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Brompheniramine Maleate

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13 API Suppliers
9 USDMF
1 CEP/COS
2 EU WC
4 NDC API
6 Listed Suppliers
$ API Reference Price

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44 FDF Dossiers
39 FDA Orange Book
2 Canada
1 South Africa
2 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem, 5 Rochem International Inc, 6 SPI Pharma, 4 DKSH, 3 Pharm-RX Chemical, 12 Gangwal Healthcare, 4 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 8 Actylis, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 1 BASF, 1 Bioplus Life Sciences, 4 DFE Pharma, 1 Finar, 6 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 19 Kerry, 9 Microlex e.U, 1 Pharmatrans-Sanaq, 5 Pluviaendo, 2 Prachin Chemical, 25 Roquette, 1 Seppic, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 9 Sigachi Industries, 1 Valens Pharmachem, 2 Vasa Pharmachem, 2 Zhejiang Huakang Pharmaceutical

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1 USP
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Synopsis

ACTIVE PHARMA INGREDIENTS

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API REF. PRICE (USD/KG)

$ 200

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Canada

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Listed Dossiers

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Chemistry

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Also known as: 980-71-2, Brompheniramine hydrogen maleate, Dimetane, Rolabromophen, Dimotane, Parabromdylamine maleate

Molecular Formula

C₂₀H₂₃BrN₂O₄

Molecular Weight

435.3 g/mol

InChI Key

SRGKFVAASLQVBO-BTJKTKAUSA-N

FDA UNII

IXA7C9ZN03

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

1 2D Structure

Brompheniramine Maleate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine;(Z)-but-2-enedioic acid

2.1.2 InChI

InChI=1S/C16H19BrN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

2.1.3 InChI Key

SRGKFVAASLQVBO-BTJKTKAUSA-N

2.1.4 Canonical SMILES

CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O

2.2 Other Identifiers

2.2.1 UNII

IXA7C9ZN03

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Brompheniramine

2. Brompheniramine Maleate (1:1)

3. Chlorphed

4. Dimetane

5. Dimetane Ten

6. Dimetane-ten

7. Dimetapp Allergy

8. Maleate, Brompheniramine

9. Oraminic 2

10. Oraminic-2

11. P Bromdylamine

12. P-bromdylamine

13. Para Bromdylamine

14. Para-bromdylamine

2.3.2 Depositor-Supplied Synonyms

1. 980-71-2

2. Brompheniramine Hydrogen Maleate

3. Dimetane

4. Rolabromophen

5. Dimotane

6. Parabromdylamine Maleate

7. Veltane

8. Dimetane-ten

9. Brompheniramine (maleate)

10. Lodrane

11. Brompheniramine Maleate [usp]

12. (+/-)-brompheniramine Maleate

13. Dimetapp Allergy

14. Nsc-758652

15. Ixa7c9zn03

16. Mls000028423

17. Chebi:3184

18. (+/-)-brompheniramine Maleate Salt

19. Drauxin

20. Gammistin

21. Nagemid

22. Smr000058417

23. Spentane

24. Allent

25. Ebalin

26. 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate

27. Brompheniramine Maleate (usp)

28. Drixoral Syrup

29. Mfcd00057367

30. Dimetane Extentabs

31. Bromopheniramine Maleate

32. Sr-01000003057

33. Einecs 213-562-9

34. Unii-ixa7c9zn03

35. Brompheniraminemaleate

36. 2-[p-bromo-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine Maleate

37. Dimetane (tn)

38. Prestwick_913

39. 3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine Maleate

40. Brompheniramine Fumarate

41. 3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-ylpropan-1-amine;(z)-but-2-enedioic Acid

42. Opera_id_399

43. 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate (1:1)

44. (y)-brompheniramine Maleate

45. (?)-brompheniramine Maleate

46. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (+-)-, (z)-2-butenedioate (1:1)

47. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (z)-butenedioate (1:1)

48. Schembl41913

49. Mls001148196

50. Spectrum1503985

51. Bioompheniramine Hydrogen Maleate

52. Chembl1200961

53. Dtxsid2052657

54. (a+/-)-brompheniramine Maleate

55. Bcpp000315

56. Hms1569o12

57. Hms1922o16

58. Hms2093o07

59. Hms2096o12

60. Hms2230i21

61. Hms2234d14

62. Hms3260j03

63. Hms3713o12

64. Hms3884j10

65. Pharmakon1600-01503985

66. Hy-b0480

67. Tox21_500201

68. Ccg-39068

69. Nsc758652

70. S2585

71. (+-)-2-p-bromo-alpha-2-(dimethylamino)ethylbenzylpyridine Maleate (1:1)

