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    Chemistry

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    Also known as: 33386-08-2, Buspar, Buspirone hcl, Narol, Buspimen, Buspirone (hydrochloride)
    Molecular Formula
    C21H32ClN5O2
    Molecular Weight
    422.0  g/mol
    InChI Key
    RICLFGYGYQXUFH-UHFFFAOYSA-N
    FDA UNII
    207LT9J9OC
    Buspirone Hydrochloride
    An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.
    1 2D Structure

    Buspirone Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride
    2.1.2 InChI
    InChI=1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H
    2.1.3 InChI Key
    RICLFGYGYQXUFH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    207LT9J9OC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Anxut

    2. Apo Buspirone

    3. Apo-buspirone

    4. Bespar

    5. Busp

    6. Buspar

    7. Buspirone

    8. Gen Buspirone

    9. Gen-buspirone

    10. Hydrochloride, Buspirone

    11. Lin Buspirone

    12. Lin-buspirone

    13. Mj 9022 1

    14. Mj-9022-1

    15. Mj90221

    16. N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide

    17. Neurosine

    18. Novo Buspirone

    19. Novo-buspirone

    20. Nu Buspirone

    21. Nu-buspirone

    22. Pms Buspirone

    23. Pms-buspirone

    24. Ratio Buspirone

    25. Ratio-buspirone

    2.3.2 Depositor-Supplied Synonyms

    1. 33386-08-2

    2. Buspar

    3. Buspirone Hcl

    4. Narol

    5. Buspimen

    6. Buspirone (hydrochloride)

    7. Mj 9022-1

    8. 8-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    9. Nsc-751138

    10. Nsc-759571

    11. Mj-9022-1

    12. Mls000069796

    13. N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1,1-cyclopentanediacetamide Monohydrochloride

    14. 207lt9j9oc

    15. Apd405

    16. Chebi:3224

    17. Apd-405

    18. Ansitec

    19. Anxinil

    20. Anxiolan

    21. Busirone

    22. Buspinol

    23. Censpar

    24. Effiplen

    25. Establix

    26. Kallmiren

    27. Lucelan

    28. Mabuson

    29. Normaton

    30. Smr000058186

    31. Spamilan

    32. Barpil

    33. Bespar

    34. Itagil

    35. Nerbet

    36. Sburol

    37. Travin

    38. Tutran

    39. Biron

    40. Relac

    41. 33386-08-2 (hcl)

    42. Apo-buspirone

    43. 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride

    44. 8-azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, Monohydrochloride

    45. 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    46. 8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione Hydrochloride

    47. Buspirone Hydrochloride [usan]

    48. Sr-01000075541

    49. Einecs 251-489-4

    50. Unii-207lt9j9oc

    51. C21h31n5o2.hcl

    52. Prestwick_711

    53. Buspirone Hydrochloride [usan:usp]

    54. Buspar (tn)

    55. Mfcd00078569

    56. Opera_id_707

    57. 1,1-cyclopentanediacetimide, N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, Hydrochloride

    58. 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione Hydrochloride

    59. Schembl41495

    60. Mls001076085

    61. Mls002548862

    62. Buspirone Hydrochloride (usp)

    63. Buspirone Hydrochloride Solution

    64. Buspirone For System Suitability

    65. Chembl1200399

    66. Dtxsid1037193

    67. Hms1569i19

    68. Hms3750o03

    69. Pharmakon1600-02300173

    70. Apc-6002

    71. Apc-6003

    72. Bcp28463

    73. Hy-b1115

    74. Buspirone Hydrochloride [mi]

    75. Tox21_500223

    76. Buspirone Hydrochloride [jan]

    77. Nsc751138

    78. Nsc759571

    79. S4256

    80. Akos015962019

    81. Ac-1905

    82. Buspirone Hydrochloride [mart.]

    83. Buspirone Hydrochloride [vandf]

    84. Ccg-213652

    85. Cs-4714

    86. H05b847

    87. Ks-5163

    88. Lp00223

    89. Nc00673

    90. Nsc 751138

    91. Nsc 759571

    92. Buspirone Hydrochloride [usp-rs]

    93. Buspirone Hydrochloride [who-dd]

    94. Ncgc00093692-01

    95. Ncgc00093692-02

    96. Ncgc00260908-01

    97. 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-8-azaspiro(4.5)decane-7,9-dione Monohydrochloride

