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Chemistry

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Also known as: 7440-70-2, Ca, Elemental calcium, Calcium, elemental, Calcium hydride (cah), Sy7q814vup
Molecular Formula
Ca
Molecular Weight
40.08  g/mol
InChI Key
OYPRJOBELJOOCE-UHFFFAOYSA-N
FDA UNII
SY7Q814VUP

Calcium
A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
1 2D Structure

Calcium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium
2.1.2 InChI
InChI=1S/Ca
2.1.3 InChI Key
OYPRJOBELJOOCE-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[Ca]
2.2 Other Identifiers
2.2.1 UNII
SY7Q814VUP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Blood Coagulation Factor Iv

2. Calcium 40

3. Calcium-40

4. Coagulation Factor Iv

5. Factor Iv

6. Factor Iv, Coagulation

2.3.2 Depositor-Supplied Synonyms

1. 7440-70-2

2. Ca

3. Elemental Calcium

4. Calcium, Elemental

5. Calcium Hydride (cah)

6. Sy7q814vup

7. Mfcd00010897

8. Mfcd00085314

9. Calcium Compounds

10. Hsdb 273

11. Einecs 231-179-5

12. Un1401

13. Unii-sy7q814vup

14. Kalzium

15. Calcium Atom

16. Calcium Ingot

17. Calcium Chelate

18. Calcium Shot

19. Calcium Granules

20. Calcium Turnings

21. Bio Lacta Cal

22. Calcium(0)

23. Calcium Turnings, 2n

24. Calcium, Natural Milk

25. Calcium [vandf]

26. Calcium [hsdb]

27. Calcium [ii]

28. Calcium [mi]

29. Calcium [usp-rs]

30. Calcium [who-dd]

31. Calcium, Granular, 99%

32. 20ca

33. Ec 231-179-5

34. Calcium Granules, -9 Mesh

35. Calcium Krebs 21% 40m

36. Calcium Milk Calcium 28%

37. Calcium Sweet Chelate 20%

38. Calcium Oratate 11% 40m

39. Ca(0)

40. Calcium [orange Book]

41. Calcium Hydride, Coarse Powder

42. Calcium Ms Plus 18% 40m

43. Chembl2146121

44. Dtxsid9050484

45. Chebi:22984

46. Chebi:29320

47. Hsdb 6931

48. Calcium, Pieces, <1 Cm, 99%

49. Calcium Crystalline Dendritic Pieces

50. Calcium, Crystalline, Dendritic, 4n

51. Calcium Shot, 1cm (0.4in) & Down

52. Db01373

53. Calcium Granules, Redistilled, -6 Mesh

54. Calcium, Saj First Grade, >=99.5%

55. Calcium Granules, Redistilled, -16 Mesh

56. Bp-31015

57. Q706

58. Calcium [un1401] [dangerous When Wet]

59. Calcium Hydride, 99.9% Trace Metals Basis

60. Calcium, Turnings, 99% Trace Metals Basis

61. Calcium Bio Calcium Ms (maxium Solubility) 40m

62. Calcium Bio Calcium Ms Plus(maxium Solubility) 40m

63. Calcium Hydride, Powder, 99.99% Trace Metals Basis

64. Calcium Hydride, Reagent Grade, 95% (gas-volumetric)

65. C000001000

66. Calcium Hydride, Chunks, +4 Mesh, Reagent Grade, 95%

67. Calcium, Aas Standard Solution, Specpure?, Ca 1000?g/ml

68. Calcium, Oil Based Standard Solution, Specpure, Ca 1000g/g

69. Calcium, Oil Based Standard Solution, Specpure?, Ca 5000?g/g

70. Calcium, Plasma Standard Solution, Specpure?, Ca 1000?g/ml

71. Calcium Hydride, Purum P.a., >=97.0% (gas-volumetric), Powder

72. Calcium, Plasma Standard Solution, Specpure(r), Ca 10,000?g/ml

73. Calcium Hydride, Powder, 0-2 Mm, Reagent Grade, >=90% (gas-volumetric)

74. Calcium, Dendritic Pieces, Purified By Distillation, 99.5% Trace Metals Basis

75. Calcium, Dendritic Pieces, Purified By Distillation, 99.9% Trace Metals Basis

76. Calcium, Dendritic Pieces, Purified By Distillation, 99.99% Trace Metals Basis

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 40.08 g/mol
Molecular Formula Ca
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count0
Exact Mass39.9625908 g/mol
Monoisotopic Mass39.9625908 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count1
Formal Charge0
Complexity0
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. It is vital in cell signaling, muscular contractions, bone health, and signalling cascades.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Calcium (Ca2+) plays a pivotal role in the physiology and biochemistry of organisms and the cell. It plays an important role in signal transduction pathways, where it acts as a second messenger, in neurotransmitter release from neurons, contraction of all muscle cell types, and fertilization. Many enzymes require calcium ions as a cofactor, those of the blood-clotting cascade being notable examples. Extracellular calcium is also important for maintaining the potential difference across excitable cell membranes, as well as proper bone formation.


