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9 API Suppliers, 5 USDMF, 1 EU WC, 1 NDC API, 5 Listed Suppliers, $ API Reference Price

9 API Suppliers
5 USDMF
1 EU WC
1 NDC API
5 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

10 FDF Dossiers, 10 FDA Orange Book

10 FDF Dossiers
10 FDA Orange Book

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relatedExcipients
1 Evonik
7 Rochem International Inc
17 SPI Pharma
2 Seqens
9 DKSH
1 Pharm-RX Chemical
8 Faran Shimi Pharmaceutical
4 Boai NKY Pharmaceuticals Ltd
15 Gangwal Healthcare
7 Nanjing Well Pharmaceutical
2 Pfanstiehl
4 ACG Worldwide
10 Actylis
1 Aeon Procare
8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
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1 Bioplus Life Sciences
1 Clariant
11 Corel Pharma Chem
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9 Ideal Cures Pvt Ltd
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3 Pharmatrans-Sanaq
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1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
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2 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
3 The Dow Chemical Company
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REF. STANDARDS & IMPURITIES

1 USP , 1 Others

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1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

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CEP/COS

JDMF

EU WC

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NDC API

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API REF. PRICE (USD/KG)

$ 1,236

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Chemistry

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Also known as: 2391-03-9, Disomer, (+)-brompheniramine maleate, (s)-brompheniramine maleate, Brompheniramine d-form maleate, Chebi:59273

Molecular Formula

C₂₀H₂₃BrN₂O₄

Molecular Weight

435.3 g/mol

InChI Key

SRGKFVAASLQVBO-DASCVMRKSA-N

FDA UNII

BPA9UT29BS

Dexbrompheniramine Maleate is the maleate salt form of dexbrompheniramine, an alkylamine derivative with anticholinergic and sedative properties. Dexbrompheniramine is a histamine H1-receptor antagonist that competes with histamine for the H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract. The antagonistic action of this agent blocks the activities of endogenous histamine, which subsequently leads to temporary relief from the negative histamine-mediated symptoms of allergic reaction such as bronchoconstriction, vasodilation, increased capillary permeability and spasmodic contractions of gastrointestinal smooth muscle.

1 2D Structure

Dexbrompheniramine Maleate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid

2.1.2 InChI

InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1

2.1.3 InChI Key

SRGKFVAASLQVBO-DASCVMRKSA-N

2.1.4 Canonical SMILES

CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

CN(C)CC[C@@H](C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

BPA9UT29BS

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Dexbrompheniramine

2. Disophrol

2.3.2 Depositor-Supplied Synonyms

1. 2391-03-9

2. Disomer

3. (+)-brompheniramine Maleate

4. (s)-brompheniramine Maleate

5. Brompheniramine D-form Maleate

6. Chebi:59273

7. Dexbrompheniramine Fumarate

8. Bpa9ut29bs

9. 2391-03-9 (maleate)

10. Dsstox_cid_27795

11. Dsstox_rid_82567

12. Dsstox_gsid_47818

13. Dexbrompheniramine Maleate (usp)

14. Dexbrompheniramine Maleate [usp]

15. Disomer Maleate

16. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine Maleate

17. 2-pyridinepropanamine, G-(4-bromophenyl)-n,n-dimethyl-, (gs)-,(2z)-2-butenedioate (1:1)

