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Cabergoline

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ACTIVE PHARMA INGREDIENTS

25 API Suppliers, 11 USDMF, 5 CEP/COS, 1 JDMF, 3 EU WC, 4 NDC API, 17 Listed Suppliers, $ API Reference Price

25 API Suppliers
11 USDMF
5 CEP/COS
1 JDMF
3 EU WC
4 NDC API
17 Listed Suppliers
$ API Reference Price

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

86 FDF Dossiers, 10 FDA Orange Book, 58 Europe, 2 Canada, 5 Australia, 4 South Africa, 7 Listed Dossiers

86 FDF Dossiers
10 FDA Orange Book
58 Europe
2 Canada
5 Australia
4 South Africa
7 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Evonik, 1 SPI Pharma, 3 Faran Shimi Pharmaceutical, 9 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 4 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 2 BASF, 6 DFE Pharma, 3 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 25 Kerry, 10 Microlex e.U, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 9 Roquette, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 10 Sigachi Industries, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

46 Fillers, Diluents & Binders, 23 Direct Compression, 14 Co-Processed Excipients, 14 Disintegrants & Superdisintegrants, 13 Granulation, 11 Lubricants & Glidants, 10 Thickeners and Stabilizers, 5 Controlled & Modified Release, 3 Coating Systems & Additives, 3 Taste Masking, 2 Rheology Modifiers, 2 Chewable & Orodispersible Aids, 1 Emulsifying Agents, 1 Parenteral, 1 Film Formers & Plasticizers, 1 Topical

excipientsByApplications
46 Fillers, Diluents & Binders
23 Direct Compression
14 Co-Processed Excipients
14 Disintegrants & Superdisintegrants
13 Granulation
11 Lubricants & Glidants
10 Thickeners and Stabilizers
5 Controlled & Modified Release
3 Coating Systems & Additives
3 Taste Masking
2 Rheology Modifiers
2 Chewable & Orodispersible Aids
1 Emulsifying Agents
1 Parenteral
1 Film Formers & Plasticizers
1 Topical

DIGITAL CONTENT

5 NEWS #PharmaBuzz

media
5 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 25 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
25 Finished Drug Prices

MARKET PLACE

10 APIs, 5 FDF Dossiers, 1 Intermediates

marketPlace
10 APIs
5 FDF Dossiers
1 Intermediates

REF. STANDARDS & IMPURITIES

1 EDQM , 1 USP , 1 Others

otherSolutions
1 EDQM
1 USP
1 Others

Lifecare Cabergoline

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 260,006

MARKET PLACE

API

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

9,805,491

Annual Reports (USD Million)

Finished Drug Prices

99 RELATED EXCIPIENT COMPANIES

150EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 81409-90-7, Dostinex, Cabaser, Cabergolinum [latin], Cabergolina [spanish], Cabergolinum

Molecular Formula

C₂₆H₃₇N₅O₂

Molecular Weight

451.6 g/mol

InChI Key

KORNTPPJEAJQIU-KJXAQDMKSA-N

FDA UNII

LL60K9J05T

An ergoline derivative and dopamine D2-agonist that inhibits PROLACTIN secretion. It is used in the management of HYPERPROLACTINEMIA, and to suppress lactation following childbirth for medical reasons. Cabergoline is also used in the management of PARKINSON DISEASE.

Cabergoline is an Ergot Derivative.

1 2D Structure

Cabergoline

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide

2.1.2 InChI

InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1

2.1.3 InChI Key

KORNTPPJEAJQIU-KJXAQDMKSA-N

2.1.4 Canonical SMILES

CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C

2.1.5 Isomeric SMILES

CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C

2.2 Other Identifiers

2.2.1 UNII

LL60K9J05T

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

2. 1-ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea Diphosphate

3. Cabaser

4. Cabaseril

5. Cabergoline Diphosphate

6. Dostinex

7. Fce 21336

8. Fce-21336

9. Galastop

2.3.2 Depositor-Supplied Synonyms

1. 81409-90-7

2. Dostinex

3. Cabaser

4. Cabergolinum [latin]

5. Cabergolina [spanish]

6. Cabergolinum

7. Cabergolina

8. Fce-21336

9. Fce 21336

10. Velactis

11. 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

12. Cabaseril

13. Chebi:3286

14. Ll60k9j05t

15. Dsstox_cid_2719

16. 1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea

17. 1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea

18. (8r)-6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide

19. Dsstox_rid_76698

20. Dsstox_gsid_22719

21. (6ar,9r,10ar)-7-allyl-n-(3-(dimethylamino)propyl)-n-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

