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    Chemistry

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    Also known as: 62-54-4, Calcium diacetate, Acetic acid, calcium salt, Lime acetate, Phoslo, Lime pyrolignite
    Molecular Formula
    C4H6CaO4
    Molecular Weight
    158.17  g/mol
    InChI Key
    VSGNNIFQASZAOI-UHFFFAOYSA-L
    FDA UNII
    Y882YXF34X
    Calcium Acetate
    Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.
    1 2D Structure

    Calcium Acetate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;diacetate
    2.1.2 InChI
    InChI=1S/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
    2.1.3 InChI Key
    VSGNNIFQASZAOI-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    CC(=O)[O-].CC(=O)[O-].[Ca+2]
    2.2 Other Identifiers
    2.2.1 UNII
    Y882YXF34X
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acetic Acid, Calcium Salt

    2. Acetic Acid, Calcium Salt (2:1)

    3. Phoslo

    2.3.2 Depositor-Supplied Synonyms

    1. 62-54-4

    2. Calcium Diacetate

    3. Acetic Acid, Calcium Salt

    4. Lime Acetate

    5. Phoslo

    6. Lime Pyrolignite

    7. Acetate Of Lime

    8. Brown Acetate

    9. Acetic Acid Calcium Salt

    10. Gray Acetate Of Lime

    11. Brown Acetate Of Lime

    12. Phoslyra

    13. Calcium;diacetate

    14. Calcium Ethanoate

    15. Fema No. 2228

    16. Calcarea Acetica

    17. Calcium(ii) Acetate

    18. Acetic Acid, Calcium Salt (2:1)

    19. Calcium Acetate Anhydrous

    20. Calcium Acetate, Anhydrous

    21. Chebi:3310

    22. Ins No.263

    23. Y882yxf34x

    24. Teltozan

    25. Sorbo-calcion

    26. Vinegar Salts

    27. Gray Acetate

    28. Ins-263

    29. Phoslo Gelcaps

    30. Calcium Di(acetate)

    31. E-263

    32. Ca(oac)2

    33. Eliphos

    34. Sanopan

    35. Ccris 4921

    36. Hsdb 928

    37. Einecs 200-540-9

    38. Calcium Acetate [usp:jan]

    39. Unii-y882yxf34x

    40. Ai3-02903

    41. Calcium Acetate Salt

    42. Phoslo (tn)

    43. Calcium Acetate, Fcc

    44. Calcium Acetate (usp)

    45. Ec 200-540-9

    46. Calcium Acetate 23% 10m

    47. Schembl23872

    48. Calcium Acetate [ii]

    49. Calcium Acetate [mi]

    50. Calcium Acetate [fcc]

    51. Calcium Acetate [fhfi]

    52. Calcium Acetate [hsdb]

    53. Calcium Acetate [inci]

    54. Calcarea Acetica [hpus]

    55. Calcium Acetate [vandf]

    56. Calcium Acetate [mart.]

    57. Chembl1200800

    58. Dtxsid0020234

    59. Calcium Acetate [usp-rs]

    60. Calcium Acetate [who-dd]

    61. Calcium Acetate (fragrance Grade)

    62. Amy23411

    63. Mfcd00012448

    64. Calcium Acetate [orange Book]

    65. Akos015904560

    66. Calcium Acetate [ep Monograph]

    67. Calcium Acetate [usp Monograph]

    68. Db00258

    69. E263

    70. Ft-0623376

    71. Ft-0623377

    72. D00931

    73. Calcium Acetate, Anhydrous [ep Impurity]

    74. Cis,cis-1,3,5-cyclohexanetricarboxylicacid

    75. Q409251

    76. Calcium Diacetate, Cac - Acetic Acid, Calcium Salt

    77. J-519530

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 158.17 g/mol
    Molecular Formula C4H6CaO4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass157.9891995 g/mol
    Monoisotopic Mass157.9891995 g/mol
    Topological Polar Surface Area80.3 Ų
    Heavy Atom Count9
    Formal Charge0
    Complexity25.5
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameCalcium acetate
    PubMed HealthCalcium Acetate (By mouth)
    Drug ClassesCalcium Supplement, Phosphate Binder
    Drug LabelEach white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
    Active IngredientCalcium acetate
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 169mg calcium
    Market StatusPrescription
    CompanyAmneal Pharms; Paddock; Invagen Pharms; Roxane

