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1. Blood Coagulation Factor Iv
2. Calcium 40
3. Calcium-40
4. Coagulation Factor Iv
5. Factor Iv
6. Factor Iv, Coagulation
1. 7440-70-2
2. Ca
3. Elemental Calcium
4. Calcium, Elemental
5. Calcium Hydride (cah)
6. Sy7q814vup
7. Mfcd00010897
8. Mfcd00085314
9. Calcium Compounds
10. Hsdb 273
11. Einecs 231-179-5
12. Un1401
13. Unii-sy7q814vup
14. Kalzium
15. Calcium Atom
16. Calcium Ingot
17. Calcium Chelate
18. Calcium Shot
19. Calcium Granules
20. Calcium Turnings
21. Bio Lacta Cal
22. Calcium(0)
23. Calcium Turnings, 2n
24. Calcium, Natural Milk
25. Calcium [vandf]
26. Calcium [hsdb]
27. Calcium [ii]
28. Calcium [mi]
29. Calcium [usp-rs]
30. Calcium [who-dd]
31. Calcium, Granular, 99%
32. 20ca
33. Ec 231-179-5
34. Calcium Granules, -9 Mesh
35. Calcium Krebs 21% 40m
36. Calcium Milk Calcium 28%
37. Calcium Sweet Chelate 20%
38. Calcium Oratate 11% 40m
39. Ca(0)
40. Calcium [orange Book]
41. Calcium Hydride, Coarse Powder
42. Calcium Ms Plus 18% 40m
43. Chembl2146121
44. Dtxsid9050484
45. Chebi:22984
46. Chebi:29320
47. Hsdb 6931
48. Calcium, Pieces, <1 Cm, 99%
49. Calcium Crystalline Dendritic Pieces
50. Calcium, Crystalline, Dendritic, 4n
51. Calcium Shot, 1cm (0.4in) & Down
52. Db01373
53. Calcium Granules, Redistilled, -6 Mesh
54. Calcium, Saj First Grade, >=99.5%
55. Calcium Granules, Redistilled, -16 Mesh
56. Bp-31015
57. Q706
58. Calcium [un1401] [dangerous When Wet]
59. Calcium Hydride, 99.9% Trace Metals Basis
60. Calcium, Turnings, 99% Trace Metals Basis
61. Calcium Bio Calcium Ms (maxium Solubility) 40m
62. Calcium Bio Calcium Ms Plus(maxium Solubility) 40m
63. Calcium Hydride, Powder, 99.99% Trace Metals Basis
64. Calcium Hydride, Reagent Grade, 95% (gas-volumetric)
65. C000001000
66. Calcium Hydride, Chunks, +4 Mesh, Reagent Grade, 95%
67. Calcium, Aas Standard Solution, Specpure?, Ca 1000?g/ml
68. Calcium, Oil Based Standard Solution, Specpure, Ca 1000g/g
69. Calcium, Oil Based Standard Solution, Specpure?, Ca 5000?g/g
70. Calcium, Plasma Standard Solution, Specpure?, Ca 1000?g/ml
71. Calcium Hydride, Purum P.a., >=97.0% (gas-volumetric), Powder
72. Calcium, Plasma Standard Solution, Specpure(r), Ca 10,000?g/ml
73. Calcium Hydride, Powder, 0-2 Mm, Reagent Grade, >=90% (gas-volumetric)
74. Calcium, Dendritic Pieces, Purified By Distillation, 99.5% Trace Metals Basis
75. Calcium, Dendritic Pieces, Purified By Distillation, 99.9% Trace Metals Basis
76. Calcium, Dendritic Pieces, Purified By Distillation, 99.99% Trace Metals Basis
Molecular Weight | 40.08 g/mol |
---|---|
Molecular Formula | Ca |
Hydrogen Bond Donor Count | 0 |
Hydrogen Bond Acceptor Count | 0 |
Rotatable Bond Count | 0 |
Exact Mass | 39.9625908 g/mol |
Monoisotopic Mass | 39.9625908 g/mol |
Topological Polar Surface Area | 0 Ų |
Heavy Atom Count | 1 |
Formal Charge | 0 |
Complexity | 0 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.
FDA Label
Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.
Calcium-Regulating Hormones and Agents
Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. (See all compounds classified as Calcium-Regulating Hormones and Agents.)
A - Alimentary tract and metabolism
A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents
A07X - Other antidiarrheals
A07XA - Other antidiarrheals
A07XA03 - Calcium compounds
Route of Elimination
The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.
Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 28169
Submission : 2014-03-31
Status : Active
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 25141
Submission : 2011-10-19
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 2709
Submission : 1976-07-15
Status : Inactive
Type : II
GDUFA
DMF Review : N/A
Rev. Date :
Pay. Date :
DMF Number : 20928
Submission : 2007-11-21
Status : Inactive
Type : II
Certificate Number : R1-CEP 2006-256 - Rev 00
Issue Date : 2014-02-20
Type : Chemical
Substance Number : 116
Status : Valid
Certificate Number : R0-CEP 2010-209 - Rev 00
Issue Date : 2012-02-07
Type : Chemical
Substance Number : 1183
Status : Withdrawn by EDQM F...
Certificate Number : R1-CEP 2009-065 - Rev 04
Issue Date : 2023-02-06
Type : Chemical
Substance Number : 1183
Status : Valid
Certificate Number : R1-CEP 1997-069 - Rev 08
Issue Date : 2018-08-09
Type : Chemical
Substance Number : 1183
Status : Valid
Certificate Number : R1-CEP 2006-255 - Rev 01
Issue Date : 2022-04-20
Type : Chemical
Substance Number : 1052
Status : Valid
Certificate Number : R1-CEP 2005-144 - Rev 00
Issue Date : 2013-11-08
Type : Chemical
Substance Number : 981
Status : Valid
API Imports and Exports
Importing Country | Total Quantity (KGS) |
Average Price (USD/KGS) |
Number of Transactions |
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Regulatory Info :
Registration Country : India
Calcium; Vitamin D3; Vitamin B12
Brand Name :
Dosage Form : Injection
Dosage Strength : 76.4MG; 5000IU; 50MCG
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : India
Regulatory Info : Generic
Registration Country : India
Calcium Carbonate; Elemental calcium; Vitamin D3
Brand Name : Ocium Kid Chewable
Dosage Form : Tablet
Dosage Strength : 625MG; 250MG; 125IU
Packaging :
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : India
Regulatory Info : Generic
Registration Country : India
Calcium Carbonate; Elemental calcium; Vitamin D3
Brand Name : Ocium 500
Dosage Form : Tablet
Dosage Strength : 1250MG; 500MG; 250IU
Packaging :
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : India
Regulatory Info : Generic
Registration Country : India
Calcium Carbonate; Elemental calcium; Vitamin D3
Brand Name : Ocium 250
Dosage Form : Tablet
Dosage Strength : 625MG; 250MG; 125IU
Packaging :
Approval Date :
Application Number :
Regulatory Info : Generic
Registration Country : India
Regulatory Info :
Registration Country : Italy
Brand Name : Haemobionine
Dosage Form : Coagulation Factor Ix Lyophilized Human 500Iu 10Ml 1 Units Parenteral Use
Dosage Strength : 1 bottle 500 IU + 1 vial of 10 ml solv + dual system filter + butterfly needle
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Italy
Regulatory Info : Originator
Registration Country : South Africa
Calcium (different salts in combination)
Brand Name : ITN 1603 A
Dosage Form : INF
Dosage Strength : 1ZZZ
Packaging : 1X1ZZZ
Approval Date :
Application Number :
Regulatory Info : Originator
Registration Country : South Africa
Regulatory Info : Originator
Registration Country : South Africa
Calcium (different salts in combination)
Brand Name : ITN 7005 A
Dosage Form : INF
Dosage Strength : 1ZZZ
Packaging : 1X1ZZZ
Approval Date :
Application Number :
Regulatory Info : Originator
Registration Country : South Africa
Regulatory Info : Originator
Registration Country : South Africa
Calcium (different salts in combination)
Brand Name : ITN 8003 A
Dosage Form : TPN
Dosage Strength : 1ZZZ
Packaging : 2140X1g
Approval Date :
Application Number :
Regulatory Info : Originator
Registration Country : South Africa
Regulatory Info :
Registration Country : Australia
Brand Name : CAL-600
Dosage Form :
Dosage Strength :
Packaging : 120
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Australia
Regulatory Info :
Registration Country : Switzerland
Calcium ionisatum; cholecalciferol (vitamin D3)
Brand Name : Calperos D3
Dosage Form : Natural Lozenges
Dosage Strength :
Packaging :
Approval Date :
Application Number :
Regulatory Info :
Registration Country : Switzerland
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