72. Akos015855858

73. Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-, Maleate (1:1)

74. Ac-1311

75. Bcp9000453

76. Brompheniramine Maleate [mart.]

77. Brompheniramine Maleate [vandf]

78. Lp00201

79. Nsc 758652

80. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (+-)-, (z)-butenedioate (1:1)

81. 2-pyridinepropanamine, Gamma-(4-bromophenyl)-n,n-dimethyl-, (2z)-2-butenedioate (1:1)

82. Brompheniramine Maleate [usp-rs]

83. Brompheniramine Maleate [who-dd]

84. Ncgc00093676-01

85. Ncgc00093676-02

86. Ncgc00093676-03

87. Ncgc00093676-04

88. Ncgc00093676-05

89. Ncgc00260886-01

90. As-14101

91. Smr000653459

92. Bcp0726000240

93. Brompheniramine Maleate [ep Impurity]

94. Brompheniramine Maleate [orange Book]

95. Eu-0100201

96. Sw197031-3

97. Brompheniramine Maleate [ep Monograph]

98. B 2390

99. Brompheniramine Maleate [usp Monograph]

100. D00663

101. ( Inverted Question Mark)-brompheniramine Maleate

102. Biphetap Component Brompheniramine Maleate

103. Dimetapp Component Brompheniramine Maleate

104. Bromanate Component Brompheniramine Maleate

105. Bromatapp Component Brompheniramine Maleate

106. Bromfed-dm Component Brompheniramine Maleate

107. Brompheniramine Maleate Component Of Biphetap

108. Brompheniramine Maleate Component Of Dimetapp

109. Dimetane-dc Component Brompheniramine Maleate

110. Dimetane-dx Component Brompheniramine Maleate

111. Sr-01000003057-2

112. Sr-01000003057-4

113. Sr-01000003057-5

114. Sr-01000003057-8

115. W-100095

116. Bromanate Dc Component Brompheniramine Maleate

117. Bromanate Dm Component Brompheniramine Maleate

118. Brompheniramine Maleate Component Of Bromanate

119. Brompheniramine Maleate Component Of Bromatapp

120. Brompheniramine Maleate Component Of Bromfed-dm

121. Myphetane Dc Component Brompheniramine Maleate

122. Q27105975

123. Brompheniramine Maleate Component Of Bromanate Dc

124. Brompheniramine Maleate Component Of Bromanate Dm

125. Brompheniramine Maleate Component Of Dimetane-dc

126. Brompheniramine Maleate Component Of Dimetane-dx

127. Brompheniramine Maleate Component Of Myphetane Dc

128. (+/-)-brompheniramine Maleate 100 Microg/ml In Methanol

129. 2- P-bromo-a-2-(dimethylamino)ethylbenzylpyridine Maleate

130. 2-(p-bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine Maleate

131. Brompheniramine Maleate 1.0 Mg/ml In Methanol (as Free Base)

132. 1-(p-bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane Maleate

133. 3-(p-bromophenyl)-3-(2-pyridyl)-n,n-dimethylpropylamine Maleate

134. Gamma-(4-bromophenyl)-n,n-dimethyl-2-pyridinepropanamine Maleate

135. (+/-)-brompheniramine Maleate 100 Microg/ml In Acetonitrile:methanol

136. 3-(4-bromophenyl)-n,n-dimethyl-3-(2-pyridinyl)-1-propanamine Maleate

137. Brompheniramine Maleate, United States Pharmacopeia (usp) Reference Standard

138. (+/-)-2-p-bromo-.alpha.-2-(dimethylamino)ethylbenzylpyridine Maleate (1:1)

139. 3-(4-bromophenyl)-n,n-dimethyl-3-(pyridin-2-yl)propan-1-amine (2z)-but-2-enedioate

140. Brompheniramine Maleate, Pharmaceutical Secondary Standard; Certified Reference Material

141. 2-pyridinepropanamine, .gamma.-(4-bromophenyl)-n,n-dimethyl-, (+/-)-, (z)-butenedioate (1:1)