22. (8beta)-n-[3-(dimethylamino)propyl]-n-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide

23. Sogilen

24. Dostinex (tn)

25. 1-[3-(dimethylamino)propyl]-3-ethyl-1-{[(2r,4r,7r)-6-(prop-2-en-1-yl)-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]carbonyl}urea

26. Cabaser (tn)

27. Cas-81409-90-7

28. Sr-05000001493

29. Brn 6020775

30. Unii-ll60k9j05t

31. Caberlin

32. Ncgc00167821-01

33. Cabergoline [usan:usp:inn:ban]

34. Cg-101

35. Mfcd00867887

36. Cabergoline [mi]

37. Cabergoline [inn]

38. Cabergoline [jan]

39. Cabergoline [usan]

40. Gtpl37

41. Cabergoline [vandf]

42. Cabergoline [mart.]

43. Schembl42292

44. Cabergoline [usp-rs]

45. Cabergoline [who-dd]

46. (8beta)-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)-6-(prop-2-en-1-yl)ergoline-8-carboxamide

47. Bidd:gt0775

48. Cabergoline (jan/usp/inn)

49. Chembl1201087

50. Dtxsid6022719

51. Cabergoline, >=98% (hplc)

52. Cabergoline [orange Book]

53. Cabergoline [ep Monograph]

54. Hms2090a09

55. Hms3886h05

56. Cabergoline [usp Monograph]

57. Zinc3800008

58. Tox21_112589

59. Bdbm50426497

60. S5842

61. Akos015961587

62. Tox21_112589_1

63. Db00248

64. Fce-21336fce-21336

65. Cabergoline [ema Epar Veterinary]

66. Ncgc00344544-01

67. (8beta)-n-[3-(dimethylamino)propyl]-n-[(ethylamino)carbonyl]-6-prop-2-en-1-ylergoline-8-carboxamide

68. Ac-26126

69. Ergoline-8-carboxamide, N-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-(2-propenyl)-, (8-beta)-

70. Ergoline-8beta-carboxamide, N-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-(2-propenyl)-

71. Hy-15296

72. C08187

73. D00987

74. F17353

75. Ab01275484-01

76. 409c907

77. Q423308

78. Sr-05000001493-1

79. Sr-05000001493-2

80. Brd-k86882815-001-01-6

81. Cabergoline, European Pharmacopoeia (ep) Reference Standard

82. Cabergoline, United States Pharmacopeia (usp) Reference Standard

83. Ethyl4-methyl-2-pyridin-3-yl-1,3-thiazole-5-carboxylate

84. 1-((6-allylergolin-8.beta.-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea

85. 6-allyl-n-[3-(dimethylamino)propyl]-n-[(ethylamino)carbonyl]-ergoline-8beta-carboxamide

86. N-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)-6-allyl-ergoline-8beta-carboxamide

87. (6ar,9r,10ar)-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carboxamide

88. (9r,10ar)-7-allyl-n-(3-(dimethylamino)propyl)-n-(ethylcarbamoyl)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxamide

89. Ergoline-8.beta.-carboxamide, N-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-(2-propenyl)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₇N₅O₂
Molecular Weight	451.6 g/mol
XLogP3	3.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	451.29472544 g/mol
Monoisotopic Mass	451.29472544 g/mol
Topological Polar Surface Area	71.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	713
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Cabergoline
PubMed Health	Cabergoline (By mouth)
Drug Classes	Antiparkinsonian, Prolactin Secretion Inhibitor
Drug Label	Cabergoline tablets contain cabergoline, a dopamine receptor agonist. The chemical name for cabergoline is 1-[(6-Allylergolin-8-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea. Its molecular formula is C26H37N5O2, and its molecular weight is 4...
Active Ingredient	Cabergoline
Dosage Form	Tablet
Route	Oral
Strength	0.5mg
Market Status	Prescription
Company	Mylan Pharms; Ivax Sub Teva Pharms; Actavis Labs Fl; Apotex; Par Pharm; Impax Labs