    2 of 6  
    Drug NamePhoslo gelcaps
    Active IngredientCalcium acetate
    Dosage FormCapsule
    RouteOral
    Strengtheq 169mg calcium
    Market StatusPrescription
    CompanyFresenius Medcl

    3 of 6  
    Drug NameProcalamine
    Active Ingredientcalcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
    Dosage FormInjectable
    RouteInjection
    Strength200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
    Market StatusPrescription
    CompanyB Braun

    4 of 6  
    Drug NameCalcium acetate
    PubMed HealthCalcium Acetate (By mouth)
    Drug ClassesCalcium Supplement, Phosphate Binder
    Drug LabelEach white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
    Active IngredientCalcium acetate
    Dosage FormTablet; Capsule
    RouteOral
    Strengtheq 169mg calcium
    Market StatusPrescription
    CompanyAmneal Pharms; Paddock; Invagen Pharms; Roxane

    5 of 6  
    Drug NamePhoslo gelcaps
    Active IngredientCalcium acetate
    Dosage FormCapsule
    RouteOral
    Strengtheq 169mg calcium
    Market StatusPrescription
    CompanyFresenius Medcl

    6 of 6  
    Drug NameProcalamine
    Active Ingredientcalcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
    Dosage FormInjectable
    RouteInjection
    Strength200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
    Market StatusPrescription
    CompanyB Braun

    4.2 Therapeutic Uses

    ... Used to restrict phosphate absorption in patients with chronic renal failure and oxalate absorption in patients with inflammatory bowel disease.

    Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1523

    Calcium acetate is indicated in patients with end-stage renal failure to lower serum phosphate concentrations. It does not promote aluminum absorption. /Included in US product labeling/

    USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719

    4.3 Drug Warning

    Except under special circumstances, this medication /calcium acetate/ should not be used when the following medical problem exists: hypercalcemia (calcium acetate may exacerbate the condition).

    USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719

    Concurrent use /with digitalis glycosides/ is not recommended because calcium acetate may cause hypercalcemia, which could precipitate cardiac arrhythmias.

    USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719

    4.4 Drug Indication

    Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.

    FDA Label

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.

    5.2 MeSH Pharmacological Classification

    Chelating Agents

    Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]
    5.4 ATC Code

    V - Various

    V03 - All other therapeutic products

    V03A - All other therapeutic products

    V03AE - Drugs for treatment of hyperkalemia and hyperphosphatemia

    V03AE07 - Calcium acetate

    5.5 Absorption, Distribution and Excretion

    Absorption

    40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.

    Route of Elimination

    Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.

    5.6 Mechanism of Action

    Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

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SOLUTIONS","customerCountry":"INDIA","quantity":"2603.80","actualQuantity":"2603.795","unit":"KGS","unitRateFc":"8.8","totalValueFC":"23147.4","currency":"USD","unitRateINR":"745","date":"04-Sep-2024","totalValueINR":"1939782.13","totalValueInUsd":"23147.4","indian_port":"JNPT","hs_no":"29152910","bill_no":"5417783","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"MONTREAL","supplierAddress":"100 RUE MC ARTHUR, SUIT 112 VALLEYF IELD QC J6S 4M5 CANADA Quebec - J6S 4M5 Canada Canada","customerAddress":"PIRAMAL ANANTA, PIRAMAL AGASTYA PARK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729881000,"product":"402850-CONF CALCIUM ACETATE MONOHYDRATE, 99+%, A.C.& (FOR LAB PURPOSE) ( 2050 GMS)","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK","city":"BANGALORE","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"CHICAGO, IL","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"2.05","actualQuantity":"2.05","unit":"KGS","unitRateFc":"2198.3","totalValueFC":"56.2","currency":"INR","unitRateINR":"2305.5","date":"26-Oct-2024","totalValueINR":"4726.25","totalValueInUsd":"56.2","indian_port":"Bangalore Air","hs_no":"29152990","bill_no":"6364935","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO, IL","supplierAddress":"6000 N TEUTONIA AVE MILWAUKEE WI MI LWAUKEE - 53209-3645, , United Sta tes United States","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK"}]
    15-Feb-2021
    26-Oct-2024
    KGS
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - CAPSULE;ORAL - 667MG

