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Chemistry

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Also known as: Butorphanol tartrate, 58786-99-5, Butorphanol (+)-tartrate salt, Stadol (tn), Butorphanol tartrate salt, Butorphanol tartrate (jan/usp)
Molecular Formula
C25H35NO8
Molecular Weight
477.5  g/mol
InChI Key
GMTYREVWZXJPLF-BTVKVFNOSA-N

Butorphanol Tartrate
A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
1 2D Structure

Butorphanol Tartrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-4,10-diol;(2R,3R)-2,3-dihydroxybutanedioic acid
2.1.2 InChI
InChI=1S/C21H29NO2.C4H6O6/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15;5-1(3(7)8)2(6)4(9)10/h6-7,13,15,19,23-24H,1-5,8-12,14H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-,20+,21-;1-,2-/m11/s1
2.1.3 InChI Key
GMTYREVWZXJPLF-BTVKVFNOSA-N
2.1.4 Canonical SMILES
C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O.C(C(C(=O)O)O)(C(=O)O)O
2.1.5 Isomeric SMILES
C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 17-(cyclobutylmethyl)morphinan-3,14-diol

2. Apo-butorphanol

3. Bc 2627

4. Bc-2627

5. Bc2627

6. Beforal

7. Butorphanol

8. Butorphanol Tartrate

9. Dolorex

10. Moradol

11. Stadol

12. Stadol Ns

13. Torbugesic

2.2.2 Depositor-Supplied Synonyms

1. Butorphanol Tartrate

2. 58786-99-5

3. Butorphanol (+)-tartrate Salt

4. Stadol (tn)

5. Butorphanol Tartrate Salt

6. Butorphanol Tartrate (jan/usp)

7. Akos015994595

8. Hs-0001

9. Butorphanol (+)-tartrate Salt, >=99%

10. D00837

11. 786b995

12. Butorphanol Tartrate, United States Pharmacopeia (usp) Reference Standard

2.2.3 Other Synonyms

1. Butorfanol

2. Torate

3. Torbutrol

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 477.5 g/mol
Molecular Formula C25H35NO8
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass477.23626707 g/mol
Monoisotopic Mass477.23626707 g/mol
Topological Polar Surface Area159 Ų
Heavy Atom Count34
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameButorphanol tartrate
Drug LabelButorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R*,R*)] 2,3 dihydroxybutanedioate (1:1) (salt). The molecul...
Active IngredientButorphanol tartrate
Dosage FormInjectable; Spray, metered
RouteNasal; Injection
Strength2mg/ml; 1mg/ml; 1mg/spray
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; Novex; Mylan; Roxane

2 of 2  
Drug NameButorphanol tartrate
Drug LabelButorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R*,R*)] 2,3 dihydroxybutanedioate (1:1) (salt). The molecul...
Active IngredientButorphanol tartrate
Dosage FormInjectable; Spray, metered
RouteNasal; Injection
Strength2mg/ml; 1mg/ml; 1mg/spray
Market StatusPrescription
CompanyBedford; Hikma Farmaceutica; Novex; Mylan; Roxane

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)


Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)


Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)


Narcotic Antagonists

Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Opioid Agonist/Antagonist [EPC]; Partial Opioid Agonists [MoA]; Competitive Opioid Antagonists [MoA]

API SUPPLIERS

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Malladi Drugs & Pharmaceuticals Li...

