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Calcium Acetate

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ACTIVE PHARMA INGREDIENTS

13 API Suppliers, 7 USDMF, 1 CEP/COS, 2 EU WC, 6 NDC API, 7 Listed Suppliers, $ API Reference Price

13 API Suppliers
7 USDMF
1 CEP/COS
2 EU WC
6 NDC API
7 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

33 FDF Dossiers, 21 FDA Orange Book, 2 Europe, 3 Canada, 2 South Africa, 5 Listed Dossiers

33 FDF Dossiers
21 FDA Orange Book
2 Europe
3 Canada
2 South Africa
5 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 667MG, SOLUTION;ORAL - 667MG/5ML

drugProductComposition
CAPSULE;ORAL - 667MG
SOLUTION;ORAL - 667MG/5ML

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2 US Medicaid Prescriptions, 2 Finished Drug Prices

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MARKET PLACE

9 APIs

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9 APIs

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Synopsis

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Chemistry

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Also known as: 62-54-4, Calcium diacetate, Acetic acid, calcium salt, Lime acetate, Phoslo, Lime pyrolignite

Molecular Formula

C₄H₆CaO₄

Molecular Weight

158.17 g/mol

InChI Key

VSGNNIFQASZAOI-UHFFFAOYSA-L

FDA UNII

Y882YXF34X

Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.

1 2D Structure

Calcium Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;diacetate

2.1.2 InChI

InChI=1S/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2

2.1.3 InChI Key

VSGNNIFQASZAOI-UHFFFAOYSA-L

2.1.4 Canonical SMILES

CC(=O)[O-].CC(=O)[O-].[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

Y882YXF34X

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Acetic Acid, Calcium Salt

2. Acetic Acid, Calcium Salt (2:1)

3. Phoslo

2.3.2 Depositor-Supplied Synonyms

1. 62-54-4

2. Calcium Diacetate

3. Acetic Acid, Calcium Salt

4. Lime Acetate

5. Phoslo

6. Lime Pyrolignite

7. Acetate Of Lime

8. Brown Acetate

9. Acetic Acid Calcium Salt

10. Gray Acetate Of Lime

11. Brown Acetate Of Lime

12. Phoslyra

13. Calcium;diacetate

14. Calcium Ethanoate

15. Fema No. 2228

16. Calcarea Acetica

17. Calcium(ii) Acetate

18. Acetic Acid, Calcium Salt (2:1)

19. Calcium Acetate Anhydrous

20. Calcium Acetate, Anhydrous

21. Chebi:3310

22. Ins No.263

23. Y882yxf34x

24. Teltozan

25. Sorbo-calcion

26. Vinegar Salts

27. Gray Acetate

28. Ins-263

29. Phoslo Gelcaps

30. Calcium Di(acetate)

31. E-263

32. Ca(oac)2

33. Eliphos

34. Sanopan

35. Ccris 4921

36. Hsdb 928

37. Einecs 200-540-9

38. Calcium Acetate [usp:jan]

39. Unii-y882yxf34x

40. Ai3-02903

41. Calcium Acetate Salt

42. Phoslo (tn)

43. Calcium Acetate, Fcc

44. Calcium Acetate (usp)

45. Ec 200-540-9

46. Calcium Acetate 23% 10m

47. Schembl23872

48. Calcium Acetate [ii]

49. Calcium Acetate [mi]

50. Calcium Acetate [fcc]

51. Calcium Acetate [fhfi]

52. Calcium Acetate [hsdb]

53. Calcium Acetate [inci]

54. Calcarea Acetica [hpus]

55. Calcium Acetate [vandf]

56. Calcium Acetate [mart.]

57. Chembl1200800

58. Dtxsid0020234

59. Calcium Acetate [usp-rs]

60. Calcium Acetate [who-dd]

61. Calcium Acetate (fragrance Grade)

62. Amy23411

63. Mfcd00012448

64. Calcium Acetate [orange Book]

65. Akos015904560

66. Calcium Acetate [ep Monograph]

67. Calcium Acetate [usp Monograph]

68. Db00258

69. E263

70. Ft-0623376

71. Ft-0623377

72. D00931

73. Calcium Acetate, Anhydrous [ep Impurity]

74. Cis,cis-1,3,5-cyclohexanetricarboxylicacid

75. Q409251

76. Calcium Diacetate, Cac - Acetic Acid, Calcium Salt

77. J-519530

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₄H₆CaO₄
Molecular Weight	158.17 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	157.9891995 g/mol
Monoisotopic Mass	157.9891995 g/mol
Topological Polar Surface Area	80.3 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	25.5
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Calcium acetate
PubMed Health	Calcium Acetate (By mouth)
Drug Classes	Calcium Supplement, Phosphate Binder
Drug Label	Each white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
Active Ingredient	Calcium acetate
Dosage Form	Tablet; Capsule
Route	Oral
Strength	eq 169mg calcium
Market Status	Prescription
Company	Amneal Pharms; Paddock; Invagen Pharms; Roxane