18. Cas-2391-03-9

19. Ncgc00162100-02

20. Alahist Ir

21. Alahist Pe

22. Disomer (tn)

23. D-brompheniramine Maleate

24. Unii-bpa9ut29bs

25. Mls001401374

26. Schembl217770

27. 3-(2-hydroxyphenyl)benzoicacid

28. Chembl1200638

29. Dtxsid6047818

30. (+)-brompheniramine Maleate Salt

31. Hms2051f10

32. Hms2235o07

33. Hms3260p05

34. Einecs 219-236-2

35. Tox21_112000

36. Tox21_500232

37. Bdbm50247924

38. Akos015962824

39. Tox21_112000_1

40. Ac-1161

41. Ccg-101017

42. Lp00232

43. Nc00267

44. Ncgc00015146-11

45. Ncgc00093697-01

46. Ncgc00260917-01

47. Dexbrompheniramine Maleate [mart.]

48. Dexbrompheniramine Maleate [vandf]

49. Smr000471616

50. Dexbrompheniramine Maleate [usp-rs]

51. Dexbrompheniramine Maleate [who-dd]

52. Brompheniramine D-form Maleate [mi]

53. Eu-0100232

54. B 5275

55. D03704

56. Dexbrompheniramine Maleate [orange Book]

57. Dexbrompheniramine Maleate [usp Monograph]

58. Sr-01000075719

59. Disobrom Component Dexbrompheniramine Maleate

60. Disophrol Component Dexbrompheniramine Maleate

61. Drixoral Component Dexbrompheniramine Maleate

62. Resporal Component Dexbrompheniramine Maleate

63. Sr-01000075719-1

64. Brompheril Component Dexbrompheniramine Maleate

65. Dexbrompheniramine Maleate Component Of Disobrom

66. Dexbrompheniramine Maleate Component Of Drixoral

67. Dexbrompheniramine Maleate Component Of Resporal

68. Q27126583

69. Dexbrompheniramine Maleate Component Of Brompheril

70. Dexbrompheniramine Maleate Component Of Disophrol

71. Drixoral Plus Component Dexbrompheniramine Maleate

72. Dexbrompheniramine Maleate Component Of Drixoral Plus

73. (+)-2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

74. (s)-1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane Maleate

75. (s)-2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

76. (+)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate

77. (+)-3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

78. (+)-3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

79. (s)-3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

80. (s)-3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

81. (+)-2-(p-bromo-.alpha.-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

82. (+)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

83. (+)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

84. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine (2z)-but-2-enedioate

85. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

86. (3s)-3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine;(z)-but-2-enedioic Acid

87. (s)-2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridinium (z)-maleate (1:1)

88. (s)-3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

89. Dexbrompheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

90. Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1), (s)-

91. 2-pyridinepropanamine, G-(4-bromophenyl)-n,n-dimethyl-, (s)-, (z)-2-butenedioate (1:1)

92. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (s)-, (z)-2-butenedioate (1:1)

2.4 Create Date

2006-04-28

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃BrN₂O₄
Molecular Weight	435.3 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	434.08412 g/mol
Monoisotopic Mass	434.08412 g/mol
Topological Polar Surface Area	90.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	368
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

API SUPPLIERS

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USDMF

01

Chunghwa Chemical Synthesis And Biot...

Taiwan

AES 2024

Not Confirmed

Chunghwa provides cost-effective APIs & advanced intermediates with complete DMF or COS, ensuring quality & reliable production.

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Digital Content

Dexbrompheniramine Maleate

GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 8625

Submission : 1990-06-28

Status : Active

Type : II

05

Ganes Chemicals Inc Pennsville Div

Country

AES 2024

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

01

Avanthi Pharma

U.S.A

AES 2024

Not Confirmed

02

Bayer AG

Germany

United Kingdom

Iraq

AES 2024

Not Confirmed

10

Sandoz B2B

Switzerland

AES 2024

Not Confirmed

Switzerland

AES 2024

Not Confirmed

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers

5 USDMF

1 EU WC

1 NDC API

5 Listed Suppliers

$ API Reference Price

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10 FDF Dossiers

10 FDA Orange Book

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EXCIPIENTS BY APPLICATIONS

96 Fillers, Diluents & Binders

59 Coating Systems & Additives

42 Direct Compression

37 Thickeners and Stabilizers

34 Controlled & Modified Release

32 Solubilizers

30 Taste Masking

30 Disintegrants & Superdisintegrants

27 Granulation

25 Parenteral

25 Film Formers & Plasticizers

21 Co-Processed Excipients

20 Topical

20 Lubricants & Glidants

18 Chewable & Orodispersible Aids