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AbbVie Inc

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Suanfarma

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Hikal

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Hikal

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Sri Krishna Pharmaceuticals

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Curia

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Tasmanian Alkaloids Pty Ltd

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Abbott Laboratories

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BUTORPHANOL TARTRATE (F11800324\/001)","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"M\/S","customerCountry":"UNITED STATES","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"49000","totalValueFC":"48357.7","currency":"USD","unitRateINR":4036876,"date":"21-Jun-2024","totalValueINR":"4036876","totalValueInUsd":"48357.7","indian_port":"Bangalore Air","hs_no":"29334900","bill_no":"1839760","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718994600,"product":"8411180001 - BUTORPHANOL TARTRATE (F11800324\/002)","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"NEWARK, NJ","customer":"M\/S","customerCountry":"UNITED STATES","quantity":"2.80","actualQuantity":"2.8","unit":"KGS","unitRateFc":"49000","totalValueFC":"135585","currency":"USD","unitRateINR":4042340.7142857146,"date":"22-Jun-2024","totalValueINR":"11318554","totalValueInUsd":"135585","indian_port":"Bangalore Air","hs_no":"29334900","bill_no":"1873658","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"8411180001 BUTORPHANOL TARTRATE","address":"717\/718, MAKER CHAMBER V,","city":"MUMBAI, MAHARASHTRA","supplier":"HIKAL","supplierCountry":"INDIA","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"M\/S....","customerCountry":"GERMANY","quantity":"0.10","actualQuantity":"0.1","unit":"KGS","unitRateFc":"80000","totalValueFC":"7695.2","currency":"USD","unitRateINR":6448684,"date":"28-Sep-2024","totalValueINR":"644868.4","totalValueInUsd":"7695.2","indian_port":"Bangalore Air","hs_no":"29334900","bill_no":"4425737","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"717\/718, MAKER CHAMBER V,, MUMBAI, MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729189800,"product":"PROD CODE: 8411180001 - 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RUZYNE","customer":"ARISTO PHARMACEUTICALS PVT LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"35000","totalValueFC":"35408.2","currency":"USD","unitRateINR":"2947000","date":"31-Oct-2023","totalValueINR":"2947000","totalValueInUsd":"35408.2","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"8552487","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"PIET HEIN BUILDING ,PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Amsterdam, AMSTERDAM, NETHERLANDS NETHERLANDS","customerAddress":"3RD FLOOR,MERCANTILE CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701282600,"product":"BUTORPHANOL TARTRATE","address":"3RD FLOOR,MERCANTILE CHAMBERS","city":"MUMBAI,MAHARASHTRA","supplier":"TEVA API","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"ARISTO PHARMACEUTICALS PVT LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"35000","totalValueFC":"35348.5","currency":"USD","unitRateINR":"2943500","date":"30-Nov-2023","totalValueINR":"2943500","totalValueInUsd":"35348.5","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"9001268","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"PIET HEIN BUILDING ,PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Amsterdam, AMSTERDAM, NETHERLANDS NETHERLANDS","customerAddress":"3RD FLOOR,MERCANTILE CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1707676200,"product":"BUTORPHANOLTARTRATE,C1BPT001","address":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB","city":"HYDERABAD,TELANGANA","supplier":"TEVA API","supplierCountry":"CZECH REPUBLIC","foreign_port":"N\/A","customer":"CRONUS PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"3.00","actualQuantity":"3","unit":"KGS","unitRateFc":"36434.9","totalValueFC":"110788.3","currency":"USD","unitRateINR":"3064175","date":"12-Feb-2024","totalValueINR":"9192525","totalValueInUsd":"110788.3","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29334900","bill_no":"1001058","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"PIET HEIN BUILDING, PIET HEINKADE 1 07 1019 GM AMSTERDAM THE NETHERLAN DS MFG BY:TEVA CZECH INDUSTRIES S.R NETHERLANDS","customerAddress":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1714069800,"product":"BUTORPHANOL TARTRATE","address":"3RD FLOOR,MERCANTILE CHAMBERS","city":"MUMBAI,MAHARASHTRA","supplier":"TEVA API","supplierCountry":"CZECH REPUBLIC","foreign_port":"PRAGUE - RUZYNE","customer":"ARISTO PHARMACEUTICALS PVT LTD","customerCountry":"INDIA","quantity":"1.60","actualQuantity":"1.6","unit":"KGS","unitRateFc":"32000","totalValueFC":"51747.3","currency":"USD","unitRateINR":"2700800","date":"26-Apr-2024","totalValueINR":"4321280","totalValueInUsd":"51747.3","indian_port":"Bombay Air","hs_no":"29334900","bill_no":"3214562","productDescription":"API","marketType":"REGULATED MARKET","country":"CZECH REPUBLIC","selfForZScoreResived":"Pharma Grade","supplierPort":"PRAGUE - RUZYNE","supplierAddress":"PIET HEIN BUILDING ,PIET HEINKADE 107 1019 GM AMSTERDAM THE NETHERLANDS Amsterdam, AMSTERDAM, NETHERLANDS NETHERLANDS","customerAddress":"3RD FLOOR,MERCANTILE CHAMBERS"}]
31-Mar-2021
18-Oct-2024
KGS
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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INTERMEDIATES SUPPLIERS

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01

Minakem

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothMinakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

CAS Number : 5006-22-4

End Use API : Butorphanol Tartrate

About The Company : MINAKEM is a cGMP custom manufacturer of small molecule API, HPAPI and steroids. All development and manufacturing activities are supported by highly skilled R&...