142. 2664-17-7

143. Brompheniramine Maleate Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃BrN₂O₄
Molecular Weight	435.3 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	434.08412 g/mol
Monoisotopic Mass	434.08412 g/mol
Topological Polar Surface Area	90.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	368
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Brompheniramine maleate
Active Ingredient	Brompheniramine maleate
Dosage Form	Tablet
Route	oral
Strength	4mg
Market Status	Prescription
Company	Phoenix Labs Ny; Nylos

2 of 4
Drug Name	Veltane
Active Ingredient	Brompheniramine maleate
Dosage Form	Tablet
Route	oral
Strength	4mg
Market Status	Prescription
Company	Lannett

3 of 4
Drug Name	Brompheniramine maleate
Active Ingredient	Brompheniramine maleate
Dosage Form	Tablet
Route	oral
Strength	4mg
Market Status	Prescription
Company	Phoenix Labs Ny; Nylos

4 of 4
Drug Name	Veltane
Active Ingredient	Brompheniramine maleate
Dosage Form	Tablet
Route	oral
Strength	4mg
Market Status	Prescription
Company	Lannett

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

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API Reference Price

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THANE, MAHARASHTRA.","supplier":"KESHAVA ORGANICS PVT LTD","supplierCountry":"INDIA","foreign_port":"NEW YORK","customer":"TO THE ORDER OF","customerCountry":"UNITED STATES","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"975","totalValueFC":"1862","currency":"USD","unitRateINR":78089.235000000001,"date":"27-Aug-2024","totalValueINR":"156178.47","totalValueInUsd":"1862","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"3532563","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"PLOT NO. : T-100, MIDC-TARAPUR,, DIST - THANE, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724956200,"product":"ACTIVE PHARMACEUTICAL INGREDIENT - BROMPHENIRAMINE MALEATE USP","address":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,","city":"MUMBAI ,MAHARASHTRA","supplier":"SUPRIYA LIFESCIENCE","supplierCountry":"INDIA","foreign_port":"GUARULHOS","customer":"CONSIGNEE","customerCountry":"BRAZIL","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"260","totalValueFC":"12329.9","currency":"USD","unitRateINR":20684.259999999998,"date":"30-Aug-2024","totalValueINR":"1034213","totalValueInUsd":"12329.9","indian_port":"Bombay Air","hs_no":"29333929","bill_no":"3602325","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BRAZIL","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"207\/208,UDYOG BHAVAN,SONAWALA ROAD,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1725042600,"product":"ACTIVE PHARMACEUTICAL INGREDIENT - 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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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List of Suppliers' Lubricants Glidants Excipients Application used in Brompheniramine Maleate on PharmaCompass.com

Brompheniramine Maleate

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers

9 USDMF

1 CEP/COS

2 EU WC

4 NDC API

6 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

44 FDF Dossiers

39 FDA Orange Book

2 Canada

1 South Africa

2 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Minakem

5 Rochem International Inc

6 SPI Pharma

4 DKSH

3 Pharm-RX Chemical

12 Gangwal Healthcare

4 Nanjing Well Pharmaceutical

1 Pfanstiehl

8 Actylis

4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

1 BASF

1 Bioplus Life Sciences

4 DFE Pharma

1 Finar

6 Gangwal Chemicals

1 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

19 Kerry

9 Microlex e.U

1 Pharmatrans-Sanaq

5 Pluviaendo

2 Prachin Chemical

25 Roquette

1 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

9 Sigachi Industries

1 Valens Pharmachem

2 Vasa Pharmachem

2 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

54 Fillers, Diluents & Binders

24 Direct Compression

19 Thickeners and Stabilizers

18 Taste Masking

14 Co-Processed Excipients

13 Film Formers & Plasticizers

11 Lubricants & Glidants

11 Parenteral

10 Coating Systems & Additives

9 Granulation

9 Disintegrants & Superdisintegrants

8 Controlled & Modified Release

8 Chewable & Orodispersible Aids

6 Topical

5 API Stability Enhancers

4 Emulsifying Agents

3 Rheology Modifiers

2 Solubilizers

1 Soft Gelatin

DIGITAL CONTENT

7 NEWS #PharmaBuzz

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1 APIs

REF. STANDARDS & IMPURITIES

1 EDQM

1 USP