5.2 MeSH Pharmacological Classification

Calcium-Regulating Hormones and Agents

Hormones and molecules with calcium-regulating hormone-like actions that modulate OSTEOLYSIS and other extra-skeletal activities to maintain calcium homeostasis. (See all compounds classified as Calcium-Regulating Hormones and Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Active Moiety
CALCIUM
5.3.2 FDA UNII
SY7Q814VUP
5.3.3 Pharmacological Classes
Calcium [EPC]; Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]; Calcium [CS]
5.4 ATC Code

A - Alimentary tract and metabolism

A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents

A07X - Other antidiarrheals

A07XA - Other antidiarrheals

A07XA03 - Calcium compounds


5.5 Absorption, Distribution and Excretion

Route of Elimination

The kidney excretes 250 mmol a day in urine, and resorbs 245 mmol, leading to a net loss in the urine of 5 mmol/d.


5.6 Mechanism of Action

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. More than 500 human proteins are known to bind or transport calcium. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream under controlled conditions. Circulating calcium is either in the free, ionized form or bound to blood proteins such as serum albumin. Parathyroid hormone (secreted from the parathyroid gland) regulates the resorption of Ca2+ from bone. Calcitonin stimulates incorporation of calcium in bone, although this process is largely independent of calcitonin. Although calcium flow to and from the bone is neutral, about 5 mmol is turned over a day. Bone serves as an important storage point for calcium, as it contains 99% of the total body calcium. Low calcium intake may also be a risk factor in the development of osteoporosis. The best-absorbed form of calcium from a pill is a calcium salt like carbonate or phosphate. Calcium gluconate and calcium lactate are absorbed well by pregnant women. Seniors absorb calcium lactate, gluconate and citrate better unless they take their calcium supplement with a full breakfast. The currently recommended calcium intake is 1,500 milligrams per day for women not taking estrogen and 800 milligrams per day for women on estrogen. There is close to 300 milligrams of calcium in one cup of fluid milk. Calcium carbonate is currently the best and least expensive form of calcium supplement available.


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OFFICE: NO. 16\/2,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727289000,"product":"ATORVASTATIN CALCIUM PROPYLENE GLYCOL SO","address":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK","city":"KURLA, MUMBAI","supplier":"APOTEX INC","supplierCountry":"MEXICO","foreign_port":"MEXICO CITY","customer":"PIRAMAL PHARMA SOLUTIONS","customerCountry":"INDIA","quantity":"372.91","actualQuantity":"372.91","unit":"KGS","unitRateFc":"308","totalValueFC":"115951.1","currency":"USD","unitRateINR":"26056.8","date":"26-Sep-2024","totalValueINR":"9716841.29","totalValueInUsd":"115951.1","indian_port":"Bombay Air","hs_no":"29339990","bill_no":"5811867","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"MEXICO","selfForZScoreResived":"Pharma Grade","supplierPort":"MEXICO CITY","supplierAddress":"AV.INDUSTRIA AUTOMOTRIZ NO.301 5007 1 TOLUCA , EDO.DE MEXICO , CP 50071 ESTADO DE MEXICO Mexico City, , Me Mexico","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"MUPIROCIN CALCIUM USP (MUPIROCIN CALCIUM MICRONIZED) (BATCHNO.83200300224)","address":"B\/2 MAHALAXMI CHAMBERS","city":"MUMBAI. MAHARASHTRA","supplier":"TEVA API","supplierCountry":"HUNGARY","foreign_port":"BUDAPEST,","customer":"GLENMARK PHARMACEUTICALS","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"7500","totalValueFC":"151429.8","currency":"USD","unitRateINR":"634500","date":"28-Sep-2024","totalValueINR":"12690000","totalValueInUsd":"151429.8","indian_port":"Bombay Air","hs_no":"29419090","bill_no":"5855324","productDescription":"API","marketType":"REGULATED MARKET","country":"HUNGARY","selfForZScoreResived":"Micronized","supplierPort":"BUDAPEST,","supplierAddress":"PIET HEIN BUILDING,PIET HEINKADE107 ,1019 GM AMSTERDAM. SDNF NETHERLANDS","customerAddress":"B\/2 MAHALAXMI CHAMBERS"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1727461800,"product":"CALCIUM PANTOTHENATE IP (400 DRM) IUPAC NAME: CALCIUM;3-[[(2R)-2,4-DIHYDROXY-3,3-DIMETHYLBUTANOYL]AMINO]PROPANOATE CAS NCALCIUM PANTOTHENATE IP (400 DRM) IUPAC NAME: CALCIUM;3-[[(2","address":"305 AGGARWAL CITY SQUARE","city":"DELHI","supplier":"SHAH TC GLOBAL ","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"SHAH TC DISTRIBUTION LLP","customerCountry":"INDIA","quantity":"1000.00","actualQuantity":"1000","unit":"KGS","unitRateFc":"47.2","totalValueFC":"47649.9","currency":"USD","unitRateINR":"3993.1","date":"28-Sep-2024","totalValueINR":"3993120","totalValueInUsd":"47649.9","indian_port":"ARSHIYA-SEZ\/PANVEL","hs_no":"29420090","bill_no":"5854693","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"UNIT NO. 142, 1ST FLOOR, ADMINISTRA TIVE BUILDING, , ARSHIYA FTWZ VILLA GE SAI TALUKA PANVEL,MAHARASHTRA, N INDIA","customerAddress":"305 AGGARWAL CITY SQUARE"}]
01-Sep-2023
30-Sep-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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