    USFDA APPLICATION NUMBER - 21160

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    DOSAGE - SOLUTION;ORAL - 667MG/5ML

    USFDA APPLICATION NUMBER - 22581

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    USP

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    ABOUT THIS PAGE

    Calcium Acetate Manufacturers

    A Calcium Acetate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Calcium Acetate, including repackagers and relabelers. The FDA regulates Calcium Acetate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Calcium Acetate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Calcium Acetate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Calcium Acetate Suppliers

    A Calcium Acetate supplier is an individual or a company that provides Calcium Acetate active pharmaceutical ingredient (API) or Calcium Acetate finished formulations upon request. The Calcium Acetate suppliers may include Calcium Acetate API manufacturers, exporters, distributors and traders.

    click here to find a list of Calcium Acetate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Calcium Acetate USDMF

    A Calcium Acetate DMF (Drug Master File) is a document detailing the whole manufacturing process of Calcium Acetate active pharmaceutical ingredient (API) in detail. Different forms of Calcium Acetate DMFs exist exist since differing nations have different regulations, such as Calcium Acetate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Calcium Acetate DMF submitted to regulatory agencies in the US is known as a USDMF. Calcium Acetate USDMF includes data on Calcium Acetate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Calcium Acetate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Calcium Acetate suppliers with USDMF on PharmaCompass.

    Calcium Acetate CEP

    A Calcium Acetate CEP of the European Pharmacopoeia monograph is often referred to as a Calcium Acetate Certificate of Suitability (COS). The purpose of a Calcium Acetate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Calcium Acetate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Calcium Acetate to their clients by showing that a Calcium Acetate CEP has been issued for it. The manufacturer submits a Calcium Acetate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Calcium Acetate CEP holder for the record. Additionally, the data presented in the Calcium Acetate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Calcium Acetate DMF.

    A Calcium Acetate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Calcium Acetate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Calcium Acetate suppliers with CEP (COS) on PharmaCompass.

    Calcium Acetate WC

    A Calcium Acetate written confirmation (Calcium Acetate WC) is an official document issued by a regulatory agency to a Calcium Acetate manufacturer, verifying that the manufacturing facility of a Calcium Acetate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Calcium Acetate APIs or Calcium Acetate finished pharmaceutical products to another nation, regulatory agencies frequently require a Calcium Acetate WC (written confirmation) as part of the regulatory process.

    click here to find a list of Calcium Acetate suppliers with Written Confirmation (WC) on PharmaCompass.

    Calcium Acetate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Calcium Acetate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Calcium Acetate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Calcium Acetate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Calcium Acetate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Calcium Acetate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Calcium Acetate suppliers with NDC on PharmaCompass.

    Calcium Acetate GMP

    Calcium Acetate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Calcium Acetate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Calcium Acetate GMP manufacturer or Calcium Acetate GMP API supplier for your needs.

    Calcium Acetate CoA

    A Calcium Acetate CoA (Certificate of Analysis) is a formal document that attests to Calcium Acetate's compliance with Calcium Acetate specifications and serves as a tool for batch-level quality control.

    Calcium Acetate CoA mostly includes findings from lab analyses of a specific batch. For each Calcium Acetate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Calcium Acetate may be tested according to a variety of international standards, such as European Pharmacopoeia (Calcium Acetate EP), Calcium Acetate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Calcium Acetate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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