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Chemistry

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Also known as: 849-55-8, Buphenine hydrochloride, Nylidrin (hydrochloride), Nylidrin hcl, Arlibide, Arlidin
Molecular Formula
C19H26ClNO2
Molecular Weight
335.9  g/mol
InChI Key
CLJHABUMMDMAFA-UHFFFAOYSA-N
FDA UNII
EC69E3PW7E

Buphenine hydrochloride
A beta-adrenergic agonist. Nylidrin causes peripheral vasodilation, a positive inotropic effect, and increased gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor.
1 2D Structure

Buphenine hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol;hydrochloride
2.1.2 InChI
InChI=1S/C19H25NO2.ClH/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17;/h3-7,10-15,19-22H,8-9H2,1-2H3;1H
2.1.3 InChI Key
CLJHABUMMDMAFA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(CCC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.Cl
2.2 Other Identifiers
2.2.1 UNII
EC69E3PW7E
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arlidin

2. Bufenine

3. Buphenin

4. Buphenine

5. Dilatol

6. Hydrochloride, Nylidrin

7. Nylidrin

2.3.2 Depositor-Supplied Synonyms

1. 849-55-8

2. Buphenine Hydrochloride

3. Nylidrin (hydrochloride)

4. Nylidrin Hcl

5. Arlibide

6. Arlidin

7. Buphedrin

8. Dilatol

9. Vasiten

10. Buphenin Hydrochloride

11. Nsc-142004

12. Mls000069387

13. Dilatyl

14. Suprifen Psb Hydrochloride

15. 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol;hydrochloride

16. Smr000058488

17. Nylidrin Hydrochloride (jan)

18. Ec69e3pw7e

19. Nylidrin Hydrochloride [jan]

20. Sr-01000002981

21. Buphenine Hcl

22. P-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]benzyl Alcohol Hydrochloride

23. P-hydroxy-.alpha.-(1-((1-methyl-3-phenylpropyl)amino)ethyl)benzyl Alcohol Hydrochloride

24. Arlidin (tn)

25. Nylidrine Hydrochloride

26. Opera_id_1722

27. Mls001076116

28. Schembl364078

29. Spectrum1500445

30. Chembl1204337

31. Chebi:31925

32. Dtxsid20957360

33. Hms1920d06

34. Pharmakon1600-01500445

35. Nylidrin Hydrochloride [mi]

36. Amy23363

37. Hy-b1404

38. Tox21_500911

39. Ccg-40183

40. Mfcd00035085

41. Nsc142004

42. Nsc757252

43. S5267

44. Nylidrin Hydrochloride [vandf]

45. Wln: Qr Dyqy1&my1&2r &gh

46. Akos030242878

47. Buphenine Hydrochloride [mart.]

48. Cs-4980

49. Lp00911

50. Nsc-757252

51. Buphenine Hydrochloride [who-dd]

52. Ncgc00094222-01

53. Ncgc00094222-02

54. Ncgc00094222-03

55. Ncgc00094222-04

56. Ncgc00261596-01

57. As-19644

58. Eu-0100911

59. Ft-0757340

60. N-153

61. D01543

62. A923155

63. Q9668243

64. Sr-01000002981-2

65. 4-(1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl)phenol Hydrochloride

66. 1-p-hydroxyphenyl-2-[(1'-methyl-3'-phenylpropyl)amino]-1-propanol Hydrochloride

67. 4-{1-hydroxy-2-[(4-phenyl-2-butanyl)amino]propyl}phenol Hydrochloride (1:1)

68. 900-01-6

69. Benzenemethanol, 4-hydroxy-.alpha.-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-, Hydrochloride

2.4 Create Date
2006-03-07
3 Chemical and Physical Properties
Molecular Weight 335.9 g/mol
Molecular Formula C19H26ClNO2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count3
Rotatable Bond Count7
Exact Mass335.1652068 g/mol
Monoisotopic Mass335.1652068 g/mol
Topological Polar Surface Area52.5 Ų
Heavy Atom Count23
Formal Charge0
Complexity296
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count3
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Sympathomimetics

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors. (See all compounds classified as Adrenergic beta-Agonists.)


Tocolytic Agents

Drugs that prevent preterm labor and immature birth by suppressing uterine contractions (TOCOLYSIS). Agents used to delay premature uterine activity include magnesium sulfate, beta-mimetics, oxytocin antagonists, calcium channel inhibitors, and adrenergic beta-receptor agonists. The use of intravenous alcohol as a tocolytic is now obsolete. (See all compounds classified as Tocolytic Agents.)


ABOUT THIS PAGE

Buphenine hydrochloride Manufacturers

A Buphenine hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Buphenine hydrochloride, including repackagers and relabelers. The FDA regulates Buphenine hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Buphenine hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Buphenine hydrochloride Suppliers

A Buphenine hydrochloride supplier is an individual or a company that provides Buphenine hydrochloride active pharmaceutical ingredient (API) or Buphenine hydrochloride finished formulations upon request. The Buphenine hydrochloride suppliers may include Buphenine hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Buphenine hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Buphenine hydrochloride USDMF

A Buphenine hydrochloride DMF (Drug Master File) is a document detailing the whole manufacturing process of Buphenine hydrochloride active pharmaceutical ingredient (API) in detail. Different forms of Buphenine hydrochloride DMFs exist exist since differing nations have different regulations, such as Buphenine hydrochloride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Buphenine hydrochloride DMF submitted to regulatory agencies in the US is known as a USDMF. Buphenine hydrochloride USDMF includes data on Buphenine hydrochloride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Buphenine hydrochloride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Buphenine hydrochloride suppliers with USDMF on PharmaCompass.

Buphenine hydrochloride GMP

Buphenine hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Buphenine hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Buphenine hydrochloride GMP manufacturer or Buphenine hydrochloride GMP API supplier for your needs.

Buphenine hydrochloride CoA

A Buphenine hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Buphenine hydrochloride's compliance with Buphenine hydrochloride specifications and serves as a tool for batch-level quality control.

Buphenine hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Buphenine hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Buphenine hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Buphenine hydrochloride EP), Buphenine hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Buphenine hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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