Global sales information of Butorphanol Tartrate with Finished Drug Prices obtained from US Medicaid's National Average Drug Acquisition Cost

Butorphanol Tartrate

Malladi Butorphanol

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Bora Pharmaceuticals- Making success more certain.

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Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

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Axplora- The partner of choice for complex APIs.

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Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 8 USDMF, 1 EU WC, 5 NDC API, 8 Listed Suppliers, $ API Reference Price

15 API Suppliers
8 USDMF
1 EU WC
5 NDC API
8 Listed Suppliers
$ API Reference Price

INTERMEDIATES

6 Intermediates Suppliers

6 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

41 FDF Dossiers, 26 FDA Orange Book, 5 Canada, 10 Listed Dossiers

41 FDF Dossiers
26 FDA Orange Book
5 Canada
10 Listed Dossiers

RELATED EXCIPIENT COMPANIES

6 Actylis

relatedExcipients
6 Actylis

EXCIPIENTS BY APPLICATIONS

3 Parenteral, 2 Controlled & Modified Release, 1 Solubilizers

excipientsByApplications
3 Parenteral
2 Controlled & Modified Release
1 Solubilizers

GLOBAL SALES INFORMATION

3 Finished Drug Prices

globalSalesInformation
3 Finished Drug Prices

MARKET PLACE

5 APIs, 1 FDF Dossiers

marketPlace
5 APIs
1 FDF Dossiers

REF. STANDARDS & IMPURITIES

1 USP , 1 Others

otherSolutions
1 USP
1 Others

Malladi Butorphanol

Synopsis

ACTIVE PHARMA INGREDIENTS

15

API Suppliers

8

USDMF

0

CEP/COS

CEP/COS Certifications

0

JDMF

1

EU WC

0

KDMF

5

NDC API

0

VMF

8

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 50,800

MARKET PLACE

5

API

1

FDF

6INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

41

FDF Dossiers

26

FDA Orange Book

FDA (Orange Book)

0

Europe

5

Canada

0

Australia

0

South Africa

10

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

1

USP

0

JP

1

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

NA

Finished Drug Prices

6 RELATED EXCIPIENT COMPANIES

6EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Butorphanol tartrate, 58786-99-5, Butorphanol (+)-tartrate salt, Stadol (tn), Butorphanol tartrate salt, Butorphanol tartrate (jan/usp)

Molecular Formula

C₂₅H₃₅NO₈

Molecular Weight

477.5 g/mol

InChI Key

GMTYREVWZXJPLF-BTVKVFNOSA-N

Butorphanol Tartrate

A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.

1 2D Structure

Butorphanol Tartrate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1S,9R,10S)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-4,10-diol;(2R,3R)-2,3-dihydroxybutanedioic acid

2.1.2 InChI

InChI=1S/C21H29NO2.C4H6O6/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15;5-1(3(7)8)2(6)4(9)10/h6-7,13,15,19,23-24H,1-5,8-12,14H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-,20+,21-;1-,2-/m11/s1

2.1.3 InChI Key

GMTYREVWZXJPLF-BTVKVFNOSA-N

2.1.4 Canonical SMILES

C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O.C(C(C(=O)O)O)(C(=O)O)O

2.1.5 Isomeric SMILES

C1CC[C@]2([C@H]3CC4=C([C@]2(C1)CCN3CC5CCC5)C=C(C=C4)O)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 17-(cyclobutylmethyl)morphinan-3,14-diol

2. Apo-butorphanol

3. Bc 2627

4. Bc-2627

5. Bc2627

6. Beforal

7. Butorphanol

8. Butorphanol Tartrate

9. Dolorex

10. Moradol

11. Stadol

12. Stadol Ns

13. Torbugesic

2.2.2 Depositor-Supplied Synonyms

1. Butorphanol Tartrate

2. 58786-99-5

3. Butorphanol (+)-tartrate Salt

4. Stadol (tn)

5. Butorphanol Tartrate Salt

6. Butorphanol Tartrate (jan/usp)

7. Akos015994595

8. Hs-0001

9. Butorphanol (+)-tartrate Salt, >=99%

10. D00837

11. 786b995

12. Butorphanol Tartrate, United States Pharmacopeia (usp) Reference Standard

2.2.3 Other Synonyms

1. Butorfanol

2. Torate

3. Torbutrol

2.3 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₅NO₈
Molecular Weight	477.5 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	477.23626707 g/mol
Monoisotopic Mass	477.23626707 g/mol
Topological Polar Surface Area	159 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	626
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Butorphanol tartrate
Drug Label	Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R,R)] 2,3 dihydroxybutanedioate (1:1) (salt). The molecul...
Active Ingredient	Butorphanol tartrate
Dosage Form	Injectable; Spray, metered
Route	Nasal; Injection
Strength	2mg/ml; 1mg/ml; 1mg/spray
Market Status	Prescription
Company	Bedford; Hikma Farmaceutica; Novex; Mylan; Roxane

2 of 2
Drug Name	Butorphanol tartrate
Drug Label	Butorphanol tartrate is a synthetically derived opioid agonist-antagonist analgesic of the phenanthrene series. The chemical name is (-)-17-(cyclobutylmethyl) morphinan-3, 14-diol [S-(R,R)] 2,3 dihydroxybutanedioate (1:1) (salt). The molecul...
Active Ingredient	Butorphanol tartrate
Dosage Form	Injectable; Spray, metered
Route	Nasal; Injection
Strength	2mg/ml; 1mg/ml; 1mg/spray
Market Status	Prescription
Company	Bedford; Hikma Farmaceutica; Novex; Mylan; Roxane

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Narcotic Antagonists

Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Opioid Agonist/Antagonist [EPC]; Partial Opioid Agonists [MoA]; Competitive Opioid Antagonists [MoA]

API SUPPLIERS

01

Malladi Drugs & Pharmaceuticals Li...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

Malladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

Contact Supplier

Contact Supplier

India

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

02

AbbVie Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

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Contact Supplier

U.S.A

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Abbvie Company Banner

Product Web Link

Digital Content

Corporate PDF

03

Suanfarma

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI Worldwide, Milan

SuanFarma is present in all origins: Natural, Chemical & Biotechnological.

Contact Supplier

Contact Supplier

Spain

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

04

Teva API

Israel

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

05

Sri Krishna Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

06

Hikal

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

07

Curia

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

08

Abbott Laboratories

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

09

Merck & Co

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

10

Tasmanian Alkaloids Pty Ltd

Australia

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Discovery on Target

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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