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Bromelain

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers, 3 USDMF, 1 JDMF, 6 Listed Suppliers, $ API Reference Price

9 API Suppliers
3 USDMF
1 JDMF
6 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

15 Drugs in Development

15 Drugs in Development

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers, 2 Europe

2 FDF Dossiers
2 Europe

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16 APIs

marketPlace
16 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Muxf, M0xf(3), Bromelain, technical grade, Chebi:53469, 9001-00-7, Fuc-alpha-(1->3)-[man-alpha-(1->6)-[xyl-beta-(1->2)]-man-beta-(1->4)-glcnac-beta-(1->4)]-glcnac

Molecular Formula

C₃₉H₆₆N₂O₂₉

Molecular Weight

1026.9 g/mol

InChI Key

UNMLVGNWZDHBRA-UFAVQCRNSA-N

Protein-digesting and milk-clotting enzymes found in PINEAPPLE fruit juice and stem tissue. Enzymes from the two sources are distinguished as fruit bromelain and stem bromelain. This enzyme was formerly listed as EC 3.4.22.4.

1 2D Structure

Bromelain

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4R,5R)-5-acetamido-6-hydroxy-2-(hydroxymethyl)-4-[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl]oxy-5-[(2S,3S,4S,5S,6R)-4,5-dihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide

2.1.2 InChI

InChI=1S/C39H66N2O29/c1-9-19(48)24(53)29(58)38(62-9)69-32-18(41-11(3)46)34(59)63-15(6-44)31(32)68-35-17(40-10(2)45)23(52)30(14(5-43)65-35)67-39-33(70-37-27(56)20(49)12(47)7-60-37)26(55)22(51)16(66-39)8-61-36-28(57)25(54)21(50)13(4-42)64-36/h9,12-39,42-44,47-59H,4-8H2,1-3H3,(H,40,45)(H,41,46)/t9-,12+,13+,14+,15+,16+,17+,18+,19+,20-,21+,22+,23+,24+,25-,26-,27+,28-,29-,30+,31+,32+,33-,34?,35-,36-,37-,38-,39-/m0/s1

2.1.3 InChI Key

UNMLVGNWZDHBRA-UFAVQCRNSA-N

2.1.4 Canonical SMILES

CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)COC5C(C(C(C(O5)CO)O)O)O)O)O)OC6C(C(C(CO6)O)O)O)O)NC(=O)C)CO)O)NC(=O)C)O)O)O

2.1.5 Isomeric SMILES

C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@H]2[C@@H]([C@H](OC([C@@H]2NC(=O)C)O)CO)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O[C@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO[C@@H]5[C@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O)O)O[C@H]6[C@@H]([C@H]([C@@H](CO6)O)O)O)O)NC(=O)C)O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Ananase

2. Bromelain

3. Bromelain Pos

4. Bromelain-pos

5. Bromelainpos

6. Bromelains

7. Bromelin

8. Bromelins

9. Dayto Anase

10. Debrase

11. Dontisanin

12. Extranase

13. Mucozym

14. Proteozym

15. Traumanase

2.2.2 Depositor-Supplied Synonyms

1. Muxf

2. M0xf(3)

3. Bromelain, Technical Grade

4. Chebi:53469

5. 9001-00-7

6. Fuc-alpha-(1->3)-[man-alpha-(1->6)-[xyl-beta-(1->2)]-man-beta-(1->4)-glcnac-beta-(1->4)]-glcnac

7. Alpha-l-fuc-(1->3)-[alpha-d-man-(1->6)-[beta-d-xyl-(1->2)]-beta-d-man-(1->4)-beta-d-glcnac-(1->4)]-d-glcnac

8. Alpha-l-fucopyranosyl-(1->3)-[alpha-d-mannopyranosyl-(1->6)-[beta-d-xylopyranosyl-(1->2)]-beta-d-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-d-glucopyranosyl-(1->4)]-2-acetamido-2-deoxy-d-glucopyranose