2 of 6
Drug Name	Phoslo gelcaps
Active Ingredient	Calcium acetate
Dosage Form	Capsule
Route	Oral
Strength	eq 169mg calcium
Market Status	Prescription
Company	Fresenius Medcl

3 of 6
Drug Name	Procalamine
Active Ingredient	calcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
Dosage Form	Injectable
Route	Injection
Strength	200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
Market Status	Prescription
Company	B Braun

4 of 6
Drug Name	Calcium acetate
PubMed Health	Calcium Acetate (By mouth)
Drug Classes	Calcium Supplement, Phosphate Binder
Drug Label	Each white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
Active Ingredient	Calcium acetate
Dosage Form	Tablet; Capsule
Route	Oral
Strength	eq 169mg calcium
Market Status	Prescription
Company	Amneal Pharms; Paddock; Invagen Pharms; Roxane

5 of 6
Drug Name	Phoslo gelcaps
Active Ingredient	Calcium acetate
Dosage Form	Capsule
Route	Oral
Strength	eq 169mg calcium
Market Status	Prescription
Company	Fresenius Medcl

6 of 6
Drug Name	Procalamine
Active Ingredient	calcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
Dosage Form	Injectable
Route	Injection
Strength	200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
Market Status	Prescription
Company	B Braun

4.2 Therapeutic Uses

... Used to restrict phosphate absorption in patients with chronic renal failure and oxalate absorption in patients with inflammatory bowel disease.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1523

Calcium acetate is indicated in patients with end-stage renal failure to lower serum phosphate concentrations. It does not promote aluminum absorption. /Included in US product labeling/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719

4.3 Drug Warning

Except under special circumstances, this medication /calcium acetate/ should not be used when the following medical problem exists: hypercalcemia (calcium acetate may exacerbate the condition).

Concurrent use /with digitalis glycosides/ is not recommended because calcium acetate may cause hypercalcemia, which could precipitate cardiac arrhythmias.

4.4 Drug Indication

Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

5.2 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

5.3 FDA Pharmacological Classification

5.3.1 Pharmacological Classes

Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]

5.4 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AE - Drugs for treatment of hyperkalemia and hyperphosphatemia

V03AE07 - Calcium acetate

5.5 Absorption, Distribution and Excretion

Absorption

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.

Route of Elimination

Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.

5.6 Mechanism of Action

Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

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API Reference Price

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CAPSULE;ORAL - 667MG

USFDA APPLICATION NUMBER - 21160

DOSAGE - SOLUTION;ORAL - 667MG/5ML

USFDA APPLICATION NUMBER - 22581

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DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 667MG

SOLUTION;ORAL - 667MG/5ML

RELATED EXCIPIENT COMPANIES

1 Minakem

3 Rochem International Inc

1 SPI Pharma

2 Seqens

9 DKSH

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1 Chynops Pharma

3 Gangwal Healthcare

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1 Pfanstiehl

4 ACG Worldwide

10 Actylis

1 Alcedo Pharmachem

3 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

18 BASF

1 Bioplus Life Sciences

10 Corel Pharma Chem

3 Finar

4 Gangwal Chemicals

4 Ideal Cures Pvt Ltd

14 Kerry

3 Kima Chemical

6 Lonza Capsugel

8 Microlex e.U

1 Nanjing Bold Chemical

1 NEWEDGE Overseas

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

4 Pluviaendo

2 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

2 Qualicaps

10 Roquette

7 Seppic

3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

2 The Dow Chemical Company

1 Valens Pharmachem

2 Vasa Pharmachem

1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

50 Coating Systems & Additives

22 Controlled & Modified Release

21 Thickeners and Stabilizers

21 Lubricants & Glidants

18 Fillers, Diluents & Binders

16 Topical

13 Taste Masking

12 Film Formers & Plasticizers

11 Solubilizers

9 Granulation

9 Parenteral

9 Empty Capsules

7 Direct Compression