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ACTIVE PHARMA INGREDIENTS

26 API Suppliers, 7 USDMF, 7 CEP/COS, 1 JDMF, 6 EU WC, 1 KDMF, 16 NDC API, 19 Listed Suppliers, $ API Reference Price

26 API Suppliers
7 USDMF
7 CEP/COS
1 JDMF
6 EU WC
1 KDMF
16 NDC API
19 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

INTERMEDIATES

4 Intermediates Suppliers

4 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

140 FDF Dossiers, 82 FDA Orange Book, 9 Europe, 18 Canada, 6 South Africa, 25 Listed Dossiers

140 FDF Dossiers
82 FDA Orange Book
9 Europe
18 Canada
6 South Africa
25 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.25%;0.0091MG/ML, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 0.25%, INJECTABLE;INJECTION - 0.5%, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML, INJECTABLE;INJECTION - 0.75%, INJECTABLE;INJECTION - 0.75%;0.0091MG/ML, INJECTABLE;INJECTION - 0.5%;0.0091MG/ML

drugProductComposition
INJECTABLE;INJECTION - 0.25%
INJECTABLE;INJECTION - 0.25%;0.0091MG/ML
INJECTABLE;INJECTION - 0.5%
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML
INJECTABLE;INJECTION - 0.75%
INJECTABLE;INJECTION - 0.75%;0.0091MG/ML
INJECTABLE;INJECTION - 0.25%
INJECTABLE;INJECTION - 0.5%
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML
INJECTABLE;INJECTION - 0.75%
INJECTABLE;INJECTION - 0.75%;0.0091MG/ML
INJECTABLE;INJECTION - 0.5%;0.0091MG/ML

RELATED EXCIPIENT COMPANIES

6 Actylis, 2 Kerry, 1 Microlex e.U, 2 Pluviaendo, 1 Roquette

relatedExcipients
6 Actylis
2 Kerry
1 Microlex e.U
2 Pluviaendo
1 Roquette

EXCIPIENTS BY APPLICATIONS

8 Parenteral, 2 Fillers, Diluents & Binders, 1 Topical, 1 Controlled & Modified Release, 1 Co-Processed Excipients, 1 Taste Masking, 1 Film Formers & Plasticizers, 1 Coating Systems & Additives

excipientsByApplications
8 Parenteral
2 Fillers, Diluents & Binders
1 Topical
1 Controlled & Modified Release
1 Co-Processed Excipients
1 Taste Masking
1 Film Formers & Plasticizers
1 Coating Systems & Additives

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 38 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
38 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

4 US Medicaid Prescriptions

globalSalesInformation
4 US Medicaid Prescriptions

MARKET PLACE

24 APIs, 2 FDF Dossiers

marketPlace
24 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 US Patents

patents
2 US Patents

REF. STANDARDS & IMPURITIES

4 EDQM , 1 USP , 1 Others

otherSolutions
4 EDQM
1 USP
1 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 880

MARKET PLACE

API

FDF

4INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

140

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

8DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

8,177

Annual Reports (USD Million)

Finished Drug Prices

12 RELATED EXCIPIENT COMPANIES

16EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Bupivacaine hcl, 18010-40-7, 14252-80-3, Carbostesin, Vivacaine, Sensorcaine

Molecular Formula

C₁₈H₂₉ClN₂O

Molecular Weight

324.9 g/mol

InChI Key

SIEYLFHKZGLBNX-UHFFFAOYSA-N

FDA UNII

AKA908P8J1

A widely used local anesthetic agent.

1 2D Structure

Bupivacaine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H

2.1.3 InChI Key

SIEYLFHKZGLBNX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

AKA908P8J1

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide

2. Bupivacain Janapharm

3. Bupivacain Rpr

4. Bupivacain-rpr

5. Bupivacaina Braun

6. Bupivacaine

7. Bupivacaine Anhydrous

8. Bupivacaine Carbonate

9. Bupivacaine Monohydrochloride, Monohydrate

10. Buvacaina

11. Carbostesin

12. Dolanaest

13. Marcain

14. Marcaine

15. Sensorcaine

16. Svedocain Sin Vasoconstr

2.3.2 Depositor-Supplied Synonyms

1. Bupivacaine Hcl

2. 18010-40-7

3. 14252-80-3

4. Carbostesin

5. Vivacaine

6. Sensorcaine

7. Bupivacaine (hydrochloride)

8. 1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

9. Marcain

10. Ah-2250

11. Bupivacaine Hydrochloride Anhydrous

12. Lac-43

13. Nsc-758631

14. 1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride

15. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-, Monohydrochloride

16. Win 11,318

17. Aka908p8j1

18. Chebi:31322

19. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide Monohydrochloride

20. Bloqueina

21. Xaracoll

22. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-, Hydrochloride (1:1)

