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    Chemistry

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    Also known as: 7440-70-2, Ca, Elemental calcium, Calcium, elemental, Calcium hydride (cah), Sy7q814vup
    Molecular Formula
    Ca
    Molecular Weight
    40.08  g/mol
    InChI Key
    OYPRJOBELJOOCE-UHFFFAOYSA-N
    FDA UNII
    SY7Q814VUP
    Calcium
    A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
    1 2D Structure

    Calcium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium
    2.1.2 InChI
    InChI=1S/Ca
    2.1.3 InChI Key
    OYPRJOBELJOOCE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    [Ca]
    2.2 Other Identifiers
    2.2.1 UNII
    SY7Q814VUP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Blood Coagulation Factor Iv

    2. Calcium 40

    3. Calcium-40

    4. Coagulation Factor Iv

    5. Factor Iv

    6. Factor Iv, Coagulation

    2.3.2 Depositor-Supplied Synonyms

    1. 7440-70-2

    2. Ca

    3. Elemental Calcium

    4. Calcium, Elemental

    5. Calcium Hydride (cah)

    6. Sy7q814vup

    7. Mfcd00010897

    8. Mfcd00085314

    9. Calcium Compounds

    10. Hsdb 273

    11. Einecs 231-179-5

    12. Un1401

    13. Unii-sy7q814vup

    14. Kalzium

    15. Calcium Atom

    16. Calcium Ingot

    17. Calcium Chelate

    18. Calcium Shot

    19. Calcium Granules

    20. Calcium Turnings

    21. Bio Lacta Cal

    22. Calcium(0)

    23. Calcium Turnings, 2n

    24. Calcium, Natural Milk

    25. Calcium [vandf]

    26. Calcium [hsdb]

    27. Calcium [ii]

    28. Calcium [mi]

    29. Calcium [usp-rs]

    30. Calcium [who-dd]

    31. Calcium, Granular, 99%

    32. 20ca

    33. Ec 231-179-5

    34. Calcium Granules, -9 Mesh

    35. Calcium Krebs 21% 40m

    36. Calcium Milk Calcium 28%

    37. Calcium Sweet Chelate 20%

    38. Calcium Oratate 11% 40m

    39. Ca(0)

    40. Calcium [orange Book]

    41. Calcium Hydride, Coarse Powder

    42. Calcium Ms Plus 18% 40m

    43. Chembl2146121

    44. Dtxsid9050484

    45. Chebi:22984

    46. Chebi:29320

    47. Hsdb 6931

    48. Calcium, Pieces, <1 Cm, 99%

    49. Calcium Crystalline Dendritic Pieces

    50. Calcium, Crystalline, Dendritic, 4n

    51. Calcium Shot, 1cm (0.4in) & Down

    52. Db01373

    53. Calcium Granules, Redistilled, -6 Mesh

    54. Calcium, Saj First Grade, >=99.5%

    55. Calcium Granules, Redistilled, -16 Mesh

    56. Bp-31015

    57. Q706

    58. Calcium [un1401] [dangerous When Wet]

    59. Calcium Hydride, 99.9% Trace Metals Basis

    60. Calcium, Turnings, 99% Trace Metals Basis

    61. Calcium Bio Calcium Ms (maxium Solubility) 40m

    62. Calcium Bio Calcium Ms Plus(maxium Solubility) 40m

    63. Calcium Hydride, Powder, 99.99% Trace Metals Basis

    64. Calcium Hydride, Reagent Grade, 95% (gas-volumetric)

    65. C000001000

    66. Calcium Hydride, Chunks, +4 Mesh, Reagent Grade, 95%

    67. Calcium, Aas Standard Solution, Specpure?, Ca 1000?g/ml

    68. Calcium, Oil Based Standard Solution, Specpure, Ca 1000g/g

    69. Calcium, Oil Based Standard Solution, Specpure?, Ca 5000?g/g

    70. Calcium, Plasma Standard Solution, Specpure?, Ca 1000?g/ml

    71. Calcium Hydride, Purum P.a., >=97.0% (gas-volumetric), Powder

    72. Calcium, Plasma Standard Solution, Specpure(r), Ca 10,000?g/ml

    73. Calcium Hydride, Powder, 0-2 Mm, Reagent Grade, >=90% (gas-volumetric)

    74. Calcium, Dendritic Pieces, Purified By Distillation, 99.5% Trace Metals Basis

    75. Calcium, Dendritic Pieces, Purified By Distillation, 99.9% Trace Metals Basis

    76. Calcium, Dendritic Pieces, Purified By Distillation, 99.99% Trace Metals Basis

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 40.08 g/mol
    Molecular Formula Ca
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count0
    Rotatable Bond Count0
    Exact Mass39.9625908 g/mol
    Monoisotopic Mass39.9625908 g/mol
    Topological Polar Surface Area0 Ų
    Heavy Atom Count1
    Formal Charge0
    Complexity0
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.

    5.2 MeSH Pharmacological Classification

    Calcium-Regulating Hormones and Agents

    Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. (See all compounds classified as Calcium-Regulating Hormones and Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    CALCIUM
    5.3.2 FDA UNII
    SY7Q814VUP
    5.3.3 Pharmacological Classes
    Calcium [EPC]; Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]; Calcium [CS]
    5.4 ATC Code

    A - Alimentary tract and metabolism

    A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

    A07X - Other antidiarrheals

    A07XA - Other antidiarrheals

    A07XA03 - Calcium compounds

    5.5 Absorption, Distribution and Excretion

    Route of Elimination

    The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.

    5.6 Mechanism of Action

    Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.

    API Reference Price

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SW\/OD\/11\/2024\/000006708 DT.ACAMPROSATE CALCIUM","address":"ASTER FLAT NO 402 REGENCY GARDENS,","city":"KHARGHAR,MAHARASHTRA","supplier":"OLON S.P.A","supplierCountry":"ITALY","foreign_port":"MILAN","customer":"PROSFORA TECHNOLOGIES PRIVATE ","customerCountry":"INDIA","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"188.8","totalValueFC":"14390.4","currency":"EUR","unitRateINR":"16686","date":"15-Feb-2025","totalValueINR":"1251450","totalValueInUsd":"14390.4","indian_port":"Bombay Air","hs_no":"29241900","bill_no":"8380839","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN","supplierAddress":"STRADA RIVOLTANA KM 6\/7 20090 RODANO (MI) SDNF ITALY","customerAddress":"ASTER FLAT NO 402 REGENCY GARDENS,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739817000,"product":"ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATE USP ATORVASTATIN CALCIUM PROPYLENE GLYCOL SOLVATE USP","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"APOTEX INC","supplierCountry":"CANADA","foreign_port":"TORONTO","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"1069.73","actualQuantity":"1069.73","unit":"KGS","unitRateFc":"308","totalValueFC":"334917.2","currency":"USD","unitRateINR":"27227.2","date":"18-Feb-2025","totalValueINR":"29125766.84","totalValueInUsd":"334917.2","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"8414168","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"TORONTO","supplierAddress":"150 SIGNET DR. TORONTO, ONTARIO M9L 1T9, CANADA Toronto, , Canada SDNF Canada","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1739989800,"product":"CALCIUM GLUCONATE TECHNICAL GRADE NOT FOR MEDICAL USE (RESTDETAILS AS PER INV & PL)CALCIUM GLUCONATE TECHNICAL GRADE NOT FOR MEDICAL USE (REST","address":"112\/209 B-1,SWAROOP NAGAR","city":"KANPUR","supplier":"SHANDONG XINHONG PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"QINGDAO","customer":"JASIA AGRO INDUSTRIES","customerCountry":"INDIA","quantity":"52000.00","actualQuantity":"52","unit":"MTS","unitRateFc":"290.9","totalValueFC":"15376.3","currency":"USD","unitRateINR":"25715.1","date":"20-Feb-2025","totalValueINR":"1337184","totalValueInUsd":"15376.3","indian_port":"Mundra","hs_no":"29181610","bill_no":"8468279","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Technical Grade","supplierPort":"QINGDAO","supplierAddress":"SHANGHE ECONOMIC DEVELOPMENT ZONE, JINAN, SHANDONG PROVINCE,CHINA SDNF CHINA","customerAddress":"112\/209 B-1,SWAROOP NAGAR"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740681000,"product":"SACUBITRIL CALCIUM 20","address":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD","city":"HYDERABAD,A.P.","supplier":"ZHEJIANG RAYBOW PHARMA","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"DIVI'S LABORATORIES LIMITED","customerCountry":"INDIA","quantity":"3494.67","actualQuantity":"3494.67","unit":"KGS","unitRateFc":"529.3","totalValueFC":"1866445.3","currency":"USD","unitRateINR":"46446.1","date":"28-Feb-2025","totalValueINR":"162313704.92","totalValueInUsd":"1866445.3","indian_port":"Vizag-DLL SEZ","hs_no":"29339990","bill_no":"8614616","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.18 NANYANGSAN ROAD ,DUQIAO LINHAI NANYANG SAN ROAD,TAIZHOU CIT SDNF China","customerAddress":"7.1.77\/E\/1\/303, DHARAM KARAM ROAD"}]
    01-Jan-2021
    28-Feb-2025
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    ABOUT THIS PAGE