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02

Minakem

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothMinakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

CAS Number : 3721-95-7

End Use API : Butorphanol Tartrate

About The Company : MINAKEM is a cGMP custom manufacturer of small molecule API, HPAPI and steroids. All development and manufacturing activities are supported by highly skilled R&...

Minakem Comapny Banner

03

Minakem

France
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothMinakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

CAS Number : 4415-82-1

End Use API : Butorphanol Tartrate

About The Company : MINAKEM is a cGMP custom manufacturer of small molecule API, HPAPI and steroids. All development and manufacturing activities are supported by highly skilled R&...

Minakem Comapny Banner

04

Antibody Engineering
Not Confirmed
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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothM2i Group, an integrated CDMO, is your French partner for development & manufacturing in fine chemistry.

CAS Number : 2987-17-9

End Use API : Butorphanol Tartrate

About The Company : Integrated solutions for all your projects.
M2i Group provides integrated solutions for all your projects. We offer our clients an integrated partner, fr...

m2i group

05

Antibody Engineering
Not Confirmed
arrow
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothM2i Group, an integrated CDMO, is your French partner for development & manufacturing in fine chemistry.

CAS Number : 5006-22-4

End Use API : Butorphanol Tartrate

About The Company : Integrated solutions for all your projects.
M2i Group provides integrated solutions for all your projects. We offer our clients an integrated partner, fr...

m2i group

06

Antibody Engineering
Not Confirmed
arrow
Antibody Engineering
Not Confirmed
arrow

CAS Number : 3721-95-7

End Use API : Butorphanol Tartrate

About The Company : Delta Finochem Pvt Ltd. is a privately owned and professionally managed company, accredited by WHO-GMP & ISO 9001:2015 (Year of establishment 1994) Delta Finoch...

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01

Brand Name : BUTORPHANOL TARTRATE

Canada
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Antibody Engineering
Not Confirmed

Brand Name : BUTORPHANOL TARTRATE

Canada
arrow
Antibody Engineering
Not Confirmed

Butorphanol Tartrate

Dosage Form : SPRAY, METERED;NASAL

Dosage Strength : 1MG/SPRAY

Price Per Pack :

Published in :

Country : USA

RX/OTC/DISCN : RX

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02

Brand Name : BUTORPHANOL TARTRATE

United Kingdom
arrow
Antibody Engineering
Not Confirmed

Brand Name : BUTORPHANOL TARTRATE

United Kingdom
arrow
Antibody Engineering
Not Confirmed

Butorphanol Tartrate

Dosage Form : SPRAY, METERED;NASAL

Dosage Strength : 1MG/SPRAY

Price Per Pack :

Published in :

Country : USA

RX/OTC/DISCN : RX

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03

Brand Name : BUTORPHANOL TARTRATE

U.S.A
arrow
Antibody Engineering
Not Confirmed

Brand Name : BUTORPHANOL TARTRATE

U.S.A
arrow
Antibody Engineering
Not Confirmed

Butorphanol Tartrate

Dosage Form : SPRAY, METERED;NASAL

Dosage Strength : 1MG/SPRAY

Price Per Pack :

Published in :

Country : USA

RX/OTC/DISCN : RX

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USP

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Others

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01

USP

U.S.A
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Antibody Engineering
Not Confirmed

USP

U.S.A
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Not Confirmed

Butorphanol Tartrate CIV (350 mg)

CAS Number : 58786-99-5

Quantity Per Vial : 350

Sale Unit : mg

Price : $370.00

Details : Material Origin- Chemical Synthesis; USMCA- N...

Monograph :

Storage :

Code/Batch No : Catalog #1082504 / R116K0

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