9. Alpha-l-fucosyl-(1->3)-[alpha-d-mannosyl-(1->6)-[beta-d-xylosyl-(1->2)]-beta-d-mannosyl-(1->4)-n-acetyl-beta-d-glucosaminyl-(1->4)]-n-acetyl-d-glucosamine

10. Alpha-l-fucp-(1->3)-[alpha-d-manp-(1->6)-[beta-d-xylp-(1->2)]-beta-d-manp-(1->4)-beta-d-glcpnac-(1->4)]-d-glcpnac

11. Bromelaine

12. Epitope Id:115005

13. Q27124066

14. N_full_22100100000000_gs_1023_c1

15. Man(a1-6)[xyl(b1-2)]man(b1-4)glcnac(b1-4)[fuc(a1-3)]glcnac

16. Wurcs=2.0/6,6,5/[a2122h-1x_1-5_2*ncc/3=o][a1221m-1a_1-5][a2122h-1b_1-5_2*ncc/3=o][a1122h-1b_1-5][a212h-1b_1-5][a1122h-1a_1-5]/1-2-3-4-5-6/a3-b1_a4-c1_c4-d1_d2-e1_d6-f1

2.3 Create Date

2009-11-19

3 Chemical and Physical Properties

Molecular Formula	C₃₉H₆₆N₂O₂₉
Molecular Weight	1026.9 g/mol
XLogP3	-11.6
Hydrogen Bond Donor Count	18
Hydrogen Bond Acceptor Count	29
Rotatable Bond Count	16
Exact Mass	1026.37512407 g/mol
Monoisotopic Mass	1026.37512407 g/mol
Topological Polar Surface Area	483 Å²
Heavy Atom Count	70
Formal Charge	0
Complexity	1680
Isotope Atom Count	0
Defined Atom Stereocenter Count	28
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Bromelain has /shown/ some success as a substitute for trypsin and pepsin in cases of pancreatic insufficiency and post-pancreatectomy.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.72 (2001)

Acute postoperative and post-traumatic conditions of swelling, especially of the nasal and paranasal sinuses.

Blumenthal M, ed; The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines p.94 (1998)

In an open case observation study involving patients with blunt injuries to the musculoskeletal system, the efficacy and tolerability of high-dose Bromelain POS, a plant-derived enzyme preparation, were investigated. The investigating physician was an orthopedic surgeon who, in addition to the usual therapeutic measures, treated 59 of his patients with the bromelaine preparation. The duration of the application was determined by the nature and severity of the lesion, and varied between one and three weeks. The test criteria were swelling, pain at rest and during movement, and tenderness. These parameters were evaluated on the day of the injury and on five subsequent dates. Treatment with bromelaine resulted in a clear reduction in all four parameters tested. Both swelling and the symptoms of pain had improved appreciably at all evaluation time points as compared with baseline. The tolerability of the preparation was very good, and patient compliance was correspondingly high.

PMID:7672747 Masson M; Fortschr Med 113 (19): 303-6 (1995)

4.2 Drug Warning

Gastrointestinal symptoms such as nausea and vomiting, diarrhea and cramping have been reported. There are occasional reports of metrorrhagia and menorrhagia.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.72 (2001)

As with papain and other proteases, bromelain may cause contact allergenic reactions in certain individuals.

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 101

Bromelain supplements should be avoided by pregnant women and nursing mothers.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.70 (2001)

In one double-blind study of 73 patients with acute thrombophlebitis, bromelain, used with analgesics, reduced pain, edema, redness, tenderness, elevated skin temperature and disability.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.72 (2001)

Those on anticoagulants or antithrombotic agents should exercise caution in the use of bromelain. Bromelain may have blood thinning activity in some.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.70 (2001)

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

Evidence that bromelains (I) is absorbed from the gastrointestinal tract of rats after oral administration is demonstrated in a bioavailability study in which 125I is given by oral route to rats and blood levels sampled at various times thereafter. A maximum level of 270 ng/ml I was found at one hr after administration.