    Looking for 7440-70-2 / Calcium API manufacturers, exporters & distributors?

    Calcium manufacturers, exporters & distributors 1

    67

    PharmaCompass offers a list of Calcium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Calcium manufacturer or Calcium supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Calcium manufacturer or Calcium supplier.

    PharmaCompass also assists you with knowing the Calcium API Price utilized in the formulation of products. Calcium API Price is not always fixed or binding as the Calcium Price is obtained through a variety of data sources. The Calcium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Calcium

    Synonyms

    7440-70-2, Ca, Elemental calcium, Calcium, elemental, Calcium hydride (cah), Sy7q814vup

    Cas Number

    7440-70-2

    Unique Ingredient Identifier (UNII)

    SY7Q814VUP

    About Calcium

    A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

    Calcium Manufacturers

    A Calcium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcium, including repackagers and relabelers. The FDA regulates Calcium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    Calcium Suppliers

    A Calcium supplier is an individual or a company that provides Calcium active pharmaceutical ingredient (API) or Calcium finished formulations upon request. The Calcium suppliers may include Calcium API manufacturers, exporters, distributors and traders.

    click here to find a list of Calcium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Calcium USDMF

    A Calcium DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcium active pharmaceutical ingredient (API) in detail. Different forms of Calcium DMFs exist exist since differing nations have different regulations, such as Calcium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Calcium DMF submitted to regulatory agencies in the US is known as a USDMF. Calcium USDMF includes data on Calcium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Calcium suppliers with USDMF on PharmaCompass.

    Calcium JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Calcium Drug Master File in Japan (Calcium JDMF) empowers Calcium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Calcium JDMF during the approval evaluation for pharmaceutical products. At the time of Calcium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Calcium suppliers with JDMF on PharmaCompass.

    Calcium CEP

    A Calcium CEP of the European Pharmacopoeia monograph is often referred to as a Calcium Certificate of Suitability (COS). The purpose of a Calcium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Calcium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Calcium to their clients by showing that a Calcium CEP has been issued for it. The manufacturer submits a Calcium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Calcium CEP holder for the record. Additionally, the data presented in the Calcium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Calcium DMF.

    A Calcium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Calcium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Calcium suppliers with CEP (COS) on PharmaCompass.

    Calcium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Calcium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Calcium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Calcium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Calcium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Calcium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Calcium suppliers with NDC on PharmaCompass.

    Calcium GMP

    Calcium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Calcium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcium GMP manufacturer or Calcium GMP API supplier for your needs.

    Calcium CoA

    A Calcium CoA (Certificate of Analysis) is a formal document that attests to Calcium's compliance with Calcium specifications and serves as a tool for batch-level quality control.

    Calcium CoA mostly includes findings from lab analyses of a specific batch. For each Calcium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Calcium may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcium EP), Calcium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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