-1,4-benzdiazepin-2-one
27. Nsc-140669
28. 1,3-dihydro-7-bromo-5-(2-pyridyl)-2h-1,4-benzodiazepin-2-one
29. 2h-1,4-benzodiazepin-2-one, 1,3-dihydro-7-bromo-5-(2-pyridyl)-
30. X015l14v0o
31. 2h-1,4-benzodiazepin-2-one, 7-bromo-1,3-dihydro-5-(2-pyridyl)-
32. 7-bromo-5-(2-pyridyl)-3h-1,4-benzodiaxepin-2(1h)-one
33. Bromazepamum
34. Bromazepamum [latin]
35. Ro-5-3350
36. Bromazepam [usan:inn:ban:jan]
37. Lectopam (tn)
38. Einecs 217-322-4
39. Ro 53350
40. Ro 4-9253
41. Brn 0618645
42. 7-bromo-5-[2-pyridyl]-3h-1,4-benzodiaxepin-2[1h]-one
43. Unii-x015l14v0o
44. Dea No. 2748
45. Bromazepam [mi]
46. Bromazepam [inn]
47. Bromazepam [jan]
48. Bromazepam [usan]
49. Bromazepam [mart.]
50. Bromazepam [who-dd]
51. Schembl43933
52. 5-26-05-00078 (beilstein Handbook Reference)
53. Mls003899212
54. Bromazepam, Analytical Standard
55. Chembl277062
56. Zinc1051
57. Bromazepam (jp17/usan/inn)
58. Bromazepam Civ [usp-rs]
59. Chebi:31302
60. Bromazepam [ep Monograph]
61. Dtxsid40171081
62. 7-bromo-1,4-benzodiazepin-2-one
63. Bromazepam 0.1 Mg/ml In Methanol
64. Bromazepam 1.0 Mg/ml In Methanol
65. Nsc140669
66. Db01558
67. Smr000058724
68. Wln: T67 Gmv Jn Ihj Ce K- Bt6nj
69. D01245
70. 2h-1, 7-bromo-1,3-dihydro-5-(2-pyridyl)-
71. 2h-1, 7-bromo-1,3-dihydro-5-(2-pyridinyl)-
72. 812b302
73. Bromazepam, Drug Standard, 1.0 Mg/ml In Methanol
74. Q422435
75. Bromazepam, European Pharmacopoeia (ep) Reference Standard
76. Bromazepam, United States Pharmacopeia (usp) Reference Standard
77. 7-bromo-5-(pyridin-2-yl)-1h-benzo[e][1,4]diazepin-2(3h)-one
78. 7-bromo-5-(pyridin-2-yl)-2,3-dihydro-1h-1,4-benzodiazepin-2-one
79. (e)-7-bromo-5-(pyridin-2-yl)-1h-benzo[e][1,4]diazepin-2(3h)-one
80. 7-bromo-5-(2-pyridinyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one #
81. Bromazepam Solution, 1.0 Mg/ml In Methanol, Ampule Of 1 Ml, Certified Reference Material
| Molecular Weight | 316.15 g/mol |
|---|---|
| Molecular Formula | C14H10BrN3O |
| XLogP3 | 1.7 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 1 |
| Exact Mass | 315.00072 g/mol |
| Monoisotopic Mass | 315.00072 g/mol |
| Topological Polar Surface Area | 54.4 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 385 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For the short-term treatment of insomnia, short-term treatment of anxiety or panic attacks, if a benzodiazepine is required, and the alleviation of the symptoms of alcohol- and opiate-withdrawal.
Bromazepam is a lipophilic, long-acting benzodiazepine and with sedative, hypnotic, anxiolytic and skeletal muscle relaxant properties. It does not possess any antidepressant qualities. Bromazepam, like other benzodiazepines, presents a risk of abuse, misuse, and dependence. According to many psychiatric experts, Bromazepam has a greater abuse potential than other benzodiazepines because of fast resorption and rapid onset of action.
GABA Modulators
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)
Anti-Anxiety Agents
Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)
N05BA08
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BA - Benzodiazepine derivatives
N05BA08 - Bromazepam
Absorption
Bioavailability is 84% following oral administration. The time to peak plasma level is 1 - 4 hours. Bromazepam is generally well absorbed after oral administration.
Route of Elimination
Urine (69%), as metabolites
Volume of Distribution
1.56 L/kg
Clearance
0.82 mL/min/kg.
Hepatically, via oxidative pathways (via an enzyme belonging to the Cytochrome P450 family of enzymes). One of the main metabolites is 3-hydroxybromazepam. It is pharmacologically active and the half life is similar to that of the parent compound.
Bromazepam has known human metabolites that include 3-Hydroxybromazepam.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
10-20 hours
Bromazepam binds to the GABA-A receptor producing a conformational change and potentiating its inhibitory effects. Other neurotransmitters are not influenced.
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