PMID:3207859 White RR et al; Biopharm Drug Dispos 9 (Jul-Aug): 397-403 (1988)

Bromelain, a standardized complex of proteases from the pineapple plant, is absorbed unchanged from the intestine of animals at a rate of 40% ... .

PMID:2203073 Lotz-Winter H; Planta Med 56 (3): 249-53 (1990)

5.2 Mechanism of Action

It has been postulated that a minor enzymatic component present in bromelain is responsible for the release of a kinin, which stimulates the production of prostaglandin E1-like compounds; These PGE1-like compounds are then responsible for the physiological activities of bromelain.

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 101

Bromelain's digestant activity is based on its ability to hydrolyze proteins to oligopeptides and amino acids. Bromelain's proteolytic enzymes are cysteine proteases. Cysteine proteases cleave peptide bonds by nucleophilic attack via active-site cysteine residues.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.71 (2001)

The mechanism of the putative anti-inflammatory activity ... may be accounted for, in part, by activation of plasmin production from plasminogen and reduction of kinin via inhibition of the conversion of kininogen to kinin. Other possibilities, may include proteolytic degradation of circulating immune complexes and inhibition of signaling by extracellular regulated kinase (ERK-2) and p21 ras.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.71 (2001)

Bromelain has been shown to increase CD2-mediated T cell activation, to enhance antigen-independent binding to monocytes and to increase interferon (IFN)-gamma-dependant, tumor necrosis factor (TNF)-alpha, Interleukin (IL)-1 beta, and interleukin (IL)-6 production in peripheral blood monocytes. These effects are thought to be due to bromelains proteolytic activity at cell surfaces, whereby it either removes surface molecules or reveals ones that already exist on cell membranes, thereby altering receptor-ligand interactions.

Medical Economics Co; Physicians Desk Reference for Nutritional Supplements 1st ed p.71 (2001)

For more Mechanism of Action (Complete) data for BROMELAINS (7 total), please visit the HSDB record page.

API SUPPLIERS

01

Zeon Pharma Industries India Pvt L...

India

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02

Jai Radhe Sales

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

03

Apollo Ingredients India Pvt Ltd

India

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Not Confirmed

04

Newgen Biotech USA

U.S.A

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Bio-gen Extracts

India

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Beloorbayir Biotech

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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07

Vaishali Pharma Ltd

India

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Guangxi Nanning Baihui Pharmaceuti...

China

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Zeon Pharma Industries India Pvt Lt...

India

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Bromelain

About the Company : Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish form...

Zeon Pharma Industries India Pvt ltd is an ISO & GMP certified manufacturer of Bulk drugs & Intermediate and also supplies our associate manufacturing plant API / Semi finish formulations/Excipients, Phytochemicals/Enzymes & Intermediate and also has a GMP certified Manufacturing facility for Phytochemicals/Herbal extract and Enzymes through our associates.

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Jai Radhe Sales

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About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

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Beloorbayir Biotech

India

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Bio-gen Extracts

India

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Newgen Biotech USA

U.S.A

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Vaishali Pharma Ltd

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API Reference Price

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2400 GDU. BATCH NO: N24176. MFG DT:JUL-24. EXP DT:JUN-27","address":"N0. 991, SWAMY NARAYANA APTS,","city":"6TH BLOCK, VIDYARANYAPURA BANGALORE","supplier":"NOVEL NUTRIENTSS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"JAKARTA SOEKARNO-HA","customer":"PT. KEMTEKINDO GLOBAL KHALIFA","customerCountry":"INDONESIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"40","totalValueFC":"7660.1","currency":"USD","unitRateINR":3201.5981999999999,"date":"18-Jul-2024","totalValueINR":"640319.64","totalValueInUsd":"7660.1","indian_port":"Bangalore Air","hs_no":"29225090","bill_no":"2509469","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0. 991, SWAMY NARAYANA APTS,, 6TH BLOCK, VIDYARANYAPURA BANGALORE","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728325800,"product":"BROMELAIN 2400 GDU. BATCH NO:N24207. MFGDT:AUG-24. EXP DT:JUL-27","address":"N0. 991, SWAMY NARAYANA APTS,","city":"6TH BLOCK, VIDYARANYAPURA BANGALORE","supplier":"NOVEL NUTRIENTSS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"JAKARTA SOEKARNO-HA","customer":"PT. LAM SENG ","customerCountry":"INDONESIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"40","totalValueFC":"7665.4","currency":"USD","unitRateINR":3220.4989500000001,"date":"08-Oct-2024","totalValueINR":"644099.79","totalValueInUsd":"7665.4","indian_port":"Bangalore Air","hs_no":"29225090","bill_no":"4667286","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"N0. 991, SWAMY NARAYANA APTS,, 6TH BLOCK, VIDYARANYAPURA BANGALORE","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

