DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

Virtual Booth

Contact Supplier

Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 2 USDMF, 5 CEP/COS

6 API Suppliers
2 USDMF
5 CEP/COS

FINISHED DOSAGE FORMULATIONS

18 FDF Dossiers, 17 Europe, 1 South Africa

18 FDF Dossiers
17 Europe
1 South Africa

GLOBAL SALES INFORMATION

17 Finished Drug Prices

globalSalesInformation
17 Finished Drug Prices

MARKET PLACE

1 APIs

marketPlace
1 APIs

REF. STANDARDS & IMPURITIES

3 EDQM

otherSolutions
3 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Buflomedil hcl, 35543-24-9, Fonzylane, Loftyl, Buflomedil (hydrochloride), 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone hydrochloride

Molecular Formula

C₁₇H₂₆ClNO₄

Molecular Weight

343.8 g/mol

InChI Key

ZDPACSAHMZADFZ-UHFFFAOYSA-N

FDA UNII

3J944AFS8S

1 2D Structure

Buflomedil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C17H25NO4.ClH/c1-20-13-11-15(21-2)17(16(12-13)22-3)14(19)7-6-10-18-8-4-5-9-18;/h11-12H,4-10H2,1-3H3;1H

2.1.3 InChI Key

ZDPACSAHMZADFZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

COC1=CC(=C(C(=C1)OC)C(=O)CCCN2CCCC2)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

3J944AFS8S

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2,4,6-trimethoxyphenyl-3-pyrrolidine Propyl Ketone

2. Blufomedil

3. Bufedil

4. Buflo 1a Pharma

5. Buflo Abz

6. Buflo-pos

7. Buflo-puren

8. Buflohexal

9. Buflomedil

10. Buflomedil Heumann

11. Buflomedil Lindo

12. Buflomedil Pyridoxal Phosphate

13. Buflomedil Stada

14. Buflomedil Von Ct

15. Buflomedil-ratiopharm

16. Bufomedil

17. Fonzylane

18. Ll 1656

19. Lofton

20. Loftyl

21. Sinoxis

2.3.2 Depositor-Supplied Synonyms

1. Buflomedil Hcl

2. 35543-24-9

3. Fonzylane

4. Loftyl

5. Buflomedil (hydrochloride)

6. 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Hydrochloride

7. Mls000028735

8. 3j944afs8s

9. Bufedil

10. Nsc-759291

11. Irrodan

12. Smr000058803

13. Lofton

14. 4-(pyrrolidin-1-yl)-1-(2,4,6-trimethoxyphenyl)butan-1-one Hydrochloride

15. Dsstox_cid_26977

16. Dsstox_rid_82032

17. Dsstox_gsid_46977

18. Buflocit

19. Buflan

20. Irrodan R

21. Buflomedil Hydrochloride [jan]

22. Sr-01000721839

23. Ncgc00016831-01

24. Cas-35543-24-9

25. Ll 1656

26. Unii-3j944afs8s

27. 4-pyrrolidin-1-yl-1-(2,4,6-trimethoxyphenyl)butan-1-one;hydrochloride

28. Prestwick_782

29. Einecs 252-611-9

30. Mfcd00078965

31. Opera_id_262

32. Bucladesine (calcium Salt)

33. A-48257

34. Buflomedil Hydrochloride,(s)

35. Mls001148174

36. Mls001401458

37. Mls002222262

38. Mls006010627

39. Schembl211907

40. Chembl1715107

41. Dtxsid6046977

42. Buflomedil For Peak Identification

43. Hms1569e14

44. Pharmakon1600-01505992

45. Bcp13305

46. Hy-b0484

47. Tox21_110636

48. Tox21_301435

49. 4-(1-pyrrolidyl)-1-(2,4,6-trimethoxyphenyl)-1-butanone Hydrochloride

50. Buflomedil Hydrochloride [mi]

51. Nsc759291

52. S2607

53. Akos015962015

54. Chlorhydrate De (trimethoxy-2-4-6) Phenyl-(pyrrolidine-3) Propylacetone

55. Tox21_110636_1

56. Ab03021

57. Ccg-100878

58. Ds-9078

59. Nc00128

60. Nsc 759291

61. Buflomedil Hydrochloride [mart.]

62. Chlorhydrate De (trimethoxy-2-4-6) Phenyl-(pyrrolidine-3) Propylacetone [french]

63. Buflomedil Hydrochloride [who-dd]

64. Ncgc00016831-06

65. Ncgc00180961-01

66. Ncgc00256242-01

67. Ac-15509

68. B3647

69. Buflomedil Hydrochloride, Analytical Standard

70. Ft-0623281

71. Sw196920-4

72. Buflomedil Hydrochloride [ep Monograph]

73. 543b249

74. Q-200766

75. Sr-01000721839-4

76. Sr-01000721839-5

77. Q27257293

78. Buflomedil Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

79. Buflomedil Hydrochloride, European Pharmacopoeia (ep) Reference Standard

80. 1-butanone, 4-(1-pyrrolidinyl)-1-(2,4,6-trimethoxyphenyl)-, Hydrochloride

81. Buflomedil For Peak Identification, European Pharmacopoeia (ep) Reference Standard

2.4 Create Date

2006-04-14

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₆ClNO₄
Molecular Weight	343.8 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	343.1550360 g/mol
Monoisotopic Mass	343.1550360 g/mol
Topological Polar Surface Area	48 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	330
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2