23. (s)-bupivacaine Hydrochloride

24. Bicain

25. Marcaine Spinal

26. Smr000058218

27. (+-)-bupivacaine Hydrochloride

28. Bupivacaine Hydrochloride [jan]

29. Mnarcaine Hydrochloride

30. Einecs 241-917-8

31. Bupivacaine Hydrochloride Kit

32. Unii-aka908p8j1

33. Lac 43

34. Sr-05000001874

35. 1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide

36. Levobupivacaine Hydrochloride (anhydrous)

37. 2',6'-pipecoloxylidide, 1-butyl-, Hydrochloride

38. Sky 0302

39. Prestwick_894

40. 2',6'-pipecoloxylidide, 1-butyl-, Monohydrochloride

41. Ah 2250

42. Marcaine Hydrochloride Preservation Free

43. Bupivacain Hydrochloride

44. Bupivacaine Hydrochloride Preservation Free

45. Bupivacaini Hydrochloridum

46. Bupivacaine Hydrochloride Rs

47. Bupivacaine Monohydrochloride

48. Win 11318 Hcl

49. Schembl34374

50. Mls001361336

51. Mls002154259

52. Spectrum1503818

53. Bupivacaine-[d9] Hydrochloride

54. Chembl1200396

55. Dtxsid0030877

56. Chebi:77441

57. Hy-b0405a

58. Bupivacaine Hydrochloride(marcain)

59. Hms1568n12

60. Hms1922i12

61. Pharmakon1600-01503818

62. Bupivacaine Hydrochloride (marcain)

63. Act04725

64. Bcp22697

65. Bcp22708

66. Bupivacaine Hydrochloride (anhydrous)

67. Ccg-39367

68. Mfcd00078956

69. Nsc119660

70. Nsc758631

71. S2454

72. Bupivacaine Hydrochloride [mi]

73. Akos015889322

74. Bcp9000461

75. Fd-0235

76. Nsc 758631

77. Nsc-119660

78. Ncgc00095072-01

79. Ncgc00095072-02

80. Anhydrous Bupivacaine Hydrochloride

81. Bupivacaine Hydrochloride [who-dd]

82. Bupivacaine Hydrochloride, Anhydrous

83. B3925

84. Ft-0607564

85. Ft-0623287

86. Ft-0658830

87. Ft-0663897

88. Ft-0663899

89. Sw197015-3

90. 52b803

91. Bupivacaine Hydrochloride [usp Impurity]

92. J-011502

93. Q-100158

94. Sr-05000001874-3

95. Q27888209

96. 1-butyl-2-piperidylformo-2',6'-xylidide Hydrochloride

97. 2-piperidinecarboxamide,6-dimethylphenyl)-, Hydrochloride

98. 1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium Chloride

99. (+/-)-1-butyl-2',6'-pipecoloxylidide Monohydrochloride

100. Rac-1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium Chloride

101. Rac-1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

102. 15233-43-9

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₉ClN₂O
Molecular Weight	324.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	324.1968412 g/mol
Monoisotopic Mass	324.1968412 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	321
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Bupivacaine hydrochloride
PubMed Health	Bupivacaine/Epinephrine (Injection)
Drug Classes	Anesthetic, Amino Amide Combination, Anesthetic, Local
Drug Label	Sensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
Active Ingredient	Bupivacaine hydrochloride
Dosage Form	Injectable
Route	injection; Spinal; Injection
Strength	0.5%; 0.75%; 0.25%
Market Status	Prescription
Company	Sagent Agila; Hospira

2 of 6
Drug Name	Marcaine
PubMed Health	Bupivacaine (Injection)
Drug Classes	Anesthetic, Local
Drug Label	MarcaineBupivacaine Hydrochloride Injection, USPMarcaineWith Epinephrine 1:200,000 (as bitartrate)Bupivacaine Hydrochloride and Epinephrine Injection, USP Rx onlyBupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylpheny...
Active Ingredient	Bupivacaine hydrochloride
Dosage Form	Injectable
Route	Spinal
Strength	0.75%
Market Status	Prescription
Company	Hospira

3 of 6
Drug Name	Sensorcaine
Drug Label	Sensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
Active Ingredient	Bupivacaine hydrochloride; epinephrine bitartrate
Dosage Form	Injectable
Route	Spinal; Injection
Strength	0.5%; 0.0091mg/ml; 0.75%; 0.25%
Market Status	Prescription
Company	Fresenius Kabi Usa

4 of 6
Drug Name	Bupivacaine hydrochloride
PubMed Health	Bupivacaine/Epinephrine (Injection)
Drug Classes	Anesthetic, Amino Amide Combination, Anesthetic, Local
Drug Label	Sensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
Active Ingredient	Bupivacaine hydrochloride
Dosage Form	Injectable
Route	injection; Spinal; Injection
Strength	0.5%; 0.75%; 0.25%
Market Status	Prescription
Company	Sagent Agila; Hospira

5 of 6
Drug Name	Marcaine
PubMed Health	Bupivacaine (Injection)
Drug Classes	Anesthetic, Local
Drug Label	MarcaineBupivacaine Hydrochloride Injection, USPMarcaineWith Epinephrine 1:200,000 (as bitartrate)Bupivacaine Hydrochloride and Epinephrine Injection, USP Rx onlyBupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylpheny...
Active Ingredient	Bupivacaine hydrochloride
Dosage Form	Injectable
Route	Spinal
Strength	0.75%
Market Status	Prescription
Company	Hospira

6 of 6
Drug Name	Sensorcaine
Drug Label	Sensorcaine (bupivacaine HCl) injections are sterile isotonic solutions that contain a local anesthetic agent with and without epinephrine (as bitartrate) 1:200,000 and are administered parenterally by injection. See INDICATIONS AND USAGE for spe...
Active Ingredient	Bupivacaine hydrochloride; epinephrine bitartrate
Dosage Form	Injectable
Route	Spinal; Injection
Strength	0.5%; 0.0091mg/ml; 0.75%; 0.25%
Market Status	Prescription
Company	Fresenius Kabi Usa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Amides [CS]; Local Anesthesia [PE]; Amide Local Anesthetic [EPC]

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - INJECTABLE;INJECTION - 0.25%