    98. Buspirone Hydrochloride [orange Book]

    99. Eu-0100223

    100. Sw155073-5

    101. Buspirone Hydrochloride [ep Monograph]

    102. B 7148

    103. Buspirone Hydrochloride [usp Monograph]

    104. D00702

    105. D96810

    106. Q-200768

    107. Sr-01000075541-1

    108. Sr-01000075541-3

    109. Sr-01000075541-7

    110. Q27105997

    111. Buspirone Hydrochloride 1.0 Mg/ml In Methanol (as Free Base)

    112. Buspirone Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    113. Buspirone Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    114. 8-azaspiro[4.5]decane-7, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, Monohydrochloride

    115. Buspirone For System Suitability, European Pharmacopoeia (ep) Reference Standard

    116. Buspirone Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    117. 1-[4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-4-(pyrimidin-2-yl)piperazin-1-ium Chloride

    118. 8-[4-[4-(2-pyrimidinyl)-1-pipirazin Yl]butyl]-8-azaspiro[4,5]decane-7,9-dione Hydrochloride

    119. 8-[4-[4-(2-pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione Hydrochloride

    120. 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione Hydrochloride

    121. 8-azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, Hydrochloride (1:1)

    122. Buspirone Hcl Pound>>mj 9022 1 Pound>> Mj-9022-1 Pound>>mj90221 Pound>>mj9022 1 Pound>>mj9022-1

    123. Buspirone Hydrochloride Solution, 1.0 Mg/ml In Methanol (as Free Base), Ampule Of 1 Ml, Certified Reference Material

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 422.0 g/mol
    Molecular Formula C21H32ClN5O2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass421.2244530 g/mol
    Monoisotopic Mass421.2244530 g/mol
    Topological Polar Surface Area69.6 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity529
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBuspirone hydrochloride
    Drug LabelBuspirone hydrochloride tablets USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.Buspirone hydrochloride is a white crystalline, water soluble co...
    Active IngredientBuspirone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 7.5mg; 30mg; 10mg; 15mg
    Market StatusPrescription
    CompanyWatson Labs; Teva; Zydus Pharms Usa; Strides Arcolab; Dr Reddys Labs; Prosam Labs; Mylan

    2 of 2  
    Drug NameBuspirone hydrochloride
    Drug LabelBuspirone hydrochloride tablets USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.Buspirone hydrochloride is a white crystalline, water soluble co...
    Active IngredientBuspirone hydrochloride
    Dosage FormTablet
    RouteOral
    Strength5mg; 7.5mg; 30mg; 10mg; 15mg
    Market StatusPrescription
    CompanyWatson Labs; Teva; Zydus Pharms Usa; Strides Arcolab; Dr Reddys Labs; Prosam Labs; Mylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)

    API Reference Price

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    27-Jan-2021
    06-Feb-2025
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    ABOUT THIS PAGE

    Looking for 33386-08-2 / Buspirone Hydrochloride API manufacturers, exporters & distributors?

    Buspirone Hydrochloride manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Buspirone Hydrochloride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Buspirone Hydrochloride manufacturer or Buspirone Hydrochloride supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Buspirone Hydrochloride manufacturer or Buspirone Hydrochloride supplier.

    PharmaCompass also assists you with knowing the Buspirone Hydrochloride API Price utilized in the formulation of products. Buspirone Hydrochloride API Price is not always fixed or binding as the Buspirone Hydrochloride Price is obtained through a variety of data sources. The Buspirone Hydrochloride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Buspirone Hydrochloride

    Synonyms

    33386-08-2, Buspar, Buspirone hcl, Narol, Buspimen, Buspirone (hydrochloride)

    Cas Number

    33386-08-2

    Unique Ingredient Identifier (UNII)

    207LT9J9OC

    About Buspirone Hydrochloride

    An anxiolytic agent and serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the BENZODIAZAPINES, but it has an efficacy comparable to DIAZEPAM.