01 MediWound

Israel

PharmaVenue

Not Confirmed

02 MediWound

Israel

PharmaVenue

Not Confirmed

03 MediWound

Israel

PharmaVenue

Not Confirmed

04 Aksigen Hospital Care

India

PharmaVenue

Not Confirmed

05 MediWound

Israel

PharmaVenue

Not Confirmed

06 MediWound

Israel

PharmaVenue

Not Confirmed

07 MediWound

Israel

PharmaVenue

Not Confirmed

08 MediWound

Israel

PharmaVenue

Not Confirmed

09 MediWound

Israel

PharmaVenue

Not Confirmed

10 MediWound

Israel

PharmaVenue

Not Confirmed

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FDF Dossiers

01

Country

PharmaVenue

Not Confirmed

02

Country

PharmaVenue

Not Confirmed

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Europe

01

MediWound Germany GmbH

Country

PharmaVenue

Not Confirmed

02

MediWound Germany GmbH

Country

PharmaVenue

Not Confirmed

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Market Place

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APIs

Bromelain (20 kg) API needed in Vietnam [ENA20915]

A company that focuses on development, manufacturing, and distribution of pharmaceuticals, health supplement, cosmeceutical products and medical devices is looking for suppliers of Bromelain (20 kg) API for development purposes. The suppliers must support this enquiry with DMF, GMP & CoA.

22 Oct 2024

Bromelain (3 MT) API needed in Egypt [ENA20214]

A company that focuses on manufacturing of various own branded generics, OTC, food supplements and veterinary products is looking for suppliers of Bromelain (3 MT) API for commercial purposes. The suppliers must support this enquiry with GMP & CoA.

07 Aug 2024

Bromelain (95 kg) API needed in Canada [ENA19434]

A contract development and manufacturing organization (CDMO) with capabilities for manufacturing and developing various powders and tablets is looking for suppliers of Bromelain (95 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.

29 Apr 2024

Various APIs needed in India [ENA17137]

A pharmaceutical manufacturing company that deals in beta-lactam, non-beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with CoA. 1. Bromelain (25 kg) API 2. Metoprolol Succinate (25 kg) API

20 May 2023

Various APIs needed in South Korea [ENA15883]

A company that focuses on the manufacturing of granules is looking for suppliers of Various APIs for commercial purposes. The suppliers must support this enquiry with GMP & CoA. 1. Pancreatin (10 MT/ annum) API 2. Lipase (2 MT/ annum) API 3. Cellulase (1.5 MT/ annum) API 4. Bromelain (2 MT/ annum) API 5. Simethicone (4 MT/ annum) API

21 Dec 2022

Various APIs needed in India [ENA15853]

A contract research organization that focuses on the formulation development of conventional and novel drug delivery products is looking for suppliers of Various APIs for development purposes. The required quantity is MOQ for each. The suppliers must support this enquiry with CoA. 1. IP/ BP Grade Amoxicillin API 2. IP/ BP Grade Bromelain API 3. IP/ BP Grade Febuxostat API 4. IP/ BP Grade Montelukast API 5. IP/ BP Grade Fexofenadine HCl API

17 Dec 2022

Various APIs needed in India [ENA12961]

