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Bykomcyin

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Also known as: Framycetin (sulfate), Fradiomycin b (sulfate); neomycin b (sulfate), Neomycin sulfate, 4146-30-9, Bcp28374, Neomycin sulfate; neomycin sulphate b

Molecular Formula

C₂₃H₅₂N₆O₂₅S₃

Molecular Weight

908.9 g/mol

InChI Key

KWBUARAINLGYMG-UHFFFAOYSA-N

Aminoglycoside antibiotic complex produced by Streptomyces fradiae. It is composed of neomycins A, B, and C, and acts by inhibiting translation during protein synthesis.

1 2D Structure

Bykomcyin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-amino-2-(aminomethyl)-6-[4,6-diamino-2-[4-[3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol;sulfuric acid

2.1.2 InChI

InChI=1S/C23H46N6O13.3H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4)

2.1.3 InChI Key

KWBUARAINLGYMG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Fradiomycin Sulfate

2. Neomycin

3. Neomycin Palmitate

4. Neomycin Sulfate

2.2.2 Depositor-Supplied Synonyms

1. Framycetin (sulfate)

2. Fradiomycin B (sulfate); Neomycin B (sulfate)

3. Neomycin Sulfate

4. 4146-30-9

5. Bcp28374

6. Neomycin Sulfate; Neomycin Sulphate B

2.3 Create Date

2009-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₃H₅₂N₆O₂₅S₃
Molecular Weight	908.9 g/mol
Hydrogen Bond Donor Count	19
Hydrogen Bond Acceptor Count	31
Rotatable Bond Count	9
Exact Mass	908.21442469 g/mol
Monoisotopic Mass	908.21442469 g/mol
Topological Polar Surface Area	602 Å²
Heavy Atom Count	57
Formal Charge	0
Complexity	953
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	19
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Information

1 of 20
Drug Name	NEO-SYNALAR
Active Ingredient	FLUOCINOLONE ACETONIDE; NEOMYCIN SULFATE
Company	MEDIMETRIKS PHARMS (Application Number: A060700)

2 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATE
Active Ingredient	NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	WATSON LABS (Application Number: A062664); X GEN PHARMS (Application Number: A065106); X GEN PHARMS (Application Number: A065108)

3 of 20
Drug Name	NEOSPORIN G.U. IRRIGANT
Active Ingredient	NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	MONARCH PHARMS (Application Number: A060707)

4 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATES AND BACITRACIN ZINC
Active Ingredient	BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	AKORN (Application Number: A065088); BAUSCH AND LOMB (Application Number: A064064); PERRIGO CO TENNESSEE (Application Number: A060764)

5 of 20
Drug Name	NEOSPORIN
Active Ingredient	BACITRACIN ZINC; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	CASPER PHARMA LLC (Application Number: N050417)

6 of 20
Drug Name	DEXASPORIN
Active Ingredient	DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	BAUSCH AND LOMB (Application Number: A064135)

7 of 20
Drug Name	MAXITROL
Active Ingredient	DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	NOVARTIS PHARMS CORP (Application Number: N050023); NOVARTIS PHARMS CORP (Application Number: N050065); SANDOZ INC (Application Number: A062341)

8 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATES AND DEXAMETHASONE
Active Ingredient	DEXAMETHASONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	BAUSCH AND LOMB (Application Number: A064063); PERRIGO CO TENNESSEE (Application Number: A062938)

9 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN
Active Ingredient	GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	AMRING PHARMS (Application Number: A065187); BAUSCH AND LOMB (Application Number: A064047)

10 of 20
Drug Name	NEOSPORIN
Active Ingredient	GRAMICIDIN; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	MONARCH PHARMS (Application Number: A060582)

11 of 20
Drug Name	CORTISPORIN
Active Ingredient	HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	MONARCH PHARMS (Application Number: N050218)

12 of 20
Drug Name	CASPORYN HC
Active Ingredient	HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	CASPER PHARMA LLC (Application Number: N060613)

13 of 20
Drug Name	CORTISPORIN
Active Ingredient	HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	MONARCH PHARMS (Application Number: N050479)

14 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATES AND HYDROCORTISONE
Active Ingredient	HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	AMRING PHARMS (Application Number: A065216); AMRING PHARMS (Application Number: A065219); BAUSCH AND LOMB (Application Number: A064053); SANDOZ INC (Application Number: A062423); SANDOZ INC (Application Number: A062488); SANDOZ INC (Application Number: A062874)

15 of 20
Drug Name	OTICAIR
Active Ingredient	HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	BAUSCH AND LOMB (Application Number: A064065)

16 of 20
Drug Name	BACITRACIN-NEOMYCIN-POLYMYXIN W/ HYDROCORTISONE ACETATE
Active Ingredient	BACITRACIN ZINC; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	PERRIGO CO TENNESSEE (Application Number: A062166)

17 of 20
Drug Name	CORTISPORIN
Active Ingredient	BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	MONARCH PHARMS (Application Number: N050168)

18 of 20
Drug Name	NEOMYCIN AND POLYMYXIN B SULFATES, BACITRACIN ZINC AND HYDROCORTISONE
Active Ingredient	BACITRACIN ZINC; HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE
Company	AKORN (Application Number: A065213); BAUSCH AND LOMB (Application Number: A064068)

19 of 20
Drug Name	COLY-MYCIN S
Active Ingredient	COLISTIN SULFATE; HYDROCORTISONE ACETATE; NEOMYCIN SULFATE; THONZONIUM BROMIDE
Company	ENDO PHARMS INC (Application Number: N050356)

20 of 20
Drug Name	NEOMYCIN SULFATE
Active Ingredient	NEOMYCIN SULFATE
Company	BRECKENRIDGE PHARM (Application Number: A065468); LANNETT CO INC (Application Number: A204435); TEVA (Application Number: A060304); X GEN PHARMS (Application Number: A065220)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

Protein Synthesis Inhibitors

Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)

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