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Chemistry

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Also known as: (+)-phenserine, R-phenserine, 116839-68-0, (+)-posiphen, Phenserine, (+)-, Buntanetap
Molecular Formula
C20H23N3O2
Molecular Weight
337.4  g/mol
InChI Key
PBHFNBQPZCRWQP-AZUAARDMSA-N
FDA UNII
Z0O4TJ588O

Buntanetap
Posiphen is under investigation in clinical trial NCT02925650 (Safety, Tolerability, PK and PD of Posiphen in Subjects With Early Alzheimer's Disease).
1 2D Structure

Buntanetap

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(3aS,8bR)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate
2.1.2 InChI
InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m0/s1
2.1.3 InChI Key
PBHFNBQPZCRWQP-AZUAARDMSA-N
2.1.4 Canonical SMILES
CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C
2.1.5 Isomeric SMILES
C[C@]12CCN([C@H]1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C
2.2 Other Identifiers
2.2.1 UNII
Z0O4TJ588O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. N-phenylcarbamoyl Eseroline

2. N-phenylcarbamoyleseroline

3. Phenserine

2.3.2 Depositor-Supplied Synonyms

1. (+)-phenserine

2. R-phenserine

3. 116839-68-0

4. (+)-posiphen

5. Phenserine, (+)-

6. Buntanetap

7. Anvs401

8. Buntanetap [usan]

9. (+)-phenylcarbamoyleseroline

10. Anvs-401

11. Z0o4tj588o

12. (+)-o-(phenylcarbamoyl)eseroline

13. (3ar,8as)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl Phenylcarbamate

14. Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(n-phenylcarbamate), (3ar,8as)-

15. Unii-z0o4tj588o

16. Chembl4297417

17. Dtxsid001110145

18. Who 12342

19. Db15317

20. Hy-16009

21. Cs-0006062

22. [(3as,8br)-3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 337.4 g/mol
Molecular Formula C20H23N3O2
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass337.17902698 g/mol
Monoisotopic Mass337.17902698 g/mol
Topological Polar Surface Area44.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)


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ABOUT THIS PAGE

Buntanetap Manufacturers

A Buntanetap manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Buntanetap, including repackagers and relabelers. The FDA regulates Buntanetap manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Buntanetap API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Buntanetap Suppliers

A Buntanetap supplier is an individual or a company that provides Buntanetap active pharmaceutical ingredient (API) or Buntanetap finished formulations upon request. The Buntanetap suppliers may include Buntanetap API manufacturers, exporters, distributors and traders.

Buntanetap GMP

Buntanetap Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Buntanetap GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Buntanetap GMP manufacturer or Buntanetap GMP API supplier for your needs.

Buntanetap CoA

A Buntanetap CoA (Certificate of Analysis) is a formal document that attests to Buntanetap's compliance with Buntanetap specifications and serves as a tool for batch-level quality control.

Buntanetap CoA mostly includes findings from lab analyses of a specific batch. For each Buntanetap CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Buntanetap may be tested according to a variety of international standards, such as European Pharmacopoeia (Buntanetap EP), Buntanetap JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Buntanetap USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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