A pharmaceutical manufacturing company that deals in beta-lactam, non beta-lactam and food supplements for both tablets and capsules is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with CoA. 1. Vildagliptin (25 kg) API 2. Calcium Citrate Malate (200 kg) API 3. Bromelain (25 kg) API

11 Mar 2022

Various APIs needed in Taiwan [ENA12663]

A company that deals in R&D and manufacturing of finished formulations is looking for suppliers of Various APIs for commercial purpose. 1. Dihydroxyaluminum Allantoinate (200 kg) API 2. Bromelain (500 kg) API 3. Aluminum Magnesium Co-Dried Gel (1 MT) API 4. Nitrofurazone (20 kg) API 5. Nicametate Citrate (100 kg) API

10 Feb 2022

Various APIs needed in India [ENA12256]

A company that deals in various pharmaceutical products like injections, syrups & hygiene products is looking for suppliers of Various APIs for commercial purpose. 1. Gentamicin (25 kg) API 2. Terlipressin (1 kg) API 3. Trypsin (10 kg) API 4. Bromelain (25 kg) API 5. Rutoside Trihydrate (5 kg) API

29 Dec 2021

Various APIs needed in Vietnam [ENA10766]

DSL Global, a company that deals in manufacturing, trading, importing and exporting of pharmaceutical products is looking for suppliers of various APIs. The suppliers must support this enquiry with DMF or CEP, GMP & CoA. Interested suppliers can contact them via their email: lientran@dslglobalvn.com. 1. D-alpha-tocopherol (7 kg) API 2. L-Arginine L-Glutamate (3 MT) API 3. Sodium Alginate (500 kg) API 4. Lovastatin (20 kg) API 5. Misoprostol (100 g) API 6. Attapulgite (2.5 MT) API 7. Bromelain (100 g) API 8. Calciferol (100 g) API

02 Jul 2021

Only 10 entries up to this point, click to access all

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ABOUT THIS PAGE

Bromelain Manufacturers

A Bromelain manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Bromelain, including repackagers and relabelers. The FDA regulates Bromelain manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Bromelain API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Bromelain manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Bromelain Suppliers

A Bromelain supplier is an individual or a company that provides Bromelain active pharmaceutical ingredient (API) or Bromelain finished formulations upon request. The Bromelain suppliers may include Bromelain API manufacturers, exporters, distributors and traders.

click here to find a list of Bromelain suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Bromelain USDMF

A Bromelain DMF (Drug Master File) is a document detailing the whole manufacturing process of Bromelain active pharmaceutical ingredient (API) in detail. Different forms of Bromelain DMFs exist exist since differing nations have different regulations, such as Bromelain USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Bromelain DMF submitted to regulatory agencies in the US is known as a USDMF. Bromelain USDMF includes data on Bromelain's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Bromelain USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Bromelain suppliers with USDMF on PharmaCompass.

Bromelain JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Bromelain Drug Master File in Japan (Bromelain JDMF) empowers Bromelain API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Bromelain JDMF during the approval evaluation for pharmaceutical products. At the time of Bromelain JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Bromelain suppliers with JDMF on PharmaCompass.

Bromelain GMP

Bromelain Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Bromelain GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Bromelain GMP manufacturer or Bromelain GMP API supplier for your needs.

Bromelain CoA

A Bromelain CoA (Certificate of Analysis) is a formal document that attests to Bromelain's compliance with Bromelain specifications and serves as a tool for batch-level quality control.

Bromelain CoA mostly includes findings from lab analyses of a specific batch. For each Bromelain CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Bromelain may be tested according to a variety of international standards, such as European Pharmacopoeia (Bromelain EP), Bromelain JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Bromelain USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers

3 USDMF

1 JDMF

6 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

15 Drugs in Development

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers

2 Europe

MARKET PLACE

16 APIs

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 35

MARKET PLACE

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

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0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

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MediWound Germany GmbH

MediWound Germany GmbH

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MediWound Germany GmbH

MediWound Germany GmbH

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