    BUSPIRONE HCL Manufacturers

    A BUSPIRONE HCL manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of BUSPIRONE HCL, including repackagers and relabelers. The FDA regulates BUSPIRONE HCL manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. BUSPIRONE HCL API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of BUSPIRONE HCL manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    BUSPIRONE HCL Suppliers

    A BUSPIRONE HCL supplier is an individual or a company that provides BUSPIRONE HCL active pharmaceutical ingredient (API) or BUSPIRONE HCL finished formulations upon request. The BUSPIRONE HCL suppliers may include BUSPIRONE HCL API manufacturers, exporters, distributors and traders.

    click here to find a list of BUSPIRONE HCL suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    BUSPIRONE HCL USDMF

    A BUSPIRONE HCL DMF (Drug Master File) is a document detailing the whole manufacturing process of BUSPIRONE HCL active pharmaceutical ingredient (API) in detail. Different forms of BUSPIRONE HCL DMFs exist exist since differing nations have different regulations, such as BUSPIRONE HCL USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A BUSPIRONE HCL DMF submitted to regulatory agencies in the US is known as a USDMF. BUSPIRONE HCL USDMF includes data on BUSPIRONE HCL's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The BUSPIRONE HCL USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of BUSPIRONE HCL suppliers with USDMF on PharmaCompass.

    BUSPIRONE HCL KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a BUSPIRONE HCL Drug Master File in Korea (BUSPIRONE HCL KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of BUSPIRONE HCL. The MFDS reviews the BUSPIRONE HCL KDMF as part of the drug registration process and uses the information provided in the BUSPIRONE HCL KDMF to evaluate the safety and efficacy of the drug.

    After submitting a BUSPIRONE HCL KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their BUSPIRONE HCL API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of BUSPIRONE HCL suppliers with KDMF on PharmaCompass.

    BUSPIRONE HCL CEP

    A BUSPIRONE HCL CEP of the European Pharmacopoeia monograph is often referred to as a BUSPIRONE HCL Certificate of Suitability (COS). The purpose of a BUSPIRONE HCL CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of BUSPIRONE HCL EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of BUSPIRONE HCL to their clients by showing that a BUSPIRONE HCL CEP has been issued for it. The manufacturer submits a BUSPIRONE HCL CEP (COS) as part of the market authorization procedure, and it takes on the role of a BUSPIRONE HCL CEP holder for the record. Additionally, the data presented in the BUSPIRONE HCL CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the BUSPIRONE HCL DMF.

    A BUSPIRONE HCL CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. BUSPIRONE HCL CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of BUSPIRONE HCL suppliers with CEP (COS) on PharmaCompass.

    BUSPIRONE HCL WC

    A BUSPIRONE HCL written confirmation (BUSPIRONE HCL WC) is an official document issued by a regulatory agency to a BUSPIRONE HCL manufacturer, verifying that the manufacturing facility of a BUSPIRONE HCL active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting BUSPIRONE HCL APIs or BUSPIRONE HCL finished pharmaceutical products to another nation, regulatory agencies frequently require a BUSPIRONE HCL WC (written confirmation) as part of the regulatory process.

    click here to find a list of BUSPIRONE HCL suppliers with Written Confirmation (WC) on PharmaCompass.

    BUSPIRONE HCL NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing BUSPIRONE HCL as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for BUSPIRONE HCL API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture BUSPIRONE HCL as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain BUSPIRONE HCL and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a BUSPIRONE HCL NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of BUSPIRONE HCL suppliers with NDC on PharmaCompass.

    BUSPIRONE HCL GMP

    BUSPIRONE HCL Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of BUSPIRONE HCL GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right BUSPIRONE HCL GMP manufacturer or BUSPIRONE HCL GMP API supplier for your needs.

    BUSPIRONE HCL CoA

    A BUSPIRONE HCL CoA (Certificate of Analysis) is a formal document that attests to BUSPIRONE HCL's compliance with BUSPIRONE HCL specifications and serves as a tool for batch-level quality control.

    BUSPIRONE HCL CoA mostly includes findings from lab analyses of a specific batch. For each BUSPIRONE HCL CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    BUSPIRONE HCL may be tested according to a variety of international standards, such as European Pharmacopoeia (BUSPIRONE HCL EP), BUSPIRONE HCL JP (Japanese Pharmacopeia) and the US Pharmacopoeia (BUSPIRONE HCL USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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