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2D Structure
Also known as: 62-54-4, Calcium diacetate, Acetic acid, calcium salt, Lime acetate, Phoslo, Lime pyrolignite
Molecular Formula
C4H6CaO4
Molecular Weight
158.17  g/mol
InChI Key
VSGNNIFQASZAOI-UHFFFAOYSA-L
FDA UNII
Y882YXF34X

Calcium Acetate is a calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is administered orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium;diacetate
2.1.2 InChI
InChI=1S/2C2H4O2.Ca/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
2.1.3 InChI Key
VSGNNIFQASZAOI-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC(=O)[O-].CC(=O)[O-].[Ca+2]
2.2 Other Identifiers
2.2.1 UNII
Y882YXF34X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Acetic Acid, Calcium Salt

2. Acetic Acid, Calcium Salt (2:1)

3. Phoslo

2.3.2 Depositor-Supplied Synonyms

1. 62-54-4

2. Calcium Diacetate

3. Acetic Acid, Calcium Salt

4. Lime Acetate

5. Phoslo

6. Lime Pyrolignite

7. Acetate Of Lime

8. Brown Acetate

9. Acetic Acid Calcium Salt

10. Gray Acetate Of Lime

11. Brown Acetate Of Lime

12. Phoslyra

13. Calcium;diacetate

14. Calcium Ethanoate

15. Fema No. 2228

16. Calcarea Acetica

17. Calcium(ii) Acetate

18. Acetic Acid, Calcium Salt (2:1)

19. Calcium Acetate Anhydrous

20. Calcium Acetate, Anhydrous

21. Chebi:3310

22. Ins No.263

23. Y882yxf34x

24. Teltozan

25. Sorbo-calcion

26. Vinegar Salts

27. Gray Acetate

28. Ins-263

29. Phoslo Gelcaps

30. Calcium Di(acetate)

31. E-263

32. Ca(oac)2

33. Eliphos

34. Sanopan

35. Ccris 4921

36. Hsdb 928

37. Einecs 200-540-9

38. Calcium Acetate [usp:jan]

39. Unii-y882yxf34x

40. Ai3-02903

41. Calcium Acetate Salt

42. Phoslo (tn)

43. Calcium Acetate, Fcc

44. Calcium Acetate (usp)

45. Ec 200-540-9

46. Calcium Acetate 23% 10m

47. Schembl23872

48. Calcium Acetate [ii]

49. Calcium Acetate [mi]

50. Calcium Acetate [fcc]

51. Calcium Acetate [fhfi]

52. Calcium Acetate [hsdb]

53. Calcium Acetate [inci]

54. Calcarea Acetica [hpus]

55. Calcium Acetate [vandf]

56. Calcium Acetate [mart.]

57. Chembl1200800

58. Dtxsid0020234

59. Calcium Acetate [usp-rs]

60. Calcium Acetate [who-dd]

61. Calcium Acetate (fragrance Grade)

62. Amy23411

63. Mfcd00012448

64. Calcium Acetate [orange Book]

65. Akos015904560

66. Calcium Acetate [ep Monograph]

67. Calcium Acetate [usp Monograph]

68. Db00258

69. E263

70. Ft-0623376

71. Ft-0623377

72. D00931

73. Calcium Acetate, Anhydrous [ep Impurity]

74. Cis,cis-1,3,5-cyclohexanetricarboxylicacid

75. Q409251

76. Calcium Diacetate, Cac - Acetic Acid, Calcium Salt

77. J-519530

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 158.17 g/mol
Molecular Formula C4H6CaO4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass157.9891995 g/mol
Monoisotopic Mass157.9891995 g/mol
Topological Polar Surface Area80.3 Ų
Heavy Atom Count9
Formal Charge0
Complexity25.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 6  
Drug NameCalcium acetate
PubMed HealthCalcium Acetate (By mouth)
Drug ClassesCalcium Supplement, Phosphate Binder
Drug LabelEach white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
Active IngredientCalcium acetate
Dosage FormTablet; Capsule
RouteOral
Strengtheq 169mg calcium
Market StatusPrescription
CompanyAmneal Pharms; Paddock; Invagen Pharms; Roxane

2 of 6  
Drug NamePhoslo gelcaps
Active IngredientCalcium acetate
Dosage FormCapsule
RouteOral
Strengtheq 169mg calcium
Market StatusPrescription
CompanyFresenius Medcl

3 of 6  
Drug NameProcalamine
Active Ingredientcalcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
Dosage FormInjectable
RouteInjection
Strength200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
Market StatusPrescription
CompanyB Braun

4 of 6  
Drug NameCalcium acetate
PubMed HealthCalcium Acetate (By mouth)
Drug ClassesCalcium Supplement, Phosphate Binder
Drug LabelEach white, round tablet (stamped CYP910) contains 667 mg calcium acetate, USP (anhydrous; Ca(CH3COO)2; MW=158.17 grams) equal to 169 mg (8.45 mEq) calcium, polyethylene glycol 8000 NF; sodium lauryl sulfate, NF; and crospovidone, NF. ELIPHOS...
Active IngredientCalcium acetate
Dosage FormTablet; Capsule
RouteOral
Strengtheq 169mg calcium
Market StatusPrescription
CompanyAmneal Pharms; Paddock; Invagen Pharms; Roxane

5 of 6  
Drug NamePhoslo gelcaps
Active IngredientCalcium acetate
Dosage FormCapsule
RouteOral
Strengtheq 169mg calcium
Market StatusPrescription
CompanyFresenius Medcl

6 of 6  
Drug NameProcalamine
Active Ingredientcalcium acetate; sodium chloride; magnesium acetate; sodium acetate; phosphoric acid; glycerin; potassium chloride; Amino acids
Dosage FormInjectable
RouteInjection
Strength200mg/100ml; 150mg/100ml; 26mg/100ml; 54mg/100ml; 120mg/100ml; 3gm/100ml; 41mg/100ml; 3%
Market StatusPrescription
CompanyB Braun

4.2 Therapeutic Uses

... Used to restrict phosphate absorption in patients with chronic renal failure and oxalate absorption in patients with inflammatory bowel disease.

Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon, A.G. Goodman (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill, 1996., p. 1523


Calcium acetate is indicated in patients with end-stage renal failure to lower serum phosphate concentrations. It does not promote aluminum absorption. /Included in US product labeling/

USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719


4.3 Drug Warning

Except under special circumstances, this medication /calcium acetate/ should not be used when the following medical problem exists: hypercalcemia (calcium acetate may exacerbate the condition).

USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719


Concurrent use /with digitalis glycosides/ is not recommended because calcium acetate may cause hypercalcemia, which could precipitate cardiac arrhythmias.

USP. Convention. USPDI - Drug Information for the Health Care Professional. 19th ed. Volume I.Micromedex, Inc. Englewood, CO., 1999. Content Prepared by the U.S. Pharmacopieal Convention, Inc., p. 719


4.4 Drug Indication

Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.


5.2 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


5.3 FDA Pharmacological Classification
5.3.1 Pharmacological Classes
Calcium [CS]; Cations, Divalent [CS]; Increased Coagulation Factor Activity [PE]; Blood Coagulation Factor [EPC]
5.4 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AE - Drugs for treatment of hyperkalemia and hyperphosphatemia

V03AE07 - Calcium acetate


5.5 Absorption, Distribution and Excretion

Absorption

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.


Route of Elimination

Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.


5.6 Mechanism of Action

Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.