2 of 2
Drug Name	Cabergoline
PubMed Health	Cabergoline (By mouth)
Drug Classes	Antiparkinsonian, Prolactin Secretion Inhibitor
Drug Label	Cabergoline tablets contain cabergoline, a dopamine receptor agonist. The chemical name for cabergoline is 1-[(6-Allylergolin-8-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea. Its molecular formula is C26H37N5O2, and its molecular weight is 4...
Active Ingredient	Cabergoline
Dosage Form	Tablet
Route	Oral
Strength	0.5mg
Market Status	Prescription
Company	Mylan Pharms; Ivax Sub Teva Pharms; Actavis Labs Fl; Apotex; Par Pharm; Impax Labs

4.2 Drug Indication

For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.

For use in the herd management programme of dairy cows as an aid in the abrupt drying-off by reducing milk production to:

- reduce milk leakage at drying off;

- reduce the risk of new intramammary infections during the dry period;

- reduce discomfort.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Cabergoline stimulates centrally-located dopaminergic receptors resulting in a number of pharmacologic effects. Five dopamine receptor types from two dopaminergic subfamilies have been identified. The dopaminergic D1 receptor subfamily consists of D₁ and D₅ subreceptors, which are associated with dyskinesias. The dopaminergic D2 receptor subfamily consists of D₂, D₃ and D₄ subreceptors, which are associated with improvement of symptoms of movement disorders. Thus, agonist activity specific for D2 subfamily receptors, primarily D₂ and D₃ receptor subtypes, are the primary targets of dopaminergic antiparkinsonian agents. It is thought that postsynaptic D2 stimulation is primarily responsible for the antiparkinsonian effect of dopamine agonists, while presynaptic D2 stimulation confers neuroprotective effects. This semisynthetic ergot derivative exhibits potent agonist activity on dopamine D₂- and D₃-receptors. It also exhibits: agonist activity (in order of decreasing binding affinities) on 5-hydroxytryptamine (5-HT)_2B, 5-HT_2A, 5-HT_1D, dopamine D₄, 5-HT_1A, dopamine D₁, 5-HT_1B and 5-HT_2C receptors and antagonist activity on α_2B, α_2A, and α_2C receptors. Parkinsonian Syndrome manifests when approximately 80% of dopaminergic activity in the nigrostriatal pathway of the brain is lost. As this striatum is involved in modulating the intensity of coordinated muscle activity (e.g. movement, balance, walking), loss of activity may result in dystonia (acute muscle contraction), Parkinsonism (including symptoms of bradykinesia, tremor, rigidity, and flattened affect), akathesia (inner restlessness), tardive dyskinesia (involuntary muscle movements usually associated with long-term loss of dopaminergic activity), and neuroleptic malignant syndrome, which manifests when complete blockage of nigrostriatal dopamine occurs. High dopaminergic activity in the mesolimbic pathway of the brain causes hallucinations and delusions; these side effects of dopamine agonists are manifestations seen in patients with schizophrenia who have overractivity in this area of the brain. The hallucinogenic side effects of dopamine agonists may also be due to 5-HT_2A agonism. The tuberoinfundibular pathway of the brain originates in the hypothalamus and terminates in the pituitary gland. In this pathway, dopamine inhibits lactotrophs in anterior pituitary from secreting prolactin. Increased dopaminergic activity in the tuberoinfundibular pathway inhibits prolactin secretion.

5.2 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)

Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

CABERGOLINE

5.3.2 FDA UNII

LL60K9J05T

5.3.3 Pharmacological Classes

Ergot Derivative [EPC]; Ergolines [CS]

5.4 ATC Code

QG02CB03

G02CB03

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

G - Genito urinary system and sex hormones

G02 - Other gynecologicals

G02C - Other gynecologicals

G02CB - Prolactine inhibitors

G02CB03 - Cabergoline

N - Nervous system

N04 - Anti-parkinson drugs

N04B - Dopaminergic agents

N04BC - Dopamine agonists

N04BC06 - Cabergoline

5.5 Absorption, Distribution and Excretion

Absorption

First-pass effect is seen, however the absolute bioavailability is unknown.

Route of Elimination

After oral dosing of radioactive cabergoline to five healthy volunteers, approximately 22% and 60% of the dose was excreted within 20 days in the urine and feces, respectively. Less than 4% of the dose was excreted unchanged in the urine.

