Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Virtual Booth

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 JDMF

2 API Suppliers
2 JDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 52712-76-2, Detantol, Bunazosin hcl, E-643, 1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one hydrochloride, E643

Molecular Formula

C₁₉H₂₈ClN₅O₃

Molecular Weight

409.9 g/mol

InChI Key

NBGBEUITCPENLJ-UHFFFAOYSA-N

FDA UNII

18V54TZ7U6

1 2D Structure

Bunazosin Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one;hydrochloride

2.1.2 InChI

InChI=1S/C19H27N5O3.ClH/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19;/h11-12H,4-10H2,1-3H3,(H2,20,21,22);1H

2.1.3 InChI Key

NBGBEUITCPENLJ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCC(=O)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC.Cl

2.2 Other Identifiers

2.2.1 UNII

18V54TZ7U6

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-amino-2-(4-butanoylhexahydro-1h-1,4-diazepin-1-yl)-6,7-dimethoxyquinazoline Hcl

2. Andante

3. Bunazocine

4. Bunazosin

5. E 643

6. E-643

7. E643

2.3.2 Depositor-Supplied Synonyms

1. 52712-76-2

2. Detantol

3. Bunazosin Hcl

4. E-643

5. 1-(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one Hydrochloride

6. E643

7. Bunazosin Hydrochloride [jan]

8. 52712-76-2 (hcl)

9. 18v54tz7u6

10. E-1015

11. Ddq (pharmaceutical)

12. Bunazocine Hydrochloride

13. Andante

14. 1h-1,4-diazepine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-,monohydrochloride

15. Ncgc00183272-01

16. Unii-18v54tz7u6

17. Detantol (tn)

18. E 643

19. 4-amino-2-(4-butanoylhexahydro-1h-1,4-diazepin-1-yl)-6,7-dimethoxyquinazoline Hydrochloride

20. Dsstox_cid_28514

21. Dsstox_rid_82786

22. Dsstox_gsid_48588

23. 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1-oxobutyl)hexahydro-1h-1,4-diazepine Monohydrochloride

24. Schembl349737

25. Bunazosin Hydrochloride (jp17)

26. Chembl3182014

27. Dtxsid7048588

28. Chebi:31320

29. Bunazosin Hydrochloride [mi]

30. Tox21_112917

31. Akos016014364

32. Bunazosin Hydrochloride [mart.]

33. Bunazosin Hydrochloride [who-dd]

34. 1h-1,4-diazepine, Hexahydro-1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1-oxobutyl)-, Monohydrochloride

35. Cas-52712-76-2

36. Ft-0659022

37. D01887

38. E 1015

39. A829218

40. Q27252034

41. 1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one;hydrochloride

42. 1-[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one; Hydron; Chloride;bunazosin Hydrochloride

43. 1-butanone, 1-(4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1h-1,4-diazepin-1-yl)-, Hydrochloride (1:1)

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₈ClN₅O₃
Molecular Weight	409.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	409.1880675 g/mol
Monoisotopic Mass	409.1880675 g/mol
Topological Polar Surface Area	93.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	494
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

API SUPPLIERS