Clearance

renal cl=0,008 L/min

nonrenal cl=3.2 L/min

5.6 Metabolism/Metabolites

Hepatic. Cabergoline is extensively metabolized, predominately via hydrolysis of the acylurea bond of the urea moiety. Cytochrome P-450 mediated metabolism appears to be minimal. The main metabolite identified in urine is 6-allyl-8b-carboxy-ergoline (4-6% of dose). Three other metabolites were identified urine (less than 3% of dose).

5.7 Biological Half-Life

The elimination half-life is estimated from urinary data of 12 healthy subjects to range between 63 to 69 hours.

5.8 Mechanism of Action

The dopamine D₂ receptor is a 7-transmembrane G-protein coupled receptor associated with G_i proteins. In lactotrophs, stimulation of dopamine D₂ causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentrations and blocks IP3-dependent release of Ca²⁺ from intracellular stores. Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition. Stimulation of dopamine D₂ receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders. Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. Receptor-binding studies indicate that cabergoline has low affinity for dopamine D1, α₁,- and α₂- adrenergic, and 5-HT₁- and 5-HT₂-serotonin receptors.

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Lifecare Laboratories Pvt Ltd

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Pfizer Inc

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Lifecare Laboratories Pvt Ltd

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About the Company : Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence throug...

Lifecare Labs specializes in producing bulk drugs (APIs) and intermediates that adhere to the industry's stringent quality parameters. Its objective is to deliver excellence through its "quality designed for excellence" mission and meet its customers' requirements. Cost-effectiveness is a top priority for the company, and it aims to establish long-term relationships with its clients. Lifecare Labs possesses state-of-the-art facilities for manufacturing bulk drugs (APIs) and intermediates and has dedicated units for products. Its mission is to become a globally recognized company responsible for its customers, business partners and society.

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Established in 1996, CF Pharma Ltd. is a privately owned, independent developer & producer of APIs headquartered in Budapest, Hungary. It specializes in the development & manufacturing of high-quality, complex APIs & advanced intermediates with proven experience in handling complex & hazardous chemistry, making it a partner of choice in the development of “difficult to make” molecules. Since 1999, 25 API manufacturing processes have been developed in its three R&D labs. It specializes in quality control & regulatory compliance, & has consistently done well in regular inspections carried out by the Hungarian authority & European agencies.

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Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

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LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

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Cabergoline

About the Company : Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their co...

Deccan Nutraceuticals Pvt. Ltd. (DNPL) is a group company of Alkaloids Corporation (India), was founded in 2001 and operates from a 22,000 sq. m. facility in Pune (India). Their commitment to quality and adherence to Current Good Manufacturing Practices (CGMP) are integral to their operations. The company has been successfully audited by USFDA (5 times) and EDQM (2 times). The company manufactures high quality phytochemicals, semi-synthetic and synthetic APIs. DNPL stands as a responsible pharmaceutical manufacturer, devoted to delivering premium products across all the regions we serve.

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06

HRV Global Life Sciences

India

Antibody Engineering

Not Confirmed

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Cabergoline

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

07

TAPI Technology & API Services

Israel

CPhI WW Frankfurt

Booth #6.1A32

TAPI offers customized CDMO Solutions for API development and manufacturing services.

Contact Supplier

Israel

Virtual Booth

Digital Content

Cabergoline

About the Company : Founded in 1935, TAPI Technology & API Services has a long-standing tradition of advancing health through innovation and dedication. Today, we proudly build upon this legacy, drivi...

Founded in 1935, TAPI Technology & API Services has a long-standing tradition of advancing health through innovation and dedication. Today, we proudly build upon this legacy, driving progress in the pharmaceutical industry. Leveraging our extensive experience and world-class expertise, we deliver one of the most comprehensive API portfolios in the industry. Additionally, we provide tailored CDMO services, harnessing our proficiency in diverse technologies to meet our partners' unique needs, ensuring flexibility and excellence in every project.

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08

Global Calcium

India

Antibody Engineering

Not Confirmed

09

Sichuan Renan Pharmaceutical

China

Antibody Engineering

Not Confirmed

10

Teva Pharmaceutical Industries

Israel

Antibody Engineering

Not Confirmed

Only 10 entries up to this point, click to access all

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API Reference Price

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